{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:43:41Z","timestamp":1764783821235,"version":"build-2065373602"},"reference-count":117,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T00:00:00Z","timestamp":1449619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Detection of specific viral antibody or nucleic acid produced by infection or immunization, using oral fluid samples, offers increased potential for wider population uptake compared to blood sampling. This methodology is well established for the control of HIV and measles infections, but can also be applied to the control of other vaccine preventable infections, and this review describes the application of oral fluid assays in support of mumps, rubella and varicella national immunization programs. In England and Wales individuals with suspected mumps or rubella, based on clinical presentation, can have an oral fluid swab sample taken for case confirmation. Universal varicella immunization of children has led to a drastic reduction of chickenpox in those countries where it is used; however, in England and Wales such a policy has not been instigated. Consequently, in England and Wales most children have had chickenpox by age 10 years; however, small, but significant, numbers of adults remain susceptible. Targeted varicella zoster virus (VZV) immunization of susceptible adolescents offers the potential to reduce the pool of susceptible adults and oral fluid determination of VZV immunity in adolescents is a potential means of identifying susceptible individuals in need of VZV vaccination. The main application of oral fluid testing is in those circumstances where blood sampling is deemed not necessary, or is undesirable, and when the documented sensitivity and specificity of the oral fluid assay methodology to be used is considered sufficient for the purpose intended.<\/jats:p>","DOI":"10.3390\/vaccines3040988","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T15:21:41Z","timestamp":1449674501000},"page":"988-1003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Application of Oral Fluid Assays in Support of Mumps, Rubella and Varicella Control Programs"],"prefix":"10.3390","volume":"3","author":[{"given":"Peter","family":"Maple","sequence":"first","affiliation":[{"name":"East Yorkshire Microbiology, Innovation Centre, York Science Park, York YO10 5DG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.5694\/j.1326-5377.2008.tb02121.x","article-title":"Mumps: A resurgent disease with protean manifrstations","volume":"189","author":"Senanayake","year":"2008","journal-title":"Med. J. Aust."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/bmj.330.7500.1132","article-title":"Mumps and the UK epidemic 2005","volume":"330","author":"Gupta","year":"2005","journal-title":"Br. Med. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3201\/eid1704.101461","article-title":"Mumps complications and effects of mumps vaccination, England and Wales, 2002\u20132006","volume":"17","author":"Yung","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_4","first-page":"1","article-title":"Viral causes of hearing loss: A review for hearing health professionals","volume":"18","author":"Cohen","year":"2014","journal-title":"Trends Hear."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000081715","article-title":"Frequency of spontaneous abortion and premature birth after acute mumps infection in pregnancy","volume":"45","author":"Enders","year":"2005","journal-title":"Gyn\u00e4kol. Geburtshilfliche Rundsch."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1128\/jvi.74.10.4831-4838.2000","article-title":"Rescue of mumps virus from cDNA","volume":"74","author":"Clarke","year":"2000","journal-title":"J. Virol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1099\/0022-1317-69-11-2893","article-title":"Molecular cloning and characterization of six genes, determination of gene order and intergenic sequences and leader sequence of mumps virus","volume":"69","author":"Elango","year":"1988","journal-title":"J. Gen. Virol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1128\/jvi.17.2.363-373.1976","article-title":"Polypeptides of mumps virus","volume":"17","author":"Jensik","year":"1976","journal-title":"J. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.virol.2005.09.007","article-title":"Paramyxovirus membrane fusion: Lessons from the F and HN atomic structures","volume":"344","author":"Lamb","year":"2006","journal-title":"Virology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/path.4445","article-title":"Molecular biology, pathogenesis and pathology of mumps virus","volume":"235","author":"Rubin","year":"2015","journal-title":"J. Pathol."