{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:05:17Z","timestamp":1784624717123,"version":"3.55.0"},"reference-count":87,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AHF"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>In March 2025, the Americas Health Foundation (AHF) convened a regional meeting, in Bogot\u00e1, Colombia, of the Latin America Dengue Task Force, a multidisciplinary regional group of arbovirus specialists, to address the growing challenges posed by dengue in the region. The primary objective of the meeting was to analyze the regional dengue landscape, identify gaps and barriers that hinder a comprehensive approach, and develop a strategic blueprint for advancing control and prevention in Latin America. The Task Force conducted a thorough review of dengue-related issues, drawing on participants\u2019 professional expertise in vaccination, prevention, diagnosis, treatment, vector control, environmental determinants, and regulatory and policy frameworks. Key barriers identified include underreporting, widespread insecticide resistance, structural weaknesses in the health system, fragmented surveillance, financial and political constraints, and socioeconomic drivers. Based on these findings, actionable recommendations were developed to optimize regional dengue surveillance, strengthen prevention and diagnosis strategies, and improve coordination among stakeholders. This narrative review summarizes the epidemiological context, presents expert guidance to overcome existing limitations, and outlines strategies to advance integrated dengue control in Latin America.<\/jats:p>","DOI":"10.3390\/vaccines14060488","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:45:08Z","timestamp":1780404308000},"page":"488","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging the Gaps in Dengue Control in Latin America: Multisectoral Strategies from an Expert Panel"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4054-5588","authenticated-orcid":false,"given":"Carlos","family":"Tejada","sequence":"first","affiliation":[{"name":"Department of Global Health, Robert Stempe, Florida International University, Miami, FL 33174, 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Available online: https:\/\/medbox.org\/document\/report-on-the-epidemiological-situation-of-dengue-in-the-americas-june-2024."},{"key":"ref_6","unstructured":"European Centre for Disease Prevention and Control (2024, February 10). Dengue Worldwide. Available online: https:\/\/www.ecdc.europa.eu\/en\/dengue-monthly."},{"key":"ref_7","unstructured":"Pan American Health Organizaion, and World Health Organization Regional Office of the Americas (2025, October 10). Integrated Management Strategy for Arboviral Disease Prevention and Control in the Americas. Available online: https:\/\/iris.paho.org\/bitstream\/handle\/10665.2\/52492\/9789275120491_eng.pdf?sequence=1&isAllowed=y."},{"key":"ref_8","unstructured":"Pan American Health Organization (2020). 2020 Strategy (IMS-Arbovirus): Integrated Management Strategy for Arboviral Disease Prevention and Control in the Americas, PAHO. Available online: https:\/\/iris.paho.org\/handle\/10665.2\/52492."},{"key":"ref_9","unstructured":"World Health Organization (2025, October 11). Global Strategy for Dengue Prevention and Control, 2012\u20132020. August 2012. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789241504034."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e20069","DOI":"10.1016\/j.heliyon.2023.e20069","article-title":"Asymptomatic dengue infection rate: A systematic literature review","volume":"9","author":"Bouscaren","year":"2023","journal-title":"Heliyon"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S1473-3099(16)00146-8","article-title":"The global economic burden of dengue: A systematic analysis","volume":"16","author":"Shepard","year":"2016","journal-title":"Lancet Infect. 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Dis., 4.","DOI":"10.3389\/fitd.2023.1118774"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8045435","DOI":"10.1155\/2017\/8045435","article-title":"Epidemiological Characteristics of Dengue Disease in Latin America and in the Caribbean: A Systematic Review of the Literature","volume":"2017","author":"Torres","year":"2017","journal-title":"J. Trop. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.epidem.2015.03.002","article-title":"Dengue disease outbreak definitions are implicitly variable","volume":"11","author":"Brady","year":"2015","journal-title":"Epidemics"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Racloz, V., Ramsey, R., Tong, S., and Hu, W. (2012). Surveillance of dengue fever virus: A review of epidemiological models and early warning systems. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001648"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Beatty, M.E., Stone, A., Fitzsimons, D.W., Hanna, J.N., Lam, S.K., Vong, S., Guzman, M.G., Mendez-Galvan, J.F., Halstead, S.B., and Letson, G.W. (2010). Best practices in dengue surveillance: A report from the Asia-Pacific and Americas Dengue Prevention Boards. PLoS Negl. Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000890"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijid.2016.01.015","article-title":"A comparative study on active and passive epidemiological surveillance for dengue in five countries of Latin America","volume":"44","author":"Sarti","year":"2016","journal-title":"Int. J. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Madoff, L.C., Fisman, D.N., and Kass-Hout, T. (2011). A new approach to monitoring dengue activity. PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001215"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4269\/ajtmh.2011.10-0503","article-title":"Economic impact of dengue illness in the Americas","volume":"84","author":"Shepard","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Undurraga, E.A., Halasa, Y.A., and Shepard, D.S. (2013). Use of expansion factors to estimate the burden of dengue in Southeast Asia: A systematic analysis. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002056"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2426348","DOI":"10.1080\/16549716.2024.2426348","article-title":"Beyond top-down: Community co-creation approaches for sustainable dengue vector control","volume":"17","author":"Dambach","year":"2024","journal-title":"Glob. 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Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2987\/5588.1","article-title":"Levels of insecticide resistance and resistance mechanisms in Aedes aegypti from some Latin American countries","volume":"23","author":"Bisset","year":"2007","journal-title":"J. Am. Mosq. Control Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Moyes, C.L., Vontas, J., Martins, A.J., Ng, L.C., Koou, S.Y., Dusfour, I., Raghavendra, K., Pinto, J., Corbel, V., and David, J.P. (2017). Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005625"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Agramonte, N.M., Bloomquist, J.R., and Bernier, U.R. (2017). Pyrethroid resistance alters the blood-feeding behavior in Puerto Rican Aedes aegypti mosquitoes exposed to treated fabric. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005954"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10393-025-01706-0","article-title":"The Ecological, Biological, and Social Determinants of Dengue Epidemiology in Latin America and the Caribbean: A Scoping Review of the Literature","volume":"22","author":"Barkhad","year":"2025","journal-title":"EcoHealth"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.36097\/rgcs.v2i1.3146","article-title":"Social determinants of health associated with dengue in South America: A systematic review","volume":"2","author":"Mendoza","year":"2025","journal-title":"Rev. Gregor. Cienc. Salud"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Tomashek, K.M., Gregory, C.J., Rivera S\u00e1nchez, A., Bartek, M.A., Garcia Rivera, E.J., Hunsperger, E., Mu\u00f1oz-Jord\u00e1n, J.L., and Sun, W. (2012). Dengue deaths in Puerto Rico: Lessons learned from the 2007 epidemic. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001614"},{"key":"ref_31","unstructured":"Negi, R., and Yadav, V. (2026, February 17). Cross-Border Health Data Sharing: A Roadmap for Regional Cooperation in Digital Health. Available online: https:\/\/www.hitlab.org\/cross-border-health-data-regional-cooperation\/."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e404","DOI":"10.1016\/S2542-5196(21)00132-7","article-title":"Projecting the risk of mosquito-borne diseases in a warmer and more populated world: A multi-model, multi-scenario intercomparison modelling study","volume":"5","author":"Sewe","year":"2021","journal-title":"Lancet Planet Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(18)32560-1","article-title":"Dengue","volume":"393","author":"Ooi","year":"2019","journal-title":"Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Runge-Ranzinger, S., Kroeger, A., Olliaro, P., McCall, P.J., S\u00e1nchez Tejeda, G., Lloyd, L.S., Hakim, L., Bowman, L.R., Horstick, O., and Coelho, G. (2016). Dengue Contingency Planning: From Research to Policy and Practice. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004916"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1038\/nrmicro2459","article-title":"Evaluation of diagnostic tests: Dengue","volume":"8","author":"Peeling","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_36","first-page":"100100","article-title":"Dengue detection: Advances and challenges in diagnostic technology","volume":"10","author":"Hegde","year":"2022","journal-title":"Biosens. Bioelectron. X"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Lana, R., Morais, M., Lima, T., Carneiro, T., Stolerman, L., Santos, J.P.C.D., Cort\u00e9s, J.J.C., Eiras, A., and Code\u00e7o, C. (2018). Assessment of a trap based Aedes aegypti surveillance program using mathematical modeling. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0190673"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Vargas, W., R\u00edos-Tapias, P., Marin-Vel\u00e1squez, K., Giraldo-Gallo, E., Segura-Cardona, \u00c1., and Arboleda, M. (2024). Density of Aedes aegypti and dengue virus transmission risk in two municipalities of Northwestern Antioquia, Colombia. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0295317"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Code\u00e7o, C., Lima, A., Ara\u00fajo, S., Lima, J., Maciel-De-Freitas, R., Hon\u00f3rio, N., Galardo, A., Braga, I., Coelho, G., and Valle, D. (2015). Surveillance of Aedes aegypti: Comparison of House Index with Four Alternative Traps. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003475"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.trstmh.2006.08.007","article-title":"What do community-based dengue control programmes achieve? A systematic review of published evaluations","volume":"101","author":"Heintze","year":"2007","journal-title":"Trans. R Soc. Trop. Med. Hyg."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Cofon, L., Sabato, M., Di Paolo, C., Di Giovanni, S., Donato, M., and Paglione, L. (2025). Urban, Architectural, and Socioeconomic Factors Contributing to the Concentration of Potential Arbovirus Vectors and Arbovirosis in Urban Environments from a One Health Perspective: A Systematic Review. Sustainability, 17.","DOI":"10.3390\/su17094077"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e000342","DOI":"10.1136\/bmjph-2023-000342","article-title":"Addressing challenges in vector control: A review of current strategies and the imperative for novel tools in India\u2019s combat against vector-borne diseases","volume":"2","author":"Kumar","year":"2024","journal-title":"BMJ Public Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.5365\/wpsar.2010.1.1.012","article-title":"Challenges and future perspective for dengue vector control in the Western Pacific Region","volume":"2","author":"Chang","year":"2011","journal-title":"West. Pac. Surveill. Response"},{"key":"ref_44","unstructured":"World Health Organization (2025, October 11). New Frontiers in Vector Control. 11 April 2022. Available online: https:\/\/www.who.int\/news-room\/feature-stories\/detail\/new-frontiers-in-vector-control."},{"key":"ref_45","unstructured":"Pan American Health Organization, and World Health Organization Regional Office for the Americas (2025, October 11). Use of Wolbachia in the Americas to Control Vectors Responsible for Diseases of Public Health Interest. August 2023. Available online: https:\/\/www.paho.org\/sites\/default\/files\/2023-08\/2023-cde-uso-wolbachia-americas-vectores-eng.pdf."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"279ra237","DOI":"10.1126\/scitranslmed.3010370","article-title":"Modeling the impact on virus transmission of Wolbachia-mediated blocking of dengue virus infection of Aedes aegypti","volume":"7","author":"Ferguson","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Velez, I.D., Tanamas, S.K., Arbelaez, M.P., Kutcher, S.C., Duque, S.L., Uribe, A., Zuluaga, L., Mart\u00ednez, L., Pati\u00f1o, A.C., and Barajas, J. (2023). Reduced dengue incidence following city-wide wMel Wolbachia mosquito releases throughout three Colombian cities: Interrupted time series analysis and a prospective case-control study. PLoS Negl. Trop. Dis., 17.","DOI":"10.1371\/journal.pntd.0011713"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1002\/ps.6226","article-title":"Applicability of attractive toxic sugar baits as a mosquito vector control tool in the context of India: A review","volume":"77","author":"Kumar","year":"2021","journal-title":"Pest. Manag. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/infdis\/jiw297","article-title":"Tetravalent Dengue Vaccine Reduces Symptomatic and Asymptomatic Dengue Virus Infections in Healthy Children and Adolescents Aged 2\u201316 Years in Asia and Latin America","volume":"214","author":"Coudeville","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1056\/NEJMoa1506223","article-title":"Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease","volume":"373","author":"Hadinegoro","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_51","unstructured":"U.S. Centers for Disease Control and Prevention (2025, October 10). Dengue Vaccine. 15 May 2025, Available online: https:\/\/www.cdc.gov\/dengue\/hcp\/vaccine\/index.html."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1056\/NEJMoa1903869","article-title":"Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents","volume":"381","author":"Biswal","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0140-6736(20)30414-1","article-title":"Efficacy of a tetravalent dengue vaccine in healthy children aged 4\u201316 years: A randomised, placebo-controlled, phase 3 trial","volume":"395","author":"Biswal","year":"2020","journal-title":"Lancet"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S1473-3099(24)00376-1","article-title":"Efficacy and safety of Butantan-DV in participants aged 2-59 years through an extended follow-up: Results from a double-blind, randomised, placebo-controlled, phase 3, multicentre trial in Brazil","volume":"24","author":"Nogueira","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"ref_55","unstructured":"Craide, S. (2025, May 20). Registration of Brazil\u2019s Dengue Vaccine Officially Announced. AgenicaBrasil. Available online: https:\/\/agenciabrasil.ebc.com.br\/en\/saude\/noticia\/2025-12\/registration-brazils-dengue-vaccine-officially-announced."