{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:07:53Z","timestamp":1772082473184,"version":"3.50.1"},"reference-count":83,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1018614 and OPP1157162"],"award-info":[{"award-number":["OPP1018614 and OPP1157162"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Numerous preventive strategies against respiratory syncytial virus (RSV) are undergoing late stage evaluation in humans and, in addition to their intended benefit for acute illness, may impact long term consequences of infection in infants. Severe RSV infection has been repeatedly associated in the literature with long term complications, including impaired lung function, recurrent wheezing, and asthma. However, whether RSV lower respiratory tract infection (LRTI) causally affects the odds for developing wheezing and\/or asthma during childhood requires further study, and the biological mechanisms underlying this hypothetical progression from viral illness to chronic lung disease are poorly characterized. In this review, we summarize the literature exploring the association between RSV LRTI in infancy and subsequent recurrent wheezing and pediatric asthma.<\/jats:p>","DOI":"10.3390\/vaccines8020201","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T05:05:32Z","timestamp":1588050332000},"page":"201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Durable Relationship: Respiratory Syncytial Virus Bronchiolitis and Asthma past Their Golden Anniversary"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5196-5836","authenticated-orcid":false,"given":"Ignacio","family":"Esteban","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n INFANT, Buenos Aires 1406, Argentina"},{"name":"Hospital de Pediatr\u00eda Prof. Dr. Juan P. Garrahan, Buenos Aires 1245, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato T.","family":"Stein","sequence":"additional","affiliation":[{"name":"Centro INFANT at Pontificia Universidade Catolica de Rio Grande do Sul, Porto Alegre 90610-000, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando P.","family":"Polack","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n INFANT, Buenos Aires 1406, Argentina"},{"name":"Department of Pediatrics, Vanderbilt University, Nashville 37240, Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(10)60206-1","article-title":"Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis","volume":"375","author":"Nair","year":"2010","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0140-6736(17)30938-8","article-title":"Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: A systematic review and modelling study","volume":"390","author":"Shi","year":"2015","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1164\/rccm.201405-0901PP","article-title":"Toward primary prevention of asthma: Reviewing the evidence for early-life respiratory viral infections as modifiable risk factors to prevent childhood asthma","volume":"191","author":"Feldman","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_4","first-page":"2","article-title":"Risk of Primary Infection and Reinfection with Respiratory Syncytial Virus","volume":"140","author":"Glezen","year":"1986","journal-title":"Am. J. Dis. Child"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1164\/rccm.200603-435PP","article-title":"Bronchiolitis to asthma: A review and call for studies of gene-virus interactions in asthma causation","volume":"175","author":"Singh","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s40121-017-0151-4","article-title":"The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood","volume":"6","author":"Fauroux","year":"2017","journal-title":"Infect. Dis. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0021-8707(59)90054-1","article-title":"The relationship between bronchiolitis and childhood asthma; a follow-up study of 100 cases of bronchiolitis","volume":"30","author":"Wittig","year":"1959","journal-title":"J. Allergy"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1056\/NEJMoa1211917","article-title":"Respiratory syncytial virus and recurrent wheeze in healthy preterm infants","volume":"368","author":"Blanken","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1542\/peds.2013-0982","article-title":"Effect of palivizumab prophylaxis on subsequent recurrent wheezing in preterm infants","volume":"132","author":"Yoshihara","year":"2013","journal-title":"Pediatrics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.prrv.2004.01.007","article-title":"Asthma phenotypes in childhood: Lessons from an epidemiological approach","volume":"5","author":"Stein","year":"2004","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1651-2227.1987.tb10555.x","article-title":"Risk factors for wheezing during infancy. A study of 5953 infants","volume":"76","author":"Bisgaard","year":"1987","journal-title":"Acta Paediatr Scand"},{"key":"ref_12","first-page":"395","article-title":"Evaluation of Risk Factors for Recurrent Wheezing Episodes","volume":"5","author":"Bozaykut","year":"2013","journal-title":"J. Clin. Med. