{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:07:11Z","timestamp":1789016831041,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Despite longstanding vaccine availability, human papillomavirus (HPV) remains the most common sexually transmitted infection in the United States and a leading cause of preventable cancers. Additionally, HPV vaccination rates remain below other routinely recommended adolescent immunizations, particularly in rural populations. This study aimed to identify barriers related to healthcare access, socioeconomic conditions, cultural beliefs, and provider\u2013patient communication in rural communities. A bibliographical review of articles published in English from 2020 to 2025 and an analysis of national datasets were conducted to establish trends in HPV vaccination rates. State-level HPV vaccination data for adolescents aged 13\u201317 years were obtained from America\u2019s Health Rankings and the Centers for Disease Control and Prevention National Immunization Survey-Teen. States were classified as predominantly rural or urban using Rural\u2013Urban Continuum Codes, and mean vaccination completion rates were compared. The mean HPV vaccination completion rate was lower in rural states (60.55%) compared to urban states (67.31%); however, this difference did not meet the selected threshold for statistical significance (p = 0.025). Barriers identified in the literature included reduced access to healthcare, differences in provider communication, socioeconomic constraints, and limited health literacy in rural communities. Of the identified barriers, healthcare provider recommendations emerged as one of the strongest predictors of vaccine acceptance. These findings highlight multilevel determinants contributing to differences in HPV vaccine uptake and underscore the need for targeted, evidence-based strategies to improve vaccine access and coverage in underserved adolescent populations.<\/jats:p>","DOI":"10.3390\/vaccines14090772","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:39:47Z","timestamp":1788363587000},"page":"772","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Analysis of Multilevel Barriers to Human Papillomavirus Vaccination Uptake Among Rural U.S. Adolescents"],"prefix":"10.3390","volume":"14","author":[{"given":"Tajauna","family":"Batchelor","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Pikeville, Pikeville, KY 41501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Pikeville, Pikeville, KY 41501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimbrionna","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Pikeville, Pikeville, KY 41501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Hanif","sequence":"additional","affiliation":[{"name":"Department of Restorative Sciences, College of Dentistry, Kuwait University, Kuwait City 12037, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumaila Nida Javed","family":"Tunio","sequence":"additional","affiliation":[{"name":"Lake Eire College of Osteopathic Medical School, 5415 Dolphin Point Blvd, Jacksonville, FL 32211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Maghiar, L., Sandor, M., Sachelarie, L., Bodog, R., and Huniadi, A. 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