{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:27:48Z","timestamp":1777674468949,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: Serological screening for HBV is standard in hemodialysis, and vaccination is recommended for non-immune patients. Objective: To determine the cause of positive HBsAg detected shortly after vaccination. Methods: We conducted a retrospective study in a tertiary hemodialysis unit. Patients with HBsAg reactivity after receiving the adjuvanted HBV vaccine (Fendrix\u00ae) were followed with serial serology until HBsAg clearance. Results: Forty-four patients were monitored; seven (15.9%) tested HBsAg-positive 1\u20137 days post-vaccination, with no evidence of acute hepatitis, prior HBV infection, transplantation, or chronic immunosuppression. Six cleared HBsAg on repeat testing; one remained positive until day 19, with HBsAg as the only marker. Conclusions: Vaccine-related transient HBsAg antigenemia can occur shortly after immunization. Recognizing this phenomenon and timing routine serology appropriately can prevent misinterpretation and unnecessary workups in CKD patients.<\/jats:p>","DOI":"10.3390\/vaccines13121216","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T09:34:37Z","timestamp":1764581677000},"page":"1216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transient Hepatitis B Surface Antigenemia Following Immunization with the Adjuvanted Hepatitis B Vaccine Fendrix\u00ae"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7146-2059","authenticated-orcid":false,"given":"Virginia","family":"Fern\u00e1ndez-Espinilla","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health, University of Valladolid, 47005 Valladolid, Spain"},{"name":"Preventive Medicine and Public Health Service, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Ardura-Agud\u00edn","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2833-2114","authenticated-orcid":false,"given":"Daniel Leonardo","family":"S\u00e1nchez-Carmona","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Public Health Service, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Sanz-Ballesteros","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenia Piedad","family":"Cobo-Campuzano","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Hern\u00e1n-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, University of Valladolid, 47005 Valladolid, Spain"},{"name":"Preventive Medicine and Public Health Service, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Javier","family":"Castrodeza-Sanz","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, University of Valladolid, 47005 Valladolid, Spain"},{"name":"Preventive Medicine and Public Health Service, Hospital Cl\u00ednico Universitario de Valladolid, 47003 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2487-9350","authenticated-orcid":false,"given":"Mar\u00eda del Camino","family":"Prada-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, University of Valladolid, 47005 Valladolid, Spain"},{"name":"Dermatology Service, Complejo Asistencial Universitario de Le\u00f3n, 24008 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2024). 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