{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:38:43Z","timestamp":1788802723363,"version":"build-2803163510"},"reference-count":99,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T00:00:00Z","timestamp":1536796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.<\/jats:p>","DOI":"10.3390\/vaccines6030062","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T11:46:04Z","timestamp":1536839164000},"page":"62","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Zika Virus Vaccines: Challenges and Perspectives"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1829-8143","authenticated-orcid":false,"given":"Raquel","family":"Das Neves Almeida","sequence":"first","affiliation":[{"name":"Laboratory of Immunology and Inflammation, University of Brasilia, Brasilia 70910-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-8661","authenticated-orcid":false,"given":"Trina","family":"Racine","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie du CHU de Qu\u00e9bec\u2014Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7435-5272","authenticated-orcid":false,"given":"Kelly G.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Inflammation, University of Brasilia, Brasilia 70910-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Kobinger","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie du CHU de Qu\u00e9bec\u2014Universit\u00e9 Laval, Qu\u00e9bec, QC G1V 4G2, Canada"},{"name":"Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada"},{"name":"Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0T5, Canada"},{"name":"D\u00e9partment de Microbiologie-Infectiologie et D\u2019immunologie, Universit\u00e9 Laval, Qu\u00e9bc, QC G1V 0A6, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4238, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2018.00096","article-title":"The immune responses of the animal hosts of west nile virus: A comparison of insects, birds, and mammals","volume":"8","author":"Ahlers","year":"2018","journal-title":"Front. 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