{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:06:50Z","timestamp":1790651210039,"version":"4.1.0"},"reference-count":83,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>The most recent monkeypox (Mpox) outbreak is mostly affecting men who have sex with men (MSM) who participate in high-risk sexual behaviors, which is typically the case among human immunodeficiency virus (HIV) carriers, according to clinical and epidemiological statistics. The objective of this research is to determine the epidemiological situation of HIV and smallpox co-infection. Until 1 October 2022, a thorough evaluation of the literature was conducted utilizing the databases PubMed, Embase, Scopus, and Web of Science. Studies were evaluated based on the criteria for selection. Fifty-three studies met the selection criteria. A total of 6345 confirmed cases of monkeypox were recorded, and 40.32% (n = 2558) of these cases also had HIV co-infection. In addition, 51.36% (n = 3259) of the men (91.44%; n = 5802), whose ages ranged from 18 to 71 years, exhibited MSM-specific sexual behaviors. Co-infection with these two viruses can be especially dangerous because it can exacerbate the symptoms of both diseases and make them more difficult to treat. People with HIV are more vulnerable to certain infections, including monkeypox, because their immune systems are weakened. Therefore, it is important that they take measures to prevent infection, such as avoiding contact with infected animals, risky behaviors, and maintaining good hygiene.<\/jats:p>","DOI":"10.3390\/vaccines11020246","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T03:21:54Z","timestamp":1674616914000},"page":"246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Epidemiologic Situation of HIV and Monkeypox Coinfection: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-5176","authenticated-orcid":false,"given":"Brando","family":"Ortiz-Saavedra","sequence":"first","affiliation":[{"name":"Universidad Nacional de San Agust\u00edn de Arequipa, Arequipa 04000, Peru"},{"name":"Unidad de Revisiones Sistem\u00e1ticas y Meta-An\u00e1lisis, Tau-Relaped Group, Trujillo 13001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2528-2089","authenticated-orcid":false,"given":"Elizbet","family":"Montes-Madariaga","sequence":"additional","affiliation":[{"name":"Universidad Nacional de San Agust\u00edn de Arequipa, Arequipa 04000, Peru"},{"name":"Unidad de Revisiones Sistem\u00e1ticas y Meta-An\u00e1lisis, Tau-Relaped Group, Trujillo 13001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3267-0255","authenticated-orcid":false,"given":"Cielo","family":"Cabanillas-Ramirez","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niza","family":"Alva","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6595-8813","authenticated-orcid":false,"given":"Alex","family":"Ricardo-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7267-0204","authenticated-orcid":false,"given":"Darwin","family":"Le\u00f3n-Figueroa","sequence":"additional","affiliation":[{"name":"Unidad de Revisiones Sistem\u00e1ticas y Meta-An\u00e1lisis, Tau-Relaped Group, Trujillo 13001, Peru"},{"name":"Facultad de Medicina Humana, Universidad de San Mart\u00edn de Porres, Chiclayo 14012, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-1407","authenticated-orcid":false,"given":"Joshuan","family":"Barboza","sequence":"additional","affiliation":[{"name":"Vicerrectorado de Investigaci\u00f3n, Universidad Norbert Wiener, Lima 15046, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5634-5014","authenticated-orcid":false,"given":"Aroop","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, Gorakhpur 273001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-2375","authenticated-orcid":false,"given":"Bijaya","family":"Padhi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-8714","authenticated-orcid":false,"given":"Ranjit","family":"Sah","sequence":"additional","affiliation":[{"name":"Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu 44600, Nepal"},{"name":"Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune 411018, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Saied, A.A., Dhawan, M., Metwally, A.A., Fahrni, M.L., Choudhary, P., and Choudhary, O.P. (2022). Disease History, Pathogenesis, Diagnostics, and Therapeutics for Human Monkeypox Disease: A Comprehensive Review. Vaccines, 10.","DOI":"10.3390\/vaccines10122091"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"102362","DOI":"10.1016\/j.tmaid.2022.102362","article-title":"The Never-Ending Global Emergence of Viral Zoonoses after COVID-19? The Rising Concern of Monkeypox in Europe, North America and Beyond","volume":"49","author":"Pachar","year":"2022","journal-title":"Travel Med. Infect. 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