{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:08:32Z","timestamp":1780988912026,"version":"3.54.1"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Vaccination against COVID-19 is one of the highly effective preventative strategies to reduce morbidity and mortality associated with COVID-19 infection. The rapid approval of COVID-19 vaccination due to the raging pandemic, media coverage, anti-vaccination groups, and concerns about adverse effects associated with vaccination has given rise to COVID-19 vaccine hesitancy. Current evidence suggests that psychosomatic and nocebo-related adverse effects account for a significant proportion of common adverse effects following COVID-19 vaccination. The most common adverse effects are headache, fatigue, and myalgia, which are highly prone to nocebo effects. In our review article, we discuss the role of psychosomatic and nocebo effects in COVID-19 vaccination-related hesitancy, predictors of such effects, and strategies to reduce vaccine hesitancy. General education regarding psychosomatic and nocebo effects and specialized education for at-risk populations may reduce psychosomatic and nocebo-related adverse effects following COVID-19 vaccination, ultimately reducing hesitancy.<\/jats:p>","DOI":"10.3390\/vaccines11050922","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T01:36:27Z","timestamp":1682991387000},"page":"922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of Psychosomatic Symptoms in COVID-19 Vaccine Hesitancy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4692-1414","authenticated-orcid":false,"given":"Saral","family":"Desai","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Tower Health-Phoenixville Hospital, Phoenixville, PA 19460, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejasvi","family":"Kainth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9517-3542","authenticated-orcid":false,"given":"Garima","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Bronx Care Health System, Bronx, NY 10456, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansini","family":"Kochhar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Maimonides Medical Center, Brooklyn, NY 11219, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Srinivas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, A.J. Institute of Medical Sciences and Research Center, Manglore 575004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saher","family":"Kamil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dell Children\u2019s Medical Center, Austin, TX 78723, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Academic Affairs, Tower Health, West Reading, PA 19611, USA"},{"name":"Department of Psychiatry, Drexel University College of Medicine, Philadelphia, PA 19102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"ref_1","unstructured":"(2022, November 15). WHO Coronavirus (COVID-19) Dashboard. Available online: https:\/\/covid19.who.int\/."},{"key":"ref_2","unstructured":"Fleming, K.E. (2022, November 27). 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