{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:01:47Z","timestamp":1773788507942,"version":"3.50.1"},"reference-count":20,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2014current research IRCCS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: Coronavirus disease 2019 (COVID-19) vaccination hesitancy is a threat as COVID-19 vaccines have reduced both viral transmission and virus-associated mortality rates, particularly in high-risk subgroups. Solid organ transplant recipients (SOTRs) are particularly vulnerable, as the underlying causes of their organ failure and the chronic immunosuppression are associated with a lower immune response to COVID-19 vaccines, and with an excessive risk of death due to SARS-CoV-2 infection. We aimed to evaluate COVID-19 vaccination hesitancy and its reasons in a population of SOTRs. Methods: All the SOTRs attending our post-transplant clinics were asked to fill in a vaccination status form with specific validated questions related to their willingness to receive a third vaccine dose. In the case of negative answers, the patients were encouraged to explain the reasons for their refusal. Among the SOTRs (1899), 1019 were investigated (53.7%). Results: Overall, 5.01% (51\/1019) of the SOTRs raised concerns regarding the future third dose vaccination. In more detail, hesitancy rates were 3.3% (15\/453), 4.2% (7\/166), and 7.3% (29\/400) among the investigated liver, lung, and kidney transplant recipients, respectively (p = 0.0018). The main reasons for hesitancy were fear of adverse events (30\/51, 58.8%) and perceived lack of efficacy (21\/51, 41.2%). Conclusions: Full adherence to ongoing or future vaccination campaigns is crucial to prevent, or at least reduce, COVID-19-related morbidity and mortality in fragile patients. The identification of the reasons influencing COVID-19 vaccination hesitancy in these patients is very important to establish appropriate and targeted patient\u2013doctor communication strategies, and to further implement specific vaccination campaigns.<\/jats:p>","DOI":"10.3390\/vaccines10111899","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T19:17:34Z","timestamp":1668107854000},"page":"1899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4345-6051","authenticated-orcid":false,"given":"Andrea","family":"Costantino","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Endoscopy, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20214 Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 Degli Studi di Milano, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-6471","authenticated-orcid":false,"given":"Letizia","family":"Morlacchi","sequence":"additional","affiliation":[{"name":"Respiratory Unit and Adult Cystic Fibrosis Center, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Francesca","family":"Donato","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gramegna","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 Degli Studi di Milano, 20124 Milan, Italy"},{"name":"Respiratory Unit and Adult Cystic Fibrosis Center, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Farina","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Dibenedetto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariarosaria","family":"Campise","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Transplantation, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Redaelli","sequence":"additional","affiliation":[{"name":"Kidney Transplantation, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-4122","authenticated-orcid":false,"given":"Marta","family":"Perego","sequence":"additional","affiliation":[{"name":"Kidney Transplantation, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Transplantation, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy"},{"name":"Department of Clinical Sciences and Community Health, Universit\u00e0 Degli Studi di Milano, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 Degli Studi di Milano, 20124 Milan, Italy"},{"name":"Respiratory Unit and Adult Cystic Fibrosis Center, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-7476","authenticated-orcid":false,"given":"Pietro","family":"Lampertico","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"},{"name":"CRC \u201cA. M. and A. Migliavacca\u201d Center for Liver Disease, Department of Pathophysiology and Transplantation, Universit\u00e0 Degli Studi di Milano, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6465-428X","authenticated-orcid":false,"given":"Evaldo","family":"Favi","sequence":"additional","affiliation":[{"name":"Kidney Transplantation, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy"},{"name":"Department of Clinical Sciences and Community Health, Universit\u00e0 Degli Studi di Milano, 20124 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-021-00592-1","article-title":"Progress of the COVID-19 vaccine effort: Viruses, vaccines and variants versus efficacy, effectiveness and escape","volume":"21","author":"Tregoning","year":"2021","journal-title":"Nat. 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