{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:17:22Z","timestamp":1793038642249,"version":"4.5.0"},"reference-count":72,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T00:00:00Z","timestamp":1678579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Mycobacterium tuberculosis (M. tb) continues to be a leading cause of mortality within developing countries. The BCG vaccine to promote immunity against M. tb is widely used in developing countries and only in specific circumstances within the United States. However, current the literature reports equivocal data on the efficacy of the BCG vaccine. Critical within their role in the innate immune response, neutrophils serve as one of the first responders to infectious pathogens such as M. tb. Neutrophils promote effective clearance of M. tb through processes such as phagocytosis and the secretion of destructive granules. During the adaptative immune response, neutrophils modulate communication with lymphocytes to promote a strong pro-inflammatory response and to mediate the containment M. tb through the production of granulomas. In this review, we aim to highlight and summarize the role of neutrophils during an M. tb infection. Furthermore, the authors emphasize the need for more studies to be conducted on effective vaccination against M. tb.<\/jats:p>","DOI":"10.3390\/vaccines11030631","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:09:56Z","timestamp":1678687796000},"page":"631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Neutrophils in Mycobacterium tuberculosis"],"prefix":"10.3390","volume":"11","author":[{"given":"Cheldon Ann","family":"Alcantara","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5651-6282","authenticated-orcid":false,"given":"Ira","family":"Glassman","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4910-3073","authenticated-orcid":false,"given":"Kevin H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9832-6575","authenticated-orcid":false,"given":"Arpitha","family":"Parthasarathy","sequence":"additional","affiliation":[{"name":"Division of Biology, Pitzer College, Claremont, CA 91711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2586-1160","authenticated-orcid":false,"given":"Vishwanath","family":"Venketaraman","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,12]]},"reference":[{"key":"ref_1","unstructured":"WHO (2023, January 02). Tuberculosis. 27 October 2022. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/tuberculosis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1001\/jama.1885.02390870004001a","article-title":"The Etiology of Tuberculosis","volume":"IV","author":"Formad","year":"1882","journal-title":"J. Am. Med. Assoc."},{"key":"ref_3","unstructured":"CDC (2011). Tuberculosis General Information Fact Sheet, CDC."},{"key":"ref_4","first-page":"22","article-title":"Chapter 2: Transmission and pathogenesis of tuberculosis","volume":"6","author":"Long","year":"2022","journal-title":"Can. J. Respir. Crit. Care Sleep Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1128\/MMBR.00010-14","article-title":"Latent Tuberculosis Infection: Myths, Models, and Molecular Mechanisms","volume":"78","author":"Dutta","year":"2014","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_6","first-page":"98","article-title":"Modeling the Mycobacterium tuberculosis Granuloma\u2014The Critical Battlefield in Host Immunity and Disease","volume":"4","author":"Eguirado","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_7","unstructured":"Sia, J.K., and Rengarajan, J. (2019). Microbiology Spectrum, American Society for Microbiology."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"828939","DOI":"10.1155\/2013\/828939","article-title":"Risk Factors for Tuberculosis","volume":"2013","author":"Narasimhan","year":"2013","journal-title":"Pulm. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"634386","DOI":"10.3389\/fimmu.2021.634386","article-title":"Interactions of HIV and Antiretroviral Therapy with Neutrophils and Platelets","volume":"12","author":"Madzime","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"678771","DOI":"10.3389\/fimmu.2021.678771","article-title":"A Bittersweet Response to Infection in Diabetes; Targeting Neutrophils to Modify Inflammation and Improve Host Immunity","volume":"12","author":"Dowey","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_11","first-page":"240","article-title":"Role of neutrophils in tuberculosis: A bird\u2019s eye view","volume":"26","author":"Hilda","year":"2019","journal-title":"J. Endotoxin Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.194.4.519","article-title":"Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense","volume":"194","author":"Ye","year":"2001","journal-title":"J. Exp. