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Alabama","award":["R01AI148711-03S1\/04S1"],"award-info":[{"award-number":["R01AI148711-03S1\/04S1"]}]},{"name":"Breast Cancer Research Foundation of Alabama","award":["R01CA276190"],"award-info":[{"award-number":["R01CA276190"]}]},{"name":"Breast Cancer Research Foundation of Alabama","award":["R21CA278853"],"award-info":[{"award-number":["R21CA278853"]}]},{"name":"Breast Cancer Research Foundation of Alabama","award":["RSG-23-1038722-01-IBCD"],"award-info":[{"award-number":["RSG-23-1038722-01-IBCD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Oncolytic virotherapy (OVT) has emerged as a promising cancer immunotherapy, and is capable of potentiating other immunotherapies due to its capacity to increase tumor immunogenicity and to boost host antitumor immunity. Natural killer (NK) cells are a critical cellular component for mediating the antitumor response, but hold a mixed reputation for their role in mediating the therapeutic efficacy of OVT. This review will discuss the pros and cons of how NK cells impact OVT, and how to harness this knowledge for the development of effective strategies that could modulate NK cells to improve OVT-based therapeutic outcomes.<\/jats:p>","DOI":"10.3390\/vaccines12070721","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T08:31:36Z","timestamp":1719563496000},"page":"721","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Role of Natural Killer Cells in Oncolytic Virotherapy: Friends or Foes?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-8156","authenticated-orcid":false,"given":"Michael L.","family":"Franks","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"},{"name":"Graduate Biomedical Sciences Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1808-5536","authenticated-orcid":false,"given":"Ju-Hyun","family":"An","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei W.","family":"Leavenworth","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"},{"name":"The O\u2019Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2017.01.017","article-title":"Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy","volume":"168","author":"Sharma","year":"2017","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.trecan.2022.10.003","article-title":"The emerging field of oncolytic virus-based cancer immunotherapy","volume":"9","author":"Ma","year":"2023","journal-title":"Trends Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/OV.S268426","article-title":"The Current State of Oncolytic Herpes Simplex Virus for Glioblastoma Treatment","volume":"10","author":"Nguyen","year":"2021","journal-title":"Oncolytic Virother."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Yin, J., Markert, J.M., and Leavenworth, J.W. 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