},{"key":"ref_11","first-page":"259","article-title":"An epidemiologic study of mumps: Its spread in schools and families","volume":"75","author":"Meyer","year":"1962","journal-title":"Am. J. Hyg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1084\/jem.88.2.223","article-title":"Isolation of mumps virus from human beings with induced apparent or inapparent infections","volume":"88","author":"Henle","year":"1948","journal-title":"J. Exp. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1128\/JCM.01803-07","article-title":"Detection of RNA of mumps virus during an outbreak in a population with a high level of measles, mumps, and rubella vaccine coverage","volume":"46","author":"Bitsko","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_14","first-page":"91","article-title":"Observations on a mumps epidemic in a \u201cvirgin\u201d population","volume":"69","author":"Philip","year":"1959","journal-title":"Am. J. Hyg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1017\/S0950268800004672","article-title":"The pre-vaccination epidemiology of measles, mumps and rubella in Europe: Implications for modelling studies","volume":"125","author":"Edmunds","year":"2000","journal-title":"Epidemiol. Infect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/archpedi.1970.02100070078008","article-title":"Mumps in a general population. A sero-epidemiologic study","volume":"120","author":"Levitt","year":"1970","journal-title":"Am. J. Dis. Child."},{"key":"ref_17","first-page":"295","article-title":"Vaccination of human beings against mumps: Vaccine administered at the start of an epidemic. I. Incidence and severity of mumps in vaccinated and control groups","volume":"54","author":"Habel","year":"1951","journal-title":"Am. J. Hyg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3181\/00379727-123-31599","article-title":"Live attenuated mumps virus vaccine: 1. Vaccine development","volume":"123","author":"Buynak","year":"1966","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Minor, P.D. (2015). Live attenuated vaccines: Historical successes and current challenges. Virology.","DOI":"10.1016\/j.virol.2015.03.032"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/epirev\/mxf002","article-title":"Evolution of surveillance of measles, mumps, and rubella in England and Wales: Providing the platform for evidence-based vaccination policy","volume":"24","author":"Vyse","year":"2002","journal-title":"Epidemiol. Rev."},{"key":"ref_21","first-page":"3","article-title":"Mumps and mumps vaccine: A global review","volume":"77","author":"Galazka","year":"1999","journal-title":"Bull. World Health Organ."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/bmj.330.7500.1119","article-title":"Mumps outbreaks across England and Wales in 2004: Observational study","volume":"330","author":"Savage","year":"2005","journal-title":"Br. Med. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.vaccine.2013.11.021","article-title":"Mumps vaccine effectiveness and risk factors for disease in households during an outbreak in New York City","volume":"32","author":"Livingston","year":"2014","journal-title":"Vaccine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3201\/eid2004.131681","article-title":"Epidemic of mumps among vaccinated persons, the Netherlands, 2009\u20132012","volume":"20","author":"Sane","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3947\/ic.2015.47.1.1","article-title":"Resurgence of mumps in Korea","volume":"47","author":"Park","year":"2015","journal-title":"Infect. Chemother."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3201\/eid1301.060649","article-title":"Vaccine effectiveness estimates, 2004\u20132005 mumps outbreak, England","volume":"13","author":"Cohen","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1086\/591196","article-title":"Mumps outbreaks in vaccinated populations: Are available mumps vaccines effective enough to prevent outbreaks?","volume":"47","author":"Dayan","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/jmv.1890400312","article-title":"Detection of measles, mumps and rubella antibodies in saliva using antibody capture radioimmunoassay","volume":"40","author":"Perry","year":"1993","journal-title":"J. Med. Virol."},{"key":"ref_29","first-page":"515","article-title":"Surveillance of measles in England and Wales: Implications of a national saliva testing programme","volume":"75","author":"Ramsay","year":"1997","journal-title":"Bull. World Health Organ."