{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:27:57Z","timestamp":1768976877030,"version":"3.49.0"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Henan Provincial Medical Science and Technology Key Projects Jointly Established Programme","award":["LHGJ20220155"],"award-info":[{"award-number":["LHGJ20220155"]}]},{"name":"Henan Provincial Key Scientific and Technological Research Project","award":["24210231119"],"award-info":[{"award-number":["24210231119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: On 1 January 2019, a 2-dose mumps-containing vaccine (MuCV) immunization strategy was adopted in Henan Province before the national Expanded Program on Immunization (EPI). This study examines the epidemiological characteristics of mumps cases during the implementation of various immunization strategies in Henan Province. Methods: We employed descriptive statistics and initially retrieved data on reported cases from 2004 to 2024. Mumps case data were sourced from the China Information System for Disease Control and Prevention (CISDCP). Results: Between 2004 and 2024, a total of 301,342 cases of mumps disease were reported in Henan Province, and the average annual reported incidence was 15.11 cases per 100,000 people. The average yearly incidence decreased by 60.29% following the implementation of the 2-dose vaccination strategy compared with the one-dose strategy. The study identifies two annual incidence peaks from 2004 to 2024: a prominent peak from April to July and a smaller peak from December to January. From 2019 to 2024, in addition to a slight dip in February, the seasonality was less pronounced, with cases distributed sporadically throughout the year. The proportion of the population over 20 years old increased annually, from 8.17% in 2004\u20132008 to 15.55% in 2019\u20132024. There was an overall negative correlation between the estimated MuCV vaccination rate and the reported incidence of mumps (r = \u22120.685, p &lt; 0.05). Conclusions: The introduction of 2-dose MuCV in the EPI significantly reduced the incidence rate and total number of cases. While continuing the 2-dose MuCV immunization strategy in the future, it is crucial to remain vigilant in preventing and controlling mumps among individuals over 20 years old.<\/jats:p>","DOI":"10.3390\/vaccines14010100","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:20:42Z","timestamp":1768929642000},"page":"100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Characteristics of Mumps Under Different Immunization Strategies in Henan Province"],"prefix":"10.3390","volume":"14","author":[{"given":"Zhanpei","family":"Xiao","sequence":"first","affiliation":[{"name":"Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxia","family":"Lu","sequence":"additional","affiliation":[{"name":"Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yating","family":"Ma","sequence":"additional","affiliation":[{"name":"Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binghui","family":"Du","sequence":"additional","affiliation":[{"name":"Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Bai","sequence":"additional","affiliation":[{"name":"Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhu","family":"Ma","sequence":"additional","affiliation":[{"name":"Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jinf.2023.01.009","article-title":"Impact of non-pharmaceutical interventions during COVID-19 pandemic on measles and mumps in Mainland China","volume":"86","author":"Xu","year":"2023","journal-title":"J. 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