{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:04:51Z","timestamp":1792523091760,"version":"4.5.0"},"reference-count":27,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Given the rising incidence of human papillomavirus (HPV)-related diseases, including cervical, penile, and oropharyngeal cancers, particularly among men, the implementation of comprehensive HPV vaccination strategies is necessary in South Korea. This position statement advocates the introduction of gender-neutral vaccination (GNV) in the country. It recommends the administration of the HPV vaccine to both men and women aged 9\u201326 years to prevent a broad spectrum of HPV-related conditions. Specifically, individuals aged 9\u201314 years are advised to receive two doses of the vaccine, whereas those aged 15\u201326 years are advised to receive three doses. The optimal age for vaccination is identified as 11\u201312 years old. Additionally, this statement recommends that women aged 27 years and older be vaccinated based on the discretion of healthcare providers. The introduction of GNV is essential to curb the spread of HPV and reduce the overall burden of HPV-related cancers, making it a critical public health initiative in Korea.<\/jats:p>","DOI":"10.3390\/vaccines12101110","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T09:16:10Z","timestamp":1727428570000},"page":"1110","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Position Statement about Gender-Neutral HPV Vaccination in Korea"],"prefix":"10.3390","volume":"12","author":[{"given":"Kyung-Jin","family":"Min","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynecology, Korea University Ansan Hospital, Ansan 15354, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-4497","authenticated-orcid":false,"given":"Yung-Taek","family":"Ouh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Korea University Ansan Hospital, Ansan 15354, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-704X","authenticated-orcid":false,"given":"Sangrak","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Urology, The Catholic University of Korea Uijeongbu St. Mary\u2019s Hospital, Uijeongbu 11765, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Bae","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hanyang University Medical Center Guri Hospital, Guri 11923, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-6403","authenticated-orcid":false,"given":"Jae-Kwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Korea University Guro Hospital, Seoul 08308, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Weon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Seoul National University Hospital, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Jae","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Catholic University of Korea Uijeongbu St. Mary\u2019s Hospital, Uijeongbu 11765, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hun","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Urology, Chosun University Hospital, Gwangju 61453, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1016\/j.vaccine.2012.07.055","article-title":"Global burden of human papillomavirus and related diseases","volume":"30","author":"Forman","year":"2012","journal-title":"Vaccine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s10147-023-02340-y","article-title":"Papillomaviruses and cancer: Commonalities and differences in HPV carcinogenesis at different sites of the body","volume":"28","author":"Egawa","year":"2023","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.canlet.2019.11.039","article-title":"Human papillomavirus vaccine against cervical cancer: Opportunity and challenge","volume":"471","author":"Wang","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Fappani, C., Bianchi, S., Panatto, D., Petrelli, F., Colzani, D., Scuri, S., Gori, M., Amendola, A., Grappasonni, I., and Tanzi, E. (2021). HPV Type-Specific Prevalence a Decade after the Implementation of the Vaccination Program: Results from a Pilot Study. Vaccines, 9.","DOI":"10.3390\/vaccines9040336"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e1345","DOI":"10.1016\/S2214-109X(23)00305-4","article-title":"Global and regional estimates of genital human papillomavirus prevalence among men: A systematic review and meta-analysis","volume":"11","author":"Bruni","year":"2023","journal-title":"Lancet Glob. Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41571-022-00603-7","article-title":"HPV-associated oropharyngeal cancer: Epidemiology, molecular biology and clinical management","volume":"19","author":"Lechner","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/ijc.34839","article-title":"Scientific approaches toward improving cervical cancer elimination strategies","volume":"154","author":"Lehtinen","year":"2024","journal-title":"Int. J. