{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T09:19:47Z","timestamp":1764580787864,"version":"3.46.0"},"reference-count":59,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council and GCRF Networks in Vaccines Research and Development"},{"name":"EDCTP2 program supported by the European Union","award":["MR\/Y033752\/1","MR\/R005990\/2"],"award-info":[{"award-number":["MR\/Y033752\/1","MR\/R005990\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background\/Objectives: New vaccines designed to combat infections such as Group B Streptococcus and respiratory syncytial virus will soon be accessible in Africa. While outbreak response vaccines are given to pregnant women, safety data for maternal vaccines in low- and middle-income countries (LMICs) are limited. This study explored Ugandan pregnant women\u2019s knowledge, attitudes, and engagement in adverse event reporting and vaccine decision-making. Methods: This nested qualitative study was part of a national gap analysis of pharmacovigilance systems for maternal vaccines. Five Focus Group Discussions (FGDs), each involving eight participants, were held with pregnant and or breastfeeding women at four healthcare facilities and one research center. The data collected from these discussions were analyzed thematically using a manifest content analysis, conducted in Atlas.ti software version 9 for qualitative data analysis. Results: Women valued maternal vaccines, particularly tetanus, but reported confusion about schedules and hesitancy when informed of potential side effects. Many adverse events were normalized, therefore not reported, and most participants were unaware of national reporting mechanisms beyond informing healthcare providers. Barriers included inadequate information, dismissive or rushed provider interactions and reliance on family, peers, and informal care networks to manage side effects. Women expressed a strong desire to be informed and actively involved in decisions about pregnancy vaccines, including the introduction of new vaccines. Conclusions: Strengthening maternal vaccine safety monitoring requires clearer, balanced communication; simplified and well-publicized reporting tools; supportive provider\u2013patient interactions; and integration of community and informal networks. Pregnant women should be engaged as active partners in pharmacovigilance and maternal vaccine introduction to build trust, improve adverse event reporting, and support vaccine uptake.<\/jats:p>","DOI":"10.3390\/vaccines13121210","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T08:13:49Z","timestamp":1764576829000},"page":"1210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnant Women and Vaccine Safety in Uganda: Knowledge, Barriers, and Opportunities for Engagement"],"prefix":"10.3390","volume":"13","author":[{"given":"Victoria Prudence","family":"Nambasa","sequence":"first","affiliation":[{"name":"Erasmus MC, University Medical Centre, Department of Hospital Pharmacy, Postbox 2040, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robinah","family":"Komuhendo","sequence":"additional","affiliation":[{"name":"Department of Community Health and Behavioral Sciences, Makerere University School of Public Health, Kampala P.O. Box 7072, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Serwanga","sequence":"additional","affiliation":[{"name":"National Drug Authority, Kampala P.O. Box 23096, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Kajungu","sequence":"additional","affiliation":[{"name":"Makerere University Centre for Health and Population Research (MUCHAP), Kampala P.O. Box 7062, Uganda"},{"name":"Division of Epidemiology and Biostatistics, Department of Global Health, Stellenbosch University, Private Bag X1, Stellenbosch 7599, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit C. P.","family":"Koch","sequence":"additional","affiliation":[{"name":"Erasmus MC, University Medical Centre, Department of Hospital Pharmacy, Postbox 2040, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-4709","authenticated-orcid":false,"given":"Beate","family":"Kampmann","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Centre for Global Health, Charit\u00e9 Universit\u00e4tsmedizin, 10117 Berlin, Germany"},{"name":"Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5104-085X","authenticated-orcid":false,"given":"Kirsty","family":"Le Doare","sequence":"additional","affiliation":[{"name":"Makerere University-Johns Hopkins University Research Collaboration, Kampala P.O. Box 23491, Uganda"},{"name":"Centre for Neonatal and Paediatric Infection, St George\u2019s, University of London, London SW17 0RE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Ssali","sequence":"additional","affiliation":[{"name":"Makerere University-Johns Hopkins University Research Collaboration, Kampala P.O. Box 23491, Uganda"},{"name":"Medical Research Council\/Uganda Virus Research Institute & LSHTM Uganda Research Unit, Entebbe P.O. Box 49, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/AOG.0000000000003161","article-title":"Maternal Immunization","volume":"133","author":"Munoz","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bergin, N., Murtagh, J., and Philip, R.K. (2018). 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