{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:16:26Z","timestamp":1764306986480,"version":"3.46.0"},"reference-count":35,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705900"],"award-info":[{"award-number":["2023YFC2705900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2023YFQ0005"],"award-info":[{"award-number":["2023YFQ0005"]}]},{"name":"Key Research Program of Chongqing Science and Technology Bureau","award":["CSTB2022TIAD-KPX0156"],"award-info":[{"award-number":["CSTB2022TIAD-KPX0156"]}]},{"name":"Chongqing Medical Scientific Research Project","award":["2023GGXM005"],"award-info":[{"award-number":["2023GGXM005"]}]},{"DOI":"10.13039\/501100001809","name":"Joint Funds of the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U21A20346"],"award-info":[{"award-number":["U21A20346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"General Program of National Natural Science Foundation of China","award":["82171662"],"award-info":[{"award-number":["82171662"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2704702"],"award-info":[{"award-number":["2022YFC2704702"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Base for Innovation and Talent Introduction in Maternal and Fetal Medicine"},{"name":"The program of Introducing Talents of Discipline to Universities"},{"name":"Study on the Safety and Immunogenicity of Quadrivalent Influenza Virus Subunit Vaccine in Pregnant Women","award":["2025-140"],"award-info":[{"award-number":["2025-140"]}]},{"name":"General Project of Chongqing Municipal Science and Health Joint Medical Research Project","award":["2024MSXM068"],"award-info":[{"award-number":["2024MSXM068"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: Seasonal influenza presents a major public health issue with a heavy disease burden on pregnant women, who are at increased risk of severe outcomes, yet vaccination uptake remains low. Objective: Investigate pregnant women\u2019s willingness to receive influenza vaccination, identify key influencing factors, and elucidate the pathways shaping this willingness. Methods: A cross-sectional web-based survey was performed. The questionnaire included their socioeconomic characteristics, pregnant status and histories, knowledge of the influenza vaccine, and attitudes toward the seasonal influenza vaccine. A univariate analysis was initially performed to screen potential variables associated with pregnant women\u2019s willingness to receive influenza vaccination. Subsequently, a multivariate binary logistic regression model was constructed to assess the independent effects of these variables on vaccination willingness. Additionally, a mediation effect model was developed to analyze the mediating pathways of factors influencing vaccination willingness. Results: A total of 1231 pregnant women participated in this survey. Five hundred and seventy-one (46.4%) were willing to receive the seasonal influenza vaccine. Multivariate analysis identified five key factors influencing willingness: higher annual income (CNY \u2265 200,000 vs. \u2264100,000: OR = 2.65, 95% CI: 1.02\u20136.85), history of delivery difficulties (OR = 0.10, 95% CI: 0.02\u20130.62), knowledge about the influenza vaccine (OR = 1.69, 95% CI: 1.28\u20132.23), supportive attitudes towards vaccination (OR = 13.35, 95% CI: 8.26\u201321.55), and willingness to pay over 500 yuan for the vaccine (OR = 2.29, 95% CI: 1.23\u20134.27). Attitudes towards vaccination were partially mediated by vaccine knowledge (\u03b2 = 0.03, 16% of total effect), with no mediation effects observed for price or delivery history. Conclusions: This study pinpointed pivotal factors contributing to pregnant women\u2019s hesitancy towards seasonal influenza vaccination. Our findings underscore the urgent need for integrating influenza vaccination programs with comprehensive educational and promotional strategies in the future.<\/jats:p>","DOI":"10.3390\/vaccines13121194","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T13:56:34Z","timestamp":1764165394000},"page":"1194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influencing Factors of Pregnant Women\u2019s Willingness to Receive Influenza Vaccination in China"],"prefix":"10.3390","volume":"13","author":[{"given":"Yi","family":"Tao","sequence":"first","affiliation":[{"name":"Phase I Clinical Trial Ward, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"},{"name":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trial Ward, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghong","family":"Sun","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trial Ward, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trial Ward, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Yang","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trial Ward, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Chongqing Yuzhong Center for Disease Prevention and Control, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Qi","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing 400016, China"},{"name":"Chongqing Yuzhong Center for Disease Prevention and Control, Chongqing 400016, China"},{"name":"Joint International Research Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Li","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trial Ward, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/EDE.0000000000001819","article-title":"Influenza Activity and Preterm Birth in the Atlanta Metropolitan Area: A Time-Series Analysis from 2010 to 2017","volume":"36","author":"Zheng","year":"2025","journal-title":"Epidemiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1016\/j.vaccine.2023.10.067","article-title":"Evaluation of intentions to get vaccinated against influenza, COVID 19, pertussis and to get a future vaccine against respiratory syncytial virus in pregnant women","volume":"41","author":"Cubizolles","year":"2023","journal-title":"Vaccine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1016\/j.vaccine.2017.07.006","article-title":"Estimating influenza disease burden among pregnant women: Application of self-control method","volume":"35","author":"Ohfuji","year":"2017","journal-title":"Vaccine"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Vygen-Bonnet, S., Hellenbrand, W., Garbe, E., von Kries, R., Bogdan, C., Heininger, U., Robl-Mathieu, M., and Harder, T. 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