{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:40:28Z","timestamp":1791646828530,"version":"4.3.4"},"reference-count":68,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is an inflammatory skin disease whose pathogenesis remains poorly defined. Over the past decades, the bacterial role in HS patients has been a focus of research. According to the literature, the HS skin (and probably gut) bacterial composition is different to that of healthy controls. To date, a key question is whether compositional changes in the microbial populations are responsible for the development of HS (primum movens), or only secondarily reflect the ongoing inflammatory process. The great diversity of methodologies that have been used to study microbial role in HS have led to an accumulation of conflicting results. Thus, in view of these considerations, the aim of this article is to provide the reader with an overview about different hypotheses proposed to explain the bacterial role in HS pathogenesis.<\/jats:p>","DOI":"10.3390\/vaccines11010179","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T02:29:55Z","timestamp":1673836195000},"page":"179","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Consistency of Bacterial Triggers in the Pathogenesis of Hidradenitis Suppurativa"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4227-7847","authenticated-orcid":false,"given":"Elia","family":"Rosi","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, University of Florence, 50125 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prisca","family":"Guerra","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, University of Florence, 50125 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Silvi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, University of Florence, 50125 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Nunziati","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, University of Florence, 50125 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Scandagli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, University of Florence, 50125 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Di Cesare","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, University of Florence, 50125 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-2045","authenticated-orcid":false,"given":"Francesca","family":"Prignano","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, University of Florence, 50125 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rosi, E., Fastame, M.T., Scandagli, I., Di Cesare, A., Ricceri, F., Pimpinelli, N., and Prignano, F. (2021). Insights into the Pathogenesis of HS and Therapeutical Approaches. Biomedicines, 9.","DOI":"10.3390\/biomedicines9091168"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jid.2018.09.036","article-title":"Are Bacteria Infectious Pathogens in Hidradenitis Suppurativa? Debate at the Symposium for Hidradenitis Suppurativa Advances Meeting, November 2017","volume":"139","author":"Naik","year":"2019","journal-title":"J. Invest. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Coates, M., Mariottoni, P., Corcoran, D.L., Kirshner, H.F., Jaleel, T., Brown, D.A., Brooks, S.R., Murray, J., Morasso, M.I., and MacLeod, A.S. (2019). The Skin Transcriptome in Hidradenitis Suppurativa Uncovers an Antimicrobial and Sweat Gland Gene Signature Which Has Distinct Overlap with Wounded Skin. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0216249"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/ced.13959","article-title":"Transcriptome Patterns in Hidradenitis Suppurativa: Support for the Role of Antimicrobial Peptides and Interferon Pathways in Disease Pathogenesis","volume":"44","author":"Shanmugam","year":"2019","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"960488","DOI":"10.3389\/fimmu.2022.960488","article-title":"Innate Immunity and Microbial Dysbiosis in Hidradenitis Suppurativa\u2014Vicious Cycle of Chronic Inflammation","volume":"13","author":"Chopra","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/exd.14141","article-title":"A Systematic Review and Critical Appraisal of Metagenomic and Culture Studies in Hidradenitis Suppurativa","volume":"30","author":"Williams","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/exd.12793","article-title":"The Bacteriology of Hidradenitis Suppurativa: A Systematic Review","volume":"24","author":"Ring","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/j.jaad.2015.07.041","article-title":"Bacteriology of Hidradenitis Suppurativa\/Acne Inversa: A Review","volume":"73","author":"Nikolakis","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.det.2015.08.010","article-title":"The Microbiology of Hidradenitis Suppurativa","volume":"34","author":"Ring","year":"2016","journal-title":"Dermatol. Clin."