{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:46:39Z","timestamp":1782902799370,"version":"3.54.5"},"reference-count":33,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>In the present study, we evaluated the influence of maternal and neonatal factors on the efficiency of the placental transfer of neutralizing antibodies against SARS-CoV-2. Vaccination during pregnancy provides fetal and neonatal protection through the passive transplacental transfer of maternal neutralizing antibodies. To date, little information is available regarding the factors that affect the transfer of antibodies against SARS-CoV-2. A retrospective, cross-sectional, observational, and analytical study was carried out. It was found that several biological factors could be altering transplacental passive immunity after vaccination against COVID-19. In our study population, type 2 diabetes mellitus and chronic hypertension tended to decrease efficiency, while data from women with pre-eclampsia showed better indices compared to those from women with healthy pregnancies. Neonates born prematurely showed lower transfer rates when compared to healthy neonates. The premature rupture of membranes significantly decreased antibody transfer. Taken together, the data suggest that vaccination against COVID-19 during pregnancy is effective even under certain unfavorable clinical conditions for the mother, fetus, and neonate. It is important to create and disseminate immunization strategies in vulnerable populations to reduce maternal and perinatal morbidity and mortality associated with infections preventable by vaccination.<\/jats:p>","DOI":"10.3390\/vaccines12080860","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T10:34:43Z","timestamp":1722422083000},"page":"860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of Maternal and Neonatal Factors on Transplacental Passive Immunity after Vaccination against COVID-19"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1287-1375","authenticated-orcid":false,"given":"Rebeca","family":"Mart\u00ednez-Quezada","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, IMSS-Bienestar, Ixtapaluca 56530, Mexico"},{"name":"Consejo Mexiquense de Ciencia y Tecnolog\u00eda (COMECYT), Toluca 50120, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Esteban","family":"Valencia-Ledezma","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, IMSS-Bienestar, Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0729-0031","authenticated-orcid":false,"given":"Tito","family":"Ram\u00edrez-Lozada","sequence":"additional","affiliation":[{"name":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Regional de Alta Especialidad de Ixtapaluca, IMSS-Bienestar, Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1965-3813","authenticated-orcid":false,"given":"Carlos Emilio","family":"Miguel-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, IMSS-Bienestar, Ixtapaluca 56530, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Fern\u00e1ndez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n, Hospital General de M\u00e9xico \u201cEduardo Liceaga\u201d, Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Acosta-Altamirano","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n, Hospital General de M\u00e9xico \u201cEduardo Liceaga\u201d, Ciudad de M\u00e9xico 06726, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Popescu, D.E., C\u00eetu, C., Jura, A.M.C., Lungu, N., Navolan, D., Craina, M., Semenescu, A., Gorun, F., Jura, M.A., and Belengeanu, V. (2022). The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother\/Newborn Dyad. Vaccines, 10.","DOI":"10.3390\/vaccines10060848"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bpobgyn.2021.03.007","article-title":"Uptake of Vaccination in Pregnancy","volume":"76","author":"Sebghati","year":"2021","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/ijgo.14981","article-title":"Vaccination during Pregnancy: A Golden Opportunity to Embrace","volume":"163","author":"Amaral","year":"2023","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bpobgyn.2020.09.005","article-title":"The Historical Aspects of Vaccination in Pregnancy","volume":"76","author":"Mackin","year":"2021","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41541-023-00698-8","article-title":"Maternal and Neonatal Outcomes of COVID-19 Vaccination during Pregnancy: A Systematic Review and Meta-Analysis","volume":"8","author":"Marchand","year":"2023","journal-title":"NPJ Vaccines"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1016\/j.vaccine.2023.06.032","article-title":"COVID-19 Booster Vaccination during Pregnancy Enhances Maternal Binding and Neutralizing Antibody Responses and Transplacental Antibody Transfer to the Newborn","volume":"41","author":"Munoz","year":"2023","journal-title":"Vaccine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/cid\/ciab266","article-title":"Efficient Maternofetal Transplacental Transfer of Anti- SARS-CoV-2 Spike Antibodies after Antenatal SARS-CoV-2 BNT162b2 MRNA Vaccination","volume":"73","author":"Rottenstreich","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Marshall, N.E., Blanton, M.B., Doratt, B.M., Malherbe, D.C., Rincon, M., True, H., Mcdonald, T., Beauregard, C., Adatorwovor, R., and Messaoudi, I. (2022). SARS-CoV-2 Vaccine Booster Elicits Robust Prolonged Maternal Antibody 1 Responses and Passive Transfer via the Placenta and Breastmilk. bioRxiv.","DOI":"10.1101\/2022.11.29.518385"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100492","DOI":"10.1016\/j.ajogmf.2021.100492","article-title":"Maternal-Neonatal Transfer of SARS-CoV-2 Immunoglobulin G Antibodies among Parturient Women Treated with BNT162b2 Messenger RNA Vaccine during Pregnancy","volume":"4","author":"Nir","year":"2021","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Rottenstreich, A., Zarbiv, G., Oiknine-Djian, E., Vorontsov, O., Zigron, R., Kleinstern, G., Wolf, D.G., and Porat, S. (2022). Timing of SARS-CoV-2 Vaccination during the Third Trimester of Pregnancy and Transplacental Antibody Transfer: A Prospective Cohort Study. Clin. Microbiol. Infect., 28.","DOI":"10.1016\/j.cmi.2021.10.003"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e274","DOI":"10.1093\/cid\/ciac480","article-title":"Kinetics of Maternally-Derived