{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:22:24Z","timestamp":1793496144295,"version":"4.5.0"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: Human papillomavirus (HPV) causes nearly all cervical cancers and a growing share of HPV-related malignancies in both sexes, yet HPV vaccine knowledge and acceptance among medical students in Saudi Arabia, the next generation of clinicians shaping recommendations, remain poorly characterized across the full training continuum. Methods: We conducted a cross-sectional online survey of 300 medical students at the College of Medicine, Qassim University. A pre-validated questionnaire captured sociodemographic data, HPV knowledge (14 items), vaccine awareness, attitudes and behavioral intent (4 items), and barriers. Multivariable logistic regression assessed independent predictors of awareness, personal willingness, and intent to recommend the vaccine to family members and future patients. Results: A total of 91.7% of students had previously heard of HPV, and 79.3% had heard of the HPV vaccine. However, only 44.3% reached the predefined threshold for good knowledge, and 56.3% reported personal willingness to receive the vaccine. Willingness to recommend the vaccine to future patients was the most frequently endorsed intent (78.3%), followed by recommending it to a family member (73.3%), with male gender reported as the leading reason among decliners. After adjustment, each one-point increase in the knowledge score independently raised the adjusted odds of vaccine awareness (aOR 1.40, 95% CI 1.22 to 1.61), of recommending the vaccine to a future patient (aOR 1.28, 95% CI 1.13 to 1.45), of recommending it to a family member (aOR 1.19, 95% CI 1.06 to 1.33), and of personal willingness (aOR 1.16, 95% CI 1.04 to 1.29). Female gender was associated with higher odds of personal willingness (aOR 2.31, 95% CI 1.37 to 3.88), and senior training phase predicted vaccine awareness (aOR 2.71, 95% CI 1.33 to 5.52). Conclusions: Human papillomavirus vaccine knowledge independently predicted both awareness and behavioral intent among medical students at Qassim University. However, personal willingness to receive the vaccine lagged behind willingness to recommend it, particularly among male students. Embedding HPV prevention more explicitly into the medical curriculum, with particular emphasis on its relevance to male health, may help narrow this gap.<\/jats:p>","DOI":"10.3390\/vaccines14060529","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:57:58Z","timestamp":1781513878000},"page":"529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Knowledge, Awareness, and Willingness Toward the HPV Vaccine Among Medical Students at Qassim University: A Cross-Sectional Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Ghadah","family":"Alhetheli","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9514-060X","authenticated-orcid":false,"given":"Rifal","family":"Alhumaid","sequence":"additional","affiliation":[{"name":"College of Medicine, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shams","family":"Alajlan","sequence":"additional","affiliation":[{"name":"College of Medicine, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9380-5032","authenticated-orcid":false,"given":"Sheyam","family":"Alajlan","sequence":"additional","affiliation":[{"name":"College of Medicine, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Alharbi","sequence":"additional","affiliation":[{"name":"College of Medicine, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamis","family":"Allahim","sequence":"additional","affiliation":[{"name":"College of Medicine, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala Ahmed","family":"Alrubah","sequence":"additional","affiliation":[{"name":"College of Medicine, Qassim University, Buraydah 52571, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bpobgyn.2017.08.006","article-title":"Epidemiology and burden of HPV-related disease","volume":"47","author":"Serrano","year":"2018","journal-title":"Best Pract. 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