{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:50:53Z","timestamp":1777024253179,"version":"3.51.4"},"reference-count":30,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T00:00:00Z","timestamp":1666569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>COVID-19 has caused devastating effects worldwide ever since its origin in December 2019. IL-6 is one of the chief markers used in the management of COVID-19. We conducted a longitudinal study to investigate the role of IL-6 in diagnosis, treatment, and prognosis of COVID-19-related cytokine storm. Patients with COVID-19 who were admitted at AIIMS Rishikesh from March to December 2020 were included in the study. Patients with no baseline IL-6 value at admission and for whom clinical data were not available were excluded. Clinical and laboratory data of these patients were collected from the e-hospital portal and entered in an excel sheet. Correlation was seen with other inflammatory markers and outcomes were assessed using MS Excel 2010 and SPSS software. A total of 131 patients were included in the study. Of these, 74.8% were males, with mean age 55.03 \u00b1 13.57 years, and mean duration from symptom onset being 6.69 \u00b1 6.3 days. A total of 82.4% had WHO severe category COVID-19, with 46.56% having severe hypoxia at presentation and 61.8% of them having some comorbidity. Spearman rank correlation coefficient of IL-6 with D-dimer was 0.203, with LDH was \u22120.005, with ferritin was 0.3, and with uric acid was 0.123. A total of 11 patients received Tocilizumab at a mean duration from symptom onset of 18.09 days, and 100% mortality was observed. Deaths were reported more in the group with IL-6 \u2265 40 pg\/mL (57.1% vs. 40.2%, p = 0.06). ICU admissions and ventilator requirement were higher in the IL-6 \u2265 40 pg\/mL group (95.9% vs. 91.4%, p = 0.32 and 55.1% vs. 37.8%, p = 0.05). The study showed that IL-6 can be used as a possible \u201cthrombotic cytokine marker\u201d. Higher values of IL-6 (\u226540 pg\/mL) are associated with more deaths, ICU admissions, and ventilator requirement.<\/jats:p>","DOI":"10.3390\/vaccines10111786","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T11:53:55Z","timestamp":1666612435000},"page":"1786","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Utility of IL-6 in the Diagnosis, Treatment and Prognosis of COVID-19 Patients: A Longitudinal Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-8296","authenticated-orcid":false,"given":"Vikram","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (ID Division), AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3778-3518","authenticated-orcid":false,"given":"Pratap","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (ID Division), AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3008-7245","authenticated-orcid":false,"given":"Prasan Kumar","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (ID Division), AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (ID Division), AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karanvir","family":"Kaushal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anissa A.","family":"Mirza","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Raina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (ID Division), AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7838-9875","authenticated-orcid":false,"given":"Sarama","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balram J.","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivekanandhan","family":"Subbiah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, AIIMS Rishikesh, Rishikesh 249203, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/jmv.26326","article-title":"Proportion of asymptomatic coronavirus disease 2019: A systematic review and meta-analysis","volume":"93","author":"He","year":"2021","journal-title":"J. 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