{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:37:37Z","timestamp":1786523857211,"version":"build-2736575974"},"reference-count":139,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2018-04737"],"award-info":[{"award-number":["RGPIN-2018-04737"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RGPIN-2018-04737"],"award-info":[{"award-number":["RGPIN-2018-04737"]}],"id":[{"id":"https:\/\/ror.org\/01h531d29","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000082","name":"Cystic Fibrosis Canada","doi-asserted-by":"publisher","award":["3017"],"award-info":[{"award-number":["3017"]}],"id":[{"id":"10.13039\/501100000082","id-type":"DOI","asserted-by":"publisher"}]},{"award":["3017"],"award-info":[{"award-number":["3017"]}],"id":[{"id":"https:\/\/ror.org\/05b6dcx13","id-type":"ROR","asserted-by":"publisher"}]},{"name":"OVC MSc and PhD Scholarship"},{"name":"Ontario Graduate Scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Existing vectored immunoprophylaxis (VIP) approaches have primarily focused on IgG, which provides systemic protection but is less specialized in mucosal immunity. In contrast, secretory IgA (sIgA) plays a central role at epithelial surfaces, promoting pathogen neutralization while limiting inflammation. Although monoclonal IgA therapies are effective, their short half-life requires repeated dosing. Thus, VIP strategies enabling sustained sIgA expression at mucosal sites could transform mucosal infection prevention and treatment. This review outlines the key challenges associated with in vivo IgA expression and discusses critical considerations for VIP-mediated IgA delivery at mucosal surfaces, with emphasis on its potential for clinical translation. We provide a detailed overview of platforms for targeted IgA expression, including adeno-associated virus (AAV), adenoviral and lentiviral vectors, and lipid nanoparticle-based systems, alongside relevant routes of administration. Additionally, we examine emerging strategies to enhance the robustness, durability, and localization of IgA expression in vivo. Overall, VIP-enabled IgA expression represents an emerging strategy for enhancing mucosal immunity, with continued advances required to establish its role in the prevention and treatment of mucosal infections.<\/jats:p>","DOI":"10.3390\/vaccines14080692","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:57:26Z","timestamp":1786521446000},"page":"692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vectored Immunoprophylaxis for Mucosal Immunity: Advances and Challenges Associated with Recombinant Secretory IgA Expression"],"prefix":"10.3390","volume":"14","author":[{"given":"Benjamin J.","family":"Manchester","sequence":"first","affiliation":[{"name":"Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Gommerman","sequence":"additional","affiliation":[{"name":"Department of Immunology, Temerty Faculty of Medicine, University of Toronto, 1 King\u2019s College Circle, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4578-6145","authenticated-orcid":false,"given":"Leonardo","family":"Susta","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-2406","authenticated-orcid":false,"given":"Sarah K.","family":"Wootton","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151710","DOI":"10.1016\/j.acthis.2021.151710","article-title":"The History of the Antibody as a Tool","volume":"123","author":"Packer","year":"2021","journal-title":"Acta Histochem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/icb.1997.10","article-title":"A Brief History of the Discovery of the Immunoglobulins and the Origin of the Modern Immunoglobulin Nomenclature","volume":"75","author":"Black","year":"1997","journal-title":"Immunol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/mi.2007.6","article-title":"The Immune Geography of IgA Induction and Function","volume":"1","author":"Macpherson","year":"2008","journal-title":"Mucosal Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-019-0592-z","article-title":"Development of Therapeutic Antibodies for the Treatment of Diseases","volume":"27","author":"Lu","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-540-73259-4_1","article-title":"Historical Development of Monoclonal Antibody Therapeutics","volume":"Volume 181","author":"Chernajovsky","year":"2008","journal-title":"Therapeutic Antibodies"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1128\/CVI.00002-10","article-title":"Intranasal Delivery of an IgA Monoclonal Antibody Effective against Sublethal H5N1 Influenza Virus Infection in Mice","volume":"17","author":"Ye","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1964317","DOI":"10.1080\/21645515.2021.1964317","article-title":"The Prospect of Orally Administered Monoclonal Secretory IgA (SIgA) Antibodies to Prevent Enteric Bacterial Infections","volume":"18","author":"Richards","year":"2022","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s40259-021-00471-0","article-title":"Recent Achievements and