{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:28:25Z","timestamp":1791271705779,"version":"4.1.0"},"reference-count":78,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"South African Medical Research Council","award":["43500"],"award-info":[{"award-number":["43500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: Immunization is a highly effective intervention for controlling over 20 life-threatening infectious diseases, significantly reducing both morbidity and mortality rates. One notable achievement in vaccination efforts was the global eradication of smallpox, which the World Health Assembly declared on 8 May 1980. Additionally, there has been a remarkable 99.9% reduction in wild poliovirus cases since 1988, decreasing from more than 350,000 cases that year to just 30 cases in 2022. Objectives: The objective of this review was to assess the effects of various interventions designed to increase vaccination uptake among adults. Search Methods: A thorough search was conducted in the CENTRAL, Embase Ovid, Medline Ovid, PubMed, Web of Science, and Global Index Medicus databases for primary studies. This search was conducted in August 2021 and updated in November 2024. Selection Criteria: Randomized trials were eligible for inclusion in this review, regardless of publication status or language. Data Analysis: Two authors independently screened the search outputs to select potentially eligible studies. Risk ratios (RR) with 95% confidence intervals (CI) were calculated for each randomized controlled trial (RCT). A meta-analysis was conducted using a random-effects model, and the quality of the evidence was assessed using the GRADE approach. Main Results: A total of 35 randomized controlled trials met the inclusion criteria and were included in this review, with the majority conducted in the United States. The interventions targeted adults aged 18 and older who were eligible for vaccination, involving a total of 403,709 participants. The overall pooled results for interventions aimed at increasing influenza vaccination showed a risk ratio of 1.41 (95% CI: 1.15, 1.73). Most studies focused on influenza vaccination (18 studies), while the remaining studies examined various other vaccines, including those for hepatitis A, COVID-19, hepatitis B, pneumococcal disease, tetanus, diphtheria, pertussis (Tdap), herpes zoster, and human papillomavirus (HPV). The results indicate that letter reminders were slightly effective in increasing influenza vaccination uptake compared to the control group (RR: 1.75, 95% CI: 0.97, 1.16; 6 studies; 161,495 participants; low-certainty evidence). Additionally, participants who received education interventions showed increased levels of influenza vaccination uptake compared to those in the control group (RR: 1.88, 95% CI: 0.61, 5.76; 3 studies; 1318 participants; low-certainty evidence). Furthermore, tracking and outreach interventions also led to an increase in influenza vaccination uptake (RR: 1.87, 95% CI: 0.78, 4.46; 2 studies; 33,752 participants; low-certainty evidence). Conclusions: Letter reminders and educational interventions targeted at recipients are effective in increasing vaccination uptake compared to control groups.<\/jats:p>","DOI":"10.3390\/vaccines13080811","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:00:41Z","timestamp":1753884041000},"page":"811","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interventions to Improve Vaccination Uptake Among Adults: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Anelisa","family":"Jaca","sequence":"first","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindi","family":"Mathebula","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-6696","authenticated-orcid":false,"given":"Thobile","family":"Malinga","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-4672","authenticated-orcid":false,"given":"Kimona","family":"Rampersadh","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masibulele","family":"Zulu","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-1265","authenticated-orcid":false,"given":"Ameer Steven-Jorg","family":"Hohlfeld","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-4779","authenticated-orcid":false,"given":"Charles Shey","family":"Wiysonge","sequence":"additional","affiliation":[{"name":"Vaccine Preventable Diseases Programme, World Health Organization Regional Office for Africa, Brazzaville P.O. Box 06, Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-0317","authenticated-orcid":false,"given":"Julie C.","family":"Jacobson Vann","sequence":"additional","affiliation":[{"name":"School of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-3865","authenticated-orcid":false,"given":"Duduzile","family":"Ndwandwe","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Cape Town 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref_1","unstructured":"Vanderslott, S. (2025, July 22). How Is the World Doing in Its Fight Against Vaccine Preventable Diseases?. Available online: https:\/\/ourworldindata.org\/vaccine-preventable-diseases."