{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:01:54Z","timestamp":1776855714383,"version":"3.51.2"},"reference-count":25,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing Talent Program","award":["CQYC20210303393"],"award-info":[{"award-number":["CQYC20210303393"]}]},{"name":"Chongqing Talent Program","award":["CSTB2024NSCQ-MSX0447"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0447"]}]},{"name":"Chongqing Talent Program","award":["CSTB2022NSCQ-BHX0685"],"award-info":[{"award-number":["CSTB2022NSCQ-BHX0685"]}]},{"name":"Chongqing Talent Program","award":["YXQN202476"],"award-info":[{"award-number":["YXQN202476"]}]},{"name":"Program for Youth Innovation in Future Medicine, Chongqing Medical University","award":["CQYC20210303393"],"award-info":[{"award-number":["CQYC20210303393"]}]},{"name":"Program for Youth Innovation in Future Medicine, Chongqing Medical University","award":["CSTB2024NSCQ-MSX0447"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0447"]}]},{"name":"Program for Youth Innovation in Future Medicine, Chongqing Medical University","award":["CSTB2022NSCQ-BHX0685"],"award-info":[{"award-number":["CSTB2022NSCQ-BHX0685"]}]},{"name":"Program for Youth Innovation in Future Medicine, Chongqing Medical University","award":["YXQN202476"],"award-info":[{"award-number":["YXQN202476"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["CQYC20210303393"],"award-info":[{"award-number":["CQYC20210303393"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["CSTB2024NSCQ-MSX0447"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0447"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["CSTB2022NSCQ-BHX0685"],"award-info":[{"award-number":["CSTB2022NSCQ-BHX0685"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["YXQN202476"],"award-info":[{"award-number":["YXQN202476"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["CQYC20210303393"],"award-info":[{"award-number":["CQYC20210303393"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["CSTB2024NSCQ-MSX0447"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0447"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["CSTB2022NSCQ-BHX0685"],"award-info":[{"award-number":["CSTB2022NSCQ-BHX0685"]}]},{"name":"Natural Science Foundation of Chongqing, China","award":["YXQN202476"],"award-info":[{"award-number":["YXQN202476"]}]},{"name":"Chongqing medical youth top-notch talent project","award":["CQYC20210303393"],"award-info":[{"award-number":["CQYC20210303393"]}]},{"name":"Chongqing medical youth top-notch talent project","award":["CSTB2024NSCQ-MSX0447"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0447"]}]},{"name":"Chongqing medical youth top-notch talent project","award":["CSTB2022NSCQ-BHX0685"],"award-info":[{"award-number":["CSTB2022NSCQ-BHX0685"]}]},{"name":"Chongqing medical youth top-notch talent project","award":["YXQN202476"],"award-info":[{"award-number":["YXQN202476"]}]},{"name":"Outstanding youth talent project of Bishan hospital","award":["CQYC20210303393"],"award-info":[{"award-number":["CQYC20210303393"]}]},{"name":"Outstanding youth talent project of Bishan hospital","award":["CSTB2024NSCQ-MSX0447"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0447"]}]},{"name":"Outstanding youth talent project of Bishan hospital","award":["CSTB2022NSCQ-BHX0685"],"award-info":[{"award-number":["CSTB2022NSCQ-BHX0685"]}]},{"name":"Outstanding youth talent project of Bishan hospital","award":["YXQN202476"],"award-info":[{"award-number":["YXQN202476"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background and aims: The transplacental vertical transfer of maternal antibodies was determined to be a crucial factor in conferring protective immunity to infants following delivery, and this study aimed to evaluate the protective effect of maternal preconception COVID-19 vaccination on infants. Methods: A prospective cohort study was conducted at the National Clinical Medical Research Center for Child Health and Diseases in Chongqing, China, spanning from July 2022 to April 2023. The study included infants from mothers with a preconception COVID-19 vaccination and (or) a SARS-CoV-2 infection during pregnancy. Titers of SARS-CoV-2 immunoglobulin G (IgG) and cross-neutralizing activity against SARS-CoV-2 variants were detected. Results: In this cohort study comprising 158 infants, it was observed that infants born to mothers who experienced a pregnancy-related breakthrough infection following a preconception vaccination had the highest titers of SARS-CoV-2 IgG and cross-neutralizing antibody activity against different variants compared to those with either of these factors alone. The transplacental vertical transmission of anti-SARS-CoV-2 antibodies decreased significantly with increasing age, from 3.16 ODs at birth to 2.29 ODs at two months, and persisted for approximately four months after birth. The predominant subclass of passively transmitted antibodies via the placenta was found to be IgG1, and a positive correlation was observed between the titers of SARS-CoV-2 IgG and IgG1 (R = 0.59, p &lt; 0.001; Slope: 0.49 \u00b1 0.070, p &lt; 0.001). Conclusions: Maternal preconception COVID-19 vaccination represents a promising immunological strategy for conferring postnatal protection to infants, especially during the period of heightened risk of exposure to SARS-CoV-2 infection. It is imperative to underscore the significance of vaccination for women who are preparing to become pregnant or are pregnant, and concerted efforts must be made to promote vaccination among eligible women.<\/jats:p>","DOI":"10.3390\/vaccines12101132","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T03:36:03Z","timestamp":1727926563000},"page":"1132","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal Preconception COVID-19 Vaccination and Its Protective Effect on Infants after a Breakthrough Infection during Pregnancy"],"prefix":"10.3390","volume":"12","author":[{"given":"Yuting","family":"Yang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China"},{"name":"Department of Laboratory Medicine, Bishan Hospital of Chongqing Medical University, Chongqing 402760, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-192X","authenticated-orcid":false,"given":"Haijun","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dapeng","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojin","family":"Wu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwu","family":"Xing","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5830-8786","authenticated-orcid":false,"given":"Ni","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400015, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.15585\/mmwr.mm7111e2","article-title":"Hospitalization