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ppul.1950070307","article-title":"Childhood asthma following hospitalization with acute viral bronchiolitis in infancy","volume":"7","author":"Sly","year":"1989","journal-title":"Pediatr. Pulmonol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/adc.67.4.482","article-title":"Respiratory status and allergy after bronchiolitis","volume":"67","author":"Murray","year":"1992","journal-title":"Arch. Dis. Child"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1136\/bmj.284.6330.1665","article-title":"Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy","volume":"284","author":"Pullan","year":"1982","journal-title":"Br. Med. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0022-3476(71)80385-2","article-title":"The relationship between proved viral bronchiolitis and subsequent wheezing","volume":"79","author":"Rooney","year":"1971","journal-title":"J. Pediatr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1164\/rccm.200809-1471OC","article-title":"Exploring the association between severe respiratory syncytial virus infection and asthma: A registry-based twin study","volume":"179","author":"Thomsen","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jaci.2009.02.021","article-title":"The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma","volume":"123","author":"Carroll","year":"2000","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"RSV Infection and Increased Wheezing","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ahanchian, H., Jones, C.M., Chen, Y., and Sly, P.D. (2012). Respiratory viral infections in children with asthma: Do they matter and can we prevent them?. BMC Pediatr., 12.","DOI":"10.1186\/1471-2431-12-147"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jaci.2013.01.009","article-title":"Risk of Childhood Asthma Following Infant Bronchiolitis During RSV Season","volume":"132","author":"James","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jaci.2010.11.037","article-title":"Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome","volume":"127","author":"Akdis","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nm.2678","article-title":"Asthma phenotypes: The evolution from clinical to molecular approaches","volume":"18","author":"Wenzel","year":"2012","journal-title":"Nat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/infdis\/jiz082","article-title":"The Syndrome We Agreed to Call Bronchiolitis","volume":"3","author":"Polack","year":"2019","journal-title":"J. Infect Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1542\/peds.31.5.859","article-title":"The Relationship of Acute Bronchiolitis to Bronchial Asthma\u2014A 4-to-14-year Follow-up","volume":"31","author":"Eisen","year":"1963","journal-title":"Pediatrics"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1164\/rccm.200804-579OC","article-title":"Evidence of a causal role of winter virus infection during infancy in early childhood asthma","volume":"178","author":"Wu","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1586\/eri.11.92","article-title":"Evidence for a causal relationship between respiratory syncytial virus infection and asthma","volume":"9","author":"Wu","year":"2011","journal-title":"Expert. Rev. Anti Infect. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/adc.58.9.713","article-title":"Respiratory problems 2 years after acute bronchiolitis in infancy","volume":"58","author":"Henry","year":"1983","journal-title":"Arch. Dis. Child"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life","volume":"332","author":"Martinez","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/bmj.1.6104.11","article-title":"Study of 8-year-old Children with a History of Respiratory Syncytial Virus Bronchiolitis in Infancy","volume":"1","author":"Sims","year":"1978","journal-title":"Br. Med. J."},{"key":"ref_32","first-page":"871","article-title":"Lung function abnormalities after acute bronchiolitis","volume":"98","author":"Stokes","year":"1981","journal-title":"Indian J. Pediatr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1164\/ajrccm.161.5.9906076","article-title":"Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7","volume":"161","author":"Sigurs","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0022-3476(79)80573-9","article-title":"Cell-mediated immune response to respiratory syncytial virus infection: Relationship to the development of reactive airway disease","volume":"94","author":"Welliver","year":"1979","journal-title":"J. Pediatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0022-3476(86)80692-8","article-title":"Predictive value of respiratory syncytial virus-specific IgE responses for recurrent wheezing following bronchiolitis","volume":"109","author":"Welliver","year":"1986","journal-title":"J. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ppul.1950150104","article-title":"The relationship of RSV-specific immunoglobulin E antibody responses in infancy, recurrent wheezing, and pulmonary function at age 7\u20138 years","volume":"15","author":"Welliver","year":"1993","journal-title":"Pediatr. Pulmonol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2006.12.669","article-title":"Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma","volume":"119","author":"Kusel","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1164\/rccm.201311-2095OC","article-title":"Risk of current asthma among adult smokers with respiratory syncytial virus illnesses in early life","volume":"190","author":"Voraphani","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/INF.0b013e31815ac585","article-title":"The role of neutralizing antibodies in protection of American Indian infants against respiratory syncytial virus disease","volume":"27","author":"Eick","year":"2008","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1034\/j.1399-3003.1999.14a03.x","article-title":"Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children","volume":"14","author":"Illi","year":"1999","journal-title":"Eur. Respir. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.immuni.2019.03.018","article-title":"The Cytokines of Asthma","volume":"50","author":"Lambrecht","year":"2019","journal-title":"Immunity"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Gadomski, A.M., and Scribani, M.B. (2014). Bronchodilators for bronchiolitis. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD001266.pub4"},{"key":"ref_44","first-page":"87","article-title":"Glucocorticoids for acute viral bronchiolitis in infants and young children","volume":"311","author":"Fernandes","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1542\/peds.2014-2742","article-title":"Clinical practice guideline: The diagnosis, management, and prevention of bronchiolitis","volume":"134","author":"Ralston","year":"2014","journal-title":"Pediatrics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1399-3003.1999.14a23.x","article-title":"IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis","volume":"14","author":"Bell","year":"1999","journal-title":"Eur. Respir. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1128\/CMR.00090-16","article-title":"The human immune response to respiratory syncytial virus infection","volume":"30","author":"Russell","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/INF.0b013e3181a3ea71","article-title":"Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus","volume":"28","author":"Ampuero","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_49","first-page":"323","article-title":"Epidemiological Characteristics and Immune Status of Children with Respiratory Syncytial Virus","volume":"87","author":"Qing","year":"2014","journal-title":"J. Med. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ppul.10140","article-title":"Peripheral blood lymphopenia and neutrophilia in children with severe respiratory syncytial virus disease","volume":"34","author":"Carrington","year":"2002","journal-title":"Pediatr. Pulmonol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/003655498750002349","article-title":"T cell subset analysis in peripheral blood of children with RSV bronchiolitis","volume":"30","author":"Twilhaar","year":"1998","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jaci.2005.04.039","article-title":"Perspectives on the past decade of asthma genetics","volume":"116","author":"Ober","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jaci.2012.02.010","article-title":"Determinants of asthma after severe respiratory syncytial virus bronchiolitis","volume":"130","author":"Bacharier","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI75183","article-title":"TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization","volume":"125","author":"Caballero","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lauhkonen, E., Koponen, P., Vuononvirta, J., and Ter\u00e4sj\u00e4rvi, J. (2016). Gene Polymorphism of Toll-Like Receptors and Lung Function at Five to Seven Years of Age after Infant Bronchiolitis. PLoS ONE.","DOI":"10.1371\/journal.pone.0146526"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2217\/fvl.15.55","article-title":"Genes associated with RSV lower respiratory tract infection and asthma: The application of genetic epidemiological methods to understand causality","volume":"10","author":"Larkin","year":"2015","journal-title":"Futur. Virol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/nm.2896","article-title":"Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma","volume":"18","author":"Krishnamoorthy","year":"2012","journal-title":"Nat. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0140799","article-title":"IL-10 gene polymorphisms are associated with post-bronchiolitis lung function abnormalities at six years of age","volume":"10","author":"Lauhkonen","year":"2015","journal-title":"PLoS ONE"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cyto.2015.07.017","article-title":"Elevated IL-3 and IL-12p40 levels in the lower airway of infants with RSV-induced bronchiolitis correlate with recurrent wheezing","volume":"76","author":"Bertrand","year":"2015","journal-title":"Cytokine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1399-3038.2009.00868.x","article-title":"Nasopharyngeal aspirate cytokine levels 1 yr after severe respiratory syncytial virus infection","volume":"20","author":"Pino","year":"2009","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_62","first-page":"76","article-title":"Severe asthma: From characteristics to phenotypes to endotypes","volume":"23","author":"Wenzel","year":"2012","journal-title":"Clin. Exp. Allergy"},{"key":"ref_63","unstructured":"(2020, February 24). Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Available online: www.ginaasthma.org."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.59.5.683","article-title":"Pulmonary function abnormalities in symptom-free children after bronchiolitis","volume":"59","author":"Kattan","year":"1977","journal-title":"Pediatrics"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0022-3476(81)80758-5","article-title":"Increased incidence of bronchial reactivity in children with a history of bronchiolitis","volume":"98","author":"Gurwitz","year":"1981","journal-title":"J. Pediatr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/j.1651-2227.2007.00458.x","article-title":"Lung function and bronchial hyper-responsiveness 11 years after hospitalization for bronchiolitis","volume":"96","author":"Reijonen","year":"2007","journal-title":"Acta Paediatr. Int. J. Paediatr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ppul.23039","article-title":"Lung function by impulse oscillometry at age 5\u20137 years after bronchiolitis at age 0\u20136 months","volume":"50","author":"Lauhkonen","year":"2015","journal-title":"Pediatr. Pulmonol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ppul.1950010206","article-title":"Bronchodilator response during acute viral bronchiolitis in infancy","volume":"1","author":"Soto","year":"1985","journal-title":"Pediatr. Pulmonol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1164\/ajrccm\/137.2.302","article-title":"Lower respiratory illness in early childhood and lung function and bronchial reactivity in adolescent males","volume":"137","author":"Voter","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ppul.20058","article-title":"Respiratory morbidity 20 years after RSV infection in infancy","volume":"38","author":"Korppi","year":"2004","journal-title":"Pediatr. Pulmonol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Backman, K., Ollikainen, H., Piipo-Savolainen, E., Nuolivirta, K., and Korppi, M. (2017). Asthma and Lung Function in Adulthood after a Viral Wheezing Episode in Early Childhood. Clin. Exp. Allergy.","DOI":"10.1111\/cea.13062"},{"key":"ref_72","first-page":"144","article-title":"Diminished lung fuction as a predisposing factor for wheezing respiratory illness in infants","volume":"314","author":"Martinez","year":"1988","journal-title":"New Engl. J. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1164\/rccm.201110-1922OC","article-title":"Interaction between asthma and lung function growth in early life","volume":"185","author":"Bisgaard","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/S1473-3099(15)00247-9","article-title":"Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: A phase 3 randomised double-blind placebo-controlled trial","volume":"15","author":"Chandran","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaci.2010.05.026","article-title":"The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children","volume":"126","author":"Rieger","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/01.inf.0000086403.50417.7c","article-title":"Effect of palivizumab prophylaxis in decreasing respiratory syncytial virus hospitalizations in premature infants","volume":"22","author":"Pedraz","year":"2003","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0002-9343(02)01095-1","article-title":"Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin","volume":"112","author":"Wenzel","year":"2002","journal-title":"Am. J. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpeds.2007.02.032","article-title":"Palivizumab Prophylaxis, Respiratory Syncytial Virus, and Subsequent Recurrent Wheezing","volume":"151","author":"Simoes","year":"2007","journal-title":"J. Pediatr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1164\/rccm.201609-1812OC","article-title":"Palivizumab Prophylaxis in Preterm Infants and Subsequent Recurrent Wheezing. Six-Year Follow-up Study","volume":"196","author":"Mochizuki","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S2213-2600(18)30055-9","article-title":"Respiratory syncytial virus prevention and asthma in healthy preterm infants: A randomised controlled trial","volume":"6","author":"Scheltema","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/INF.0000000000001167","article-title":"The impact of respiratory syncytial virus disease prevention on pediatric asthma","volume":"35","author":"Caballero","year":"2016","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Bockova, J., O\u2019Brien, K.L., Oski, J., Croll, J., Reid, R., Weatherholtz, R.C., Santosham, M., and Karron, R.A. (2002). Respiratory syncytial virus infection in Navajo and White Mountain Apache children. 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