{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:31:49Z","timestamp":1790285509313,"version":"4.1.0"},"reference-count":28,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Pudong New Area Health Commission Key Discipline\u2014Immunoprophylaxis","award":["Number PWZxk2022-25"],"award-info":[{"award-number":["Number PWZxk2022-25"]}]},{"name":"Shanghai Pudong New Area Health Commission Key Discipline\u2014Immunoprophylaxis","award":["Number GWVI-11.2-XD08"],"award-info":[{"award-number":["Number GWVI-11.2-XD08"]}]},{"name":"Shanghai Pudong New Area Health Commission Key Discipline\u2014Immunoprophylaxis","award":["Number PKJ2023-Y34"],"award-info":[{"award-number":["Number PKJ2023-Y34"]}]},{"name":"Shanghai Pudong New Area Health Commission Key Discipline\u2014Immunoprophylaxis","award":["Number PDCDC-XY-2024-09"],"award-info":[{"award-number":["Number PDCDC-XY-2024-09"]}]},{"name":"Shanghai Three-year Action Plan to Strengthen the Construction of Public Health System Excellent Academic Leader Project","award":["Number PWZxk2022-25"],"award-info":[{"award-number":["Number PWZxk2022-25"]}]},{"name":"Shanghai Three-year Action Plan to Strengthen the Construction of Public Health System Excellent Academic Leader Project","award":["Number GWVI-11.2-XD08"],"award-info":[{"award-number":["Number GWVI-11.2-XD08"]}]},{"name":"Shanghai Three-year Action Plan to Strengthen the Construction of Public Health System Excellent Academic Leader Project","award":["Number PKJ2023-Y34"],"award-info":[{"award-number":["Number PKJ2023-Y34"]}]},{"name":"Shanghai Three-year Action Plan to Strengthen the Construction of Public Health System Excellent Academic Leader Project","award":["Number PDCDC-XY-2024-09"],"award-info":[{"award-number":["Number PDCDC-XY-2024-09"]}]},{"name":"Shanghai Pudong New Area Science and Technology Development Fund Project","award":["Number PWZxk2022-25"],"award-info":[{"award-number":["Number PWZxk2022-25"]}]},{"name":"Shanghai Pudong New Area Science and Technology Development Fund Project","award":["Number GWVI-11.2-XD08"],"award-info":[{"award-number":["Number GWVI-11.2-XD08"]}]},{"name":"Shanghai Pudong New Area Science and Technology Development Fund Project","award":["Number PKJ2023-Y34"],"award-info":[{"award-number":["Number PKJ2023-Y34"]}]},{"name":"Shanghai Pudong New Area Science and Technology Development Fund Project","award":["Number PDCDC-XY-2024-09"],"award-info":[{"award-number":["Number PDCDC-XY-2024-09"]}]},{"name":"Shanghai Pudong New Area Eagle Talent Program","award":["Number PWZxk2022-25"],"award-info":[{"award-number":["Number PWZxk2022-25"]}]},{"name":"Shanghai Pudong New Area Eagle Talent Program","award":["Number GWVI-11.2-XD08"],"award-info":[{"award-number":["Number GWVI-11.2-XD08"]}]},{"name":"Shanghai Pudong New Area Eagle Talent Program","award":["Number PKJ2023-Y34"],"award-info":[{"award-number":["Number PKJ2023-Y34"]}]},{"name":"Shanghai Pudong New Area Eagle Talent Program","award":["Number PDCDC-XY-2024-09"],"award-info":[{"award-number":["Number PDCDC-XY-2024-09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>The aim of this study was to investigate the level of inactivated A71 (EV-A71) vaccination in Pudong New Area of Shanghai and its effects on the epidemiology and pathogen spectrum of hand\u2013foot\u2013mouth disease (HFMD) in this area, as well as to provide a basis for improving the prevention and control strategy of HFMD in this area. Data were collected from the \u201cComprehensive Management Cloud Platform for Immunization Program\u201d system from December 2016 to December 2022. The data on HFMD cases from January 2012 to December 2022 were extracted from the \u201cChina Information System for Disease Control and Prevention\u201d. A total of 484,056 doses were administered. The vaccination rate of the first dose was 14.03%, and the full vaccination rate was 13.33%. There were significant differences between the first dose and the full vaccination rate in different years (\u03c72 = 46,538.831, p &lt; 0.001, \u03c72 = 50,013.946, p &lt; 0.001). A total of 91625 cases of HFMD were reported, including 58 severe cases, and no deaths. Before and after the administration of the inactivated EV-A71 vaccine, there were statistical differences in the distribution of HFMD cases in terms of gender, household registration, occupation, and age (p &lt; 0.001). The etiological surveillance results showed that the rate of enterovirus positivity was 84.15%, with 9.85% being EV-A71, 23.74% CV-A16, and 50.56% non-EV-A71 and non-CV-A16. The coverage rate of the inactivated EV-A71 vaccine in Pudong New Area was not high, and the incidence of HFMD showed a downward trend after the postmarketing of the vaccine. The majority of HFMD infections were non-EV-A71 and non-CV-A16, with CV-A6 accounting for the highest proportion. It is recommended to accelerate the development of combined vaccines to provide more antibody protection.<\/jats:p>","DOI":"10.3390\/vaccines12090962","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T10:01:51Z","timestamp":1724666511000},"page":"962","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of the Impact of Inactivated A71 Vaccine on the Incidence of Hand\u2013Foot\u2013Mouth Disease in Pudong New Area, Shanghai"],"prefix":"10.3390","volume":"12","author":[{"given":"Dandan","family":"Yang","sequence":"first","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Deng","sequence":"additional","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-4111","authenticated-orcid":false,"given":"Chuchu","family":"Ye","sequence":"additional","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laibao","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caoyi","family":"Xue","sequence":"additional","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yuan, J.-J., Shen, L., Wu, J., Zou, X.-R., Gu, J.-Q., Chen, J.-G., and Mao, L.-X. 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