of Infants and Children Aged 0\u20134 Years with Laboratory-Confirmed COVID-19\u2014COVID-NET, 14 States, March 2020\u2013February 2022","volume":"71","author":"Marks","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/jmv.26398","article-title":"A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19)","volume":"93","author":"Cui","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ajog.2021.10.041","article-title":"Maternal vaccination: A review of current evidence and recommendations","volume":"226","author":"Etti","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"264","DOI":"10.15585\/mmwr.mm7107e3","article-title":"Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine during Pregnancy against COVID-19-Associated Hospitalization in Infants Aged <6 Months\u201417 States, July 2021\u2013January 2022","volume":"71","author":"Halasa","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMoa2204399","article-title":"Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants","volume":"387","author":"Halasa","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/jamainternmed.2022.2442","article-title":"Association of COVID-19 Vaccination during Pregnancy with Incidence of SARS-CoV-2 Infection in Infants","volume":"182","author":"Carlsen","year":"2022","journal-title":"JAMA Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e28296","DOI":"10.1002\/jmv.28296","article-title":"Transplacental transmission of SARS-CoV-2 immunoglobulin G antibody to infants from maternal COVID-19 vaccine immunization before pregnancy","volume":"95","author":"Yang","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.46234\/ccdcw2023.070","article-title":"Effectiveness of COVID-19 Vaccination Against SARS-CoV-2 Omicron Variant Infection and Symptoms\u2014China, December 2022\u2013February 2023","volume":"28","author":"Fu","year":"2023","journal-title":"China CDC Wkly."},{"key":"ref_9","unstructured":"The Central People\u2019s Government of the China (2022, December 24). Available online: https:\/\/www.gov.cn\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.gendis.2020.07.006","article-title":"Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2","volume":"7","author":"Hu","year":"2020","journal-title":"Genes Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-022-04865-0","article-title":"Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination","volume":"607","author":"Suryawanshi","year":"2022","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41586-022-04830-x","article-title":"Omicron infection enhances Delta antibody immunity in vaccinated persons","volume":"607","author":"Khan","year":"2022","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S1473-3099(23)00060-9","article-title":"Protective immunity of SARS-CoV-2 infection and vaccines against medically attended symptomatic omicron BA.4, BA.5, and XBB reinfections in Singapore: A national cohort study","volume":"23","author":"Tan","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S1473-3099(22)00801-5","article-title":"Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: A systematic review and meta-regression","volume":"23","author":"Bobrovitz","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.cell.2022.01.011","article-title":"SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses","volume":"185","author":"Walls","year":"2022","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"486.e1","DOI":"10.1016\/j.ajog.2022.04.010","article-title":"Boosting maternal and neonatal humoral immunity following SARS-CoV-2 infection using a single messenger RNA vaccine dose","volume":"227","author":"Nevo","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1001\/jama.2014.3633","article-title":"Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: A randomized clinical trial","volume":"311","author":"Munoz","year":"2014","journal-title":"JAMA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e274","DOI":"10.1093\/cid\/ciac480","article-title":"Kinetics of Maternally Derived Anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies in Infants in Relation to the Timing of Antenatal Vaccination","volume":"76","author":"Rottenstreich","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1001\/jama.2022.1206","article-title":"Durability of Anti-Spike Antibodies in Infants after Maternal COVID-19 Vaccination or Natural Infection","volume":"327","author":"Shook","year":"2022","journal-title":"JAMA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"eabq5901","DOI":"10.1126\/sciimmunol.abq5901","article-title":"Immune memory to SARS-CoV-2 Omicron BA.1 breakthrough infections: To change the vaccine or not?","volume":"7","year":"2022","journal-title":"Sci. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41586-021-04266-9","article-title":"Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation","volume":"602","author":"Saito","year":"2022","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e2120456","DOI":"10.1001\/jamanetworkopen.2021.20456","article-title":"Characteristics and Outcomes of Women with COVID-19 Giving Birth at US Academic Centers during the COVID-19 Pandemic","volume":"4","author":"Chinn","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ajog.2021.07.009","article-title":"SARS-CoV-2 infection during pregnancy and risk of preeclampsia: A systematic review and meta-analysis","volume":"226","author":"Romero","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"510.e1","DOI":"10.1016\/j.ajog.2020.11.022","article-title":"Pregnant women with severe or critical coronavirus disease 2019 have increased composite morbidity compared with nonpregnant matched controls","volume":"224","author":"DeBolt","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1056\/NEJMe2206730","article-title":"Covid-19 Vaccination during Pregnancy\u2014Two for the Price of One","volume":"387","author":"Rasmussen","year":"2022","journal-title":"N. Engl. J. Med."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/12\/10\/1132\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:09:42Z","timestamp":1760112582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/12\/10\/1132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":25,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["vaccines12101132"],"URL":"https:\/\/doi.org\/10.3390\/vaccines12101132","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]}}}