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jcv.2005.10.008","article-title":"Evaluation of a commercial assay for the detection of mumps specific IgM antibodies in oral fluid and serum specimens","volume":"35","author":"Warrener","year":"2006","journal-title":"J. Clin. Virol."},{"key":"ref_31","first-page":"76","article-title":"The role of RT-PCR assay of oral fluid for diagnosis and surveillance of measles, mumps and rubella","volume":"80","author":"Jin","year":"2002","journal-title":"Bull. World Health Organ."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1017\/S0950268808000927","article-title":"Feasibility of collecting oral fluid samples in the home setting to determine seroprevalence of infections in a large-scale cohort of preschool-aged children","volume":"137","author":"Bartington","year":"2009","journal-title":"Epidemiol. Infect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF03405383","article-title":"Participant-collected, mail-delivered oral fluid specimens can replace traditional serosurveys: A demonstration-of-feasibility survey of hepatitis A virus-specific antibodies in adults","volume":"98","author":"Ochnio","year":"2007","journal-title":"Can. J. Public Health"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0033-3506(01)00444-9","article-title":"A comparison of oral fluid collection devices for use in the surveillance of virus diseases in children","volume":"115","author":"Vyse","year":"2001","journal-title":"Public Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.1016\/j.vaccine.2012.08.015","article-title":"Could oral fluid be used to evaluate anti-hepatitis A virus status in individuals living in difficult-to-access areas?","volume":"30","author":"Tourinho","year":"2012","journal-title":"Vaccine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1016\/j.jcv.2013.09.002","article-title":"Evaluation of the CDC proposed laboratory HIV testing algorithm among men who have sex with men (MSM) from five US metropolitan statistical areas using specimens collected in 2011","volume":"58","author":"Masciotra","year":"2013","journal-title":"J. Clin. Virol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1331\/JAPhA.2014.14045","article-title":"HIV testing in community pharmacies and retail clinics: A model to expand access to screening for HIV infection","volume":"54","author":"Weidle","year":"2003","journal-title":"J. Am. Pharm. Assoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s10096-006-0216-x","article-title":"Application of a noninvasive oral fluid test for detection of treponemal IgG in a predominantly HIV-infected population","volume":"25","author":"Maple","year":"2006","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/01.inf.0000154325.85754.a3","article-title":"Oral fluid human immunodeficiency virus tests: Improved access to diagnosis for infants in poorly resourced prevention of mother to child transmission programs","volume":"24","author":"Sherman","year":"2005","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/bmj.308.6935.1015","article-title":"Salivary diagnosis of measles: A study of notified cases in the United Kingdom, 1991\u20131993","volume":"308","author":"Brown","year":"1994","journal-title":"Br. Med. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1473-3099(01)00169-4","article-title":"Novel methods for the detection of microbial antibodies in oral fluid","volume":"2","author":"McKie","year":"2002","journal-title":"Lancet Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jmv.21693","article-title":"Development and evaluation of a rapid immunochromatographic test for mumps-specific IgM in oral fluid specimens and use as a matrix for preserving viral nucleic acid for RT-PCR","volume":"82","author":"Warrener","year":"2010","journal-title":"J. Med. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10096-008-0460-3","article-title":"Detection of measles- and mumps-specific IgG antibodies in paired serum and oral fluid samples from Norwegian conscripts","volume":"27","author":"Vainio","year":"2008","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1001\/jama.1994.03520030061029","article-title":"Determination of measles, mumps, and rubella immunization status using oral fluid samples","volume":"272","author":"Thieme","year":"1994","journal-title":"J. Am. Med. Assoc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9271","DOI":"10.1016\/j.vaccine.2011.09.072","article-title":"Assessment of serological evidence for mumps virus infection in vaccinated children","volume":"29","author":"Dittrich","year":"2011","journal-title":"Vaccine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/jmv.20880","article-title":"Real-time PCR and its application to mumps rapid diagnosis","volume":"79","author":"Jin","year":"2007","journal-title":"J. Med. