{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:21:29Z","timestamp":1783052489245,"version":"3.54.6"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center for Tropical Diseases and Global Health (CTDGH) at the Catholic University of Bukavu (UCB)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>COVID-19 vaccine hesitancy and its enablers shape community uptake of non-covid vaccines such as the oral cholera vaccine (OCV) in the post-COVID-19 era. This study assessed the impact of COVID-19 vaccine hesitancy and its drivers on OCV hesitancy in a cholera-endemic region of the Democratic Republic of Congo. We conducted a community-based survey in Bukavu. The survey included demographics, intention to take OCV and COVID-19 vaccines, reasons for COVID-19 hesitancy, and thoughts and feelings about COVID-19 vaccines. Poisson regression analyses were performed. Of the 1708 respondents, 84.66% and 77.57% were hesitant to OCV alone and to both OCV and COVID-19, respectively. Hesitancy to COVID-19 vaccines rose OCV hesitancy by 12% (crude prevalence ratio, [cPR] = 1.12, 95%CI [1.03\u20131.21]). Independent predictors of OCV hesitancy were living in a semi-urban area (adjusted prevalence ratio [aPR] = 1.10, 95%CI [1.03\u20131.12]), religious refusal of vaccines (aPR = 1.06, 95%CI [1.02\u20131.12]), concerns about vaccine safety (aPR = 1.05, 95%CI [1.01\u20131.11]) and adverse effects (aPR = 1.06, 95%CI [1.01\u20131.12]), as well as poor vaccine literacy (aPR = 1.07, 95%CI [1.01\u20131.14]). Interestingly, the belief in COVID-19 vaccine effectiveness reduced OCV hesitancy by 24% (aPR = 0.76, 95%CI [0.62\u20130.93]). COVID-19 vaccine hesitancy and its drivers exhibited a significant domino effect on OCV uptake. Addressing vaccine hesitancy through community-based health literacy and trust-building interventions would likely improve the introduction of novel non-COVID-19 vaccines in the post-COVID-19 era.<\/jats:p>","DOI":"10.3390\/vaccines12040444","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:44:09Z","timestamp":1713771849000},"page":"444","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["COVID-19 Vaccine Hesitancy and Associated Oral Cholera Vaccine Hesitancy in a Cholera-Endemic Country: A Community-Based Cross-Sectional Study in the Democratic Republic of Congo"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-3928","authenticated-orcid":false,"given":"Arsene Daniel","family":"Nyalundja","sequence":"first","affiliation":[{"name":"Center for Tropical Diseases and Global Health (CTDGH), Catholic University of Bukavu (UCB), Bukavu 285, Democratic Republic of the Congo"},{"name":"Faculty of Medicine, Catholic University of Bukavu (UCB), Bukavu 285, Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-0265","authenticated-orcid":false,"given":"Patrick Musole","family":"Bugeme","sequence":"additional","affiliation":[{"name":"Center for Tropical Diseases and Global Health (CTDGH), Catholic University of Bukavu (UCB), Bukavu 285, Democratic Republic of the Congo"},{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9970-8120","authenticated-orcid":false,"given":"Alain Balola","family":"Ntaboba","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Catholic University of Bukavu (UCB), Bukavu 285, Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoire Urbain","family":"Hatu\u2019m","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Catholic University of Bukavu (UCB), Bukavu 285, Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0678-4013","authenticated-orcid":false,"given":"Guillaume Shamamba","family":"Ashuza","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Catholic University of Bukavu (UCB), Bukavu 285, Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1070-1962","authenticated-orcid":false,"given":"Jacques Lukenze","family":"Tamuzi","sequence":"additional","affiliation":[{"name":"Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duduzile","family":"Ndwandwe","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7501, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-7497","authenticated-orcid":false,"given":"Chinwe","family":"Iwu-Jaja","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7501, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Shey","family":"Wiysonge","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7501, South Africa"},{"name":"Vaccine-Preventable Diseases Programme, World Health Organization Regional Office for Africa, Brazzaville P.O. Box 06, Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D. M. C.","family":"Katoto","sequence":"additional","affiliation":[{"name":"Center for Tropical Diseases and Global Health (CTDGH), Catholic University of Bukavu (UCB), Bukavu 285, Democratic Republic of the Congo"},{"name":"Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa"},{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7501, South Africa"},{"name":"Centre for General Medicine and Global Health, Department of Medicine, University of Cape Town, Cape Town 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"ref_1","unstructured":"(2023, March 24). Cholera\u2014Global Situation. 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