{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:00:09Z","timestamp":1790226009727,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Objective: To evaluate vaccination coverage and reasons for non-vaccination in patients with primary Sj\u00f6gren\u2019s syndrome (pSS). Method: A total of 111 patients fulfilling American\u2013European Consensus Group criteria for pSS were interviewed by use of a standardized questionnaire between January 2016 and November 2017 in two French tertiary referral centers for auto-immune diseases. Results: Updated immunization coverage for influenza was 31.5% (n = 35), pneumococcus was 11.7% (n = 13), and diphtheria\u2013tetanus\u2013poliomyelitis (DTP) was 24.3% (n = 27). The main reasons for non-vaccination were fear of side effects from the influenza vaccine (40.3%) and a lack of proposal for the pneumococcal vaccine (72.3%). In vaccinated patients, vaccination was mainly proposed by general practitioners for the influenza vaccine (42.6%) and rheumatologists for the pneumococcal vaccine (41.2%). Probability of influenza vaccination was associated with age (odds ratio\/year (OR) 1.04, 95% confidence interval (CI) 1.0\u20131.1; p = 0.016), history of severe infection (OR 15.9, 95% CI 1.35\u2013186; p = 0.028), low EULAR Sj\u00f6gren\u2019s syndrome disease activity index (OR 0.85, 95% CI 0.75\u20130.96; p = 0.013), and comorbidities (OR 3.52, 95% CI 1.22\u201310.2; p = 0.02). Probability of vaccination against pneumococcus was associated with lung comorbidities (OR 3.83, 95% CI 1.11\u201313.12; p = 0.033) and up-to-date influenza vaccination (OR 3.71, 95% CI 1.08\u201312.8; p = 0.038). Conclusion: Influenza, pneumococcal, and DTP vaccine coverage was low in patients with pSS included in this study. These results underline the relevance of systematically screening vaccine status in pSS patients and educating patients and physicians on the need for vaccination to improve vaccine coverage in this population.<\/jats:p>","DOI":"10.3390\/vaccines8010003","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:15:01Z","timestamp":1577070901000},"page":"3","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Low Influenza, Pneumococcal and Diphtheria\u2013Tetanus\u2013Poliomyelitis Vaccine Coverage in Patients with Primary Sj\u00f6gren\u2019s Syndrome: A Cross-Sectional Study"],"prefix":"10.3390","volume":"8","author":[{"given":"Morel","family":"Jacques","sequence":"first","affiliation":[{"name":"Department of Rheumatology, CHU and Montpellier University, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hind","family":"Letaief","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU and Montpellier University, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilpain","family":"Philippe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Multi-Organic Diseases, CHU and Montpellier University, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariette","family":"Xavier","sequence":"additional","affiliation":[{"name":"AP-HP, Universit\u00e9 Paris-Saclay, Department of Rheumatology, University of Paris Sud, INSERM, UMR1184, Center of Immunology of Viral Infections, Auto-Immune Diseases, 94270 Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4002-1861","authenticated-orcid":false,"given":"Combe","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU and Montpellier University, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Lukas","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU and Montpellier University, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","article-title":"Sj\u00f6gren syndrome","volume":"2","author":"Baldini","year":"2016","journal-title":"Nat. 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