Challenges in Prolonging the Serum Half-Lives of Therapeutic IgG Antibodies Through Fc Engineering","volume":"35","author":"Ko","year":"2021","journal-title":"BioDrugs"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0090-1229(86)90073-5","article-title":"The Human IgA System: A Reassessment","volume":"40","author":"Mestecky","year":"1986","journal-title":"Clin. Immunol. Immunopathol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"De Sousa-Pereira, P., and Woof, J.M. (2019). IgA: Structure, Function, and Developability. Antibodies, 8.","DOI":"10.3390\/antib8040057"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/mi.2011.39","article-title":"Structure and Function Relationships in IgA","volume":"4","author":"Woof","year":"2011","journal-title":"Mucosal Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e56098","DOI":"10.7554\/eLife.56098","article-title":"The Structures of Secretory and Dimeric Immunoglobulin A","volume":"9","author":"Parker","year":"2020","journal-title":"eLife"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13480","DOI":"10.1073\/pnas.1904204116","article-title":"MZB1 Promotes the Secretion of J-Chain\u2013Containing Dimeric IgA and Is Critical for the Suppression of Gut Inflammation","volume":"116","author":"Xiong","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.0105-2896.2005.00278.x","article-title":"The Polymeric Immunoglobulin Receptor: Bridging Innate and Adaptive Immune Responses at Mucosal Surfaces","volume":"206","author":"Kaetzel","year":"2005","journal-title":"Immunol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wei, H., and Wang, J.-Y. (2021). Role of Polymeric Immunoglobulin Receptor in IgA and IgM Transcytosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052284"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2567.2004.01914.x","article-title":"Multiple Cleavage Sites for Polymeric Immunoglobulin Receptor","volume":"112","author":"Asano","year":"2004","journal-title":"Immunology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e10640","DOI":"10.7554\/eLife.10640","article-title":"The Structure and Dynamics of Secretory Component and Its Interactions with Polymeric Immunoglobulins","volume":"5","author":"Stadtmueller","year":"2016","journal-title":"eLife"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nri2322","article-title":"The Regulation of IgA Class Switching","volume":"8","author":"Cerutti","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_19","first-page":"31","article-title":"Innate Signaling Networks in Mucosal IgA Class Switching","volume":"Volume 107","author":"Chorny","year":"2010","journal-title":"Advances in Immunology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Pietrzak, B., Tomela, K., Olejnik-Schmidt, A., Mackiewicz, A., and Schmidt, M. (2020). Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239254"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/mi.2011.41","article-title":"Secretory IgA\u2019s Complex Roles in Immunity and Mucosal Homeostasis in the Gut","volume":"4","author":"Mantis","year":"2011","journal-title":"Mucosal Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/pathogens3020390","article-title":"Secretory IgA Is Concentrated in the Outer Layer of Colonic Mucus along with Gut Bacteria","volume":"3","author":"Rogier","year":"2014","journal-title":"Pathogens"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1074-7613(02)00341-2","article-title":"Secretory Component","volume":"17","author":"Phalipon","year":"2002","journal-title":"Immunity"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1053\/j.gastro.2009.06.047","article-title":"Immunoglobulin A: Fc\u03b1RI Interactions Induce Neutrophil Migration Through Release of Leukotriene B4","volume":"137","author":"Tuk","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.molimm.2006.05.002","article-title":"IgA Is a More Potent Inducer of NADPH Oxidase Activation and Degranulation in Blood Eosinophils than IgE","volume":"44","author":"Pleass","year":"2007","journal-title":"Mol. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/imr.12337","article-title":"The Era of the Immunoglobulin A Fc Receptor Fc\u03b1RI; Its Function and Potential as Target in Disease","volume":"268","author":"Aleyd","year":"2015","journal-title":"Immunol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Rochereau, N., Drocourt, D., Perouzel, E., Pavot, V., Redelinghuys, P., Brown, G.D., Tiraby, G., Roblin, X., Verrier, B., and Genin, C. (2013). Dectin-1 Is Essential for Reverse Transcytosis of Glycosylated SIgA-Antigen Complexes by Intestinal M Cells. PLoS Biol., 11.","DOI":"10.1371\/journal.pbio.1001658"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"11526","DOI":"10.1128\/JVI.01111-08","article-title":"Excretion of Human Immunodeficiency Virus Type 1 through Polarized Epithelium by Immunoglobulin A","volume":"82","author":"Wright","year":"2008","journal-title":"J. Virol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S1074-7613(03)00122-5","article-title":"Anti-Inflammatory