{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:13Z","timestamp":1785437953364,"version":"3.56.0"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-03205-24"],"award-info":[{"award-number":["APQ-03205-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-04839-24"],"award-info":[{"award-number":["APQ-04839-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"award":["APQ-03205-24"],"award-info":[{"award-number":["APQ-03205-24"]}],"id":[{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"publisher"}]},{"award":["APQ-04839-24"],"award-info":[{"award-number":["APQ-04839-24"]}],"id":[{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["405731\/2023-0"],"award-info":[{"award-number":["405731\/2023-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301522\/2025-1"],"award-info":[{"award-number":["301522\/2025-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background\/Objectives: Individuals with alcohol use disorder (AUD) and tobacco use disorder (TUD) are at increased risk for severe COVID-19 outcomes. However, real-world evidence on vaccine effectiveness (VE) in these populations remains limited, particularly in low- and middle-income countries. This study aimed to evaluate the effectiveness of three or more COVID-19 vaccine doses against mortality in hospitalized patients with AUD and TUD in Brazil. Methods: This retrospective cohort study used data from the SIVEP Gripe database, a national surveillance system of hospitalized COVID-19 cases in Brazil. The study included adults aged \u226518 years with confirmed SARS-CoV 2 infection between February 2020 and June 2025. The intervention was defined as receipt of three or more vaccine doses (fully vaccinated) versus no doses (unvaccinated). Propensity score matching was performed separately for AUD and TUD cohorts. Vaccine effectiveness was estimated using McNemar\u2019s test for paired samples, and the average treatment effect (ATE) and number needed to vaccinate (NNV) were calculated. Results: Among 2,184,723 hospitalized patients, 12,115 had AUD and 45,679 had TUD. After matching, VE against mortality was 42% (95% CI: 27.5\u201353.5) in the AUD group and 52.6% (95% CI: 46.5\u201358.1) in the TUD group, compared to 58.5% and 58.9% in their respective non-exposed counterparts. The ATE was consistent across groups (approximately \u22120.12), and the NNV to prevent one death was 8 (95% CI: 6\u201315 for AUD; 7\u201312 for TUD). Conclusions: Although VE was attenuated in individuals with AUD and TUD compared to the general population, the absolute benefit of vaccination remained substantial.<\/jats:p>","DOI":"10.3390\/vaccines14050376","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:04:42Z","timestamp":1776945882000},"page":"376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["COVID-19 Vaccine Effectiveness in Individuals with Alcohol and Tobacco Use Disorders: A Propensity Score-Matched Study Using Nationwide Brazilian Data"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-1179","authenticated-orcid":false,"given":"Fabr\u00edcio Emanuel S.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Health Science\/Primary Care Postgraduate Program, State University of Montes Claros (Unimontes), Montes Claros 39401-089, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3979-7497","authenticated-orcid":false,"given":"Daniella R. B.","family":"Martelli","sequence":"additional","affiliation":[{"name":"Health Science\/Primary Care Postgraduate Program, State University of Montes Claros (Unimontes), Montes Claros 39401-089, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2511-6769","authenticated-orcid":false,"given":"Maria Christina L.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine, University Federal of Minas Gerais (UFMG), R. Engenheiro Amaro Lanari 389\/501, Belo Horizonte 30310-580, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico A.","family":"Colosimo","sequence":"additional","affiliation":[{"name":"Department of Statistics, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-3882","authenticated-orcid":false,"given":"Ana Cristina","family":"Sim\u00f5es e Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine, University Federal of Minas Gerais (UFMG), R. Engenheiro Amaro Lanari 389\/501, Belo Horizonte 30310-580, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Livia O.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine, University Federal of Minas Gerais (UFMG), R. Engenheiro Amaro Lanari 389\/501, Belo Horizonte 30310-580, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1918-3839","authenticated-orcid":false,"given":"Rafaela R.","family":"Herrerias","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine, University Federal of Minas Gerais (UFMG), R. Engenheiro Amaro Lanari 389\/501, Belo Horizonte 30310-580, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lays R. C.","family":"Foligno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine, University Federal of Minas Gerais (UFMG), R. Engenheiro Amaro Lanari 389\/501, Belo Horizonte 30310-580, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella O.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine, University Federal of Minas Gerais (UFMG), R. Engenheiro Amaro Lanari 389\/501, Belo Horizonte 30310-580, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-2802","authenticated-orcid":false,"given":"Herc\u00edlio","family":"Martelli-Junior","sequence":"additional","affiliation":[{"name":"Health Science\/Primary Care Postgraduate Program, State University of Montes Claros (Unimontes), Montes Claros 39401-089, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5642-7164","authenticated-orcid":false,"given":"Eduardo A.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences Postgraduate Program, School of Medicine, University Federal of Minas Gerais (UFMG), R. Engenheiro Amaro Lanari 389\/501, Belo Horizonte 30310-580, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108070","DOI":"10.1016\/j.addbeh.2024.108070","article-title":"The Impact of Smoking on COVID-19-Related Mortality: A Brazilian National Cohort Study","volume":"156","author":"Oliveira","year":"2024","journal-title":"Addict. Behav."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"De Oliveira, F.E.S., Martelli, D.R.B., Oliveira, M.C.L., Colosimo, E.A., Martelli J\u00fanior, H., and Oliveira, E.A. (2025). Outcomes and Risk Factors of Death among Individuals with Alcohol Use Disorder Hospitalized with COVID-19: An Observational Brazilian Cohort Study. 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