{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:00:38Z","timestamp":1783472438725,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation (FAPESP)","doi-asserted-by":"publisher","award":["2013\/21719-3"],"award-info":[{"award-number":["2013\/21719-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation (FAPESP)","doi-asserted-by":"publisher","award":["2019\/06572-2"],"award-info":[{"award-number":["2019\/06572-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation (FAPESP)","doi-asserted-by":"publisher","award":["U01 AI151807"],"award-info":[{"award-number":["U01 AI151807"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. National Institutes of Health","award":["2013\/21719-3"],"award-info":[{"award-number":["2013\/21719-3"]}]},{"name":"U.S. National Institutes of Health","award":["2019\/06572-2"],"award-info":[{"award-number":["2019\/06572-2"]}]},{"name":"U.S. National Institutes of Health","award":["U01 AI151807"],"award-info":[{"award-number":["U01 AI151807"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>The disease burden of yellow fever virus infection (YFV) is quite high in the tropics where vaccination coverage is low. To date, vaccination is the most effective control strategy to mitigate and eliminate the burden of YF disease. The licensed YF vaccines are safe and effective and serious adverse events are rare. Herein, we report three cases of neurological syndrome, compatible with meningoencephalitis following 17DD vaccination. In all cases, YFV-specific IgM antibodies were detected in the cerebrospinal fluid. Our observations confirm the development of YF vaccine-associated neurotropic disease, a rare serious adverse event, from which all three patients have fully recovered without any long-term sequelae. This report reinforces the need for awareness among health professionals to recognize and effectively manage such events in a timely manner.<\/jats:p>","DOI":"10.3390\/vaccines11020445","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T03:09:21Z","timestamp":1676430561000},"page":"445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9815-8479","authenticated-orcid":false,"given":"Flora","family":"de Andrade Gandolfi","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas em Virologia (LPV), Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"},{"name":"Hospital da Crian\u00e7a e Maternidade de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto 15091-240, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7324-1591","authenticated-orcid":false,"given":"Cassia Fernanda","family":"Estofolete","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas em Virologia (LPV), Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"},{"name":"Hospital de Base de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Catelan","family":"Wakai","sequence":"additional","affiliation":[{"name":"Hospital da Crian\u00e7a e Maternidade de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto 15091-240, SP, Brazil"},{"name":"Municipal Health Departament, S\u00e3o Jos\u00e9 do Rio Preto 15084-010, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia Francesli","family":"Negri","sequence":"additional","affiliation":[{"name":"Hospital de Base de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela Dias","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Hospital de Base de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-3289","authenticated-orcid":false,"given":"Nikos","family":"Vasilakis","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA"},{"name":"Department of Preventive Medicine and Population Health, The University of Texas Medical Branch, Galveston, TX 77555, USA"},{"name":"Center for Vector-Borne and Zoonotic Diseases, The University of Texas Medical Branch, Galveston, TX 77555, USA"},{"name":"Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch, Galveston, TX 77555, USA"},{"name":"Center for Tropical Diseases, The University of Texas Medical Branch, Galveston, TX 77555, USA"},{"name":"Institute for Human Infection and Immunity, The University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-2419","authenticated-orcid":false,"given":"Mauricio Lacerda","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisas em Virologia (LPV), Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"},{"name":"Hospital de Base de S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"},{"name":"Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022, April 22). 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