{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T12:29:18Z","timestamp":1780144158320,"version":"3.54.0"},"reference-count":161,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Vaccines prevent a significant number of deaths annually. However, certain populations do not respond adequately to vaccination due to impaired immune systems. Cirrhosis, a condition marked by a profound disruption of immunity, impairs the normal immunization process. Critical vaccines for cirrhotic patients, such as the hepatitis A virus (HAV), hepatitis B virus (HBV), influenza, pneumococcal, and coronavirus disease 19 (COVID-19), often elicit suboptimal responses in these individuals. The humoral response, essential for immunization, is less effective in cirrhosis due to a decline in B memory cells and an increase in plasma blasts, which interfere with the creation of a long-lasting response to antigen vaccination. Additionally, some T cell subtypes exhibit reduced activation in cirrhosis. Nonetheless, the persistence of memory T cell activity, while not preventing infections, may help to attenuate the severity of diseases in these patients. Alongside that, the impairment of innate immunity, particularly in dendritic cells (DCs), prevents the normal priming of adaptive immunity, interrupting the immunization process at its onset. Furthermore, cirrhosis disrupts the gut\u2013liver axis balance, causing dysbiosis, reduced production of short-chain fatty acids (SCFAs), increased intestinal permeability, and bacterial translocation. Undermining the physiological activity of the immune system, these alterations could impact the vaccine response. Enhancing the understanding of the molecular and cellular factors contributing to impaired vaccination responses in cirrhotic patients is crucial for improving vaccine efficacy in this population and developing better prevention strategies.<\/jats:p>","DOI":"10.3390\/vaccines12040349","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:40:11Z","timestamp":1711370411000},"page":"349","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vaccine Responses in Patients with Liver Cirrhosis: From the Immune System to the Gut Microbiota"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-924X","authenticated-orcid":false,"given":"Carlo","family":"Airola","sequence":"first","affiliation":[{"name":"Liver Unit, CEMAD Centro Malattie dell\u2019Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0734-9712","authenticated-orcid":false,"given":"Silvia","family":"Andaloro","sequence":"additional","affiliation":[{"name":"Liver Unit, CEMAD Centro Malattie dell\u2019Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-1779","authenticated-orcid":false,"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[{"name":"Liver Unit, CEMAD Centro Malattie dell\u2019Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Department of Translational Medicine and Surgery, Catholic University, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5924-6238","authenticated-orcid":false,"given":"Francesca Romana","family":"Ponziani","sequence":"additional","affiliation":[{"name":"Liver Unit, CEMAD Centro Malattie dell\u2019Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Department of Translational Medicine and Surgery, Catholic University, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41577-020-00479-7","article-title":"A guide to vaccinology: From basic principles to new developments","volume":"21","author":"Pollard","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/j.vaccine.2016.03.060","article-title":"Progress towards hepatitis B prevention through vaccination in the Western Pacific, 1990\u20132014","volume":"34","author":"Wiesen","year":"2016","journal-title":"Vaccine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S1473-3099(22)00320-6","article-title":"Global impact of the first year of COVID-19 vaccination: A mathematical modelling study","volume":"22","author":"Watson","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"934476","DOI":"10.3389\/fimmu.2022.934476","article-title":"Antibody response following the third and fourth SARS-CoV-2 vaccine dose in individuals with common variable immunodeficiency","volume":"13","author":"Nielsen","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1089\/apc.2014.0121","article-title":"Vaccination in HIV-infected adults","volume":"28","author":"Wallace","year":"2014","journal-title":"AIDS Patient Care STDS"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.12659\/MSM.915637","article-title":"Microbial Infections as a Trigger for Acute-on-Chronic Liver Failure: A Review","volume":"25","author":"Cai","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13054-023-04540-4","article-title":"Acute-on-chronic liver failure: Far to go\u2014A review","volume":"27","author":"Luo","year":"2023","journal-title":"Crit. Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1053\/jhep.2002.36509","article-title":"HBV superinfection in hepatitis C virus chronic carriers, viral interaction, and clinical course","volume":"36","author":"Sagnelli","year":"2002","journal-title":"Hepatology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/1097-0142(19941101)74:9<2442::AID-CNCR2820740909>3.0.CO;2-#","article-title":"Concurrent hepatitis B and C virus infection and risk of hepatocellular carcinoma in cirrhosis. A prospective study","volume":"74","author":"Fattovich","year":"1994","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1056\/NEJM199801293380503","article-title":"Fulminant hepatitis associated with hepatitis A virus superinfection in patients with chronic hepatitis C","volume":"338","author":"Vento","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/00034983.1999.11813480","article-title":"Acute, hepatitis-A super-infection in HBV carriers, or chronic liver disease related to HBV or HCV","volume":"93","author":"Pramoolsinsap","year":"1999","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e018553","DOI":"10.1136\/bmjopen-2017-018553","article-title":"Risk of pneumococcal diseases in adults with underlying medical conditions: A retrospective, cohort study using two Japanese healthcare databases","volume":"8","author":"Imai","year":"2018","journal-title":"BMJ Open"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.jhep.2018.11.015","article-title":"Influenza virus infection as precipitating event of acute-on-chronic liver failure","volume":"70","author":"Ciesek","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archinte.160.1.113","article-title":"Hepatic decompensation in patients with cirrhosis during infection with influenza A","volume":"160","author":"Duchini","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.31649","article-title":"Cirrhosis and Severe Acute Respiratory Syndrome Coronavirus 2 Infection in US Veterans: Risk of Infection, Hospitalization, Ventilation, and Mortality","volume":"74","author":"Ioannou","year":"2021","journal-title":"Hepatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s12072-020-10072-8","article-title":"Pre-existing liver disease is associated with poor outcome in patients with SARS CoV2 infection; The APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study)","volume":"14","author":"Sarin","year":"2020","journal-title":"Hepatol. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jhep.2020.06.001","article-title":"High rates of 30-day mortality in patients with cirrhosis and COVID-19","volume":"73","author":"Iavarone","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jceh.2021.05.003","article-title":"Outcomes of COVID-19 in Patients with Cirrhosis or Liver Transplantation","volume":"11","author":"Choudhary","year":"2021","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100776","DOI":"10.1016\/j.jhepr.2023.100776","article-title":"Vaccination in liver diseases and liver Transplantation: Recommendations, implications and opportunities in the post-covid era","volume":"5","author":"Ballester","year":"2023","journal-title":"JHEP Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1177\/1060028020962050","article-title":"Heplisav-B: A Hepatitis B Vaccine With a Novel Adjuvant","volume":"55","author":"Champion","year":"2021","journal-title":"Ann. Pharmacother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.3748\/wjg.v28.i31.4249","article-title":"Insights into induction of the immune response by the hepatitis B vaccine","volume":"28","author":"Flichman","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e1942","DOI":"10.1002\/rmv.1942","article-title":"Response to hepatitis B vaccination in patients with liver cirrhosis","volume":"27","author":"Aggeletopoulou","year":"2017","journal-title":"Rev. Med. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1177\/08971900221078742","article-title":"Efficacy of Hepatitis B Vaccine in Adults with Chronic Liver Disease","volume":"36","author":"Kim","year":"2023","journal-title":"J. Pharm. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/00042737-200104000-00010","article-title":"Immunogenicity of two accelerated hepatitis B vaccination protocols in liver transplant candidates","volume":"13","author":"Engler","year":"2001","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1053\/jlts.2001.23069","article-title":"Double-dose accelerated hepatitis B vaccine in patients with end-stage liver disease","volume":"7","author":"Arslan","year":"2001","journal-title":"Liver Transpl."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10620-011-1996-0","article-title":"Efficacy of high-dose intra-dermal hepatitis B virus vaccine in previous vaccination non-responders with chronic liver disease","volume":"57","author":"Dhillon","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/S0264-410X(03)00221-4","article-title":"Intramuscular versus intradermal administration of anti-hepatitis B vaccine in non-cirrhotic hepatitis C patients","volume":"21","author":"Arbizu","year":"2003","journal-title":"Vaccine"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1007\/s10620-020-06437-6","article-title":"Two-Dose Hepatitis B Vaccine (Heplisav-B) Results in Better Seroconversion Than Three-Dose Vaccine (Engerix-B) in Chronic Liver Disease","volume":"66","author":"Amjad","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.transproceed.2012.05.071","article-title":"Response to vaccination against hepatitis B virus with a schedule of four 40-\u03bcg doses in cirrhotic patients evaluated for liver transplantation: Factors associated with a response","volume":"44","year":"2012","journal-title":"Transplant. Proc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"196704","DOI":"10.1155\/2013\/196704","article-title":"Safety and efficacy of hepatitis B vaccination in cirrhosis of liver","volume":"2013","author":"Roni","year":"2013","journal-title":"Adv. Virol."