{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:40:53Z","timestamp":1769193653679,"version":"3.49.0"},"reference-count":12,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Since May 2022, the monkeypox (MPX) virus has represented an emerging issue due to outbreaks in non-endemic areas. This report presents the first case of paraphimosis caused by an MPX infection during the outbreak. The patient accessed the emergency department for a sudden onset of swelling of the penis and paraphimosis caused by MPX lesions that brought about stenosis of the foreskin. He therefore underwent a dorsal slit procedure with resolution. No antiviral therapy was required. A multidisciplinary approach should be preferred for the management of MPX, due to the possibility of uncommon and disseminated presentations.<\/jats:p>","DOI":"10.3390\/vaccines11010063","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T08:38:19Z","timestamp":1672216699000},"page":"63","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["First Case of Paraphimosis as a Severe Complication of Monkeypox"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-223X","authenticated-orcid":false,"given":"Eugenio","family":"Milano","sequence":"first","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Belati","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"De Santis","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Tanese","sequence":"additional","affiliation":[{"name":"Urology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Vavallo","sequence":"additional","affiliation":[{"name":"Urology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Dachille","sequence":"additional","affiliation":[{"name":"Urology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-9745","authenticated-orcid":false,"given":"Daniela","family":"Loconsole","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine\u2014Hygiene Section, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4833-7118","authenticated-orcid":false,"given":"Davide Fiore","family":"Bavaro","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3453-5647","authenticated-orcid":false,"given":"Francesco","family":"Di Gennaro","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-1256","authenticated-orcid":false,"given":"Maria","family":"Chironna","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Medicine\u2014Hygiene Section, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Ditonno","sequence":"additional","affiliation":[{"name":"Urology, Andrology and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Saracino","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Di Gennaro, F., Veronese, N., Marotta, C., Shin, J.I., Koyanagi, A., Silenzi, A., Antunes, M., Saracino, A., Bavaro, D.F., and Soysal, P. (2022). Human Monkeypox: A Comprehensive Narrative Review and Analysis of the Public Health Implications. Microorganisms, 10.","DOI":"10.3390\/microorganisms10081633"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1699-0463.1959.tb00328.x","article-title":"A pox-like disease in cynomolgus monkeys","volume":"46","author":"Magnus","year":"1959","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"306","DOI":"10.15585\/mmwr.mm6710a5","article-title":"Emergence of Monkeypox-West and Central Africa, 1970\u20132017","volume":"67","author":"Durski","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Bunge, E.M., Hoet, B., Chen, L., Lienert, F., Weidenthaler, H., Baer, L.R., and Steffen, R. (2022). The changing epidemiology of human monkeypox-A potential threat? A systematic review. PLoS Negl. Trop. Dis., 16.","DOI":"10.1371\/journal.pntd.0010141"},{"key":"ref_5","unstructured":"World Health Organization (2022, November 01). Second Meeting of the International Health Regulations (2005) (IHR) Emergency Committee Regarding the Multi-Country Outbreak of Monkeypox, Available online: www.who.int\/news\/item\/23-07-2022-second-meeting-of-the-international-health-regulations."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jviromet.2010.07.012","article-title":"Real-time PCR assays for the specific detection of monkeypox virus West African and Congo Basin strain DNA","volume":"169","author":"Li","year":"2010","journal-title":"J. Virol. Methods"},{"key":"ref_7","unstructured":"Centre for Disease Prevention and Control (2021). Sexually Transmitted Infections Treatment Guidelines."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Su\u00f1er, C., Ubals, M., Tar\u00edn-Vicente, E.J., Mendoza, A., Alemany, A., Hern\u00e1ndez-Rodr\u00edguez, \u00c1., Casa\u00f1, C., Descalzo, V., Ouchi, D., and Marc, A. (Lancet Infect. Dis., 2022). Viral dynamics in patients with monkeypox infection: A prospective cohort study in Spain, Lancet Infect. Dis., in press.","DOI":"10.2139\/ssrn.4248017"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rodriguez-Morales, A.J., and Lopardo, G. (2022). Monkeypox: Another Sexually Transmitted Infection?. Pathogens, 11.","DOI":"10.3390\/pathogens11070713"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1056\/NEJMoa2207323","article-title":"Monkeypox Virus Infection in Humans across 16 Countries-April-June 2022","volume":"387","author":"Thornhill","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.eururo.2022.08.034","article-title":"Genitourinary Lesions Due to Monkeypox","volume":"82","year":"2022","journal-title":"Eur. Urol."},{"key":"ref_12","unstructured":"(2022, November 01). Centers for Disease Control and Prevention, Available online: https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/clinicians\/treatment.html#anchor_1655488137245."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/1\/63\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:53:22Z","timestamp":1760147602000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/1\/63"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,28]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["vaccines11010063"],"URL":"https:\/\/doi.org\/10.3390\/vaccines11010063","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,28]]}}}