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13071-018-2808-6","article-title":"Effects of desiccation stress on adult female longevity in Aedes aegypti and Ae. albopictus (Diptera: Culicidae): Results of a systematic review and pooled survival analysis","volume":"11","author":"Schmidt","year":"2018","journal-title":"Parasites Vectors"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e000801","DOI":"10.1136\/bmjgh-2018-000801","article-title":"Determining environmental and anthropogenic factors which explain the global distribution of Aedes aegypti and Ae. albopictus","volume":"3","author":"Dickens","year":"2018","journal-title":"BMJ Glob. Health"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.15585\/mmwr.mm7007a4","article-title":"Decline in Receipt of Vaccines by Medicare Beneficiaries During the COVID-19 Pandemic\u2014United States, 2020","volume":"70","author":"Hong","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_59","unstructured":"World Health Organization (2025, October 10). Global Strategic Preparedness, Readiness, and Response Plan for Dengue and Other Aedes-Borne Arboviruses. Available online: https:\/\/cdn.who.int\/media\/docs\/default-source\/ntds\/dengue\/global-sprp-for-dengue-and-other-aedes-borne-arboviruses.pdf."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1473-3099(22)00025-1","article-title":"Measuring the effects of COVID-19-related disruption on dengue transmission in southeast Asia and Latin America: A statistical modelling study","volume":"22","author":"Chen","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1179\/2046904712Z.00000000046","article-title":"Dengue: An escalating public health problem in Latin America","volume":"32","year":"2012","journal-title":"Paediatr. Int. Child. Health"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Mulderij-Jansen, V., Pundir, P., Grillet, M., Lakiang, T., Gerstenbluth, I., Duits, A., Tami, A., and Bailey, A. (2022). Effectiveness of Aedes-borne infectious disease control in Latin America and the Caribbean region: A scoping review. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0277038"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Agha, S.B., Chepkorir, E., Mulwa, F., Tigoi, C., Arum, S., Guarido, M.M., Ambala, P., Chelangat, B., Lutomiah, J., and Tchouassi, D.P. (2017). Vector competence of populations of Aedes aegypti from three distinct cities in Kenya for chikungunya virus. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005860"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/trstmh\/tru187","article-title":"Entomological impact and social participation in dengue control: A cluster randomized trial in Fortaleza, Brazil","volume":"109","author":"Caprara","year":"2015","journal-title":"Trans. R Soc. Trop. Med. Hyg."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Bowman, L.R., Donegan, S., and McCall, P.J. (2016). Is Dengue Vector Control Deficient in Effectiveness or Evidence?: Systematic Review and Meta-analysis. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004551"},{"key":"ref_66","unstructured":"Association of Southeast Asian Nations (2023). ASEAN Centre for Public Health Emergencies and Emerging Diseases (ACPHEED), ASEAN Secretariat."},{"key":"ref_67","unstructured":"Caribbean Public Health Agency (2026, March 20). About CARPHA. Port of Spain: CARPHA. Available online: https:\/\/carpha.org\/Who-We-Are."},{"key":"ref_68","unstructured":"Africa Centres for Disease Control and Prevention (2024). About Africa CDC, African Union. Available online: https:\/\/africacdc.org\/."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/20477724.2018.1547541","article-title":"Building the evidence base for dengue vector control: Searching for certainty in an uncertain world","volume":"112","author":"Horstick","year":"2018","journal-title":"Pathog. Glob. Health"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Quintero, J., Brochero, H., Manrique-Saide, P., Barrera-P\u00e9rez, M., Basso, C., Romero, S., Caprara, A., De Lima Cunha, J.C., Ayala, E.B., and Mitchell-Foster, K. (2014). Ecological, biological and social dimensions of dengue vector breeding in five urban settings of Latin America: A multi-country study. BMC Infect. Dis., 14.","DOI":"10.1186\/1471-2334-14-38"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Kolimenakis, A., Heinz, S., Wilson, M., Winkler, V., Yakob, L., Michaelakis, A., Papachristos, D., Richardson, C., and Horstick, O. (2021). The role of urbanisation in the spread of Aedes mosquitoes and the diseases they transmit\u2014A systematic review. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009631"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2149\/tmh.2011-S05","article-title":"Dengue, Urbanization and Globalization: The Unholy Trinity of the 21(st) Century","volume":"39","author":"Gubler","year":"2011","journal-title":"Trop. Med. Health"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6","DOI":"10.26719\/2025.31.3.163","article-title":"Factors affecting establishment of dengue fever vectors in urban areas","volume":"31","author":"Nasirian","year":"2025","journal-title":"East. Mediterr. Health J."},{"key":"#cr-split#-ref_74.1","unstructured":"UN Economic and Social Council (2026, March 20). Observaci\u00f3n General N\u00ba 14 (2000): El Derecho al Disfrute del m\u00e1s ALTO nivel Posible de Salud (Art\u00edculo 12 del Pacto Internacional de Derechos Econ\u00f3micos, Sociales y Culturales)"},{"key":"#cr-split#-ref_74.2","unstructured":"E\/C.12\/2000\/4, ONU: Comit\u00e9 de Derechos Econ\u00f3micos, Sociales y Cul-turales (CESCR), 11 August 2000. Available online: https:\/\/www.refworld.org\/es\/leg\/coment\/cescr\/2000\/es\/36991."},{"key":"ref_75","first-page":"714","article-title":"Urgent Response Needed: Addressing the Dengue Crisis in the Andean and Southern Cone Latin American Regions","volume":"111","year":"2024","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Morrison, A.C., Zielinski-Gutierrez, E., Scott, T.W., and Rosenberg, R. (2008). Defining challenges and proposing solutions for control of the virus vector Aedes aegypti. PLoS Med., 5.","DOI":"10.1371\/journal.pmed.0050068"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Mat\u00edas-P\u00e9rez, D., Guerra-Mart\u00ednez, A., Hern\u00e1ndez-Bautista, E., P\u00e9rez-Santiago, A.D., Antonio-Cruz, A.L., and Garc\u00eda-Montalvo, I.A. (2025). Impact of migratory flows and socio-environmental factors on dengue epidemiology in Oaxaca, Mexico. Front. Sociol., 10.","DOI":"10.3389\/fsoc.2025.1617789"},{"key":"ref_78","first-page":"86062010000100002","article-title":"Dengue outbreak response: Documented effective interventions and evidence gaps","volume":"1","author":"Pilger","year":"2010","journal-title":"Trop. Rev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1016\/S1473-3099(18)30757-6","article-title":"Venezuela\u2019s humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region","volume":"19","author":"Grillet","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"42","DOI":"10.11604\/pamj.2025.51.42.47457","article-title":"Unveiling dengue fever prevention and control strategy in Ethiopia: A policy landscape analysis","volume":"51","author":"Sisay","year":"2025","journal-title":"Pan Afr. Med. J."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Xu, C., Xu, J., and Wang, L. (2024). Long-term effects of climate factors on dengue fever over a 40-year period. BMC Public Health, 24.","DOI":"10.1186\/s12889-024-18869-0"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.apgeog.2018.10.005","article-title":"Revisiting the role of rainfall variability and its interactive effects with the built environment in urban dengue outbreaks","volume":"101","author":"Chen","year":"2018","journal-title":"Appl. Geogr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"100452","DOI":"10.1016\/j.onehlt.2022.100452","article-title":"The association between dengue case and climate: A systematic review and meta-analysis","volume":"15","author":"Abdullah","year":"2022","journal-title":"One Health"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s13071-021-04668-8","article-title":"Use of effective lids reduces presence of mosquito larvae in household water storage containers in urban and peri-urban Zika risk areas of Guatemala, Honduras, and El Salvador","volume":"14","author":"Pinchoff","year":"2021","journal-title":"Parasites Vectors"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1186\/s13071-017-2371-6","article-title":"Community participation in mosquito breeding site control: An interdisciplinary mixed methods study in Cura\u00e7ao","volume":"10","author":"Elsinga","year":"2017","journal-title":"Parasites Vectors"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40249-018-0464-x","article-title":"Impact, economic evaluation, and sustainability of integrated vector management in urban settings to prevent vector-borne diseases: A scoping review","volume":"7","author":"Degroote","year":"2018","journal-title":"Infect. Dis. Poverty"}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/14\/6\/488\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:43:54Z","timestamp":1784623434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/14\/6\/488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":87,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["vaccines14060488"],"URL":"https:\/\/doi.org\/10.3390\/vaccines14060488","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,30]]}}}