},{"key":"ref_31","first-page":"166","article-title":"Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: An open-label randomised clinical trial","volume":"73","year":"2023","journal-title":"Gut"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/hep.510270336","article-title":"Safety and immunogenicity of hepatitis A vaccine in patients with chronic liver disease","volume":"27","author":"Keeffe","year":"1998","journal-title":"Hepatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/jhep.2001.25883","article-title":"Immunogenicity of hepatitis A vaccination in decompensated cirrhotic patients","volume":"34","author":"Arguedas","year":"2001","journal-title":"Hepatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/hep.1840040527","article-title":"Pneumococcal vaccination: The response of patients with alcoholic liver cirrhosis","volume":"4","author":"Pirovino","year":"1984","journal-title":"Hepatology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1164\/ajrccm\/146.4.1054","article-title":"Effect of cirrhosis on the production and efficacy of pneumococcal capsular antibody in a rat model","volume":"146","author":"Preheim","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1086\/315245","article-title":"Pneumococcal vaccine response in cirrhosis and liver transplantation","volume":"181","author":"McCashland","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e031070","DOI":"10.1136\/bmjopen-2019-031070","article-title":"Effectiveness of influenza vaccines in adults with chronic liver disease: A systematic review and meta-analysis","volume":"9","author":"Parisinos","year":"2019","journal-title":"BMJ Open"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"B33","DOI":"10.1016\/S0264-410X(02)00510-8","article-title":"Immunogenicity and safety of an adjuvanted influenza vaccine in patients with decompensated cirrhosis","volume":"20","author":"Gaeta","year":"2002","journal-title":"Vaccine"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.jhep.2021.08.008","article-title":"Analysis of antibody responses after COVID-19 vaccination in liver transplant recipients and those with chronic liver diseases","volume":"75","author":"Thuluvath","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bakasis, A.D., Bitzogli, K., Mouziouras, D., Pouliakis, A., Roumpoutsou, M., Goules, A.V., and Androutsakos, T. (2022). Antibody Responses after SARS-CoV-2 Vaccination in Patients with Liver Diseases. Viruses, 14.","DOI":"10.3390\/v14020207"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.dld.2022.09.010","article-title":"Spike-specific humoral and cellular immune responses after COVID-19 mRNA vaccination in patients with cirrhosis: A prospective single center study","volume":"55","author":"Iavarone","year":"2023","journal-title":"Dig. Liver Dis."},{"key":"ref_42","first-page":"151","article-title":"Real-world effectiveness of COVID-19 vaccination in liver cirrhosis: A systematic review with meta-analysis of 51,834 patients","volume":"36","author":"Beran","year":"2023","journal-title":"Proceedings (Bayl. Univ. Med. Cent.)"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jcv.2009.05.006","article-title":"Why actively promote vaccination in patients with cirrhosis?","volume":"46","author":"Loulergue","year":"2009","journal-title":"J. Clin. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Casella, G., Ingravalle, F., Ingravalle, A., Andreotti, S., Bonetti, F., Monti, C., Falbo, R., and Rumi, M.G. (2023). Approaches for Selective Vaccinations in Cirrhotic Patients. Vaccines, 11.","DOI":"10.3390\/vaccines11020460"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s10620-005-2873-5","article-title":"Immunization needs of chronic liver disease patients seen in primary care versus specialist settings","volume":"50","author":"Jacobs","year":"2005","journal-title":"Dig. Dis. Sci."},{"key":"ref_46","unstructured":"Advisory Committee on Immunization Practices (ACIP), Fiore, A.E., Wasley, A., and Bell, B.P. (2006). Prevention of hepatitis A through active or passive immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep., 55, 1\u201323."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.15585\/mmwr.mm7206a2","article-title":"Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older\u2014United States, 2023","volume":"72","author":"Murthy","year":"2023","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.lpm.2008.11.015","article-title":"Vaccinations chez les patients ayant une cirrhose [Vaccination in patients with cirrhosis]","volume":"38","author":"Loulergue","year":"2009","journal-title":"Presse Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jcv.2007.04.018","article-title":"Clinical impact of influenza immunization in patients with liver cirrhosis","volume":"39","author":"Song","year":"2007","journal-title":"J. Clin. Virol."