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13555-020-00465-w","article-title":"The Microbiome in Hidradenitis Suppurativa: A Review","volume":"11","author":"Wark","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1111\/exd.14398","article-title":"Yin and Yang: A Disrupted Skin Microbiome and an Aberrant Host Immune Response in Hidradenitis Suppurativa","volume":"30","author":"Schell","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s40257-022-00724-w","article-title":"The Skin and Gut Microbiome in Hidradenitis Suppurativa: Current Understanding and Future Considerations for Research and Treatment","volume":"23","author":"Luck","year":"2022","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mintoff, D., Borg, I., and Pace, N.P. (2021). The Clinical Relevance off the Microbiome in Hidradenitis Suppurativa: A Systematic Review. Vaccines, 9.","DOI":"10.3390\/vaccines9101076"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1001\/archderm.1988.01670070035015","article-title":"Bacteriology and Antibiotic Treatment of Perineal Suppurative Hidradenitis","volume":"124","author":"Highet","year":"1988","journal-title":"Arch. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000246246","article-title":"The Bacteriology of Hidradenitis Suppurativa","volume":"193","author":"Jemec","year":"1996","journal-title":"Dermatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000504537","article-title":"Staphylococcus Aureus Carriage Status in Patients with Hidradenitis Suppurativa: An Observational Cohort Study in a Tertiary Referral Hospital in Athens, Greece","volume":"236","author":"Katoulis","year":"2020","journal-title":"Dermatology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/bjd.18962","article-title":"Cross-Sectional Study Identifies Lower Risk of Staphylococcus Aureus Nasal Colonization in Danish Blood Donors with Hidradenitis Suppurativa Symptoms","volume":"183","author":"Dinh","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1159\/000512617","article-title":"Staphylococcus Aureus Carriage in Hidradenitis Suppurativa: Impact on Response to Adalimumab","volume":"237","author":"Stergianou","year":"2021","journal-title":"Dermatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jid.2021.07.168","article-title":"The Temporal Evolution of Distinct Skin Surface Microbiome in Asian Patients with Severe Hidradenitis Suppurativa during Effective Adalimumab Treatment","volume":"142","author":"Hsu","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10096-020-04002-7","article-title":"Irrelevance of Panton-Valentine Leukocidin in Hidradenitis Suppurativa: Results from a Pilot, Observational Study","volume":"40","author":"Corazza","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e140598","DOI":"10.1172\/jci.insight.140598","article-title":"Dysregulation of Tryptophan Catabolism at the Host-Skin Microbiota Interface in Hidradenitis Suppurativa","volume":"5","author":"Morel","year":"2020","journal-title":"JCI Insight"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1099\/00222615-48-1-103","article-title":"Aerobic and Anaerobic Microbiology of Axillary Hidradenitis Suppurativa","volume":"48","author":"Brook","year":"1999","journal-title":"J. Med. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2133.1999.02613.x","article-title":"Coagulase-Negative Staphylococci Are the Most Common Bacteria Found in Cultures from the Deep Portions of Hidradenitis Suppurativa Lesions, as Obtained by Carbon Dioxide Laser Surgery","volume":"140","author":"Lapins","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1365-2133.2011.10747.x","article-title":"Bacteriology of Hidradenitis Suppurativa Exacerbations and Deep Tissue Cultures Obtained during Carbon Dioxide Laser Treatment","volume":"166","author":"Sartorius","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2340\/00015555-1841","article-title":"Bacteriology of Hidradenitis Suppurativa\u2014Which Antibiotics Are the Treatment of Choice?","volume":"94","author":"Matusiak","year":"2014","journal-title":"Acta Derm. Venereol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000381959","article-title":"Aerobic and Anaerobic Bacteriology of Hidradenitis Suppurativa: A Study of 22 Cases","volume":"1","author":"Katoulis","year":"2015","journal-title":"Ski. Appendage Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.3201\/eid2012.140064","article-title":"Bacterial Pathogens Associated with Hidradenitis Suppurativa, France","volume":"20","author":"Jais","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/jdv.15183","article-title":"Biofilm Production and Antibiotic Susceptibility of Staphylococcus Epidermidis Strains from Hidradenitis Suppurativa Lesions","volume":"33","author":"Ardon","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1111\/jdv.15523","article-title":"Virulent