{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:24:23Z","timestamp":1780374263032,"version":"3.54.1"},"reference-count":88,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Government of Aragon"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Rabies, a viral disease spread by infected animal bites that causes encephalitis in humans and other mammals, is a neglected infectious disease present on all continents except Antarctica. Spain has been free of terrestrial rabies since 1978. However, due to its geographical situation, it represents a bridge for imported cases from an endemic continent such as Africa to Europe. Rabies vaccination in dogs is an essential preventive tool against this zoonosis. The aim of this study was to determine the state of the immune response against rabies virus in dogs in Spain and to demonstrate whether several factors that have been previously related to the influence of the seroprevalence of this species are involved here. The seroconversion level of this zoonotic virus was assessed in a total of 1060 animals. Indirect ELISA was used to obtain data for statistical analysis to evaluate the studied variables. Working under the concept of One Health, this study provides relevant information to be taken into consideration not only to prevent re-emergence in countries free of this disease but also for prevention and control in endemic countries.<\/jats:p>","DOI":"10.3390\/vaccines12030293","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T03:55:34Z","timestamp":1710215734000},"page":"293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors Involved in the Immunological Protection against Rabies Virus in Dogs in Spain"],"prefix":"10.3390","volume":"12","author":[{"given":"Mar\u00eda Dolores","family":"Manzano","sequence":"first","affiliation":[{"name":"Research Centre for Encephalopathies and Transmissible Emerging Diseases, Institute for Health Research Arag\u00f3n (IIS), University of Zaragoza, 50013 Zaragoza, Spain"},{"name":"Programa de Doctorado en Ciencias Biom\u00e9dicas y Salud P\u00fablica UNED-IMIENS, Universidad Nacional de Educaci\u00f3n a Distancia (UNED), 28015 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cereza","sequence":"additional","affiliation":[{"name":"Centro T\u00e9cnico Veterinario (Diputaci\u00f3n de Zaragoza), 22002 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Colegio Oficial de Veterinarios de Zaragoza, 50010 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Javier","family":"Yus","sequence":"additional","affiliation":[{"name":"Colegio Oficial de Veterinarios de Zaragoza, 50010 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Badiola","sequence":"additional","affiliation":[{"name":"Research Centre for Encephalopathies and Transmissible Emerging Diseases, Institute for Health Research Arag\u00f3n (IIS), University of Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7522-850X","authenticated-orcid":false,"given":"Juan Emilio","family":"Echevarria","sequence":"additional","affiliation":[{"name":"Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2787-9671","authenticated-orcid":false,"given":"Marta","family":"Monz\u00f3n","sequence":"additional","affiliation":[{"name":"Research Centre for Encephalopathies and Transmissible Emerging Diseases, Institute for Health Research Arag\u00f3n (IIS), University of Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.2460\/javma.253.12.1555","article-title":"Rabies Surveillance in the United States during 2017","volume":"253","author":"Ma","year":"2018","journal-title":"J. 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