{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:06:43Z","timestamp":1769306803868,"version":"3.49.0"},"reference-count":23,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Monkeypox infection is an emerging problem and a new challenge for modern medicine. With an increasing number of new cases worldwide, new data regarding the clinical manifestations, characteristics of the patients, risk factors and treatment options are coming to light. Knowing more about the disease will allow to elaborate new helpful methods to facilitate its diagnosis. Special attention should be paid to the careful dermatologic and dermoscopic examination of the patient. The analysis of available data also suggests possible strategies for the prevention of Monkeypox virus spread; the vaccine against Smallpox seems to be an effective solution. This case report describes the diagnostic approach and management of a non-vaccinated adult patient with several risk factors and a history of sexually transmitted disease. The patient had no history of travel abroad. Even though a clinical diagnose of Monkeypox can be challenging due to its similarities with skin rashes caused by other Orthopoxviral infections, there are fine differences between the rashes which can be helpful in their differentiation, although laboratory analysis is required for a definitive identification. A careful study of the characteristics of the rash, such as diameter, its presence on palms and soles and its evolution in time, provided important clues for the diagnosis of Monkeypox infection. The lack of vaccinations in the history of the patient was another crucial finding in the diagnostic process.<\/jats:p>","DOI":"10.3390\/vaccines10111903","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T19:17:34Z","timestamp":1668107854000},"page":"1903","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Case Report of Monkeypox in an Adult Patient from Italy: Clinical and Dermoscopic Manifestations, Diagnosis and Management"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3795-3190","authenticated-orcid":false,"given":"Ilaria","family":"Proietti","sequence":"first","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-088X","authenticated-orcid":false,"given":"Paolo Emilio","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Health Science and Public Health, Catholic University of the Sacred Heart, 00168 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4478-5404","authenticated-orcid":false,"given":"Nevena","family":"Skroza","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Tieghi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Public Health and Organs of Sense, Infectious Diseases Unit, Sapienza University of Rome, Santa Maria Goretti Hospital, 04100 Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersilia","family":"Tolino","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka Ewa","family":"Dybala","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Di Guardo","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Rallo","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Di Fraia","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-7864","authenticated-orcid":false,"given":"Maria Francesca","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Health Science and Public Health, Catholic University of the Sacred Heart, 00168 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Vitiello","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2568-3966","authenticated-orcid":false,"given":"Umberto","family":"Moscato","sequence":"additional","affiliation":[{"name":"Department of Health Science and Public Health, Catholic University of the Sacred Heart, 00168 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Lichtner","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Public Health and Organs of Sense, Infectious Diseases Unit, Sapienza University of Rome, Santa Maria Goretti Hospital, 04100 Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Potenza","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Biotechnologies, Dermatology Unit \u201cDaniele Innocenzi\u201d, Sapienza University of Rome, Polo Pontino, Fiorini Hospital, 04019 Terracina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1473-3099(03)00856-9","article-title":"Human monkeypox: An emerging zoonosis","volume":"4","author":"Eckburg","year":"2004","journal-title":"Lancet Infect. 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