{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:17:37Z","timestamp":1785151057523,"version":"3.55.0"},"reference-count":77,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>The ongoing monkeypox (MPX) outbreak has been declared a public health emergency of international concern. People in close contact with active MPX cases, including healthcare workers (HCWs), are at higher risk of virus acquisition since the MPX virus can be transmitted by skin contact or respiratory secretions. In this study, we aimed to assess the psychological antecedents of MPX vaccination among Nigerian HCWs using the 5C scale. We used an anonymous online cross-sectional survey to recruit potential participants using snowball sampling. The questionnaire aimed to assess the geo\/socioeconomic features and the 5C psychological antecedents of vaccine acceptance (confidence, complacency, constraints, calculation, and collective responsibility). A total of 389 responses were included, with a median age of 37 years (IQR: 28\u201348), 55.5% males, and 60.7% married participants. Among the studied Nigerian HCWs, only 31.1% showed confidence in MPX vaccination, 58.4% expressed complacency towards vaccination, 63.8% perceived constraints towards MPX vaccination, 27.2% calculated the benefits and risks of vaccination, and 39.2% agreed to receive MPX vaccination to protect others. The determinants of MPX vaccine confidence were being single (OR = 5.07, 95% CI: 1.26\u201320.34, p = 0.022), a higher education level (with pre-college\/high school as a reference, professional\/technical: OR = 4.12, 95% CI: 1.57\u201310.73, p = 0.004, undergraduate: OR = 2.94, 95% CI: 1.32\u20136.55, p = 0.008, and postgraduate degree (OR = 3.48, 95% CI: 1.51\u20138.04, p = 0.003), and absence of chronic disease (OR = 2.57, 95% CI: 1.27\u20135.22, p = 0.009). The significant complacency predictors were having a middle-income (OR = 0.53, 95% CI: 0.33\u20130.89, p = 0.008), having a bachelor\u2019s degree (OR = 2.37, 95% CI: 1.10\u20135.11, p = 0.027), and knowledge of someone who died due to MPX (OR = 0.20, 95% CI: 0.05\u20130.93, p = 0.040). Income was associated with perceived vaccination constraints (OR = 0.62, 95% CI: 0.39\u20130.99, p = 0.046). Participants aged 46\u201360 years had decreased odds in the calculation domain (OR = 0.52, 95% CI: 0.27\u20130.98, p = 0.044). Middle-income and bachelor degree\/postgraduate education significantly influenced the collective responsibility domain (OR = 2.10, 95% CI: 1.19\u20133.69, p = 0.010; OR = 4.17, 95% CI: 1.85\u20139.38, p &lt; 0.001; and OR = 3.45, 95% CI: 1.50\u20137.90, p = 0.003, respectively). An investigation of the 5C pattern-based psychological antecedents of MPX vaccination in a sample of Nigerian HCWs revealed low levels of vaccine confidence and collective responsibility with high levels of constraints and complacency. These psychological factors are recommended to be considered in any efforts aiming to promote MPX vaccination needed in a country where MPX is endemic.<\/jats:p>","DOI":"10.3390\/vaccines10122151","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T03:43:49Z","timestamp":1671075829000},"page":"2151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Psychological Antecedents of Healthcare Workers towards Monkeypox Vaccination in Nigeria"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-706X","authenticated-orcid":false,"given":"Ramy Mohamed","family":"Ghazy","sequence":"first","affiliation":[{"name":"Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria 21561, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-7817","authenticated-orcid":false,"given":"Debra Ukamaka","family":"Okeh","sequence":"additional","affiliation":[{"name":"Epidemiology and Surveillance Unit, Caritas Nigeria, Abuja 900104, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-9670","authenticated-orcid":false,"given":"Malik","family":"Sallam","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, Jordan"},{"name":"Department of Clinical Laboratories and Forensic Medicine, Jordan University Hospital, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Hussein","sequence":"additional","affiliation":[{"name":"Clinical Research Administration, Alexandria Directorate of Health Affairs, Egyptian Ministry of Health and Population, Alexandria 21554, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-2165","authenticated-orcid":false,"given":"Horeya M.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, High Institute of Public Health, Alexandria University, Alexandria 21561, Egypt"},{"name":"Department of Biostatistics, Prime for Integrated Research Solutions, Alexandria 21561, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-8709","authenticated-orcid":false,"given":"Saja","family":"Yazbek","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Lebanese University, Beirut 6573, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Mahboob","sequence":"additional","affiliation":[{"name":"Occupational Health and Industrial Medicine Department, High Institute of Public Health, Alexandria University, Alexandria 21561, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-2780","authenticated-orcid":false,"given":"Samar","family":"Abd ElHafeez","sequence":"additional","affiliation":[{"name":"Epidemiology Department, High Institute of Public Health, Alexandria University, Alexandria 21561, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Harapan, H., Ophinni, Y., Megawati, D., Frediansyah, A., Mamada, S.S., Salampe, M., Bin Emran, T., Winardi, W., Fathima, R., and Sirinam, S. 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