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1590\/0074-02760150411","article-title":"The mc2-CMX vaccine induces an enhanced immune response against Mycobacterium tuberculosis compared to Bacillus Calmette-Gu\u00e9rin but with similar lung inflammatory effects","volume":"111","author":"Trentini","year":"2016","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Heemskerk, D., Caws, M., Marais, B., and Farrar, J. (2015). Tuberculosis in Adults and Children, Springer.","DOI":"10.1007\/978-3-319-19132-4"},{"key":"ref_15","first-page":"297","article-title":"Singing and the dissemination of tuberculosis","volume":"98","author":"Loudon","year":"1968","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.4049\/jimmunol.1800993","article-title":"The End of the Binary Era: Revisiting the Spectrum of Tuberculosis","volume":"201","author":"Lin","year":"2018","journal-title":"J. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1086\/338342","article-title":"Molecular Evidence of Endogenous Reactivation of Mycobacterium tuberculosis after 33 Years of Latent Infection","volume":"185","author":"Lillebaek","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhai, W., Wu, F., Zhang, Y., Fu, Y., and Liu, Z. (2019). The Immune Escape Mechanisms of Mycobacterium Tuberculosis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020340"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/j.1462-5822.2012.01783.x","article-title":"Escape of Mycobacterium tuberculosis from oxidative killing by neutrophils","volume":"14","author":"Corleis","year":"2012","journal-title":"Cell. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Simeone, R., Bobard, A., Lippmann, J., Bitter, W., Majlessi, L., Brosch, R., and Enninga, J. (2012). Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002507"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tube.2018.06.010","article-title":"Neutrophil CD64, TLR2 and TLR4 expression increases but phagocytic potential decreases during tuberculosis","volume":"111","author":"Hilda","year":"2018","journal-title":"Tuberculosis"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphys.2018.00113","article-title":"Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?","volume":"9","author":"Rosales","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Cheng, A.-C., Yang, K.-Y., Chen, N.-J., Hsu, T.-L., Jou, R., Hsieh, S.-L., and Tseng, P.-H. (2017). CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186780"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.humimm.2008.11.003","article-title":"Augmented chemokine levels and chemokine receptor expression on immune cells during pulmonary tuberculosis","volume":"70","author":"Pokkali","year":"2009","journal-title":"Hum. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3389\/fimmu.2019.00417","article-title":"Neutrophils and Close Relatives in the Hypoxic Environment of the Tuberculous Granuloma: New Avenues for Host-Directed Therapies?","volume":"10","author":"Remot","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Cacciotto, C., and Alberti, A. (2022). Eating the Enemy: Mycoplasma Strategies to Evade Neutrophil Extracellular Traps (NETs) Promoting Bacterial Nucleotides Uptake and Inflammatory Damage. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232315030"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2741\/4423","article-title":"Pathophysiology of neutrophil-mediated extracellular redox reactions","volume":"21","author":"Jaganjac","year":"2016","journal-title":"Front. Biosci."},{"key":"ref_28","first-page":"1027","article-title":"The potential of human neutrophil peptides in tuberculosis therapy","volume":"7","author":"Fu","year":"2003","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1152\/physrev.00012.2018","article-title":"The Neutrophil\u2019s Role During Health and Disease","volume":"99","author":"Liew","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/dxr007","article-title":"Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation","volume":"23","author":"Abdallah","year":"2011","journal-title":"Int. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.4049\/jimmunol.177.3.1864","article-title":"Macrophages Acquire Neutrophil Granules for Antimicrobial Activity against Intracellular Pathogens","volume":"177","author":"Tan","year":"2006","journal-title":"J. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"854507","DOI":"10.1155\/2015\/854507","article-title":"Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers","volume":"2015","author":"Lyadova","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11475","DOI":"10.1038\/s41598-018-29659-1","article-title":"Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis","volume":"8","author":"Ong","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tube.2008.09.009","article-title":"Neutrophil extracellular traps are induced by Mycobacterium tuberculosis","volume":"89","year":"2009","journal-title":"Tuberculosis"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Meier, S., Seddon, J.A., Maasdorp, E., Kleynhans, L., du Plessis, N., Loxton, A.G., Malherbe, S.T., Zak, D.E., Thompson, E., and Duffy, F.J. (2022). Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis. PLoS ONE, 17.","DOI":"10.1101\/2022.06.10.495597"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Loh, W., and Vermeren, S. (2022). Anti-Inflammatory Neutrophil Functions in the Resolution of Inflammation and Tissue Repair. Cells, 11.","DOI":"10.3390\/cells11244076"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e1474","DOI":"10.1038\/cddis.2014.394","article-title":"Mycobacterium tuberculosis ESAT-6 is a leukocidin causing Ca2+ influx, necrosis and neutrophil extracellular trap formation","volume":"5","author":"Francis","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3389\/fimmu.2018.00677","article-title":"Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps","volume":"9","author":"Dang","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12931-017-0663-1","article-title":"Neutrophil extracellular traps in patients with pulmonary tuberculosis","volume":"18","author":"Zeerleder","year":"2017","journal-title":"Respir. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5566","DOI":"10.1038\/s41467-020-19412-6","article-title":"Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis","volume":"11","author":"Stimpson","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.3389\/fimmu.2018.03147","article-title":"Imbalance of NET and Alpha-1-Antitrypsin in Tuberculosis Patients Is Related with Hyper Inflammation and Severe Lung Tissue Damage","volume":"9","author":"Mesquita","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1159\/000348676","article-title":"Mycobacterium tuberculosis-Induced Neutrophil Extracellular Traps Activate Human Macrophages","volume":"5","author":"Braian","year":"2013","journal-title":"J. Innate Immun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3389\/fmicb.2019.01468","article-title":"Mycobacterium tuberculosis infection induces low-density granulocyte generation by promoting neutrophil extracellular trap formation via ROS pathway","volume":"10","author":"Su","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Deng, Y., Ye, J., Luo, Q., Huang, Z., Peng, Y., Xiong, G., Guo, Y., Jiang, H., and Li, J. (2016). Low-Density Granulocytes Are Elevated in Mycobacterial Infection and Associated with the Severity of Tuberculosis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153567"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"622389","DOI":"10.3389\/fmicb.2020.622389","article-title":"Low-Density Granulocytes Affect T-SPOT.TB Assay by Inhibiting the Production of Interferon-\u03b3 in T Cells via PD-L1\/PD-1 Pathway","volume":"11","author":"Rao","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1378\/chest.09-0903","article-title":"Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients with Active Pulmonary TB","volume":"137","author":"Eum","year":"2010","journal-title":"Chest"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.3389\/fimmu.2018.02637","article-title":"Neutrophils: Innate Effectors of TB Resistance?","volume":"9","author":"Kroon","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.4049\/jimmunol.162.4.2347","article-title":"Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways","volume":"162","author":"Laan","year":"1999","journal-title":"J. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.4049\/jimmunol.170.9.4665","article-title":"Endogenous IL-17 as a Mediator of Neutrophil Recruitment Caused by Endotoxin Exposure in Mouse Airways","volume":"170","author":"Miyamoto","year":"2003","journal-title":"J. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1128\/IAI.72.3.1804-1806.2004","article-title":"Rat Neutrophils Prevent the Development of Tuberculosis","volume":"72","author":"Sugawara","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1128\/IAI.68.2.577-583.2000","article-title":"Neutrophils Play a Protective Nonphagocytic Role in Systemic Mycobacterium tuberculosis Infection of Mice","volume":"68","author":"Pedrosa","year":"2000","journal-title":"Infect. Immun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chom.2012.07.009","article-title":"Neutrophils Exert Protection in the Early Tuberculous Granuloma by Oxidative Killing of Mycobacteria Phagocytosed from Infected Macrophages","volume":"12","author":"Yang","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrmicro2236","article-title":"The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies","volume":"7","author":"Barry","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/mi.2011.14","article-title":"Macrophages and control of granulomatous inflammation in