{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:39:43Z","timestamp":1789616383104,"version":"build-2803163510"},"reference-count":21,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: Monkeypox is a global public health concern, given the recent outbreaks in non-endemic countries where little scientific evidence exists on the disease. Specifically, there is a lack of data on asymptomatic monkeypox virus infection. This study aims to evaluate the overall prevalence of asymptomatic monkeypox virus infection. Methods: In this systematic review and meta-analysis, we performed an extensive literature search in PubMed, Scopus, Web of Science, ProQuest, EMBASE, EBSCOHost, Cochrane, and preprint servers (medRxiv, arXiv, bioRxiv, BioRN, ChiRxiv, ChiRN, and SSRN) and assessed all published articles till September 2022. Primary studies reporting monkeypox infections among asymptomatic participants were included after quality assessment. The characteristics of the study and information on the number of cases and symptomatic status were extracted from the included studies. The heterogeneity between studies was assessed using the I2 statistic. Publication bias was analyzed using funnel plots and Egger regression tests. The primary outcome was the pooled prevalence of asymptomatic infections within the examined population. Results: A total of 16 studies were included for qualitative synthesis, while five studies, including 645 individuals, were included for quantitative synthesis. There was substantial heterogeneity between studies (I2 = 94.86%; p &lt; 0.01), with a pooled percentage of asymptomatic infections in the studied population of 10.2% (95%CI, 2.5\u201317.9%). Conclusion: This meta-analysis suggests that many people infected with the monkeypox virus are asymptomatic and difficult to detect. Therefore, prompt detection of these cases of monkeypox virus and appropriate subsequent management is of utmost importance to global public health.<\/jats:p>","DOI":"10.3390\/vaccines10122083","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T02:49:35Z","timestamp":1670381375000},"page":"2083","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Potentially Asymptomatic Infection of Monkeypox Virus: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7614-8587","authenticated-orcid":false,"given":"Prakasini","family":"Satapathy","sequence":"first","affiliation":[{"name":"Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1442-5299","authenticated-orcid":false,"given":"Parimala","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Institute of Medical Sciences, SUM Hospital, Siksha \u2018O\u2019 Anusandhan Deemed to be University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-2061","authenticated-orcid":false,"given":"Subhanwita","family":"Manna","sequence":"additional","affiliation":[{"name":"Indian Institute of Public Health, Delhi 122002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3418-8171","authenticated-orcid":false,"given":"Muhammad","family":"Shamim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur 342005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Rao","sequence":"additional","affiliation":[{"name":"Indian Institute of Public Health, Gandhinagar 382042, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9058-4278","authenticated-orcid":false,"given":"Jagdish","family":"Khubchandani","sequence":"additional","affiliation":[{"name":"Department of Public Health, New Mexico State University, Las Cruces, NM 88003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aroop","family":"Mohanty","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, Gorakhpur 273008, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5586-4282","authenticated-orcid":false,"given":"Behdin","family":"Nowrouzi-Kia","sequence":"additional","affiliation":[{"name":"ReSTORE Lab, Department of Occupational Science & Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9840-8335","authenticated-orcid":false,"given":"Vijay","family":"Chattu","sequence":"additional","affiliation":[{"name":"ReSTORE Lab, Department of Occupational Science & Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada"},{"name":"Center for Transdisciplinary Research, Saveetha Dental College, Saveetha Institute of Medical and Technological Sciences, Saveetha University, Chennai 602105, India"},{"name":"Department of Community Medicine, Faculty of Medicine, Datta Meghe Institute of Medical Sciences, Wardha 442107, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-2375","authenticated-orcid":false,"given":"Bijaya","family":"Padhi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-2192","authenticated-orcid":false,"given":"Alfonso","family":"Rodriguez-Morales","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Biomedicina, Faculty of Medicine, Fundacion Universitaria Autonoma de las Americas\u2014Institucion Universitaria Vision de las Americas, Pereira 660003, Risaralda, Colombia"},{"name":"Master of Clinical Epidemiology and Biostatistics, Universidad Cientifica del Sur, Lima 15024, Peru"},{"name":"Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut P.O. Box 36, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-8714","authenticated-orcid":false,"given":"Ranjit","family":"Sah","sequence":"additional","affiliation":[{"name":"Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu 44600, Nepal"},{"name":"Department of Global Health and Clinical Research, Harvard Medical School, Boston, MA 02115, USA"},{"name":"Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune 411018, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/23779497.2022.2124185","article-title":"Public Health Emergency of International Concern declared by the World Health Organization for Monkeypox","volume":"7","author":"Sah","year":"2022","journal-title":"Glob. Secur. Health Sci. 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