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1086\/382134","article-title":"Genetic diversity of mumps virus in oral fluid specimens: Application to mumps epidemiological study","volume":"189","author":"Jin","year":"2004","journal-title":"J. Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jcv.2007.10.009","article-title":"Epidemiologic and diagnostic evaluation of a recent mumps outbreak using oral fluid samples","volume":"41","author":"Reid","year":"2008","journal-title":"J. Clin. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1017\/S0950268812001136","article-title":"Seroepidemiology of mumps in Europe (1996\u20132008): Why do outbreaks occur in highly vaccinated populations?","volume":"141","author":"Eriksen","year":"2013","journal-title":"Epidemiol. Infect."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s10096-013-1836-6","article-title":"New preventive strategy to eliminate measles, mumps and rubella from Europe based on the serological assessment of herd immunity levels in the population","volume":"32","author":"Plans","year":"2013","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1093\/clinids\/7.Supplement_1.S2","article-title":"The history and medical consequences of rubella","volume":"7","author":"Cooper","year":"1985","journal-title":"Rev. Infect. Dis."},{"key":"ref_52","unstructured":"Ashby, H., and Wright, G.A. (1889). The Diseases of Children: Medical and Surgical, Longmans, Green, and Co.. [1st ed.]."},{"key":"ref_53","first-page":"35","article-title":"Congenital cataract following German measles in the mother","volume":"3","author":"Gregg","year":"1941","journal-title":"Trans. Ophthalamol. Soc. Aust."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(46)91420-1","article-title":"Congenital defects from German measles","volume":"247","author":"Parsons","year":"1946","journal-title":"Lancet"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0140-6736(52)91211-7","article-title":"Congenital defects from maternal rubella","volume":"260","author":"Robin","year":"1952","journal-title":"Lancet"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1001\/jama.1957.02980240033009","article-title":"Frequency of defects in infants whose mothers had rubella during pregnancy","volume":"165","author":"Greenberg","year":"1957","journal-title":"J. Am. Med. Assoc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0140-6736(82)92677-0","article-title":"Consequences of confirmed maternal rubella at successive stages of pregnancy","volume":"2","author":"Miller","year":"1982","journal-title":"Lancet"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/jmv.21941","article-title":"Application of new assays for rapid confirmation and genotyping of isolates of rubella virus","volume":"83","author":"Feng","year":"2011","journal-title":"J. Med. Virol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/jmv.20847","article-title":"Application of molecular and serological assays to case based investigations of rubella and congenital rubella syndrome","volume":"79","author":"Jin","year":"2007","journal-title":"J. Med. Virol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"389","DOI":"10.7883\/yoken.67.389","article-title":"Detection and genotyping of rubella virus from exanthematous patients suspected of having measles using reverse transcription-PCR","volume":"67","author":"Yasui","year":"2014","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Abernathy, E., Chen, M.-H., Bera, J., Shrivastava, S., Kirkness, E., Zheng, Q., Bellini, W., and Icenogle, J. (2013). Analysis of whole genome sequences of 16 strains of rubella virus from the United States, 1961\u20132009. Virol. J.","DOI":"10.1186\/1743-422X-10-32"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"11078","DOI":"10.1128\/JVI.01390-12","article-title":"Cryo-electron tomography of rubella virus","volume":"86","author":"Battisti","year":"2012","journal-title":"J. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1006\/viro.1995.1007","article-title":"Identification of the rubella virus nonstructural proteins","volume":"206","author":"Forng","year":"1995","journal-title":"Virology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1128\/jcm.30.9.2323-2329.1992","article-title":"Cellular and humoral immune responses to rubella virus structural proteins E1, E2, and C","volume":"30","author":"Chave","year":"1992","journal-title":"J. Clin. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"S524","DOI":"10.1093\/infdis\/jir099","article-title":"Status of global virologic surveillance for rubella viruses","volume":"204","author":"Abernathy","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.siny.2007.01.017","article-title":"Rubella","volume":"12","author":"Best","year":"2007","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1017\/S0950268800048640","article-title":"Rubella vaccines: Past, present and future","volume":"107","author":"Best","year":"1991","journal-title":"Epidemiol. Infect."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1017\/S0950268800048664","article-title":"Rubella in Europe","volume":"107","author":"Galazka","year":"1991","journal-title":"Epidemiol. Infect."},{"key":"ref_69","first-page":"107","article-title":"Epidemiology of rubella","volume":"118","author":"Witte","year":"1969","journal-title":"Am. J. Dis. Child."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1016\/S0264-410X(01)00073-1","article-title":"Rubella eradication","volume":"19","author":"Plotkin","year":"2001","journal-title":"Vaccine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/jama.281.6.561","article-title":"The eradication of rubella","volume":"281","author":"Plotkin","year":"1999","journal-title":"J. Am. Med. Assoc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/S0140-6736(14)60539-0","article-title":"Rubella","volume":"385","author":"Lambert","year":"2015","journal-title":"Lancet"},{"key":"ref_73","unstructured":"Best, J.M., and Reef, S. (2008). The Immunological Basis for Immunization Series, Module 11: Rubella, World Health Organization."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0140-6736(87)92737-1","article-title":"Sensitive assays for viral antibodies in saliva","volume":"2","author":"Parry","year":"1987","journal-title":"Lancet"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0035-9203(95)90680-0","article-title":"Salivary antibody detection in epidemiological surveys: A pilot study after a mass vaccination campaign against rubella in S\u00e3o Paulo, Brazil","volume":"89","author":"Richards","year":"1995","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0035-9203(98)90811-2","article-title":"An evaluation of oral-fluid collection devices for the determination of rubella antibody status in a rural Ethiopian community","volume":"92","author":"Nokes","year":"1998","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1046\/j.1365-3156.1998.00227.x","article-title":"A comparison of oral fluid and serum for the detection of rubella-specific antibodies in a community study in Addis Ababa, Ethiopia","volume":"3","author":"Nokes","year":"1998","journal-title":"Trop. Med. Int. Health"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1017\/S0950268898008838","article-title":"Salivary diagnosis of rubella: A study of notified cases in the United Kingdom, 1991\u20131994","volume":"120","author":"Ramsay","year":"1998","journal-title":"Epidemiol. Infect."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1128\/JCM.37.2.391-395.1999","article-title":"Detection of rubella virus-specific immunoglobulin G in saliva by an amplification-based enzyme-linked immmunosorbent assay using monoclonal antibody to fluorescein isothiocyanate","volume":"37","author":"Vyse","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1017\/S0950268802008051","article-title":"Improving sensitivity of oral fluid testing in IgG prevalence studies: Application of mixture models to a rubella antibody survey","volume":"130","author":"Gay","year":"2003","journal-title":"Epidemiol. Infect."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jviromet.2003.09.008","article-title":"Validation of a modified commercial assay for the detection of rubella-specific IgG in oral fluid for use in population studies","volume":"114","author":"Pomery","year":"2003","journal-title":"J. Virol. Methods"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/S0264-410X(01)00474-1","article-title":"Time-resolved fluorometric immunoassay for rubella antibody\u2014A useful method for surveillance studies","volume":"20","author":"Jones","year":"2002","journal-title":"Vaccine"},{"key":"ref_83","unstructured":"Centers for Disease Control and Prevention (CDC) (2008). Recommendations from an ad hoc meeting of the WHO measles and rubella laboratory network (LabNet) on use of alternative diagnostic samples for measles and rubella surveillance. Morb. Mortal. Wkly. Rep., 57, 657\u2013660."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0140-6736(04)15897-2","article-title":"Rubella","volume":"363","author":"Banatvala","year":"2004","journal-title":"Lancet"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jmv.1890210409","article-title":"Serological study of rubella-like illnesses","volume":"21","author":"Shirley","year":"1987","journal-title":"J. Med. Virol."