{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:46:43Z","timestamp":1782784003628,"version":"3.54.5"},"reference-count":20,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background\/Objectives: Human papillomavirus (HPV) vaccination is an important cancer prevention strategy, yet uptake remains incomplete. Although provider recommendation is a key driver of HPV vaccination, less is known about how future physicians\u2019 own vaccination behaviors are shaped. This study examined whether family vaccination context was associated with HPV vaccine uptake among medical students, with attention to implications for future vaccine counseling and prevention training. Materials and Methods: We conducted a cross-sectional analysis of survey data from 230 medical students at Wayne State University School of Medicine. The primary outcome was self-reported HPV vaccination status, dichotomized as fully vaccinated versus not fully vaccinated or unsure. Predictors included family vaccination context, gender, religious affiliation, age, year in medical school, prior HPV education, HPV knowledge, and HPV stigma. Family vaccination context was modeled as an ordinal predictor based on agreement that family members of age were vaccinated. HPV knowledge was modeled using a 22-item baseline pre-survey composite score. HPV stigma was modeled as a 2-item composite assessing perceived stigma associated with HPV and disclosure. Analyses included univariate and bivariate tests, followed by complete-case multivariable logistic regression. A sensitivity analysis restricted the outcome to vaccinated versus unvaccinated students, excluding those who were unsure. Results: Of 230 students, 189 (82.2%) reported being fully vaccinated against HPV. In bivariate analyses, family vaccination context, gender, and HPV knowledge were associated with vaccination status, whereas religion, age, year in medical school, prior HPV education, and HPV stigma were not. In the adjusted model (n = 165), family vaccination context remained the strongest independent correlate of HPV vaccination status (OR, 3.95; 95% CI, 2.11\u20137.42; p &lt; 0.001). Female gender was also associated with higher odds of vaccination (OR, 3.80; 95% CI, 1.01\u201314.29; p = 0.048), as was higher HPV knowledge (OR, 1.26; 95% CI, 1.03\u20131.53; p = 0.024). HPV stigma showed a borderline inverse association with vaccination status (OR, 0.53; 95% CI, 0.26\u20131.07; p = 0.076). Religion, age, year in medical school, and prior HPV education were not statistically significant after adjustment. The family vaccination association remained robust in the vaccinated-versus-unvaccinated sensitivity analysis (OR, 7.70; 95% CI, 2.45\u201324.26; p &lt; 0.001). Exploratory secondary analyses suggested that family vaccination context may also be associated with stronger intention to recommend HPV vaccination to future patients and greater intent to vaccinate among students who were not fully vaccinated or unsure, although these findings should be interpreted cautiously. Conclusions: Perceived family vaccination context was the strongest and most consistent correlate of self-reported HPV vaccine completion among medical students in this cross-sectional study. Gender and HPV knowledge were also associated with vaccination status in the primary adjusted model, although these estimates were less precise and less consistent across model specifications. Findings should be interpreted as associations rather than causal effects. HPV prevention training may benefit from addressing not only factual knowledge, but also trainees\u2019 vaccination histories, perceived family and social norms, HPV-related stigma, and comfort discussing vaccination as part of preparation for future cancer prevention counseling.<\/jats:p>","DOI":"10.3390\/vaccines14070569","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:55:11Z","timestamp":1782780911000},"page":"569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Family Vaccination Context Predicts HPV Vaccine Uptake Among Medical Students"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1720-2538","authenticated-orcid":false,"given":"Farah","family":"Harb","sequence":"first","affiliation":[{"name":"School of Medicine, Wayne State University, 540 E. Canfield St., Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakhnozakhon","family":"Mukhtorova","sequence":"additional","affiliation":[{"name":"School of Medicine, Wayne State University, 540 E. Canfield St., Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akarsh","family":"Lal","sequence":"additional","affiliation":[{"name":"School of Medicine, Wayne State University, 540 E. Canfield St., Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Al-Jerdi","sequence":"additional","affiliation":[{"name":"School of Medicine, Wayne State University, 540 E. Canfield St., Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morhaf","family":"Al Achkar","sequence":"additional","affiliation":[{"name":"School of Medicine, Wayne State University, 540 E. Canfield St., Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Gogoi","sequence":"additional","affiliation":[{"name":"School of Medicine, Wayne State University, 540 E. Canfield St., Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, May 05). Human Papillomavirus and Cancer. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/human-papilloma-virus-and-cancer."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","article-title":"Global burden of cancer attributable to infections in 2018: A worldwide incidence analysis","volume":"8","author":"Georges","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1200\/JCO.2015.61.6995","article-title":"Epidemiology of HPV-positive head and neck squamous cell carcinoma","volume":"33","author":"Gillison","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"djv086","DOI":"10.1093\/jnci\/djv086","article-title":"US assessment of HPV types in cancers: Implications for current and 9-valent HPV vaccines","volume":"107","author":"Saraiya","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"912","DOI":"10.15585\/mmwr.mm7234a3","article-title":"Vaccination coverage among adolescents aged 13\u201317 years\u2014National Immunization Survey\u2013Teen, United States, 2022","volume":"72","author":"Pingali","year":"2023","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.15585\/mmwr.mm6933a1","article-title":"National, regional, state, and selected local area vaccination coverage among adolescents aged 13\u201317 years\u2014United States, 2019","volume":"69","author":"Yankey","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.vaccine.2016.01.023","article-title":"Provider communication and HPV vaccination: The impact of recommendation quality","volume":"34","author":"Gilkey","year":"2016","journal-title":"Vaccine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e20161764","DOI":"10.1542\/peds.2016-1764","article-title":"Announcements versus conversations to improve HPV vaccination coverage: A randomized trial","volume":"139","author":"Brewer","year":"2017","journal-title":"Pediatrics"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lin, C., Mullen, J., Smith, D., Kotarba, M., Kaplan, S.J., and Tu, P. (2021). Healthcare providers\u2019 vaccine perceptions, hesitancy, and recommendation to patients: A systematic review. Vaccines, 9.","DOI":"10.3390\/vaccines9070713"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Levy, M.S., Finch, L., Lindsay, K.A., Jeudin, P., and Huang, M. (2022). Leveraging teachable moments in cancer prevention by improving HPV vaccination in health professional students (HPS): A systematic review. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.978843"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/07448481.2011.580028","article-title":"Human papillomavirus vaccine intent and uptake among female college students","volume":"60","author":"Patel","year":"2012","journal-title":"J. Am. Coll. Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1037\/a0027012","article-title":"Human papillomavirus vaccination intentions and uptake in college women","volume":"31","author":"Krawczyk","year":"2012","journal-title":"Health Psychol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.vaccine.2017.01.028","article-title":"US medical students\u2019 willingness to offer the HPV vaccine by vaccination status","volume":"35","author":"Berenson","year":"2017","journal-title":"Vaccine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","article-title":"A simulation study of the number of events per variable in logistic regression analysis","volume":"49","author":"Peduzzi","year":"1996","journal-title":"J. Clin. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/aje\/kwk052","article-title":"Relaxing the rule of ten events per variable in logistic and Cox regression","volume":"165","author":"Vittinghoff","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/sti.2006.023333","article-title":"The association between knowledge of HPV and feelings of stigma, shame and anxiety","volume":"83","author":"Waller","year":"2007","journal-title":"Sex. Transm. Infect."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1158\/1055-9965.EPI-08-0357","article-title":"The impact of human papillomavirus information on perceived risk of cervical cancer","volume":"18","author":"Marlow","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/03630242.2011.540744","article-title":"Correlates of HPV knowledge in the era of HPV vaccination: A study of unvaccinated young adult women","volume":"51","author":"Gerend","year":"2011","journal-title":"Women Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1177\/109019817400200403","article-title":"Historical origins of the health belief model","volume":"2","author":"Rosenstock","year":"1974","journal-title":"Health Educ. Monogr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0749-5978(91)90020-T","article-title":"The theory of planned behavior","volume":"50","author":"Ajzen","year":"1991","journal-title":"Organ. Behav. Hum. Decis. Process."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/14\/7\/569\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:28:15Z","timestamp":1782782895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/14\/7\/569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":20,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["vaccines14070569"],"URL":"https:\/\/doi.org\/10.3390\/vaccines14070569","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]}}}