tuberculosis","volume":"4","author":"Flynn","year":"2011","journal-title":"Mucosal Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"170077","DOI":"10.1183\/16000617.0077-2017","article-title":"Tuberculosis and lung damage: From epidemiology to pathophysiology","volume":"27","author":"Ravimohan","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/s41385-019-0195-8","article-title":"Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques","volume":"12","author":"Gideon","year":"2019","journal-title":"Mucosal Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/thoraxjnl-2015-207402","article-title":"Hypoxia and Tissue Destruction in Pulmonary TB","volume":"71","author":"Belton","year":"2016","journal-title":"Thorax"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1182\/blood-2010-12-324186","article-title":"Activation of hypoxia-inducible factor-1\u03b1 (Hif-1\u03b1) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model","volume":"118","author":"Elks","year":"2011","journal-title":"Blood"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Elks, P.M., Brizee, S., Van Der Vaart, M., Walmsley, S.R., Van Eeden, F.J., Renshaw, S.A., and Meijer, A.H. (2013). Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003789"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20040624","article-title":"Hypoxia-induced neutrophil survival is mediated by HIF-1\u03b1\u2013dependent NF-\u03baB activity","volume":"201","author":"Walmsley","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_61","first-page":"457","article-title":"The Dual Roles of Neutrophils and Macrophages in Inflammation: A Critical Balance Between Tissue Damage and Repair","volume":"41","author":"Butterfield","year":"2006","journal-title":"J. Athl. Train."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"8619307","DOI":"10.1155\/2017\/8619307","article-title":"Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?","volume":"2017","author":"Lyadova","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1172\/JCI130546","article-title":"S100A8\/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis","volume":"130","author":"Scott","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1128\/IAI.73.3.1744-1753.2005","article-title":"Neutrophil Responses to Mycobacterium tuberculosis Infection in Genetically Susceptible and Resistant Mice","volume":"73","author":"Eruslanov","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.4049\/jimmunol.179.4.2532","article-title":"The Cellular Immune Response to Mycobacterium tuberculosis Infection in the Guinea Pig","volume":"179","author":"Ordway","year":"2007","journal-title":"J. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.chest.2021.07.041","article-title":"The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End","volume":"160","author":"Jones","year":"2021","journal-title":"Chest"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3389\/fimmu.2018.00903","article-title":"Differential Effect of Viable Versus Necrotic Neutrophils on Mycobacterium tuberculosis Growth and Cytokine Induction in Whole Blood","volume":"9","author":"Lowe","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Warren, E., Teskey, G., and Venketaraman, V. (2017). Effector Mechanisms of Neutrophils within the Innate Immune System in Response to Mycobacterium tuberculosis Infection. J. Clin. Med., 6.","DOI":"10.3390\/jcm6020015"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Borkute, R., Woelke, S., Pei, G., and Dorhoi, A. (2021). Neutrophils in Tuberculosis: Cell Biology, Cellular Networking and Multitasking in Host Defense. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094801"},{"key":"ref_70","unstructured":"(2023, January 02). BCG Vaccine Fact Sheet, Available online: https:\/\/www.cdc.gov\/tb\/publications\/factsheets\/prevention\/bcg.htm#print."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1016\/j.vaccine.2017.07.073","article-title":"A novel nanoemulsion vaccine induces mucosal Interleukin-17 responses and confers protection upon Mycobacterium tuberculosis challenge in mice","volume":"35","author":"Ahmed","year":"2017","journal-title":"Vaccine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"898","DOI":"10.3389\/fmicb.2016.00898","article-title":"The Role of Neutrophils in the Induction of Specific Th1 and Th17 during Vaccination against Tuberculosis","volume":"7","author":"Trentini","year":"2016","journal-title":"Front. Microbiol."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/3\/631\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:53:09Z","timestamp":1760122389000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/3\/631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,12]]},"references-count":72,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["vaccines11030631"],"URL":"https:\/\/doi.org\/10.3390\/vaccines11030631","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,12]]}}}