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1473-3099(07)70158-5","article-title":"Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: A meta-analysis","volume":"7","author":"Diaz","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ijc.30716","article-title":"Worldwide burden of cancer attributable to HPV by site, country and HPV type","volume":"141","author":"Plummer","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.21053\/ceo.2015.01123","article-title":"Trends in Head and Neck Cancer in South Korea between 1999 and 2012","volume":"9","author":"Suh","year":"2016","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/S2214-109X(22)00501-0","article-title":"Global estimates of incidence and mortality of cervical cancer in 2020: A baseline analysis of the WHO Global Cervical Cancer Elimination Initiative","volume":"11","author":"Singh","year":"2023","journal-title":"Lancet Glob. Health"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cao, X., Wei, R., Zhang, X., Zhou, J., Lou, J., and Cui, Y. (2020). Impact of human papillomavirus infection in semen on sperm progressive motility in infertile men: A systematic review and meta-analysis. Reprod. Biol. Endocrinol., 18.","DOI":"10.1186\/s12958-020-00604-0"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Park, J.O., Nam, I.C., Kim, C.S., Park, S.J., Lee, D.H., Kim, H.B., Han, K.D., and Joo, Y.H. (2022). Sex Differences in the Prevalence of Head and Neck Cancers: A 10-Year Follow-Up Study of 10 Million Healthy People. Cancers, 14.","DOI":"10.3390\/cancers14102521"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102566","DOI":"10.1016\/j.pmedr.2023.102566","article-title":"Human papillomavirus (HPV) vaccination in males: Associations of HPV-related knowledge and perceptions with HPV vaccination intention among Korean mothers of boys","volume":"37","author":"Choi","year":"2024","journal-title":"Prev. Med. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"(2024). Predominant genotypes of human papillomavirus in Korean men. J. Men\u2019s Health, 20, 70\u201377.","DOI":"10.22514\/jomh.2024.093"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4132\/jptm.2020.06.22","article-title":"Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas","volume":"54","author":"Kim","year":"2020","journal-title":"J. Pathol. Transl. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Choi, J., Markham, C., Tami-Maury, I., Kim, S., and Cuccaro, P. (2023). Maternal perceptions of vaccinating boys against human papillomavirus (HPV) in Seoul, South Korea: A descriptive exploratory qualitative study. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0282811"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Grandahl, M., and Neveus, T. (2021). Barriers towards HPV Vaccinations for Boys and Young Men: A Narrative Review. Viruses, 13.","DOI":"10.3390\/v13081644"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.15585\/mmwr.mm7301a3","article-title":"Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older\u2014United States, 2024","volume":"73","author":"Murthy","year":"2024","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3322\/caac.21616","article-title":"Human papillomavirus vaccination 2020 guideline update: American Cancer Society guideline adaptation","volume":"70","author":"Saslow","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_21","unstructured":"World Health Organization (2022). Human papillomavirus vaccines: WHO position paper, December 2022. Wkly. Epidemiol. Rec., 97, 645\u2013672."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1016\/S2468-2667(16)30001-9","article-title":"Population-level impact, herd immunity, and elimination after human papillomavirus vaccination: A systematic review and meta-analysis of predictions from transmission-dynamic models","volume":"1","author":"Brisson","year":"2016","journal-title":"Lancet Public Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.epidem.2015.01.003","article-title":"Impact of coverage-dependent marginal costs on optimal HPV vaccination strategies","volume":"11","author":"Ryser","year":"2015","journal-title":"Epidemics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S1473-3099(21)00071-2","article-title":"Effect on genital warts in Australian female and heterosexual male individuals after introduction of the national human papillomavirus gender-neutral vaccination programme: An analysis of national sentinel surveillance data from 2004\u201318","volume":"21","author":"Chow","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/EDE.0000000000001324","article-title":"Sex- and Type-specific Genital Human Papillomavirus Transmission Rates between Heterosexual Partners: A Bayesian Reanalysis of the HITCH Cohort","volume":"32","author":"Malagon","year":"2021","journal-title":"Epidemiology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S1470-2045(22)00543-5","article-title":"Evidence-based impact projections of single-dose human papillomavirus vaccination in India: A modelling study","volume":"23","author":"Man","year":"2022","journal-title":"Lancet Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e85735","DOI":"10.7554\/eLife.85735","article-title":"Building resilient cervical cancer prevention through gender-neutral HPV vaccination","volume":"12","author":"Man","year":"2023","journal-title":"Elife"}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/12\/10\/1110\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:05:14Z","timestamp":1760112314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/12\/10\/1110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":27,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["vaccines12101110"],"URL":"https:\/\/doi.org\/10.3390\/vaccines12101110","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,27]]}}}