{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T21:18:55Z","timestamp":1768166335625,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pudong New Area Science and Technology Development Fund","award":["PKJ2021-Y31"],"award-info":[{"award-number":["PKJ2021-Y31"]}]},{"name":"Pudong New Area Science and Technology Development Fund","award":["202240112"],"award-info":[{"award-number":["202240112"]}]},{"name":"Clinical Research Fund of Shanghai Municipal Commission of Health","award":["PKJ2021-Y31"],"award-info":[{"award-number":["PKJ2021-Y31"]}]},{"name":"Clinical Research Fund of Shanghai Municipal Commission of Health","award":["202240112"],"award-info":[{"award-number":["202240112"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Coronavirus disease 2019 (COVID-19) vaccine has effectively suppressed the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and alleviated its symptoms, but there are also many adverse events. Joint diseases caused by COVID-19 vaccine have been reported in many studies. Some are well-controlled arthritis patients who developed arthritis after COVID-19 vaccination, while others are new-onset joint pain and swelling problems after COVID-19 vaccination. The purpose of this systematic review is to examine the literature reports in existing databases and analyze the incidence of new-onset arthritis after COVID-19 vaccination. We included 31 eligible articles and described 45 patients, ranging in age from 17 to over 90, with more females than males. The majority (84.4%) of patients received the adenovirus vector vaccine (ChAdOx1) and the mRNA-based vaccine (BNT126b2 and mRNA-1273). Most (64.4%) patients developed joint-related symptoms after the first dose of vaccine, and 66.7% developed symptoms within the first week of vaccination. The joint symptoms involved were mainly joint swelling, joint pain, limited range of motion, and so on. A total of 71.1% of the patients involved multiple joints, both large and small; 28.9% of patients involved only a single joint. Some (33.3%) patients were confirmed by imaging, and the most common diagnoses were bursitis and synovitis. Two nonspecific inflammatory markers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were monitored in almost all cases, and all patients showed varying degrees of increase in these two markers. Most of the patients received the treatment of glucocorticoid drugs or nonsteroidal anti-inflammatory drugs (NSAIDs). Clinical symptoms markedly improved in most patients, with 26.7% making a full recovery and no relapse after a few months of follow-up. To determine whether there is a causal relationship between COVID-19 vaccination and the triggering of arthritis, large-scale and well-controlled research studies are needed in the future to verify this relationship and to further study its pathogenesis in detail. Clinicians should raise awareness of this complication with a view to early diagnosis and appropriate treatment.<\/jats:p>","DOI":"10.3390\/vaccines11030665","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T03:50:45Z","timestamp":1678938645000},"page":"665","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["New-Onset Arthritis Following COVID-19 Vaccination: A Systematic Review of Case Reports"],"prefix":"10.3390","volume":"11","author":[{"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine Library, No. 280, South Chongqing Road, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2079-7991","authenticated-orcid":false,"given":"Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine Library, No. 280, South Chongqing Road, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Li","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhoupu Zhouyuan Road, Pudong New Area, Shanghai 201318, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/jmv.25678","article-title":"Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle","volume":"92","author":"Lu","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Pormohammad, A., Zarei, M., Ghorbani, S., Mohammadi, M., Razizadeh, M., Turner, D., and Turner, R. (2021). Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Vaccines, 9.","DOI":"10.2139\/ssrn.3812422"},{"key":"ref_3","first-page":"e28440","article-title":"COVID-19-Induced Myocarditis and mRNA Vaccine-Related Pericarditis: A Case Report","volume":"14","author":"Voltarelli","year":"2022","journal-title":"Cureus"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.31486\/toj.21.0114","article-title":"Shoulder Injury Related to Vaccine Administration","volume":"22","author":"Flores","year":"2022","journal-title":"Ochsner J."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Katsikas Triantafyllidis, K., Giannos, P., Mian, I.T., Kyrtsonis, G., and Kechagias, K.S. (2021). Varicella Zoster Virus Reactivation Following COVID-19 Vaccination: A Systematic Review of Case Reports. Vaccines, 9.","DOI":"10.3390\/vaccines9091013"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.avsg.2022.05.001","article-title":"Thromboembolism after COVID-19 Vaccination: A Systematic Review of Such Events in 286 Patients","volume":"84","author":"Mani","year":"2022","journal-title":"Ann. Vasc. Surg."