Staphylococcus Lugdunensis with Limited Genetic Diversity in Hidradenitis Suppurativa Lesions","volume":"33","author":"Ardon","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2340\/00015555-2591","article-title":"Bacterial Colonization in Hidradenitis Suppurativa\/Acne Inversa: A Cross-Sectional Study of 50 Patients and Review of the Literature","volume":"97","author":"Nikolakis","year":"2017","journal-title":"Acta Derm. Venereol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.23736\/S0392-0488.18.05875-3","article-title":"Hidradenitis Suppurativa\/Acne Inversa: A Prospective Bacteriological Study and Review of the Literature","volume":"155","author":"Benzecry","year":"2020","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jid.2019.08.445","article-title":"Skin Microbiota Perturbations Are Distinct and Disease Severity-Dependent in Hidradenitis Suppurativa","volume":"140","author":"Naik","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.jid.2020.02.046","article-title":"The Surface Microbiome of Clinically Unaffected Skinfolds in Hidradenitis Suppurativa: A Cross-Sectional Culture-Based and 16S RRNA Gene Amplicon Sequencing Study in 60 Patients","volume":"140","author":"Jais","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000446812","article-title":"Microbial Profile and Antimicrobial Susceptibility of Bacteria Found in Inflammatory Hidradenitis Suppurativa Lesions","volume":"29","author":"Hessam","year":"2016","journal-title":"Ski. Pharmacol. Physiol."},{"key":"ref_35","first-page":"25","article-title":"Microbial Profile and Antibiotic Susceptibility of Bacteria Isolated from Patients with Hidradenitis Suppurativa","volume":"22","author":"Mahdi","year":"2019","journal-title":"Iran. J. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/cid\/cix285","article-title":"The Microbiological Landscape of Anaerobic Infections in Hidradenitis Suppurativa: A Prospective Metagenomic Study","volume":"65","author":"Jais","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/jdv.15597","article-title":"The Microbiome of Tunnels in Hidradenitis Suppurativa Patients","volume":"33","author":"Ring","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jamadermatol.2017.0904","article-title":"The Follicular Skin Microbiome in Patients with Hidradenitis Suppurativa and Healthy Controls","volume":"153","author":"Ring","year":"2017","journal-title":"JAMA Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jid.2019.06.151","article-title":"Loss of Skin Microbial Diversity and Alteration of Bacterial Metabolic Function in Hidradenitis Suppurativa","volume":"140","author":"Schneider","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e731","DOI":"10.1111\/jdv.18254","article-title":"Culture-Based Analyses of Skin Bacteria in Lesional Moist, and Unaffected Dry and Sebaceous Skin Regions of Hidradenitis Suppurativa Patients","volume":"36","author":"Antal","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/jdv.15332","article-title":"Rates of Antibiotic Resistance\/Sensitivity in Bacterial Cultures of Hidradenitis Suppurativa Patients","volume":"33","author":"Bettoli","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/apm.12220","article-title":"Microbiology of Hidradenitis Suppurativa (Acne Inversa): A Histological Study of 27 Patients","volume":"122","author":"Jahns","year":"2014","journal-title":"APMIS"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/bjd.14805","article-title":"Bacterial Biofilm in Acute Lesions of Hidradenitis Suppurativa","volume":"176","author":"Okoye","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/bjd.15007","article-title":"Bacterial Biofilm in Chronic Lesions of Hidradenitis Suppurativa","volume":"176","author":"Ring","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2340\/00015555-2503","article-title":"Normal Skin Microbiota Is Altered in Pre-Clinical Hidradenitis Suppurativa","volume":"97","author":"Ring","year":"2017","journal-title":"Acta Derm. Venereol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/exd.13885","article-title":"Bacterial Biofilm Is Associated with Higher Levels of Regulatory T Cells in Unaffected Hidradenitis Suppurativa Skin","volume":"28","author":"Ring","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/jdv.14538","article-title":"Moderate to Severe Hidradenitis Suppurativa Patients Do Not Have an Altered Bacterial Composition in Peripheral Blood Compared to Healthy Controls","volume":"32","author":"Ring","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00403-019-01965-2","article-title":"Identification of Bacterial DNA in the Peripheral Blood of Patients with Active Hidradenitis Suppurativa","volume":"312","author":"Murcia","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jid.2020.04.017","article-title":"Gut Microbiome Perturbations in Patients with Hidradenitis Suppurativa: A Case Series","volume":"141","author":"Kam","year":"2021","journal-title":"J. Invest. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/ecco-jcc\/jjw070","article-title":"Similar Depletion of Protective Faecalibacterium Prausnitzii in Psoriasis and Inflammatory Bowel Disease, but Not in Hidradenitis Suppurativa","volume":"10","author":"Eppinga","year":"2016","journal-title":"J. Crohns Colitis"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jdermsci.2020.12.008","article-title":"A Microbiome Study to Explore the Gut-Skin Axis in Hidradenitis Suppurativa","volume":"101","author":"Lam","year":"2021","journal-title":"J. Dermatol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jid.2021.05.036","article-title":"Altered Skin and Gut Microbiome in Hidradenitis Suppurativa","volume":"142","author":"McCarthy","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/bjd.18320","article-title":"Staphylococcus Aureus and Host Interaction in the Flare-Ups of Hidradenitis Suppurativa","volume":"181","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e580","DOI":"10.1111\/jdv.18075","article-title":"Amplicon Sequencing Demonstrates Comparable Follicular Mycobiomes in Patients with Hidradenitis Suppurativa Compared with Healthy Controls","volume":"36","author":"Ring","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/exd.14036","article-title":"Clinical, Microbiological, Immunological and Imaging Characteristics of Tunnels and Fistulas in Hidradenitis Suppurativa and Crohn\u2019s Disease","volume":"29","author":"Thomsen","year":"2020","journal-title":"Exp. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.jid.2019.11.011","article-title":"Predictive Metagenomic Analysis Reveals a Role of Cutaneous Dysbiosis in the Development of Hidradenitis Suppurativa","volume":"140","author":"Ring","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.jid.2020.02.003","article-title":"Response to Ring et al.: In Silico Predictive Metagenomic Analyses Highlight Key Metabolic Pathways Impacted in the Hidradenitis Suppurativa Skin Microbiome","volume":"140","author":"Schneider","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/ced.14838","article-title":"Probiotics in Hidradenitis Suppurativa: A Potential Treatment Option?","volume":"47","author":"Ring","year":"2022","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.anaerobe.2016.11.010","article-title":"Actinotignum Schaalii Subcutaneous Abscesses in a Patient with Hidradenitis Suppurativa: Case Report and Literature Review","volume":"43","author":"Maraki","year":"2017","journal-title":"Anaerobe"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1111\/bjd.19600","article-title":"Hidradenitis Suppurativa Associated with Actinomycosis Owing to Actinomyces Meyeri","volume":"184","author":"Bonifaz","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1574-695X.2012.00946.x","article-title":"Considering Hidradenitis Suppurativa as a Bacterial Biofilm Disease","volume":"65","author":"Kathju","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature09074","article-title":"Staphylococcus Epidermidis Esp Inhibits Staphylococcus Aureus Biofilm Formation and Nasal Colonization","volume":"465","author":"Iwase","year":"2010","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.3389\/fimmu.2020.01730","article-title":"Hidradenitis Suppurativa and 1-Carbon Metabolism: Role of Gut Microbiome, Matrix Metalloproteinases, and Hyperhomocysteinemia","volume":"11","author":"Molnar","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.jid.2020.03.946","article-title":"Standardizing Hidradenitis Suppurativa Skin Microbiome Research: The Methods Matter","volume":"140","author":"Naik","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Langan, E.A., Recke, A., Bokor-Billmann, T., Billmann, F., Kahle, B.K., and Zillikens, D. (2020). The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa-Light at the End of the Microbiological Tunnel. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041205"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1111\/bcp.13662","article-title":"A Systematic Literature Review of the Human Skin Microbiome as Biomarker for Dermatological Drug Development","volume":"84","author":"Balmforth","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/exd.12830","article-title":"Deciphering the Microbiology of Hidradenitis Suppurativa: A Step Forward towards Understanding an Enigmatic Inflammatory Skin Disease","volume":"24","author":"Delage","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.csbj.2021.01.001","article-title":"Skin Microbiome Transplantation and Manipulation: Current State of the Art","volume":"19","author":"Callewaert","year":"2021","journal-title":"Comput. Struct. Biotechnol. 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