{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:13:44Z","timestamp":1772990024772,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yonsei University College of Medicine","award":["6-2021-0145"],"award-info":[{"award-number":["6-2021-0145"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Live immunization is contraindicated in patients with DiGeorge syndrome (DGS). We retrospectively investigated the occurrence of adverse events after live immunization in patients with DGS in Korea. The data of patients matching the International Classification of Disease-10 code of DGS (D82.1) at Severance Hospital Seoul, Korea, were extracted; patients without genetically diagnosed DGS were excluded. Based on T cell immunity status, the included patients were categorized into group A (CD3 &lt; 500 or CD8 &lt; 200 cells\/mm3); group B (CD3 \u2265 500 and CD8 \u2265 200 cells\/mm3); or group C (unknown). Among 94 patients, 38 (~40%, group A: 8 [21%]; group B: 30 [79%]) underwent immunological testing and 73 (~80%) received at least one live immunization (measles\u2013mumps\u2013rubella vaccination was most common [66\/94, ~70%]). Fifty adverse events (fever [n = 29], upper respiratory infection [n = 9], diarrhea [n = 4], rash [n = 3], thrombocytopenia [n = 3], injection site pus [n = 1], and febrile convulsion [n = 1]) were observed; 13 (26%) occurred in group A, with no significant difference in incidence between groups A and B. Serious adverse events, including intensive care unit hospitalization or death, or diseases due to vaccine strains were not observed. In this study, live immunization was well tolerated by patients with partial DGS.<\/jats:p>","DOI":"10.3390\/vaccines10122165","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T06:24:44Z","timestamp":1671431084000},"page":"2165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety of Live Immunization in DiGeorge Syndrome: A Retrospective Single-Center Study in Korea, 2005\u20132021"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5208-5892","authenticated-orcid":false,"given":"Sung Min","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Severance Children\u2019s Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Hee","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Severance Children\u2019s Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6674-8618","authenticated-orcid":false,"given":"Jee Yeon","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Severance Children\u2019s Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Severance Children\u2019s Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Man","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Severance Children\u2019s Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5748-0015","authenticated-orcid":false,"given":"Jong Gyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Severance Children\u2019s Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"},{"name":"Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0140-6736(07)61601-8","article-title":"Velocardiofacial syndrome, DiGeorge syndrome: The chromosome 22q11.2 deletion syndromes","volume":"370","author":"Kobrynski","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jpeds.2021.07.020","article-title":"Clinical Features in a Large Cohort of Patients With 22q11.2 Deletion Syndrome","volume":"238","author":"Nissan","year":"2021","journal-title":"J. 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