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e008310","DOI":"10.1136\/bmjopen-2015-008310","article-title":"Electronic and postal reminders for improving immunisation coverage in children: Protocol for a systematic review and meta-analysis","volume":"5","author":"Chachou","year":"2015","journal-title":"BMJ Open"},{"key":"ref_3","unstructured":"World Health Organization (2025, July 20). Global Immunization Coverage 2019. Available online: http:\/\/www.who.int\/news-room\/facts-in-pictures\/detail\/immunization."},{"key":"ref_4","unstructured":"World Health Organization (2025, July 22). Poliomyelitis Eradication Report by the Director-General. 74th World Health Assembly. A74\/19. 21 April 2021. Available online: https:\/\/apps.who.int\/gb\/ebwha\/pdf_files\/WHA74\/A74_19-en.pdf."},{"key":"ref_5","unstructured":"Wiysonge, C.S. (2025, July 22). How Ending Polio in Africa Has Had Positive Spinoffs for Public Health. The Conversation, 3 November 2020. Available online: https:\/\/the conversation.com\/Africa."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S2213-2600(20)30121-1","article-title":"Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases","volume":"8","author":"Ramanathan","year":"2020","journal-title":"Lancet Respir Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0140-6736(20)32657-X","article-title":"Estimating the health impact of vaccination against ten pathogens in 98 low-income and middle-income countries from 2000 to 2030: A modelling study","volume":"397","author":"Li","year":"2021","journal-title":"Lancet"},{"key":"ref_8","unstructured":"Centers for Disease Control and Prevention (2025, July 20). Estimated Influenza-Related Illnesses, Medical Visits, Hospitalizations, and Deaths in the United States\u20142019\u20132020 Influenza Season\u2014Estimates Represent Data as of October 2021, Available online: https:\/\/archive.cdc.gov\/www_cdc_gov\/flu\/about\/burden\/2019-2020\/archive-09292021.html."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Cassimos, D.C., Effraimidou, E., Medic, S., Konstantinidis, T., Theodoridou, M., and Maltezou, H.C. (2020). Vaccination programs for adults in Europe, 2019. Vaccines, 8.","DOI":"10.3390\/vaccines8010034"},{"key":"ref_10","unstructured":"World Health Organization (2025, July 22). Table 1: Summary of WHO Position Papers-Recommendations for Routine Immunization; Updated September 2020. Available online: https:\/\/www.afro.who.int\/sites\/default\/files\/2018-03\/Immunization_routine_table1.pdf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7003a1","article-title":"Surveillance of vaccination coverage among adult populations\u2014United States, 2018","volume":"70","author":"Lu","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep. Surveill. Summ."},{"key":"ref_12","unstructured":"Hung, M.-C., Srivastav, A., Lu, P.-J., Black, C.L., Lindley, M.C., and Singleton, J.A. (2021). Vaccination Coverage Among Adults in the United States, National Health Interview Survey, 2021, Centers for Disease Control and Prevention (CDC)."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.15585\/mmwr.mm7030e2","article-title":"Guidance for Implementing COVID-19 Prevention Strategies in the Context of Varying Community Transmission Levels and Vaccination Coverage","volume":"70","author":"Christie","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_14","unstructured":"World Health Organization (2025, July 20). Table 4: Summary of WHO Position Papers\u2014Immunization of Health Care Workers; Updated September 2020. Available online: https:\/\/www.who.int\/publications\/m\/item\/table-4-summary-of-who-position-papers-immunization-of-health-care-workers."},{"key":"ref_15","unstructured":"(2025, July 20). Control EC for DP and. Seasonal Influenza Vaccination and Antiviral Use in EU\/EEA Member States\u2014Overview of Vaccine Recommendations for 2017\u20132018 and Vaccination Coverage Rates for 2015\u20132016 and 2016\u20132017 Influenza Seasons. Stockholm. ECDC. November 2018. Available online: http:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/seasonal-influenza-antiviral-use-2018.pdf."},{"key":"ref_16","unstructured":"Hull, B., Hendry, A., Macartney, K., and Beard, F. (2025, July 22). Annual Immunization Coverage Report 2016:1\u201323, Available online: https:\/\/www1.health.gov.au\/internet\/main\/publishing.nsf\/Content\/75F30C0D2C126CAECA2583940015EDE3\/$File\/annual_immunisation_coverage_report_2016.pdf."},{"key":"ref_17","unstructured":"PHAC (2025, July 22). Vaccination Coverage in Canada. Available online: https:\/\/www.canada.ca\/en\/public-health\/services\/immunization-vaccines\/vaccination-coverage.html."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pvr.2017.11.003","article-title":"Barriers, facilitators, and potential strategies for increasing HPV vaccination: A statewide assessment to inform action","volume":"5","author":"Cartmell","year":"2018","journal-title":"Papillomavirus Res."},{"key":"ref_19","unstructured":"Ritchie, H., Ortiz-Ospina, E., Beltekian, D., Mathieu, E., Hasell, J., and Macdonald, B. (2025, July 22). Coronavirus Pandemic (COVID-19). Available online: https:\/\/ourworldindata.org\/covid-vaccinations."