{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:40:02Z","timestamp":1793248802859,"version":"4.5.0"},"reference-count":52,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sanofi","award":["#PER00079"],"award-info":[{"award-number":["#PER00079"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: The reported incidence of pertussis, a vaccine-preventable disease, has been increasing in recent years. This study aimed to estimate the burden of pertussis and the vaccination rate in Australian adults in primary care. Methods: Deidentified data for participants aged \u226518 years were extracted from the MedicalDirector (MD) primary care software from 2008 to 2019. We estimated the cumulative incidence of diagnosed pertussis in adults by age and risk groups and vaccine coverage in cases and a control group (not diagnosed with pertussis or a coughing illness). We also examined the incidence of unspecified coughing illness in the study population. Results: Of the 764,864 subjects included in the study, 1788 (0.2%) were diagnosed with pertussis between 2008 and 2019, corresponding to an average annual diagnosis rate of 76.9 per 100,000 population. About 31,110 (4.1%) of adults had an unspecified coughing illness. The highest rate was observed in 2011 and higher in females (63.3%), and the diagnosis rate was stable across all age groups. Underlying chronic conditions were more prevalent among pertussis cases than controls (58.7% vs. 18.8%), with asthma or chronic obstructive pulmonary disease (COPD) being the most common. Overall, 14% of cases received a pertussis vaccination during the study period. Diagnostic testing for pertussis was performed in 34.1% of pertussis cases. Estimated conservative costs per pertussis patient ranged from AUD 473 to AUD 909, with higher costs observed in individuals with complications. Conclusions: In the outpatient setting, there was a notable burden of pertussis among adults under 65 years of age, particularly those with underlying medical conditions, such as asthma and COPD, which appear to be significant risk factors. Due to the low rate of pertussis testing among all coughing illnesses, a proportion of non-specific coughing illness may be undiagnosed pertussis. The observed low vaccination rates highlight a need for increased awareness, improved diagnostic efforts, and prevention strategies in primary care.<\/jats:p>","DOI":"10.3390\/vaccines13101029","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T09:38:08Z","timestamp":1759397888000},"page":"1029","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Burden of Pertussis Disease and Vaccination Coverage in Australian Adults Attending Primary Health Care"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-6241","authenticated-orcid":false,"given":"Aye M.","family":"Moa","sequence":"first","affiliation":[{"name":"Biosecurity Program, The Kirby Institute, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5609-7046","authenticated-orcid":false,"given":"Juan C.","family":"Vargas-Zambrano","sequence":"additional","affiliation":[{"name":"Sanofi Vaccines Global Medical Affairs, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Maruszak","sequence":"additional","affiliation":[{"name":"Sanofi Australia & New Zealand Medical Affairs, Sydney, NSW 2000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Costantino","sequence":"additional","affiliation":[{"name":"Biosecurity Program, The Kirby Institute, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Raina","family":"MacIntyre","sequence":"additional","affiliation":[{"name":"Biosecurity Program, The Kirby Institute, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/JAA.S335960","article-title":"Burden of Pertussis in Individuals with a Diagnosis of Asthma: A Retrospective Database Study in England","volume":"15","author":"Bhavsar","year":"2022","journal-title":"J. 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