{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:53:36Z","timestamp":1761710016727,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Acute neurologic complications from Varicella-Zoster-Virus reactivation occur in both immunocompromised and immunocompetent patients. In this report, we describe a case of a previously healthy immunocompetent boy who had received two doses of varicella vaccine at 1 and 4 years. At the age of 12 he developed acute aseptic meningitis caused by vaccine-type varicella-zoster-virus without concomitant skin eruptions. VZV-vaccine strain DNA was detected in the cerebrospinal fluid. The patient made a full recovery after receiving intravenous acyclovir therapy. This disease course documents another case of a VZV vaccine-associated meningitis without development of a rash, i.e., a form of VZV infection manifesting as \u201czoster sine herpete\u201d.<\/jats:p>","DOI":"10.3390\/vaccines11020309","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T10:19:28Z","timestamp":1675073968000},"page":"309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Meningitis without Rash after Reactivation of Varicella Vaccine Strain in a 12-Year-Old Immunocompetent Boy"],"prefix":"10.3390","volume":"11","author":[{"given":"Sibylle","family":"Bierbaum","sequence":"first","affiliation":[{"name":"Center for Microbiology and Hygiene, Institute for Virology, Medical Center, University of Freiburg, 79104 Freiburg, Germany"},{"name":"Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany"},{"name":"German Consulting Laboratory for HSV and VZV, Medical Center, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Fischer","sequence":"additional","affiliation":[{"name":"Helios Kliniken Schwerin, 19055 Schwerin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Briedigkeit","sequence":"additional","affiliation":[{"name":"Helios Kliniken Schwerin, 19055 Schwerin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudius","family":"Werner","sequence":"additional","affiliation":[{"name":"Helios Kliniken Schwerin, 19055 Schwerin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3482-816X","authenticated-orcid":false,"given":"Hartmut","family":"Hengel","sequence":"additional","affiliation":[{"name":"Center for Microbiology and Hygiene, Institute for Virology, Medical Center, University of Freiburg, 79104 Freiburg, Germany"},{"name":"Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany"},{"name":"German Consulting Laboratory for HSV and VZV, Medical Center, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Huzly","sequence":"additional","affiliation":[{"name":"Center for Microbiology and Hygiene, Institute for Virology, Medical Center, University of Freiburg, 79104 Freiburg, Germany"},{"name":"Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany"},{"name":"German Consulting Laboratory for HSV and VZV, Medical Center, University of Freiburg, 79104 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1056\/NEJM198405313102201","article-title":"Live attenuated varicella virus vaccine. 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