},{"key":"ref_20","first-page":"CD011895","article-title":"Improving vaccination uptake among adolescents","volume":"1","author":"Abdullahi","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_21","first-page":"CD003941","article-title":"Patient reminder and recall interventions to improve immunization rates","volume":"1","author":"Jacobson","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_22","first-page":"1465","article-title":"Face to face interventions for informing or educating parents about early childhood vaccination","volume":"5","author":"Kaufman","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_23","first-page":"CD008145","article-title":"Interventions for improving coverage of childhood immunisation in low- and middle-income countries (Review)","volume":"7","author":"Wiysonge","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_24","first-page":"1465","article-title":"Interventions aimed at communities to inform and\/or educate about early childhood vaccination","volume":"11","author":"Saeterdal","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"892","DOI":"10.7196\/SAMJ.2015.v105i11.10177","article-title":"Interventions for improving childhood vaccination coverage in low- and middle-income countries","volume":"105","author":"Wiysonge","year":"2015","journal-title":"S. Afr. Med. J."},{"key":"ref_26","unstructured":"Force CPST (2025, July 22). Increasing Appropriate Vaccination: Reducing Client out-of-Pocket Costs for Vaccinations. Task Force Finding and Rationale Statement. Available online: http:\/\/www.thecommunityguide.org\/findings\/vaccination-programs-reducing-client-out-pocket-costs."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Mavundza, E.J., Iwu-Jaja, C.J., Wiyeh, A.B., Gausi, B., Abdullahi, L.H., and Halle-Ekane, G. (2021). A systematic review of interventions to improve HPV vaccination coverage. Vaccines, 9.","DOI":"10.3390\/vaccines9070687"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"McKeirnan, K., Colorafi, K., Sun, Z., Daratha, K., Potyk, D., and McCarthy, J. (2021). Improving pneumococcal vaccination rates among older adults through academic detailing: Medicine, nursing and pharmacy partnership. Vaccines, 9.","DOI":"10.3390\/vaccines9040317"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/14760584.2020.1791088","article-title":"A systematic review of vaccine availability at the national, district, and health facility level in the WHO African Region","volume":"19","author":"Iwu","year":"2020","journal-title":"Expert Rev. Vaccines"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.coi.2021.05.009","article-title":"Vaccine hesitancy in migrant communities: A rapid review of latest evidence","volume":"71","author":"Tankwanchi","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e028476","DOI":"10.1136\/bmjopen-2018-028476","article-title":"Contextualised strategies to increase childhood and adolescent vaccination coverage in South Africa: A mixed-methods study","volume":"10","author":"Wiysonge","year":"2020","journal-title":"BMJ Open"},{"key":"ref_32","first-page":"213","article-title":"Barriers to adult immunization and solutions: Personalized approaches","volume":"1","author":"Alici","year":"2016","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.amjmed.2008.05.005","article-title":"Barriers to adult immunization","volume":"12","author":"Johnson","year":"2008","journal-title":"Am. J. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1016\/j.vaccine.2020.04.052","article-title":"Barriers and drivers to adult vaccination among family physicians\u2014Insights for tailoring the immunization program in Germany","volume":"38","author":"Neufeind","year":"2020","journal-title":"Vaccine"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1080\/21645515.2019.1582402","article-title":"Is patient insurance type related to physician recommendation, administration and referral for adult vaccination? A survey of US physicians","volume":"15","author":"McNamara","year":"2019","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_36","first-page":"PA934","article-title":"Facilitators and barriers to adult vaccination in South East Asia and Latin America","volume":"20","author":"Davis","year":"2017","journal-title":"Value Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S422","DOI":"10.1513\/AnnalsATS.201602-095AW","article-title":"Aging of the immune system. Mechanisms and therapeutic targets","volume":"13","author":"Weyand","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/gerona\/glz029","article-title":"Assessment of lymph node stromal cells as an underlying factor in age-related immune impairment","volume":"74","author":"Masters","year":"2019","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Thompson, H.L., Smithey, M.J., Surh, C.D., and Nikolich-\u017dugich, J. (2017). Functional and homeostatic impact of age-related changes in lymph node stroma. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00706"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.4161\/21645515.2014.982998","article-title":"Adult vaccination: Now is the time to realize an unfulfilled potential","volume":"11","author":"Tan","year":"2015","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_41","unstructured":"Care CEP and O of Data Collection Form (2025, July 22). EPOC Resources for Review Authors. Available online: https:\/\/epoc.cochrane.org\/epoc-specific-resources-review-authors."