Role for Intracellular Dimeric Immunoglobulin A by Neutralization of Lipopolysaccharide in Epithelial Cells","volume":"18","author":"Fernandez","year":"2003","journal-title":"Immunity"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1084\/jem.188.7.1223","article-title":"Immunocytochemical Colocalization of Specific Immunoglobulin A with Sendai Virus Protein in Infected Polarized Epithelium","volume":"188","author":"Fujioka","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"13574","DOI":"10.1038\/s41598-019-49923-2","article-title":"IgA-Deficient Humans Exhibit Gut Microbiota Dysbiosis despite Secretion of Compensatory IgM","volume":"9","author":"Catanzaro","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.imlet.2014.01.015","article-title":"IgG-Effector Functions: \u201cThe Good, The Bad and The Ugly\u201d","volume":"160","author":"Kapur","year":"2014","journal-title":"Immunol. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.immuni.2004.05.007","article-title":"Human Neonatal Fc Receptor Mediates Transport of IgG into Luminal Secretions for Delivery of Antigens to Mucosal Dendritic Cells","volume":"20","author":"Yoshida","year":"2004","journal-title":"Immunity"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Caddy, S.L., Vaysburd, M., Wing, M., Foss, S., Andersen, J.T., O\u2018Connell, K., Mayes, K., Higginson, K., Iturriza-G\u00f3mara, M., and Desselberger, U. (2020). Intracellular Neutralisation of Rotavirus by VP6-Specific IgG. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008732"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1073\/pnas.89.15.6901","article-title":"Intracellular Neutralization of Virus by Immunoglobulin A Antibodies","volume":"89","author":"Mazanec","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrd2909","article-title":"Fc Receptor-Targeted Therapies for the Treatment of Inflammation, Cancer and Beyond","volume":"11","author":"Hogarth","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.imbio.2012.07.015","article-title":"The Immunoglobulin, IgG Fc Receptor and Complement Triangle in Autoimmune Diseases","volume":"217","author":"Karsten","year":"2012","journal-title":"Immunobiology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s11882-023-01105-x","article-title":"The Role of IgA in the Manifestation and Prevention of Allergic Immune Responses","volume":"23","author":"Scheurer","year":"2023","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Demir, S., Yet, I., Sardan Ekiz, M., Sag, E., Bilginer, Y., Celikbicak, O., Lay, I., and Ozen, S. (2023). Plasma Proteomic Analysis Reveals the Potential Role of Lectin and Alternative Complement Pathways in IgA Vasculitis Pathogenesis. Diagnostics, 13.","DOI":"10.3390\/diagnostics13101729"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.immuni.2019.02.006","article-title":"Anti-Commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis","volume":"50","author":"Dennison","year":"2019","journal-title":"Immunity"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s12967-018-1723-0","article-title":"Clinical Significance of Soluble Immunoglobulins A and G and Their Coated Bacteria in Feces of Patients with Inflammatory Bowel Disease","volume":"16","author":"Lin","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Fahrbach, K.M., Malykhina, O., Stieh, D.J., and Hope, T.J. (2013). Differential Binding of IgG and IgA to Mucus of the Female Reproductive Tract. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076176"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1939605","DOI":"10.1080\/21645515.2021.1939605","article-title":"The Biophysical Principles Underpinning Muco-Trapping Functions of Antibodies","volume":"18","author":"Schaefer","year":"2022","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_44","first-page":"331","article-title":"Estimation of the Intravascular Half-Lives of Normal Rhesus Monkey IgG, IgA and IgM","volume":"36","author":"Challacombe","year":"1979","journal-title":"Immunology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/iai.58.6.1979-1985.1990","article-title":"A Proteolytic Enzyme Secreted by Proteus Mirabilis Degrades Immunoglobulins of the Immunoglobulin A1 (IgA1), IgA2, and IgG Isotypes","volume":"58","author":"Loomes","year":"1990","journal-title":"Infect. Immun."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Okuya, K., Eguchi, N., Manzoor, R., Yoshida, R., Saito, S., Suzuki, T., Sasaki, M., Saito, T., Kida, Y., and Mori-Kajihara, A. (2020). Comparative Analyses of the Antiviral Activities of IgG and IgA Antibodies to Influenza A Virus M2 Protein. Viruses, 12.","DOI":"10.3390\/v12070780"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.molimm.2004.05.006","article-title":"Human Polymeric IgA Is Superior to IgG and Single-Chain Fv of the Same Monoclonal Specificity to Inhibit Urease Activity Associated with Helicobacter Pylori","volume":"41","author":"Berdoz","year":"2004","journal-title":"Mol. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wegman, A.D., Waldran, M.J., Bahr, L.E., Lu, J.Q., Baxter, K.E., Thomas, S.J., and Waickman, A.T. (2023). DENV-Specific IgA Contributes Protective and Non-Pathologic Function during Antibody-Dependent Enhancement of DENV Infection. PLoS Pathog., 19.","DOI":"10.1101\/2023.04.01.535210"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wegman, A.D., Fang, H., Rothman, A.L., Thomas, S.J., Endy, T.P., McCracken, M.K., Currier, J.R., Friberg, H., Gromowski, G.D., and Waickman, A.T. (2021). Monomeric IgA Antagonizes IgG-Mediated Enhancement of DENV Infection. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.777672"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10529-014-1686-z","article-title":"Upstream and Downstream Processing of Recombinant IgA","volume":"37","author":"Reinhart","year":"2015","journal-title":"Biotechnol. Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4049\/jimmunol.2300717","article-title":"Structural and Biochemical Requirements for Secretory Component Interactions with Dimeric IgA","volume":"213","author":"Stadtmueller","year":"2024","journal-title":"J. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1073\/pnas.94.12.6364","article-title":"Production of Secretory Immunoglobulin A by a Single Mammalian Cell","volume":"94","author":"Chintalacharuvu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00018-015-2074-0","article-title":"Recombinant IgA Production for Mucosal Passive Immunization, Advancing beyond the Hurdles","volume":"73","author":"Virdi","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"130536","DOI":"10.1016\/j.bbagen.2023.130536","article-title":"Each N-Glycan on Human IgA and J-Chain Uniquely Affects Oligomericity and Stability","volume":"1868","author":"Pan","year":"2024","journal-title":"Biochim. Biophys. Acta BBA-Gen. Subj."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1021\/acs.jproteome.7b00121","article-title":"Exploring Site-Specific N-Glycosylation of HEK293 and Plant-Produced Human IgA Isotypes","volume":"16","author":"Maresch","year":"2017","journal-title":"J. Proteome Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.omtm.2022.08.003","article-title":"AAV-Monoclonal Antibody Expression Protects Mice from Ebola Virus without Impeding the Endogenous Antibody Response to Heterologous Challenge","volume":"26","author":"Rghei","year":"2022","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1089\/hum.2020.29117.trf","article-title":"Revisiting the \u201cNew\u201d Inflammatory Toxicities of Adeno-Associated Virus Vectors","volume":"31","author":"Flotte","year":"2020","journal-title":"Hum. Gene Ther."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Hamilton, B.A., and Wright, J.F. (2021). Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.675897"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1038\/s12276-023-01086-x","article-title":"Immunogenicity of Lipid Nanoparticles and Its Impact on the Efficacy of mRNA Vaccines and Therapeutics","volume":"55","author":"Lee","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jaci.2011.06.047","article-title":"The Role of Anti-IgA Antibodies in Causing Adverse Reactions to Gamma Globulin Infusion in Immunodeficient Patients: A Comprehensive Review of the Literature","volume":"129","author":"Rachid","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ymthe.2019.01.004","article-title":"Anti-Drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies","volume":"27","author":"Gardner","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature10660","article-title":"Antibody-Based Protection against HIV Infection by Vectored Immunoprophylaxis","volume":"481","author":"Balazs","year":"2012","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-024-01780-w","article-title":"Adeno-Associated Virus as a Delivery Vector for Gene Therapy of Human Diseases","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.1128\/JVI.78.12.6381-6388.2004","article-title":"Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues","volume":"78","author":"Gao","year":"2004","journal-title":"J. Virol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"113902","DOI":"10.1016\/j.celrep.2024.113902","article-title":"Capsid-Mediated Control of Adeno-Associated Viral Transcription Determines Host Range","volume":"43","author":"Loeb","year":"2024","journal-title":"Cell Rep."