{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:48:18Z","timestamp":1793296098428,"version":"4.5.0"},"reference-count":13,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GC Biopharma Corp"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Two live attenuated varicella vaccine (VZV) strains have been mainly used across the globe: MAV\/06 and OKA strains. We aimed to explore the safety of interchanging the two VZV strains for primary and booster immunizations. South Korea\u2019s vaccine adverse event reporting system (VAERS) was accessed and searched to find filed reports of all adverse events (AEs) following immunization with the second dose of the varicella vaccine. The electronic medical records were reviewed for all visits to the hospital following the second dose of the varicella vaccine. Of the total 406 study participants, 27.5% (n = 112) were in the MAV\/06\u2013MAV\/06 group, 30.3% (n = 123) in the MAV\/06\u2013OKA, 17.5% (n = 71) in the OKA\u2013MAV\/06 group, and 24.6% (n = 100) in the OKA\u2013OKA group. Mean age at immunization with the first dose was 1.10 (standard deviation [SD] \u00b10.34) years old, and second dose was 4.77 (SD \u00b1 1.13) (p = 0.772 and 0.933, respectively). There were no filed reports of AEs following the second dose in the national VAERS. Hospital visit records showed a total of 10.3% (95% confidence interval [CI], 7.6\u201313.7) (n = 42) had recorded AEs following the 2nd administered dose; however, only 0.7% (95% CI, 0.2\u20132.4) (n = 3) were regarded as possibly vaccine related. Two patients in the MAV\/06\u2013OKA group were diagnosed with Henoch-Schonlein purpura after the second dose; however, both had also received the MMR vaccine on the same day. No safety signals associated with interchanging the MAV\/06 and OKA strain live attenuated varicella vaccines were observed in this patient cohort of healthy children.<\/jats:p>","DOI":"10.3390\/vaccines11091442","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T08:19:39Z","timestamp":1693556379000},"page":"1442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety of Interchanging the Live Attenuated MAV\/06 Strain and OKA Strain Varicella Vaccines in Children"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-8407","authenticated-orcid":false,"given":"Hyun Mi","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwanglok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Corporate Development, GC Biopharma Corporation, Yongin 16924, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young June","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Korea University College of Medicine, Korea University Anam Hospital, Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1097\/00006454-200111001-00004","article-title":"Interchangeability of vaccines","volume":"20","author":"Feldman","year":"2001","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_2","first-page":"1","article-title":"General Recommendations on Immunization\u2014Recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"60","author":"Atkinson","year":"2011","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3345\/cep.2021.01564","article-title":"Global varicella vaccination programs","volume":"65","author":"Lee","year":"2022","journal-title":"Clin. Exp. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hong, K., Sohn, S., Choe, Y.J., Rhie, K., Lee, J.K., Han, M.S., Chun, B.C., and Choi, E.H. (2021). Waning Effectiveness of One-dose Universal Varicella Vaccination in Korea, 2011\u20132018: A Propensity Score Matched National Population Cohort. J. Korean Med. 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Pediatr."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/9\/1442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:44:22Z","timestamp":1760129062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/9\/1442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["vaccines11091442"],"URL":"https:\/\/doi.org\/10.3390\/vaccines11091442","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,31]]}}}