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Borenstein, M., Hedges, L.V., Higgins, J.P., and Rothstein, H.R. (2009). When Does It Make Sense to Perform A Meta-Analysis?. Introduction to Meta-Analysis, John Wiley & Sons, Ltd.","DOI":"10.1002\/9780470743386"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1525-1497.1998.00136.x","article-title":"Influenza immunization in a managed care organization","volume":"13","author":"Baker","year":"1998","journal-title":"J. Gen. Intern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s11606-017-4266-9","article-title":"Improving Rates of Outpatient Influenza Vaccination Through EHRPortal Messages and Interactive Automated Calls: A Randomized Controlled Trial","volume":"33","author":"Cutrona","year":"2018","journal-title":"J. Gen. Intern. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2105\/AJPH.2013.301620","article-title":"Influenza Vaccine Text Message Reminders for Urban, Low-Income Pregnant Women: A Randomized Controlled Trial","volume":"104","author":"Stockwell","year":"2014","journal-title":"Am. J. Public Health"},{"key":"ref_46","first-page":"989","article-title":"Effect of Automated Immunization Registry-Based Telephonic Interventions on Adult Vaccination Rates in Community Pharmacies: A Randomized Controlled Trial","volume":"25","author":"Stolpe","year":"2019","journal-title":"J. Manag. Care Spec. Pharm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ajic.2007.10.019","article-title":"A novel approach to improve influenza vaccination rates among health care professionals: A prospective randomized controlled trial","volume":"36","author":"Doratotaj","year":"2008","journal-title":"Am. J. Infect. Control"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s11606-021-07023-w","article-title":"Effect of Personalized Messages Sent by a Health System\u2019s Patient Portal on Influenza Vaccination Rates:a Randomized Clinical Trial","volume":"37","author":"Szilagyi","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/108155890305100316","article-title":"Patient education strategies to improve pneumococcal vaccination rates: Randomized trial. TT-Journal of Investigational medicine","volume":"51","author":"Thomas","year":"2003","journal-title":"J. Investig. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1007\/s11606-021-06941-z","article-title":"Impact of Patient Portal Messaging Reminders with Self-Scheduling Option on Influenza Vaccination Rates:a Prospective, Randomized Trial","volume":"37","author":"Ueberroth","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41562-018-0432-2","article-title":"Letters designed with behavioural science increase influenza vaccination in Medicare beneficiaries","volume":"2","author":"Yokum","year":"2018","journal-title":"Nat. Hum. Behav."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/00333549111260S206","article-title":"Increasing Inner-City Adult Influenza Vaccination Rates: A Randomized Controlled Trial","volume":"126","author":"Humiston","year":"2011","journal-title":"Public Health Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.amepre.2018.04.022","article-title":"RCT of Centralized Vaccine Reminder\/Recall for Adults","volume":"55","author":"Hurley","year":"2018","journal-title":"Am. J. Prev. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1001\/jama.282.7.646","article-title":"Use of a low-literacy patient education tool to enhance pneumococcal vaccination rates","volume":"282","author":"Jacobson","year":"1999","journal-title":"JAMA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2105\/AJPH.2013.301458","article-title":"A Randomized Trial of a Hepatitis Care Coordination Model in Methadone Maintenance Treatment","volume":"103","author":"Masson","year":"2013","journal-title":"Am. J. Public Health"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Juon, H.-S., Strong, C., Kim, F., Park, E., and Lee, S. (2016). Lay Health Worker Intervention Improved Compliance with Hepatitis B Vaccination in Asian Americans: Randomized Controlled Trial. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162683"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101589","DOI":"10.1016\/j.dhjo.2024.101589","article-title":"Partners in vaccination: A community-based intervention to promote COVID-19 vaccination among low-income homebound and disabled adults","volume":"17","author":"Kim","year":"2024","journal-title":"Disabil. Health J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1001\/archinte.1983.00350100040012","article-title":"Pneumococcal Vaccine in the Hospital Improved Use and Implications for High-Risk Patients","volume":"143","author":"Klein","year":"1983","journal-title":"Arch. Intern. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1016\/j.vaccine.2019.11.053","article-title":"Large-scale influenza vaccination promotion on a mobile app platform: A randomized controlled trial","volume":"38","author":"Lee","year":"2020","journal-title":"Vaccine"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/BF02599460","article-title":"Computer-generated Mailed Reminders for Influenza Immunization:A Clinical Trial","volume":"7","author":"Moran","year":"1992","journal-title":"J. Gen. Intern. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1177\/0890117118823157","article-title":"Promoting Influenza Vaccination Among an ACA Health Plan Subscriber Population: A Randomized Trial","volume":"33","author":"Nehme","year":"2019","journal-title":"Am. J. Health Promot."