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Rghei, A.D., van Lieshout, L.P., Santry, L.A., Guilleman, M.M., Thomas, S.P., Susta, L., Karimi, K., Bridle, B.W., and Wootton, S.K. (2020). AAV Vectored Immunoprophylaxis for Filovirus Infections. Trop. Med. Infect. Dis., 5.","DOI":"10.3390\/tropicalmed5040169"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Campbell, E.S.B., Goens, M.M., Cao, W., Thompson, B., Susta, L., Banadyga, L., and Wootton, S.K. (2023). Recent Advancements in AAV-Vectored Immunoprophylaxis in the Nonhuman Primate Model. Biomedicines, 11.","DOI":"10.3390\/biomedicines11082223"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Lopes, J.A., Rghei, A.D., Thompson, B., Susta, L., Khursigara, C.M., and Wootton, S.K. (2022). Overcoming Barriers to Preventing and Treating P. aeruginosa Infections Using AAV Vectored Immunoprophylaxis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123162"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Phelps, M., and Balazs, A.B. (2021). Contribution to HIV Prevention and Treatment by Antibody-Mediated Effector Function and Advances in Broadly Neutralizing Antibody Delivery by Vectored Immunoprophylaxis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.734304"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S682","DOI":"10.1093\/infdis\/jiad345","article-title":"AAV-Vectored Expression of Marburg Virus-Neutralizing Antibody MR191 Provides Complete Protection From Challenge in a Guinea Pig Model","volume":"228","author":"Rghei","year":"2023","journal-title":"J. Infect. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41434-022-00361-2","article-title":"Adeno-Associated Virus Mediated Expression of Monoclonal Antibody MR191 Protects Mice against Marburg Virus and Provides Long-Term Expression in Sheep","volume":"32","author":"Rghei","year":"2025","journal-title":"Gene Ther."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Leikas, A.J., Yl\u00e4-Herttuala, S., and Hartikainen, J.E.K. (2023). Adenoviral Gene Therapy Vectors in Clinical Use\u2014Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216519"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/mt.2009.202","article-title":"Adenovirus Virion Stability and the Viral Genome: Size Matters","volume":"17","author":"Kennedy","year":"2009","journal-title":"Mol. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"ftw078","DOI":"10.1093\/femspd\/ftw078","article-title":"Intravenous Adenovirus Expressing a Multi-Specific, Single-Domain Antibody Neutralizing TcdA and TcdB Protects Mice from Clostridium difficile Infection","volume":"74","author":"Yang","year":"2016","journal-title":"Pathog. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.ymthe.2020.01.006","article-title":"Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial","volume":"28","author":"Somanathan","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"114416","DOI":"10.1016\/j.addr.2022.114416","article-title":"The Role of Lipid Components in Lipid Nanoparticles for Vaccines and Gene Therapy","volume":"188","author":"Kulkarni","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"10085","DOI":"10.1039\/D5TB01556A","article-title":"Lipid Nanoparticle-Mediated Targeted mRNA Delivery and Its Application in Cancer Therapy","volume":"13","author":"Sui","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41422-022-00630-0","article-title":"Lipid Nanoparticle-Encapsulated mRNA Antibody Provides Long-Term Protection against SARS-CoV-2 in Mice and Hamsters","volume":"32","author":"Deng","year":"2022","journal-title":"Cell Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jargalsaikhan, B.-E., Muto, M., and Ema, M. (2025). The Era of Gene Therapy: The Advancement of Lentiviral Vectors and Their Pseudotyping. Viruses, 17.","DOI":"10.20944\/preprints202505.0815.v1"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12929-022-00865-4","article-title":"Delivering Genes with Human Immunodeficiency Virus-Derived Vehicles: Still State-of-the-Art after 25 Years","volume":"29","author":"Wolff","year":"2022","journal-title":"J. Biomed. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1182\/blood-2012-04-422303","article-title":"Inhibitory Effect of HIV-Specific Neutralizing IgA on Mucosal Transmission of HIV in Humanized Mice","volume":"120","author":"Hur","year":"2012","journal-title":"Blood"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1128\/JVI.02339-09","article-title":"Inhibition of In Vivo HIV Infection in Humanized Mice by Gene Therapy of Human Hematopoietic Stem Cells with a Lentiviral Vector Encoding a Broadly Neutralizing Anti-HIV Antibody","volume":"84","author":"Joseph","year":"2010","journal-title":"J. Virol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"101253","DOI":"10.1016\/j.xcrm.2023.101253","article-title":"An mRNA-Based Platform for the Delivery of Pathogen-Specific IgA into Mucosal Secretions","volume":"4","author":"Deal","year":"2023","journal-title":"Cell Rep. Med."