{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:53:15Z","timestamp":1775861595251,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310088\/2023-2"],"award-info":[{"award-number":["310088\/2023-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["APQ-01972-23"],"award-info":[{"award-number":["APQ-01972-23"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["D24ZO-349"],"award-info":[{"award-number":["D24ZO-349"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais","award":["310088\/2023-2"],"award-info":[{"award-number":["310088\/2023-2"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais","award":["APQ-01972-23"],"award-info":[{"award-number":["APQ-01972-23"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais","award":["D24ZO-349"],"award-info":[{"award-number":["D24ZO-349"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["310088\/2023-2"],"award-info":[{"award-number":["310088\/2023-2"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["APQ-01972-23"],"award-info":[{"award-number":["APQ-01972-23"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["D24ZO-349"],"award-info":[{"award-number":["D24ZO-349"]}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["310088\/2023-2"],"award-info":[{"award-number":["310088\/2023-2"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["APQ-01972-23"],"award-info":[{"award-number":["APQ-01972-23"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D24ZO-349"],"award-info":[{"award-number":["D24ZO-349"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background\/Objective: Yellow fever (YF) is an acute infectious disease caused by the yellow fever virus which is transmitted by mosquitoes. Neotropical primates are susceptible to infection, which is often presented as epizootic outbreaks. The aim was to evaluate and characterize the immune response against YF in different species of neotropical primates from the Belo Horizonte Zoo. Methods: Vaccine 17DD was administered to 24 neotropical primates, with a single subcutaneous dose. Clinical exams, RNAemia, and detection of IgG and neutralizing antibodies against YFV were performed. In addition, an ethogram was performed to assess clinical changes and animal welfare. Results: At 4 days post-vaccination, RNAemia was detected in nine animals. There was seroconversion and persistence of immune response in Alouatta guariba clamitans, Sapajus xanthosternos, Saguinus imperator and Aotus infulatus. However, the vaccine was not immunogenic for Lagothrix cana. In Pithecia irrorata seroconversion did not persist long term, while the Ateles sp. had a transient immune response. No significant clinical manifestations were observed in any of the vaccinated animals. Conclusions: This study demonstrated a safe, immunogenic and persistent immune response induced by the attenuated 17DD vaccine strain in A. guariba clamitans, S. xanthosternos, S. imperator, and A. infulatus.<\/jats:p>","DOI":"10.3390\/vaccines13050487","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T05:50:17Z","timestamp":1745992217000},"page":"487","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety and Immunogenicity of the Attenuated Yellow Fever Vaccine in Several Neotropical Primate Species"],"prefix":"10.3390","volume":"13","author":[{"given":"Nayara Ferreira de","family":"Paula","sequence":"first","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1rias, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais (UFMG), Av. Ant\u00f4nio Carlos 6627, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5283-2429","authenticated-orcid":false,"given":"Andr\u00e9 Duarte","family":"Vieira","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1rias, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais (UFMG), Av. Ant\u00f4nio Carlos 6627, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Oliveira dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1rias, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais (UFMG), Av. Ant\u00f4nio Carlos 6627, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-5348","authenticated-orcid":false,"given":"Lucas dos Reis de","family":"Souza","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica e Cirurgia Veterin\u00e1rias, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais (UFMG), Av. Ant\u00f4nio Carlos 6627, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlyle Mendes","family":"Coelho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Parques Municipais e Zoobot\u00e2nica, Jardim Zool\u00f3gico, Av. Otac\u00edlio Negr\u00e3o de Lima 8000, Belo Horizonte 31365-450, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herlandes Penha","family":"Tinoco","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Parques Municipais e Zoobot\u00e2nica, Jardim Zool\u00f3gico, Av. Otac\u00edlio Negr\u00e3o de Lima 8000, Belo Horizonte 31365-450, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Cristina Senra","family":"Lima","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Parques Municipais e Zoobot\u00e2nica, Jardim Zool\u00f3gico, Av. Otac\u00edlio Negr\u00e3o de Lima 8000, Belo Horizonte 31365-450, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Ot\u00e1vio Can\u00e7ado","family":"Motta","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Parques Municipais e Zoobot\u00e2nica, Jardim Zool\u00f3gico, Av. 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Ant\u00f4nio Carlos 6627, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais Alkifeles","family":"Costa","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Av. Ant\u00f4nio Carlos 6627, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betania Paiva","family":"Drumond","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Av. 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