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1016\/j.amepre.2019.05.018","article-title":"Efficacy of a Web-Based Intervention to Increase Uptake of Maternal Vaccines: An RCT","volume":"57","author":"Narwaney","year":"2019","journal-title":"Am. J. Prev. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"832.e1","DOI":"10.1016\/j.amjmed.2013.02.018","article-title":"Improving Herpes Zoster Vaccination Rates Through Use of aClinical Pharmacist and a Personal Health Record","volume":"126","author":"Otsuka","year":"2013","journal-title":"Am. J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s11606-024-09170-2","article-title":"Behaviorally Informed Text Message Nudges to Schedule COVID-19 Vaccinations: A Randomized Controlled Trial","volume":"40","author":"Reddy","year":"2024","journal-title":"J. Gen. Intern. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/07448481.2015.1117466","article-title":"A randomized intervention study to evaluate whether electronic messaging canincrease human papillomavirus vaccine completion and knowledge among college students","volume":"64","author":"Richman","year":"2016","journal-title":"J. Am. Coll. Health"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1532-5415.1985.tb04888.x","article-title":"Increasing the Pneumococcal Vaccination Rate of Elderly Patients in a General Internal Medicine Clinic","volume":"33","author":"Siebers","year":"1985","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_67","first-page":"254","article-title":"Postcard reminders from GPs for influenza vaccine: Are they more effective than an ad hoc approach?","volume":"22","author":"Puech","year":"1998","journal-title":"J. Public Health"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.vaccine.2024.03.020","article-title":"The effect of a financial incentive on COVID-19 vaccination uptake, and predictors of uptake, in people experiencing homelessness: A randomized controlled trial","volume":"42","author":"Mccosker","year":"2024","journal-title":"Vaccine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ypmed.2013.04.013","article-title":"A randomised controlled trial of financial incentives to increase hepatitis B vaccination completion among people who inject drugs in Australia","volume":"57","author":"Topp","year":"2013","journal-title":"Prev. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12529-024-10258-6","article-title":"How to Improve People\u2019s Intentions Regarding COVID-19 Vaccination in China: A Randomized Controlled Trial","volume":"32","author":"Ju","year":"2024","journal-title":"Int. J. Behav. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/MIB.0000000000001013","article-title":"Effects of Education and Information on Vaccination Behavior in Patients with Inflammatory Bowel Disease","volume":"23","author":"Coenen","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12995-020-00285-w","article-title":"Promotion of the influenza vaccination to hospital staff during pre-employment health check: A prospective, randomised, controlled trial","volume":"15","author":"Currat","year":"2020","journal-title":"J. Occup. Med. Toxicol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/her\/cyx053","article-title":"Impact of patient education on influenza vaccine uptake among community-dwelling elderly: A randomized controlled trial","volume":"32","author":"Leung","year":"2017","journal-title":"Health Educ. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/02813439709018497","article-title":"Impact of postal invitations and user fee oninfluenza vaccination rates among the elderly: A randomized controlled trial in general practice","volume":"15","author":"Kragstrup","year":"1997","journal-title":"Scand. J. Prim. Health Care"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/bmjqs-2019-009775","article-title":"Randomised controlled trial of a theory-based intervention to prompt front-line staff to take up the seasonal influenza vaccine","volume":"29","author":"Schmidtke","year":"2020","journal-title":"BMJ Qual. Saf."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0749-3797(01)00372-5","article-title":"The Effect of a Combined Influenza\/Pneumococcal Immunization Reminder Letter","volume":"21","author":"Effler","year":"2001","journal-title":"Am. J. Prev. Med."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Batteux, E., Mills, F., Jones, L.F., and Dale Weston, C.S. (2022). The Effectiveness of Interventions for Increasing COVID-19Vaccine Uptake: A Systematic Review. Vaccines, 10.","DOI":"10.3390\/vaccines10030386"},{"key":"ref_78","first-page":"CD013430","article-title":"Factors that influence acceptance of human papillomavirus (HPV) vaccination for adolescents: A qualitative evidence synthesis","volume":"9","author":"Cooper","year":"2019","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/13\/8\/811\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:19:05Z","timestamp":1760033945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/13\/8\/811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":78,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["vaccines13080811"],"URL":"https:\/\/doi.org\/10.3390\/vaccines13080811","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]}}}