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Minskaia, E., Nicholson, J., and Ryan, M.D. (2013). Optimisation of the Foot-and-Mouth Disease Virus 2A Co-Expression System for Biomedical Applications. BMC Biotechnol., 13.","DOI":"10.1186\/1472-6750-13-67"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1038\/s41598-017-02460-2","article-title":"Systematic Comparison of 2A Peptides for Cloning Multi-Genes in a Polycistronic Vector","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1038\/s41467-020-17577-8","article-title":"A Lung Tropic AAV Vector Improves Survival in a Mouse Model of Surfactant B Deficiency","volume":"11","author":"Kang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.omtm.2019.11.010","article-title":"Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys","volume":"16","author":"Fuchs","year":"2020","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1093\/nar\/gkw137","article-title":"Quantitative Assessment of Ribosome Drop-off in E. coli","volume":"44","author":"Sin","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Fuchs, S.P., Martinez-Navio, J.M., Gao, G., and Desrosiers, R.C. (2016). Recombinant AAV Vectors for Enhanced Expression of Authentic IgG. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158009"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Chen, Z.-R., Guo, J.-Y., He, L., Liu, S., Xu, J.-Y., Yang, Z.-J., Su, W., Liu, K., Gong, S.-S., and Wang, G.-P. (2022). Co-Transduction of Dual-Adeno-Associated Virus Vectors in the Neonatal and Adult Mouse Utricles. Front. Mol. Neurosci., 15.","DOI":"10.3389\/fnmol.2022.1020803"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Carrara, S.C., Fiebig, D., Bogen, J.P., Grzeschik, J., Hock, B., and Kolmar, H. (2021). Recombinant Antibody Production Using a Dual-Promoter Single Plasmid System. Antibodies, 10.","DOI":"10.3390\/antib10020018"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/sj.gt.3303105","article-title":"Bidirectional Promoter Interference between Two Widely Used Internal Heterologous Promoters in a Late-Generation Lentiviral Construct","volume":"15","author":"Curtin","year":"2008","journal-title":"Gene Ther."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"275","DOI":"10.52547\/ibj.25.4.275","article-title":"Woodchuck Hepatitis Virus Post-Transcriptional Regulation Element (WPRE) Promotes Anti-CD19 BiTE Expression in Expi293 Cells","volume":"25","author":"Moazzami","year":"2021","journal-title":"Iran. Biomed. J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/19420862.2015.1008351","article-title":"Cleavage Efficient 2A Peptides for High Level Monoclonal Antibody Expression in CHO Cells","volume":"7","author":"Chng","year":"2015","journal-title":"mAbs"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Wang, X., Du, Q., Zhang, W., Xu, D., Zhang, X., Jia, Y., and Wang, T. (2022). Enhanced Transgene Expression by Optimization of Poly A in Transfected CHO Cells. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.722722"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jgm.2712","article-title":"Mir-142-3p Target Sequences Reduce Transgene-directed Immunogenicity Following Intramuscular Adeno-associated Virus 1 Vector-mediated Gene Delivery","volume":"15","author":"Majowicz","year":"2013","journal-title":"J. Gene Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"28853","DOI":"10.1038\/s41598-024-75698-2","article-title":"AAV-Mediated Co-Expression of an Immunogenic Transgene plus PD-L1 Enables Sustained Expression through Immunological Evasion","volume":"14","author":"McMurphy","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Kuipa, M., Koroma, A.A., Leguizamo, I., Dhole, P., Barot, Y., Lee, M.Y.-H., Tharp, G.K., Liang, S., Chouinard, M., and Ehnert, S. (2026). Co-Delivered PD-L1 Rescues the Protective Efficacy Mediated by an AAV-Expressed HIV-1 bNAb. bioRxiv.","DOI":"10.64898\/2026.05.29.728706"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1021\/bp0498241","article-title":"Effect of Increased Expression of Protein Disulfide Isomerase and Heavy Chain Binding Protein on Antibody Secretion in a Recombinant CHO Cell Line","volume":"21","author":"Borth","year":"2008","journal-title":"Biotechnol. Prog."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12969","DOI":"10.1038\/s41598-021-92320-x","article-title":"Multiplexed Engineering Glycosyltransferase Genes in CHO Cells via Targeted Integration for Producing Antibodies with Diverse Complex-Type N-Glycans","volume":"11","author":"Nguyen","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1182\/blood-2010-05-282707","article-title":"Codon Optimization of Human Factor VIII cDNAs Leads to High-Level Expression","volume":"117","author":"Ward","year":"2011","journal-title":"Blood"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Santry, L.A., Ingrao, J.C., Yu, D.L., De Jong, J.G., Van Lieshout, L.P., Wood, G.A., and Wootton, S.K. (2017). AAV Vector Distribution in the Mouse Respiratory Tract Following Four Different Methods of Administration. BMC Biotechnol., 17.","DOI":"10.1186\/s12896-017-0365-2"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/j.ymthe.2022.01.010","article-title":"Non-Invasive Administration of AAV to Target Lung Parenchymal Cells and Develop SARS-CoV-2-Susceptible Mice","volume":"30","author":"Yang","year":"2022","journal-title":"Mol. