{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:15:12Z","timestamp":1784250912546,"version":"3.55.0"},"reference-count":17,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH-2022-C-013"],"award-info":[{"award-number":["FEMH-2022-C-013"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been used worldwide to control the coronavirus disease pandemic. However, several adverse effects have been reported following vaccination. Therefore, further research on the adverse effects in individuals predisposed to life-threatening conditions is needed. Herein, we present a 39-year-old woman without any systemic disease who developed fulminant type 1 diabetes mellitus (T1DM) (low glycohemoglobin levels, despite hyperglycemia and diabetic ketoacidosis (DKA)) following SARS-CoV-2 vaccination. The patient was initially misdiagnosed as having fresh type 2 diabetes mellitus after the first episode of DKA, which was resolved by short-term insulin therapy and treated with oral anti-diabetic agents after the DKA was resolved. This made her develop a second episode of DKA shortly after treatment. The course and presentation of our case are noteworthy for alerting clinicians to vaccine-related fulminant T1DM.<\/jats:p>","DOI":"10.3390\/vaccines10111905","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T02:33:10Z","timestamp":1668393190000},"page":"1905","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Fulminant Type 1 Diabetes Mellitus after SARS-CoV-2 Vaccination: A Case Report"],"prefix":"10.3390","volume":"10","author":[{"given":"Rong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of General Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-0750","authenticated-orcid":false,"given":"Yu-Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Education, Division of General Practice, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-5560","authenticated-orcid":false,"given":"Mei-Hsiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Biomedical Engineering, Ming Chuang University, Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ecl.2010.05.011","article-title":"Epidemiology of type 1 diabetes","volume":"39","author":"Maahs","year":"2010","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/jdi.13638","article-title":"Prevalence and clinical characteristics of fulminant type 1 diabetes mellitus in Korean adults: A multi-institutional joint research","volume":"13","author":"Song","year":"2022","journal-title":"J. Diabetes Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2169\/internalmedicine.9004-21","article-title":"New-onset Type 1 diabetes after COVID-19 mRNA vaccination","volume":"61","author":"Yano","year":"2022","journal-title":"Intern. 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Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12020-022-03130-8","article-title":"Type 1 diabetes mellitus following SARS-CoV-2 mRNA vaccination","volume":"78","author":"Cesur","year":"2022","journal-title":"Endocrine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101412","DOI":"10.1016\/j.beem.2020.101412","article-title":"ASIA syndrome and endocrine autoimmune disorders","volume":"34","author":"Bragazzi","year":"2020","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1056\/NEJM200002033420501","article-title":"A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group","volume":"342","author":"Imagawa","year":"2000","journal-title":"N. Engl. J. 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Vaccin Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"108665","DOI":"10.1016\/j.clim.2021.108665","article-title":"Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? In reply to \u201cpotential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases\u201d","volume":"224","author":"Talotta","year":"2021","journal-title":"Clin Immunol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12020-022-03119-3","article-title":"Influence of COVID-19 vaccines on endocrine system","volume":"78","author":"Zhao","year":"2022","journal-title":"Endocrine"}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/11\/1905\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:14:25Z","timestamp":1760145265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/10\/11\/1905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,11]]},"references-count":17,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["vaccines10111905"],"URL":"https:\/\/doi.org\/10.3390\/vaccines10111905","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,11]]}}}