},{"key":"ref_50","first-page":"1","article-title":"A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: Immunization of infants, children, and adolescents","volume":"54","author":"Mast","year":"2005","journal-title":"MMWR Recomm. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.jhep.2021.06.035","article-title":"Acute-on-chronic liver failure: A complex clinical entity in patients with autoimmune hepatitis","volume":"75","author":"Granito","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Al-Dury, S., and Kanberg, N. (2024). Advancements in Vaccine Strategies for Chronic Liver Disease Patients: Navigating Post-COVID Challenges and Opportunities. Vaccines, 12.","DOI":"10.3390\/vaccines12020197"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s11894-012-0300-6","article-title":"Immunizations in chronic liver disease: What should be done and what is the evidence","volume":"15","author":"Leise","year":"2013","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jceh.2021.12.003","article-title":"Vaccination in Chronic Liver Disease: An Update","volume":"12","author":"Alukal","year":"2022","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1053\/jlts.2000.8313","article-title":"Vaccination against hepatitis B virus in cirrhotic patients on liver transplant waiting list","volume":"6","year":"2000","journal-title":"Liver Transpl."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1086\/315125","article-title":"Immunogenicity and safety of hepatitis A vaccine in liver and renal transplant recipients","volume":"180","author":"Stark","year":"1999","journal-title":"J. Infect. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/00007890-199903150-00019","article-title":"Influenza vaccination in liver transplant recipients","volume":"67","author":"Burbach","year":"1999","journal-title":"Transplantation"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00007890-200008150-00026","article-title":"Influenza A myocarditis developing in an adult liver transplant recipient despite vaccination: A case report and review of the literature","volume":"70","author":"Vilchez","year":"2000","journal-title":"Transplantation"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1529-8019.2009.01223.x","article-title":"Vaccine immunology","volume":"22","author":"Bartlett","year":"2009","journal-title":"Dermatol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Soto, J.A., D\u00edaz, F.E., Retamal-D\u00edaz, A., G\u00e1lvez, N.M.S., Melo-Gonz\u00e1lez, F., Pi\u00f1a-Iturbe, A., Ram\u00edrez, M.A., Bohmwald, K., Gonz\u00e1lez, P.A., and Bueno, S.M. (2022). BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus. Vaccines, 10.","DOI":"10.3390\/vaccines10050721"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.it.2004.12.006","article-title":"CD69 is an immunoregulatory molecule induced following activation","volume":"26","author":"Sancho","year":"2005","journal-title":"Trends Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1182\/blood.V95.7.2312","article-title":"Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice","volume":"95","author":"Lauzurica","year":"2000","journal-title":"Blood"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/416094a","article-title":"Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position","volume":"416","author":"Reif","year":"2002","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.3389\/fimmu.2019.01787","article-title":"Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination","volume":"10","author":"Palm","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2567.2011.03517.x","article-title":"T-cell-inducing vaccines\u2014What\u2019s the future","volume":"135","author":"Gilbert","year":"2012","journal-title":"Immunology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/21548331.1989.11703779","article-title":"Infections in patients with humoral immunodeficiency","volume":"24","author":"Heinzel","year":"1989","journal-title":"Hosp. Pract. (Off. Ed.)"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"15016","DOI":"10.1038\/nrdp.2015.16","article-title":"Varicella zoster virus infection","volume":"1","author":"Gershon","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1126\/science.add2897","article-title":"T cell immunity to COVID-19 vaccines","volume":"377","author":"Wherry","year":"2022","journal-title":"Science"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1073\/pnas.0501254102","article-title":"CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization","volume":"102","author":"Malley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.4049\/jimmunol.0801694","article-title":"Antigen load governs the differential priming of CD8 T cells in response to the bacille Calmette Guerin vaccine or Mycobacterium tuberculosis infection","volume":"182","author":"Ryan","year":"2009","journal-title":"J. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"abm0829","DOI":"10.1126\/science.abm0829","article-title":"mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern","volume":"374","author":"Goel","year":"2021","journal-title":"Science"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Echaide, M., Chocarro de Erauso, L., Bocanegra, A., Blanco, E., Kochan, G., and Escors, D. (2023). mRNA Vaccines against SARS-CoV-2: Advantages and Caveats. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065944"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/ni.1814","article-title":"Multiple layers of B cell memory with different effector functions","volume":"10","author":"Dogan","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-065X.2010.00938.x","article-title":"Memory B and memory plasma cells","volume":"237","author":"Yoshida","year":"2010","journal-title":"Immunol. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1615\/CritRevImmunol.2018024985","article-title":"Heterogeneity of Memory Marginal Zone B Cells","volume":"38","author":"Hendricks","year":"2018","journal-title":"Crit. Rev. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e2204607119","DOI":"10.1073\/pnas.2204607119","article-title":"Early human B cell signatures of the primary antibody response to mRNA vaccination","volume":"119","author":"Kardava","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/s41467-017-01728-5","article-title":"Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA","volume":"8","author":"Tian","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.3389\/fimmu.2018.01860","article-title":"CD4 TRM Cells Following Infection and Immunization: Implications for More Effective Vaccine Design","volume":"9","author":"Wilk","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3389\/fimmu.2018.01214","article-title":"Niches for the Long-Term Maintenance of Tissue-Resident Memory T Cells","volume":"9","author":"Takamura","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1039194","DOI":"10.3389\/fimmu.2022.1039194","article-title":"Tissue resident memory T cells\u2014A new benchmark for the induction of vaccine-induced mucosal immunity","volume":"13","author":"Hassert","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41577-023-00853-1","article-title":"Assessing the generation of tissue resident memory T cells by vaccines","volume":"23","author":"Rotrosen","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Lumsden, J.M., Schwenk, R.J., Rein, L.E., Moris, P., Janssens, M., Ofori-Anyinam, O., Cohen, J., Kester, K.E., Heppner, D.G., and Krzych, U. (2011). Protective immunity induced with the RTS,S\/AS vaccine is associated with IL-2 and TNF-\u03b1 producing effector and central memory CD4 T cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020775"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/imm.12929","article-title":"The roles of resident, central and effector memory CD4 T-cells in protective immunity following infection or vaccination","volume":"154","author":"Gray","year":"2018","journal-title":"Immunology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","article-title":"Follicular Helper T Cells","volume":"34","author":"Vinuesa","year":"2016","journal-title":"Annu. Rev. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri3803","article-title":"A brief history of T cell help to B cells","volume":"15","author":"Crotty","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.3389\/fimmu.2018.03176","article-title":"Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy","volume":"9","author":"Patente","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nri3689","article-title":"Follicular dendritic cells: Dynamic antigen libraries","volume":"14","author":"Heesters","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-1-4939-3606-9_14","article-title":"Cross-Presentation Assay for Human Dendritic Cells","volume":"1423","author":"Segura","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Xu, R.H., Remakus, S., Ma, X., Roscoe, F., and Sigal, L.J. (2010). Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000768"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nm1257","article-title":"Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination","volume":"11","author":"Badovinac","year":"2005","journal-title":"Nat. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1084\/jem.20051720","article-title":"Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity","volume":"203","author":"Querec","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41573-021-00163-y","article-title":"Emerging concepts in the science of vaccine adjuvants","volume":"20","author":"Pulendran","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3109\/08820131003680369","article-title":"Function of mucosa-associated lymphoid tissue in antibody formation","volume":"39","author":"Brandtzaeg","year":"2010","journal-title":"Immunol. Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nri3251","article-title":"Recent progress in mucosal vaccine development: Potential and limitations","volume":"12","author":"Lycke","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1016\/j.vaccine.2021.06.010","article-title":"Cytoplasmic expression of a model antigen with M Cell-Targeting moiety in lactic acid bacteria and implication of the mechanism as a mucosal vaccine via oral route","volume":"39","author":"Oh","year":"2021","journal-title":"Vaccine"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nri2729","article-title":"Effector and regulatory B cells: Modulators of CD4+ T cell immunity","volume":"10","author":"Lund","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"113928","DOI":"10.1016\/j.addr.2021.113928","article-title":"Advanced oral vaccine delivery strategies for improving the immunity","volume":"177","author":"Zhang","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.addr.2011.07.003","article-title":"Gut-associated lymphoid tissues for the development of oral vaccines","volume":"64","author":"Kunisawa","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1093\/infdis\/171.6.1387","article-title":"Perspective: Hypothesis: Serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculum","volume":"171","author":"Robbins","year":"1995","journal-title":"J. Infect. Dis."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Kwong, K.W., Xin, Y., Lai, N.C., Sung, J.C., Wu, K.C., Hamied, Y.K., Sze, E.T., and Lam, D.M. (2023). Oral Vaccines: A Better Future of Immunization. Vaccines, 11.","DOI":"10.3390\/vaccines11071232"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jhep.2014.08.010","article-title":"Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance","volume":"61","author":"Albillos","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41575-021-00520-7","article-title":"Cirrhosis-associated immune dysfunction","volume":"19","author":"Albillos","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"100697","DOI":"10.1016\/j.jhepr.2023.100697","article-title":"Cirrhosis is associated with lower serological responses to COVID-19 vaccines in patients with chronic liver disease","volume":"5","author":"Palma","year":"2023","journal-title":"JHEP Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e309","DOI":"10.1016\/S2666-5247(23)00012-5","article-title":"Correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel (ICoFS): A prospective cohort study","volume":"4","author":"Lustig","year":"2023","journal-title":"Lancet Microbe"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/CVI.00131-10","article-title":"Correlates of protection induced by vaccination","volume":"17","author":"Plotkin","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_107","first-page":"407","article-title":"Flow Cytometry in the Diagnosis and Follow Up of Human Primary Immunodeficiencies","volume":"30","author":"Salzer","year":"2019","journal-title":"EJIFCC"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/00002030-200105250-00003","article-title":"Loss of memory (CD27) B lymphocytes in HIV-1 infection","volume":"15","author":"Chiodi","year":"2001","journal-title":"AIDS"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/hep.24689","article-title":"Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population","volume":"55","author":"Doi","year":"2012","journal-title":"Hepatology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3109\/00365521.2014.907335","article-title":"B-cell-associated immune profiles in patients with decompensated cirrhosis","volume":"50","author":"Jhun","year":"2015","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/jgh.14123","article-title":"Enhanced B-cell differentiation driven by advanced cirrhosis resulting in hyperglobulinemia","volume":"33","author":"Doi","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Liu, W.T., Jing, Y.Y., Han, Z.P., Li, X.N., Liu, Y., Lai, F.B., Li, R., Zhao, Q.D., Wu, M.C., and Wei, L.X. (2015). The injured liver induces hyperimmunoglobulinemia by failing to dispose of antigens and endotoxins in the portal system. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122739"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"20383","DOI":"10.1038\/s41598-020-77416-0","article-title":"Impact of deranged B cell subsets distribution in the development of HCV-related cirrhosis and HCC in type two diabetes mellitus","volume":"10","author":"Abdelwahab","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_114","first-page":"4545","article-title":"Characteristics of peripheral and intrahepatic regulatory B cells in HBV-related liver cirrhosis","volume":"11","author":"Xiong","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/s41419-020-03060-1","article-title":"Metabolic defects in splenic B cell compartments from patients with liver cirrhosis","volume":"11","author":"Huang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"E546","DOI":"10.1073\/pnas.1416276112","article-title":"Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions","volume":"112","author":"Seifert","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.3389\/fimmu.2019.01915","article-title":"Hyperactive Follicular Helper T Cells Contribute to Dysregulated Humoral Immunity in Patients With Liver Cirrhosis","volume":"10","author":"Zhao","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1499-3872(16)60054-1","article-title":"CD4+CXCR5+ T cells activate CD27+IgG+ B cells via IL-21 in patients with hepatitis C virus infection","volume":"15","author":"Kong","year":"2016","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"ref_119","first-page":"50","article-title":"Immune Dysfunction in Cirrhosis","volume":"5","author":"Noor","year":"2017","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jhep.2023.02.026","article-title":"Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury","volume":"79","author":"Hackstein","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ebiom.2019.10.011","article-title":"CD8+ T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction","volume":"49","author":"Gudd","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Shive, C.L., Kowal, C.M., Desotelle, A.F., Nguyen, Y., Carbone, S., Kostadinova, L., Davitkov, P., O\u2019Mara, M., Reihs, A., and Siddiqui, H. (2023). Endotoxemia Associated with Liver Disease Correlates with Systemic Inflammation and T Cell Exhaustion in Hepatitis C Virus Infection. Cells, 12.","DOI":"10.3390\/cells12162034"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jhep.2013.05.042","article-title":"Defective thymopoiesis and poor peripheral homeostatic replenishment of T-helper cells cause T-cell lymphopenia in cirrhosis","volume":"59","author":"Lario","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/hep.32337","article-title":"Postvaccination COVID-19 infection is associated with reduced mortality in patients with cirrhosis","volume":"76","author":"John","year":"2022","journal-title":"Hepatology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s10020-022-00484-7","article-title":"MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine","volume":"28","author":"Boulouis","year":"2022","journal-title":"Mol. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/hep.31153","article-title":"MAIT Cells Are Enriched and Highly Functional in Ascites of Patients With Decompensated Liver Cirrhosis","volume":"72","author":"Niehaus","year":"2020","journal-title":"Hepatology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/s41467-018-04450-y","article-title":"Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver","volume":"9","author":"Hegde","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/livers3030028","article-title":"Dysfunctions of Circulating Adaptive Immune Cells in End-Stage Liver Disease","volume":"3","author":"Liu","year":"2023","journal-title":"Livers"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1038\/s41598-021-85148-y","article-title":"Patterns of dendritic cell and monocyte subsets are associated with disease severity and mortality in liver cirrhosis patients","volume":"11","author":"Cardoso","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1038\/srep03459","article-title":"Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell","volume":"3","author":"Kakazu","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2567.2007.02577.x","article-title":"Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4+ T-cell proliferation in patients with hepatitis C virus infection","volume":"121","author":"Crosignani","year":"2007","journal-title":"Immunology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.3748\/wjg.v22.i4.1393","article-title":"Analysis of peripheral blood dendritic cells as a non-invasive tool in the follow-up of patients with chronic hepatitis C","volume":"22","author":"Crosignani","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fimmu.2019.00112","article-title":"Circulating and Hepatic BDCA1+, BDCA2+, and BDCA3+ Dendritic Cells Are Differentially Subverted in Patients With Chronic HBV Infection","volume":"10","author":"Ouaguia","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.20092627","article-title":"MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity","volume":"207","author":"Irla","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/TP.0000000000002867","article-title":"Plasmacytoid Dendritic Cell-driven Induction of Treg Is Strain Specific and Correlates With Spontaneous Acceptance of Kidney Allografts","volume":"104","author":"Oh","year":"2020","journal-title":"Transplantation"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1034\/j.1600-6143.2003.00109.x","article-title":"Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients","volume":"3","author":"Mazariegos","year":"2003","journal-title":"Am. J. Transplant."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/ajt.12229","article-title":"Plasmacytoid dendritic cells: No longer an enigma and now key to transplant tolerance?","volume":"13","author":"Rogers","year":"2013","journal-title":"Am. J. Transplant."