},{"key":"ref_7","first-page":"100","article-title":"Progression from palindromic rheumatism to rheumatoid arthritis after COVID-19 vaccination","volume":"1","author":"Bansal","year":"2022","journal-title":"ARP Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e305","DOI":"10.1093\/rheumatology\/keac281","article-title":"Immune transcriptome and antibody response in adult-onset Still\u2019s disease with mild flare following administration of mRNA vaccine BNT162b2","volume":"61","author":"Knabl","year":"2022","journal-title":"Rheumatology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.3346\/jkms.2021.36.e245","article-title":"Polyarthralgia and Myalgia Syndrome after ChAdOx1 nCOV-19 Vaccination","volume":"36","author":"Hyun","year":"2021","journal-title":"J. Korean Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1080\/21645515.2021.1920274","article-title":"Reactive arthritis after COVID-19 vaccination","volume":"17","author":"An","year":"2021","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/1756-185X.14202","article-title":"Arthritis of the left elbow joint after vaccination against SARS-CoV-2 infection","volume":"24","author":"Baimukhamedov","year":"2021","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/1756-185X.14220","article-title":"Seropositive rheumatoid arthritis after vaccination against SARS-CoV-2 infection","volume":"24","author":"Baimukhamedov","year":"2021","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_14","first-page":"e25020","article-title":"Unilateral Erosive Arthritis Following Moderna COVID-19 Vac-cination","volume":"14","author":"Emran","year":"2022","journal-title":"Cureus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e243066","DOI":"10.1136\/bcr-2021-243066","article-title":"Streptococcus gordonii septic arthritis of the glenohumeral joint following deltoid intramuscular vaccination","volume":"14","author":"Flowers","year":"2021","journal-title":"BMJ Case Rep."},{"key":"ref_16","first-page":"e25346","article-title":"Polymyalgia Rheumatica After ChAdOx1 nCov-19 Vaccine: A Case Report","volume":"14","author":"Pascoal","year":"2022","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.2106\/JBJS.CC.21.00090","article-title":"Septic Arthritis of the Shoulder After SARS-CoV-2 Pfizer Vaccination: A Case Report","volume":"11","author":"Massel","year":"2021","journal-title":"JBJS Case Connect"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10067-022-06065-7","article-title":"New-onset Adult-onset Still\u2019s disease-like syndrome after ChAdOx1 nCoV-19 vaccination\u2014A case series with review of literature","volume":"41","author":"Padiyar","year":"2022","journal-title":"Clin. Rheumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.3346\/jkms.2021.36.e344","article-title":"Adult-onset Still\u2019s Disease after BNT162b2 mRNA COVID-19 Vaccine","volume":"36","author":"Park","year":"2021","journal-title":"J. Korean Med. Sci."},{"key":"ref_20","first-page":"333","article-title":"New Onset of Inflammatory Arthritis Following Moderna COVID-19 Vaccination","volume":"24","year":"2022","journal-title":"Isr. Med. Assoc. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e249063","DOI":"10.1136\/bcr-2022-249063","article-title":"Case of reactive sacroiliitis possibly induced by an mRNA coronavirus disease vaccine","volume":"15","author":"Roux","year":"2022","journal-title":"BMJ Case Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e246533","DOI":"10.1136\/bcr-2021-246533","article-title":"Marked increase of interferon-\u03b2 after BNT162b2 mRNA vaccination: A case of polyarthritis with pleurisy","volume":"15","author":"Shimagami","year":"2022","journal-title":"BMJ Case Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1002\/jmv.27742","article-title":"Refractory hypereosinophilia associated with newly diagnosed rheumatoid arthritis following inactivated BBV152 COVID-19 vaccine","volume":"94","author":"Singh","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1111\/imj.15563","article-title":"Adult-onset Still disease post-adenovirus vector COVID-19 vaccine","volume":"51","author":"Sweeney","year":"2021","journal-title":"Intern. Med. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"108256","DOI":"10.1016\/j.intimp.2021.108256","article-title":"Arthritis following COVID-19 vaccination: Report of two cases","volume":"101","author":"Enginar","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"859926","DOI":"10.3389\/fimmu.2022.859926","article-title":"Case Report: New-Onset Rheumatoid Arthritis Following COVID-19 Vaccination","volume":"13","author":"Watanabe","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/1756-185X.14411","article-title":"Reactive synovitis of the knee joint after COVID-19 vaccination: The first ultra-structural analysis of synovial fluid","volume":"25","author":"Vanaskova","year":"2022","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jdcr.2022.04.026","article-title":"Reactive arthritis following COVID-19 vaccination with BNT162b2","volume":"24","author":"Lebowitz","year":"2022","journal-title":"JAAD Case Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e678","DOI":"10.1016\/S2665-9913(21)00218-6","article-title":"Adult-onset Still\u2019s disease following COVID-19 vaccination","volume":"3","author":"Leone","year":"2021","journal-title":"Lancet Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"108878","DOI":"10.1016\/j.clim.2021.108878","article-title":"Adult-onset Still\u2019s disease following mRNA COVID-19 vaccination","volume":"233","author":"Sharabi","year":"2021","journal-title":"Clin. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4103\/injr.injr_145_21","article-title":"The Emergence of Rheumatic Immune-Mediated Inflammatory Disease Manifestations Following SARS-CoV-2 Vaccination","volume":"17","author":"Nune","year":"2022","journal-title":"Ind. J. Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"107686","DOI":"10.1016\/j.ijscr.2022.107686","article-title":"Septic arthritis of shoulder joint following a COVID-19 vaccination: A case report","volume":"99","author":"Klabklay","year":"2022","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.12688\/wellcomeopenres.17345.1","article-title":"Case Report: Adult Onset Still\u2019s Disease after vaccination against Covid-19","volume":"6","author":"Risal","year":"2021","journal-title":"Wellcome Open Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.2169\/internalmedicine.0257-22","article-title":"New-onset Seropositive Rheumatoid Arthritis Following COVID-19 Vaccination in a Patient with Seronegative Status","volume":"61","author":"Yonezawa","year":"2022","journal-title":"Intern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2169\/internalmedicine.0590-22","article-title":"New-onset Adult-onset Still\u2019s Disease Following COVID-19 Vaccination: Three Case Reports and a Literature Review","volume":"62","author":"Matsuda","year":"2022","journal-title":"Intern Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e2021403","DOI":"10.4322\/acr.2021.403","article-title":"Adult-onset Still\u2019s disease after ChAdOx1 nCoV-19 vaccine: A possible association","volume":"12","author":"Albertino","year":"2022","journal-title":"Autops. Case Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Chua, X.H., Lin, W.L., and Lee, Y.T. (2022). Adult-Onset Still\u2019s Disease following Coronavirus 2 (SARS-CoV-2) Vaccination: A Case Report. Vaccines, 10.","DOI":"10.3390\/vaccines10101687"},{"key":"ref_38","first-page":"e12492","article-title":"A Case Series on the COVID-19 Vaccines and Possible Immune-Related Adverse Events: A New Challenge for the Rheumatologists","volume":"14","author":"Nahra","year":"2022","journal-title":"Cureus"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Winichakoon, P., Chanloung, W., Nantsupawat, T., and Louthrenoo, W. (2022). Adult-Onset Still\u2019s Disease-like Syndrome following COVID-19 Vaccination: A Case Report and Review of the Literature. Vaccines, 10.","DOI":"10.3390\/vaccines10071022"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Koh, S., Chen, H., and Hsu, C. (2022). Prolonged peripheral seronegative spondyloarthritis following BioNTech coronavirus disease 2019 vaccination: A case report. Int. J. Rheum. Dis., 1\u20134.","DOI":"10.1111\/1756-185X.14512"},{"key":"ref_41","first-page":"9","article-title":"Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still\u2019s disease","volume":"21","author":"Hu","year":"2019","journal-title":"Thromb. Haemost."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/art.40071","article-title":"Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era","volume":"69","author":"Behrens","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e249290","DOI":"10.1136\/bcr-2022-249290","article-title":"Reactivation of adult-onset Still\u2019s disease after use of the COVID-19 ChAdOx1-S vaccine","volume":"15","author":"Vodnizza","year":"2022","journal-title":"BMJ Case Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s10067-022-06106-1","article-title":"Flare of adult-onset Still\u2019s disease following mRNA COVID-19 vaccination: A case report and review of literature","volume":"41","author":"Kim","year":"2022","journal-title":"Clin. Rheumatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"SI143","DOI":"10.1093\/rheumatology\/keac249","article-title":"Baseline factors associated with self-reported disease flares following COVID-19 vaccination among adults with systemic rheumatic disease: Results from the COVID-19 global rheumatology alliance vaccine survey","volume":"61","author":"Rider","year":"2022","journal-title":"Rheumatology"}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/3\/665\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:56:00Z","timestamp":1760122560000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/3\/665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["vaccines11030665"],"URL":"https:\/\/doi.org\/10.3390\/vaccines11030665","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}