},{"key":"ref_86","first-page":"R26","article-title":"The epidemiology of rubella in England and Wales before and after the 1994 measles and rubella vaccination campaign: Fourth joint report from the PHLS and the National Congenital Rubella Surveillance Programme","volume":"7","author":"Miller","year":"1997","journal-title":"Commun. Dis. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.3201\/eid1610.100560","article-title":"Oral fluid testing during 10 years of rubella elimination, England and Wales","volume":"16","author":"Manikkavasagan","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1590\/S0037-86822000000400001","article-title":"Diagnosis of rubella infection by detecting specific immunoglobulin M antibodies in saliva samples: A clinic-based study in Niter\u00f3i, RJ, Brazil","volume":"33","author":"Siqueira","year":"2000","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Vijaylakshmi, P., Muthukkaruppan, V.R., Rajasundari, A., Korukluoglu, G., Nigatu, W., Warrener, L.A., Samuel, D., and Brown, D.W. (2006). Evaluation of a commercial rubella IgM assay for use on oral fluid samples for diagnosis and surveillance of congenital rubella syndrome and postnatal rubella. J. Clin. Virol., 265\u2013268.","DOI":"10.1016\/j.jcv.2006.09.005"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/mcpr.2001.0390","article-title":"An RT-PCR assay using oral fluid samples to detect rubella virus genome for epidemiological surveillance","volume":"16","author":"Vyse","year":"2002","journal-title":"Mol. Cell. Probes"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1128\/JCM.00181-10","article-title":"Phylogenetic analysis of rubella viruses involved in congenital rubella infections in France between 1995 and 2009","volume":"48","author":"Abernathy","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1128\/JCM.01231-08","article-title":"Confirmation of rubella within 4 days of rash onset: Comparison of rubella virus RNA detection in oral fluid with immunoglobulin M detection in serum or oral fluid","volume":"47","author":"Abernathy","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"S506","DOI":"10.1093\/infdis\/jir117","article-title":"Improving global virologic surveillance for measles and rubella","volume":"204","author":"Rota","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/jcp.55.2.154","article-title":"Changes in age related seroprevalence of antibody to varicella zoster virus: Impact on vaccine strategy","volume":"55","author":"Kudesia","year":"2002","journal-title":"J. Clin. Pathol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"7699","DOI":"10.1016\/j.vaccine.2010.09.017","article-title":"The epidemiology of chickenpox in UK 5-year olds: An analysis to inform vaccine policy","volume":"28","author":"Manikkavasagan","year":"2010","journal-title":"Vaccine"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/00013542-199310000-00006","article-title":"Epidemiology, outcome and control of varicella-zoster infection","volume":"4","author":"Miller","year":"1993","journal-title":"Rev. Med. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jinf.2008.03.004","article-title":"Chickenpox in adults\u2014Clinical management","volume":"57","author":"Tunbridge","year":"2008","journal-title":"J. Infect."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1479-828X.2007.00797.x","article-title":"Varicella and the pregnant woman: Prevention and management","volume":"48","author":"Daley","year":"2008","journal-title":"Aust. N. Zeal. J. Obstetr. Gynaecol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1136\/jcp.54.10.743","article-title":"Vaccination to prevent varicella and shingles","volume":"54","author":"Breuer","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1002\/jmv.10317","article-title":"Varicella vaccination: Impact of vaccine efficacy on the epidemiology of VZV","volume":"70","author":"Brisson","year":"2003","journal-title":"J. Med. Virol."},{"key":"ref_101","unstructured":"Joint Committee on Vaccination and Immunisation (JCVI) Sub-committee on Adolescent Vaccinations Minutes of Meeting Held on 27 January 2012, Available online:http:\/\/www.wp.dh.gov.uk\/transparencyfiles\/2012\/JCVI-Minutes-of-sub-committee-on-adolescent-vaccinations-27-January-2012.pdf."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1017\/S0950268804003140","article-title":"Seroprevalence of antibody to varicella zoster virus in England and Wales in children and young adults","volume":"132","author":"Vyse","year":"2004","journal-title":"Epidemiol. Infect."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/infdis\/130.6.669","article-title":"Serologic response to varicella-zoster membrane antigens measured by indirect immunofluorescence","volume":"130","author":"Williams","year":"1974","journal-title":"J. Infect. Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.4161\/hv.24849","article-title":"Validity of medical record documented varicella-zoster virus among unvaccinated cohorts","volume":"9","author":"Mohanty","year":"2013","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1542\/peds.56.6.1005","article-title":"Seroepidemiologic survey of varicella: Value of specific fluorescent antibody test","volume":"56","author":"Gershon","year":"1975","journal-title":"Pediatrics"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1128\/CVI.13.2.214-218.2006","article-title":"Performance of a time-resolved fluorescence immunoassay for measuring varicella-zoster virus immunoglobulin G levels in adults and comparison with commercial enzyme immunoassays and Merck glycoprotein enzyme immunoassay","volume":"13","author":"Maple","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jviromet.2008.12.007","article-title":"Performance characteristics of a quantitative, standardised varicella zoster IgG time resolved fluorescence immunoassay (VZV TRFIA) for measuring antibody following natural infection","volume":"157","author":"Gray","year":"2009","journal-title":"J. Virol. Methods"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1159\/000053952","article-title":"Reported exposure to chickenpox: A predictor of positive anti-varicella-zoster antibodies in parturient women","volume":"16","author":"Linder","year":"2001","journal-title":"Fetal Diagn. Ther."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1365-3016.2010.01180.x","article-title":"Seroepidemiology of Varicella-zoster virus and reliability of varicella history in Turkish children, adolescents and adults","volume":"25","author":"Koturoglu","year":"2011","journal-title":"Pediatr. Perinat. Epidemiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1136\/oem.57.9.621","article-title":"Occupational risk of infection by varicella zoster virus in Belgian healthcare workers: A seroprevalence study","volume":"57","author":"Vandersmissen","year":"2000","journal-title":"Occup. Environ. Med."},{"key":"ref_111","first-page":"252","article-title":"Reliability of varicella history in children and adolescents","volume":"135","author":"Heininger","year":"2005","journal-title":"Swiss Med. Wkly."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1016\/j.vaccine.2004.04.024","article-title":"Comparison of varicella history with presence of varicella antibody in refugees","volume":"22","author":"Christiansen","year":"2004","journal-title":"Vaccine"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S1201-9712(03)90106-8","article-title":"How reliable is the history of chickenpox? Varicella serology among children up to 14 years of age","volume":"7","author":"Kavaliotis","year":"2003","journal-title":"Int. J. Infect. Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.vaccine.2013.06.098","article-title":"Validity of a reported history of chickenpox in targeting varicella vaccination at susceptible adolescents in England","volume":"32","author":"Field","year":"2014","journal-title":"Vaccine"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.vaccine.2004.10.003","article-title":"Seroprevalence of varicella antibodies in healthcare workers and health sciences students. Reliability of a self-reported history of varicella","volume":"23","author":"Gil","year":"2005","journal-title":"Vaccine"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1054-139X(00)00174-9","article-title":"Serotesting versus presumptive varicella vaccination of adolescents with a negative or uncertain history of chickenpox","volume":"28","author":"Harel","year":"2001","journal-title":"J. Adolesc. Health"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/j.jcv.2013.09.018","article-title":"Relative accuracy of serum, whole blood, and oral fluid HIV tests among Seattle men who have sex with men","volume":"58","author":"Stekler","year":"2013","journal-title":"J. Clin. Virol."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/3\/4\/988\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:53:45Z","timestamp":1760216025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/3\/4\/988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,9]]},"references-count":117,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,12]]}},"alternative-id":["vaccines3040988"],"URL":"https:\/\/doi.org\/10.3390\/vaccines3040988","relation":{},"ISSN":["2076-393X"],"issn-type":[{"type":"electronic","value":"2076-393X"}],"subject":[],"published":{"date-parts":[[2015,12,9]]}}}