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"102083","DOI":"10.1016\/j.omtn.2023.102083","article-title":"mRNA Vaccine Trafficking and Resulting Protein Expression after Intramuscular Administration","volume":"35","author":"Hassett","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/jgm.916","article-title":"Utility of Intraperitoneal Administration as a Route of AAV Serotype 5 Vector-mediated Neonatal Gene Transfer","volume":"8","author":"Ogura","year":"2006","journal-title":"J. Gene Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ygyno.2014.07.105","article-title":"AAV-Mediated Persistent Bevacizumab Therapy Suppresses Tumor Growth of Ovarian Cancer","volume":"135","author":"Xie","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s13346-024-01709-4","article-title":"Oral Delivery of Stabilized Lipid Nanoparticles for Nucleic Acid Therapeutics","volume":"15","author":"Suri","year":"2025","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12951-023-01991-3","article-title":"Cracking the Intestinal Lymphatic System Window Utilizing Oral Delivery Vehicles for Precise Therapy","volume":"21","author":"Miao","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-61779-370-7_6","article-title":"AAV-Mediated Liver-Directed Gene Therapy","volume":"Volume 807","author":"Snyder","year":"2012","journal-title":"Adeno-Associated Virus"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ymthe.2004.05.029","article-title":"Widespread Correction of Lysosomal Storage Following Intrahepatic Injection of a Recombinant Adeno-Associated Virus in the Adult MPS VII Mouse","volume":"10","author":"Sferra","year":"2004","journal-title":"Mol. Ther."},{"key":"ref_111","first-page":"66934","article-title":"Consistent Delivery of Adeno-Associated Virus via Lateral Tail-Vein Injection in Adult Mice","volume":"210","author":"Guirguis","year":"2024","journal-title":"J. Vis. Exp."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.ymthe.2024.02.002","article-title":"High-Dose Systemic Adeno-Associated Virus Vector Administration Causes Liver and Sinusoidal Endothelial Cell Injury","volume":"32","author":"Hordeaux","year":"2024","journal-title":"Mol. Ther."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2206187","DOI":"10.1002\/advs.202206187","article-title":"Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions","volume":"10","author":"Nawaz","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41434-023-00385-2","article-title":"Antibody-Based Protection against Respiratory Syncytial Virus in Mice and Their Offspring through Vectored Immunoprophylaxis","volume":"32","author":"Rghei","year":"2025","journal-title":"Gene Ther."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"103601","DOI":"10.1016\/j.jpet.2025.103601","article-title":"Investigation of Dose-Exposure-Response Relationship for Adeno-Associated Virus\u2013Mediated Delivery of Antibody Genes","volume":"392","author":"Rajwade","year":"2025","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41434-024-00453-1","article-title":"AAV-Vectored Expression of Monospecific or Bispecific Monoclonal Antibodies Protects Mice from Lethal Pseudomonas aeruginosa Pneumonia","volume":"31","author":"Lopes","year":"2024","journal-title":"Gene Ther."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1164\/rccm.202308-1403OC","article-title":"A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of Pseudomonas aeruginosa in Patients with Bronchiectasis","volume":"210","author":"Long","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Welles, H.C., Jennewein, M.F., Mason, R.D., Narpala, S., Wang, L., Cheng, C., Zhang, Y., Todd, J.-P., Lifson, J.D., and Balazs, A.B. (2018). Vectored Delivery of Anti-SIV Envelope Targeting mAb via AAV8 Protects Rhesus Macaques from Repeated Limiting Dose Intrarectal Swarm SIVsmE660 Challenge. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1007395"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"G\u00f6ritzer, K., Strasser, R., and Ma, J.K.-C. (2024). Stability Engineering of Recombinant Secretory IgA. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25136856"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1080\/19420862.2019.1622940","article-title":"Production, Characterization, and in Vivo Half-Life Extension of Polymeric IgA Molecules in Mice","volume":"11","author":"Lombana","year":"2019","journal-title":"mAbs"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1046\/j.1365-2567.2000.00094.x","article-title":"Increased Immunoglobulin A Levels in Milk by Over-expressing the Murine Polymeric Immunoglobulin Receptor Gene in the Mammary Gland Epithelial Cells of Transgenic Mice","volume":"101","author":"Lee","year":"2000","journal-title":"Immunology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/19420862.2015.1106658","article-title":"Improved in Vivo Anti-Tumor Effects of IgA-Her2 Antibodies through Half-Life Extension and Serum Exposure Enhancement by FcRn Targeting","volume":"8","author":"Meyer","year":"2016","journal-title":"mAbs"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e201303009","DOI":"10.5936\/csbj.201303009","article-title":"THE ALBUMIN-BINDING DOMAIN AS A SCAFFOLD FOR PROTEIN