Anti- SARS-CoV-2 Antibodies in Infants in Relation to the Timing of Antenatal Vaccination","volume":"76","author":"Rottenstreich","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e150319","DOI":"10.1172\/JCI150319","article-title":"Efficient Maternal to Neonatal Transfer of Antibodies against SARS-CoV-2 and BNT162b2 MRNA COVID-19 Vaccine","volume":"131","author":"Beharier","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ajog.2021.03.035","article-title":"Cord Blood Antibodies Following Maternal Coronavirus Disease 2019 Vaccination during Pregnancy","volume":"225","author":"Mithal","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zdanowski, W., and Wa\u015bniewskii, T. (2021). Evaluation of SARS-CoV-2 Spike Protein Antibody Titers in Cord Blood after COVID-19 Vaccination during Pregnancy in Polish Healthcare Workers: Preliminary Results. Vaccines, 9.","DOI":"10.22541\/au.162023176.65260617\/v1"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1038\/s41467-022-32188-1","article-title":"Evaluation of Transplacental Transfer of MRNA Vaccine Products and Functional Antibodies during Pregnancy and Infancy","volume":"13","author":"Prahl","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Quezada, R., Miguel-Rodr\u00edguez, C.E., Ram\u00edrez-Lozada, T., Valencia-Ledezma, O.E., and Acosta-Altamirano, G. (2024). Placental Transfer Efficiency of Neutralizing Antibodies on SARS-CoV-2 Vaccination before and after Pregnancy in Mexican Women. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031516"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1016\/j.vaccine.2022.06.034","article-title":"Biological Factors That May Impair Transplacental Transfer of RSV Antibodies: Implications for Maternal Immunization Policy and Research Priorities for Low- and Middle-Income Countries","volume":"40","author":"Atwell","year":"2022","journal-title":"Vaccine"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wilcox, C.R., Holder, B., and Jones, C.E. (2017). Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.01294"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.earlhumdev.2010.11.003","article-title":"Transplacental Transport of IgG Antibodies to Preterm Infants: A Review of the Literature","volume":"87","author":"Westerbeek","year":"2011","journal-title":"Early Hum. Dev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.cell.2020.12.027","article-title":"Compromised SARS-CoV-2-Specific Placental Antibody Transfer","volume":"184","author":"Atyeo","year":"2021","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e2030455","DOI":"10.1001\/jamanetworkopen.2020.30455","article-title":"Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies during the COVID-19 Pandemic","volume":"3","author":"Edlow","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1038\/s41467-022-31169-8","article-title":"Maternal Immune Response and Placental Antibody Transfer after COVID-19 Vaccination across Trimester and Platforms","volume":"13","author":"Atyeo","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0020-7292(02)00442-3","article-title":"Placental Transfer of Rubella-Specific IgG in Fullterm and Preterm Newborns","volume":"81","author":"Doroudchi","year":"2003","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_24","first-page":"928187","article-title":"Transfer of Maternal Immunity to Newborns of Diabetic Mothers","volume":"2012","author":"Calderon","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/sji.12258","article-title":"Placental Transfer of IgG Antibodies Specific to Klebsiella and Pseudomonas LPS and to Group B Streptococcus in Twin Pregnancies","volume":"81","author":"Stach","year":"2015","journal-title":"Scand. J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/sji.12466","article-title":"Maternal-Foetal Diabetes Modifies Neonatal Fc Receptor Expression on Human Leucocytes","volume":"84","author":"Hara","year":"2016","journal-title":"Scand. J. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Alcorta-Nu\u00f1ez, F., P\u00e9rez-Ibave, D.C., Burciaga-Flores, C.H., Garza, M.\u00c1., Gonz\u00e1lez-Escamilla, M., Rodr\u00edguez-Ni\u00f1o, P., Gonz\u00e1lez-Guerrero, J.F., Alcorta-Garza, A., Vidal-Guti\u00e9rrez, O., and Ram\u00edrez-Correa, G.A. (2023). SARS-CoV-2 Neutralizing Antibodies in Mexican Population: A Five Vaccine Comparison. Diagnostics, 13.","DOI":"10.3390\/diagnostics13061194"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/jpids\/piaa040","article-title":"Transplacental Respiratory Syncytial Virus and Influenza Virus Antibody Transfer in Alaska Native and Seattle Mother-Infant Pairs","volume":"10","author":"Chu","year":"2021","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.12688\/wellcomeopenres.17636.2","article-title":"Efficiency of Transplacental Transfer of Respiratory Syncytial Virus (RSV) Specific Antibodies among Pregnant Women in Kenya","volume":"7","author":"Nyiro","year":"2022","journal-title":"Wellcome Open Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0264-410X(01)00418-2","article-title":"Materno-Foetal Transfer of H. Influenzae and Pneumococcal Antibodies Is Influenced by Prematurity and Low Birth Weight: Implications for Conjugate Vaccine Trials","volume":"20","author":"Okoko","year":"2001","journal-title":"Vaccine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/INF.0b013e3181dc4f77","article-title":"Transplacental Transport of IgG Antibodies Specific for Pertussis, Diphtheria, Tetanus, Haemophilus Influenzae Type b, and Neisseria Meningitidis Serogroup C Is Lower in Preterm Compared with Term Infants","volume":"29","author":"Westerbeek","year":"2010","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Van Den Berg, J.P., Westerbeek, E.A.M., Smits, G.P., Van Der Klis, F.R.M., Berbers, G.A.M., and Van Elburg, R.M. (2014). Lower Transplacental Antibody Transport for Measles, Mumps, Rubella and Varicella Zoster in Very Preterm Infants. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094714"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"E2352387","DOI":"10.1001\/jamanetworkopen.2023.52387","article-title":"Timing of Maternal COVID-19 Vaccine and Antibody Concentrations in Infants Born Preterm","volume":"7","author":"Kachikis","year":"2024","journal-title":"JAMA Netw. 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