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Brezar, V., Godot, V., Cheng, L., Su, L., L\u00e9vy, Y., and Seddiki, N. (2016). T-Regulatory Cells and Vaccination \u201cPay Attention and Do Not Neglect Them\u201d: Lessons from HIV and Cancer Vaccine Trials. Vaccines, 4.","DOI":"10.3390\/vaccines4030030"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"26984","DOI":"10.1038\/srep26984","article-title":"The Balance between Conventional DCs and Plasmacytoid DCs Is Pivotal for Immunological Tolerance during Pregnancy in the Mouse","volume":"6","author":"Fang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3389\/fimmu.2019.01222","article-title":"What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity","volume":"10","author":"Musumeci","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/14760584.2021.1908133","article-title":"CpG-Adjuvanted Hepatitis B Vaccine (HEPLISAV-B\u00ae) Update","volume":"20","author":"Lee","year":"2021","journal-title":"Expert. Rev. Vaccines"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/JLB.3A0218-072R","article-title":"Ascitic fluid regulates the local innate immune response of patients with cirrhosis","volume":"104","author":"Nieto","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1139554","DOI":"10.3389\/fimmu.2023.1139554","article-title":"The shaping of gut immunity in cirrhosis","volume":"14","author":"Albillos","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"B55","DOI":"10.1016\/j.vaccine.2015.03.058","article-title":"Beyond adjuvants: Antagonizing inflammation to enhance vaccine immunity","volume":"33","author":"Alter","year":"2015","journal-title":"Vaccine"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/gut.23.6.475","article-title":"Serum and intestinal secretory IgA in alcoholic cirrhosis of the liver","volume":"23","author":"Pelletier","year":"1982","journal-title":"Gut"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jhep.2020.11.048","article-title":"The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis","volume":"74","author":"Arroyo","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"7537649","DOI":"10.1155\/2019\/7537649","article-title":"Immune Dysfunction and Albumin-Related Immunity in Liver Cirrhosis","volume":"2019","author":"Wilde","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Chen, D., Le, T.H., Shahidipour, H., Read, S.A., and Ahlenstiel, G. (2019). The Role of Gut-Derived Microbial Antigens on Liver Fibrosis Initiation and Progression. Cells, 8.","DOI":"10.3390\/cells8111324"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.immuni.2018.12.018","article-title":"The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages","volume":"50","author":"Schulthess","year":"2019","journal-title":"Immunity"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1038\/ncomms4611","article-title":"The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism","volume":"5","author":"Frost","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/BJ20082222","article-title":"The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: Implications for epithelial protection","volume":"420","author":"Vincent","year":"2009","journal-title":"Biochem. J."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/liv.14106","article-title":"Faecal microbiota from patients with cirrhosis has a low capacity to ferment non-digestible carbohydrates into short-chain fatty acids","volume":"39","author":"Jin","year":"2019","journal-title":"Liver Int."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s12967-023-04262-9","article-title":"Integrative analysis of the gut microbiota and faecal and serum short-chain fatty acids and tryptophan metabolites in patients with cirrhosis and hepatic encephalopathy","volume":"21","author":"Wang","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.chom.2016.07.001","article-title":"Gut Microbial Metabolites Fuel Host Antibody Responses","volume":"20","author":"Kim","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"718783","DOI":"10.3389\/fphys.2021.718783","article-title":"Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction","volume":"12","author":"Sauerbruch","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.femsre.2004.09.003","article-title":"The interaction between bacteria and bile","volume":"29","author":"Begley","year":"2005","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/hep.24525","article-title":"The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor \u03ba light-chain enhancer of activated B cells (NF-\u03baB) in mice","volume":"54","author":"Wang","year":"2011","journal-title":"Hepatology"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1038\/s41598-024-52969-6","article-title":"Bile acid profiles in adult patients with biliary atresia who achieve native liver survival after portoenterostomy","volume":"14","author":"Takeda","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.cell.2019.08.010","article-title":"Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans","volume":"178","author":"Hagan","year":"2019","journal-title":"Cell"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"642546","DOI":"10.3389\/fimmu.2021.642546","article-title":"Bile Acids Impair Vaccine Response in Children with Biliary Atresia","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Ponziani, F.R., Coppola, G., Rio, P., Caldarelli, M., Borriello, R., Gambassi, G., Gasbarrini, A., and Cianci, R. (2023). Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go. 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