ENGINEERING","volume":"6","author":"Nilvebrant","year":"2013","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/0008-5472.CAN-15-1232","article-title":"An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo","volume":"76","author":"Lohse","year":"2016","journal-title":"Cancer Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e230","DOI":"10.1016\/S2352-3018(19)30003-7","article-title":"Adeno-Associated Virus Vectored Immunoprophylaxis to Prevent HIV in Healthy Adults: A Phase 1 Randomised Controlled Trial","volume":"6","author":"Priddy","year":"2019","journal-title":"Lancet HIV"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41591-022-01762-x","article-title":"Safety and Tolerability of AAV8 Delivery of a Broadly Neutralizing Antibody in Adults Living with HIV: A Phase 1, Dose-Escalation Trial","volume":"28","author":"Casazza","year":"2022","journal-title":"Nat. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/hum.2010.202","article-title":"Good Manufacturing Practice Production of Self-Complementary Serotype 8 Adeno-Associated Viral Vector for a Hemophilia B Clinical Trial","volume":"22","author":"Allay","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e00138-18","DOI":"10.1128\/CMR.00138-18","article-title":"Cystic Fibrosis and Pseudomonas aeruginosa: The Host-Microbe Interface","volume":"32","author":"Malhotra","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.imj.2023.05.003","article-title":"Pseudomonas aeruginosa: Infections and Novel Approaches to Treatment \u201cKnowing the Enemy\u201d the Threat of Pseudomonas aeruginosa and Exploring Novel Approaches to Treatment","volume":"2","author":"Sathe","year":"2023","journal-title":"Infect. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.vaccine.2009.10.080","article-title":"Systemic, Nasal and Oral Live Vaccines against Pseudomonas aeruginosa: A Clinical Trial of Immunogenicity in Lower Airways of Human Volunteers","volume":"28","author":"Bumann","year":"2010","journal-title":"Vaccine"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.4049\/jimmunol.173.9.5671","article-title":"Human Monoclonal Antibodies to Pseudomonas aeruginosa Alginate That Protect against Infection by Both Mucoid and Nonmucoid Strains","volume":"173","author":"Pier","year":"2004","journal-title":"J. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Awwad, S., and Angkawinitwong, U. (2018). Overview of Antibody Drug Delivery. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10030083"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40794-017-0046-0","article-title":"Vectored Immunoprophylaxis: An Emerging Adjunct to Traditional Vaccination","volume":"3","author":"Sanders","year":"2017","journal-title":"Trop. Dis. Travel Med. Vaccines"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1128\/jvi.69.2.1339-1343.1995","article-title":"Intracellular Neutralization of Influenza Virus by Immunoglobulin A Anti-Hemagglutinin Monoclonal Antibodies","volume":"69","author":"Mazanec","year":"1995","journal-title":"J. Virol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"100516","DOI":"10.1016\/j.ijregi.2024.100516","article-title":"A Systematic Review of Recent Outbreaks and the Efficacy and Safety of Drugs Approved for the Treatment of Salmonella Infections","volume":"14","author":"Sivanandy","year":"2025","journal-title":"IJID Reg."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Sears, K.T., Nasrin, S., Baliban, S.M., Council, D.N., Pasetti, M.F., and Tennant, S.M. (2023). Evaluation of Three Candidate Live-Attenuated Salmonella Enterica Serovar Typhimurium Vaccines to Prevent Non-Typhoidal Salmonella Infection in an Infant Mouse Model. Vaccines, 11.","DOI":"10.3390\/vaccines11101562"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Richards, A.F., Doering, J.E., Lozito, S.A., Varrone, J.J., Willsey, G.G., Pauly, M., Whaley, K., Zeitlin, L., and Mantis, N.J. (2020). Inhibition of Invasive Salmonella by Orally Administered IgA and IgG Monoclonal Antibodies. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0007803"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Qiu, P., Ishimoto, T., Fu, L., Zhang, J., Zhang, Z., and Liu, Y. (2022). The Gut Microbiota in Inflammatory Bowel Disease. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.733992"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1007\/s00535-024-02121-y","article-title":"Mouse IgA Modulates Human Gut Microbiota with Inflammatory Bowel Disease Patients","volume":"59","author":"Takahashi","year":"2024","journal-title":"J. Gastroenterol."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/14\/8\/692\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:16:43Z","timestamp":1786522603000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/14\/8\/692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":139,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["vaccines14080692"],"URL":"https:\/\/doi.org\/10.3390\/vaccines14080692","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}