{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:54:48Z","timestamp":1767840888563,"version":"3.49.0"},"reference-count":24,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Although vaccines have been shown to reduce the number of COVID-19 infection cases significantly, vaccine-related reactions, long COVID-19 syndrome, and COVID-19 infection following vaccination continue to be a burden on healthcare services and warrant further scientific research. The purpose of this study was to research the severity of pulmonary COVID-19 infection following vaccination and the sequelae rates of recurrent infections in vaccinated cases by imaging. Patients who underwent follow-up CTs at 1 month, 3 months, and 6 months in our hospital with a diagnosis of COVID-19 were scanned retrospectively. Furthermore, all essential information was gathered from patients\u2019 immunization records. The major findings of our study were: (1) sequelae were frequently observed in unvaccinated cases; (2) the correlation between vaccination status and the severity of sequelae was significant; (3) there was not any significant relationship between the vaccine type and the severity of sequelae; and (4) hematocrit, hemoglobin, and lymphocyte parameters may be used as predictors of sequelae rates. COVID-19 infection, although reduced in prevalence following the development of vaccines, still remains a public health concern because of reinfection. Vaccination not only appears to protect against primary infection, but also seems to reduce reinfection and sequalae rates following reinfection.<\/jats:p>","DOI":"10.3390\/vaccines11081321","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T09:28:04Z","timestamp":1691141284000},"page":"1321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effects of Vaccines on the Sequelae Rates of Recurrent Infections and the Severity of Pulmonary COVID-19 Infection by Imaging"],"prefix":"10.3390","volume":"11","author":[{"given":"Suzan","family":"Bahadir","sequence":"first","affiliation":[{"name":"Department of Radiology, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch, WA 6150, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Kabacaoglu","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Baskent University Alanya Research and Training Center, Yunus Emre Avenue, Alanya 07400, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6746-3906","authenticated-orcid":false,"given":"Kemal Bugra","family":"Memis","sequence":"additional","affiliation":[{"name":"Department of Radiology, Erzincan Binali Yildirim University, Basbaglar, 1429th Street, Erzincan 24100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan Ilksen","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch, WA 6150, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-6333","authenticated-orcid":false,"given":"Sonay","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Erzincan Binali Yildirim University, Basbaglar, 1429th Street, Erzincan 24100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"ref_1","unstructured":"(2023, March 18). WHO Coronavirus (COVID-19) Dashboard. Available online: https:\/\/covid19.who.int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-021-03553-9","article-title":"High-dimensional characterization of post-acute sequelae of COVID-19","volume":"594","author":"Xie","year":"2021","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e068414","DOI":"10.1136\/bmj-2021-068414","article-title":"Risk of persistent and new clinical sequelae among adults aged 65 years and older during the post-acute phase of SARS-CoV-2 infection: Retrospective cohort study","volume":"376","author":"Cohen","year":"2022","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"713","DOI":"10.15585\/mmwr.mm7121e1","article-title":"Post\u2013COVID conditions among adult COVID-19 survivors aged 18\u201364 and \u226565 years\u2014United States, March 2020\u2013November 2021","volume":"71","author":"Baca","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"n1098","DOI":"10.1136\/bmj.n1098","article-title":"Risk of clinical sequelae after the acute phase of SARS-CoV-2 infection: Retrospective cohort study","volume":"373","author":"Daugherty","year":"2021","journal-title":"BMJ"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"n693","DOI":"10.1136\/bmj.n693","article-title":"Post-covid syndrome in individuals admitted to hospital with Covid-19: Retrospective cohort study","volume":"372","author":"Ayoubkhani","year":"2021","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jama.2020.12603","article-title":"Persistent symptoms in patients after acute COVID-19","volume":"324","author":"Carfi","year":"2020","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.1038\/s41467-021-26513-3","article-title":"Burdens of post-acute sequelae of COVID-19 by severity of acute infection, demographics and health status","volume":"12","author":"Xie","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1084002","DOI":"10.3389\/fmed.2023.1084002","article-title":"Predictors of pulmonary sequelae after COVID-19 pneumonia: A 12-month follow-up study","volume":"10","author":"Bernardinello","year":"2023","journal-title":"Front. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gao, P., Liu, J., and Liu, M. (2022). Effect of COVID-19 vaccines on reducing the risk of long COVID in the real world: A systematic review and meta-analysis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph191912422"},{"key":"ref_11","unstructured":"British Thoracic Society (2020). British Thoracic Society Guidance on Respiratory Follow Up of Patients with a Clinico-Radiological Diagnosis of COVID-19 Pneumonia, British Thoracic Society."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/resp.14311","article-title":"One-year follow-up CT findings in COVID-19 patients: A systematic review and meta-analysis","volume":"27","author":"Watanabe","year":"2022","journal-title":"Respirology"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Gao, P., Cai, S., Liu, Q., Du, M., Liu, J., and Liu, M. (2022). Effectiveness and Safety of SARS-CoV-2 Vaccines among Children and Adolescents: A Systematic Review and Meta-Analysis. Vaccines, 10.","DOI":"10.3390\/vaccines10030421"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1016\/j.vaccine.2022.05.090","article-title":"The effect of SARS-CoV-2 vaccination on post-acute sequelae of COVID-19 (PASC): A prospective cohort study","volume":"40","author":"Wynberg","year":"2022","journal-title":"Vaccine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1038\/s41591-022-02051-3","article-title":"Acute and postacute sequelae associated with SARS-CoV-2 reinfection","volume":"28","author":"Bowe","year":"2022","journal-title":"Nat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1148\/radiol.2462070712","article-title":"Fleischner Society: Glossary of terms for thoracic imaging","volume":"246","author":"Hansell","year":"2008","journal-title":"Radiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"101209","DOI":"10.1016\/j.eclinm.2021.101209","article-title":"Usual interstitial pneumonia is the most common finding in surgical lung biopsies from patients with persistent interstitial lung disease following infection with SARS-CoV-2","volume":"42","author":"Konopka","year":"2021","journal-title":"EClinicalMedicine"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s40249-021-00915-3","article-title":"Effectiveness and safety of SARS-CoV-2 vaccine in real-world studies: A systematic review and meta-analysis","volume":"10","author":"Liu","year":"2021","journal-title":"Infect. Dis. Poverty"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s10787-021-00839-2","article-title":"Real-world effectiveness of BNT162b2 mRNA vaccine: A meta-analysis of large observational studies","volume":"29","author":"Kow","year":"2021","journal-title":"Inflammopharmacology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41564-021-01053-0","article-title":"Effectiveness of COVID-19 vaccines against symptomatic SARS-CoV-2 infection and severe outcomes with variants of concern in Ontario","volume":"7","author":"Nasreen","year":"2022","journal-title":"Nat. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e069676","DOI":"10.1136\/bmj-2021-069676","article-title":"Trajectory of long COVID symptoms after COVID-19 vaccination: Community based cohort study","volume":"377","author":"Ayoubkhani","year":"2022","journal-title":"BMJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41590-021-01104-y","article-title":"Pathological sequelae of long-haul COVID","volume":"23","author":"Mehandru","year":"2022","journal-title":"Nat. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s12098-023-04473-4","article-title":"Post-COVID-19 Sequelae in Children","volume":"90","author":"Kumar","year":"2023","journal-title":"Indian J. Pediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/qjmed\/hcac206","article-title":"Potential mechanisms for lung fibrosis associated with COVID-19 infection","volume":"116","author":"Parimon","year":"2023","journal-title":"QJM Int. J. 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