{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:23:45Z","timestamp":1775921025589,"version":"3.50.1"},"reference-count":160,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>African Animal Trypanosomiasis (AAT) is a disease caused by pathogenic trypanosomes which affects millions of livestock every year causing huge economic losses in agricultural production especially in sub-Saharan Africa. The disease is spread by the tsetse fly which carries the parasite in its saliva. During the disease progression, the cattle are prominently subjected to anaemia, weight loss, intermittent fever, chills, neuronal degeneration, congestive heart failure, and finally death. According to their different genetic programs governing the level of tolerance to AAT, cattle breeds are classified as either resistant or susceptible. In this study, we focus on the cattle breeds N\u2019Dama and Boran which are known to be resistant and susceptible to trypanosomiasis, respectively. Despite the rich literature on both breeds, the gene regulatory mechanisms of the underlying biological processes for their resistance and susceptibility have not been extensively studied. To address the limited knowledge about the tissue-specific transcription factor (TF) cooperations associated with trypanosomiasis, we investigated gene expression data from these cattle breeds computationally. Consequently, we identified significant cooperative TF pairs (especially     D B P \u2212 P P A R A     and     D B P \u2212 T H A P 1     in N\u2019Dama and     D B P \u2212 P A X 8     in Boran liver tissue) which could help understand the underlying AAT tolerance\/susceptibility mechanism in both cattle breeds.<\/jats:p>","DOI":"10.3390\/vaccines8020246","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T06:43:40Z","timestamp":1590389020000},"page":"246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4179-2668","authenticated-orcid":false,"given":"Abirami","family":"Rajavel","sequence":"first","affiliation":[{"name":"Breeding Informatics Group, Department of Animal Sciences, Georg-August University, Margarethe von Wrangell-Weg 7, 37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-8522","authenticated-orcid":false,"given":"Felix","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Breeding Informatics Group, Department of Animal Sciences, Georg-August University, Margarethe von Wrangell-Weg 7, 37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4910-9467","authenticated-orcid":false,"given":"Armin Otto","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Breeding Informatics Group, Department of Animal Sciences, Georg-August University, Margarethe von Wrangell-Weg 7, 37075 G\u00f6ttingen, Germany"},{"name":"Center for Integrated Breeding Research (CiBreed), Albrecht-Thaer-Weg 3, Georg-August University, 37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3297-3192","authenticated-orcid":false,"given":"Mehmet","family":"G\u00fcltas","sequence":"additional","affiliation":[{"name":"Breeding Informatics Group, Department of Animal Sciences, Georg-August University, Margarethe von Wrangell-Weg 7, 37075 G\u00f6ttingen, Germany"},{"name":"Center for Integrated Breeding Research (CiBreed), Albrecht-Thaer-Weg 3, Georg-August University, 37075 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,23]]},"reference":[{"key":"ref_1","first-page":"12","article-title":"Deadly by the Dozen: 12 Diseases climate change may Worsen","volume":"8","author":"Biello","year":"2008","journal-title":"Sci. Am."},{"key":"ref_2","unstructured":"Radostits, O.M., Gay, C.C., Hinchcliff, K.W., and Constable, P.D. (2006). Veterinary Medicine E-Book: A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats, Elsevier Health Sciences."},{"key":"ref_3","first-page":"220","article-title":"Epidemiology and Impacts of Trypanosomiasis in Cattle","volume":"7","author":"Firesbhat","year":"2015","journal-title":"Eur. J. Appl. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0166-6851(97)00209-0","article-title":"Multiple mechanisms of immune evasion by African trypanosomes","volume":"91","author":"Donelson","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/030098587200901s01","article-title":"Review of pathology of diseases in domestic and laboratory animals caused by Trypanosoma congolense, T. vivax, T. brucei, T. rhodesiense and T. gambiense","volume":"9","author":"Losos","year":"1972","journal-title":"Vet. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.pt.2016.04.012","article-title":"Animal African trypanosomiasis: Time to increase focus on clinically relevant parasite and host species","volume":"32","author":"Morrison","year":"2016","journal-title":"Trends Parasitol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0308-521X(98)00086-9","article-title":"Measuring the costs of African animal trypanosomosis, the potential benefits of control and returns to research","volume":"59","author":"Kristjanson","year":"1999","journal-title":"Agric. Syst."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fimmu.2018.00218","article-title":"African trypanosomiasis-associated anemia: The contribution of the interplay between parasites and the mononuclear phagocyte system","volume":"9","author":"Stijlemans","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.vetpar.2016.05.003","article-title":"Combatting African animal trypanosomiasis (AAT) in livestock: The potential role of trypanotolerance","volume":"225","author":"Yaro","year":"2016","journal-title":"Vet. Parasitol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ijpara.2006.02.012","article-title":"Bovine trypanotolerance: A natural ability to prevent severe anaemia and haemophagocytic syndrome?","volume":"36","author":"Naessens","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.20506\/rst.17.1.1088","article-title":"Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomosis","volume":"17","author":"Murray","year":"1998","journal-title":"OIE Rev. Sci. Tech."},{"key":"ref_12","first-page":"2","article-title":"N\u2019Dama cattle-a productive trypanotolerant breed","volume":"50","author":"Starkey","year":"1984","journal-title":"FAO World Anim. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0304-4017(90)90057-I","article-title":"Susceptibility of African buffalo and Boran cattle to Trypanosoma congolense transmitted by Glossina morsitans centralis","volume":"35","author":"Grootenhuis","year":"1990","journal-title":"Vet. Parasitol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0092-8674(02)00711-0","article-title":"Antigenic variation and allelic exclusion","volume":"109","author":"Borst","year":"2002","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0166-6851(97)00186-2","article-title":"Regulation of vsg expression site transcription and switching in Trypanosoma brucei","volume":"91","author":"Cross","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-308X(01)49037-3","article-title":"Antigenic variation in trypanosomes: Enhanced phenotypic variation in a eukaryotic parasite","volume":"49","author":"Barry","year":"2001","journal-title":"Adv. Parasitol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1017\/S0031182014001838","article-title":"Escape mechanisms of African trypanosomes: Why trypanosomosis is keeping us awake","volume":"142","author":"Cnops","year":"2015","journal-title":"Parasitology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-4017(00)00427-1","article-title":"Drug resistance in pathogenic African trypanosomes: What hopes for the future?","volume":"96","author":"Anene","year":"2001","journal-title":"Vet. Parasitol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Michel-Tod\u00f3, L., Bigey, P., Reche, P.A., Pinazo, M.J., Gasc\u00f3n, J., and Alonso-Padilla, J. (2020). Design of an Epitope-Based Vaccine Ensemble for Animal Trypanosomiasis by Computational Methods. Vaccines, 8.","DOI":"10.3390\/vaccines8010130"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9304","DOI":"10.1073\/pnas.1013486108","article-title":"Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection","volume":"108","author":"Noyes","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.4049\/jimmunol.0804324","article-title":"Secondary lymphoid organs: Responding to genetic and environmental cues in ontogeny and the immune response","volume":"183","author":"Ruddle","year":"2009","journal-title":"J. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1128\/iai.28.3.824-831.1980","article-title":"Murine trypanosomiasis: Cellular proliferation and functional depletion in the blood, peritoneum, and spleen related to changes in bone marrow stem cells","volume":"28","author":"Clayton","year":"1980","journal-title":"Infect. Immun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fimmu.2016.00181","article-title":"Host intracellular signaling events and pro-inflammatory cytokine production in African trypanosomiasis","volume":"7","author":"Kuriakose","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wang, H.W., Sun, H.J., Chang, T.Y., Lo, H.H., Cheng, W.C., Tseng, G.C., Lin, C.T., Chang, S.J., Pal, N.R., and Chung, I.F. (2015). Discovering monotonic stemness marker genes from time-series stem cell microarray data. BMC Genom., 16.","DOI":"10.1186\/1471-2164-16-S2-S2"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Tian, S. (2019). Identification of monotonically differentially expressed genes for non-small cell lung cancer. BMC Bioinform., 20.","DOI":"10.1186\/s12859-019-2775-8"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Meckbach, C., Tacke, R., Hua, X., Waack, S., Wingender, E., and G\u00fcltas, M. (2015). PC-TraFF: Identification of potentially collaborating transcription factors using pointwise mutual information. BMC Bioinform., 16.","DOI":"10.1186\/s12859-015-0827-2"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fgene.2016.00042","article-title":"Computational identification of key regulators in two different colorectal cancer cell lines","volume":"7","author":"Wlochowitz","year":"2016","journal-title":"Front. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fcimb.2020.00096","article-title":"Circadian Regulation of Immunity Through Epigenetic Mechanisms","volume":"10","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S1357-2725(97)00085-X","article-title":"Transcription factors: An overview","volume":"29","author":"Latchman","year":"1997","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1186\/gb-2012-13-9-r50","article-title":"Functional analysis of transcription factor binding sites in human promoters","volume":"13","author":"Whitfield","year":"2012","journal-title":"Genome Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1101\/gr.6902","article-title":"Discovery of regulatory elements by a computational method for phylogenetic footprinting","volume":"12","author":"Blanchette","year":"2002","journal-title":"Genome Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/10665270252935421","article-title":"Algorithms for phylogenetic footprinting","volume":"9","author":"Blanchette","year":"2002","journal-title":"J. Comput. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cell.2012.12.009","article-title":"DNA-binding specificities of human transcription factors","volume":"152","author":"Jolma","year":"2013","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e04837","DOI":"10.7554\/eLife.04837","article-title":"Conservation of transcription factor binding specificities across 600 million years of bilateria evolution","volume":"4","author":"Nitta","year":"2015","journal-title":"Elife"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.cell.2014.08.009","article-title":"Determination and inference of eukaryotic transcription factor sequence specificity","volume":"158","author":"Weirauch","year":"2014","journal-title":"Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1073\/pnas.1316278111","article-title":"DNA-binding specificities of plant transcription factors and their potential to define target genes","volume":"111","author":"Carrasco","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Xie, Y., Moussaif, M., Choi, S., Xu, L., and Sze, J.Y. (2013). RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis elegans. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003324"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/mi.2010.53","article-title":"Transcriptional regulation of the mucosal immune system mediated by T-bet","volume":"3","author":"Powell","year":"2010","journal-title":"Mucosal Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-immunol-032712-100024","article-title":"Transcriptional control of early T and B cell developmental choices","volume":"32","author":"Rothenberg","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2174\/0929867053202197","article-title":"Transcription factor therapeutics: Long-shot or lodestone","volume":"12","author":"Ghosh","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Moustaqil, M., Gambin, Y., and Sierecki, E. (2020). Biophysical Techniques for Target Validation and Drug Discovery in Transcription-Targeted Therapy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072301"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1002\/jcb.25605","article-title":"Transcription factor drug targets","volume":"117","author":"Papavassiliou","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"D493","DOI":"10.1093\/nar\/gkh103","article-title":"The UCSC Table Browser data retrieval tool","volume":"32","author":"Karolchik","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/bib\/bbn016","article-title":"The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation","volume":"9","author":"Wingender","year":"2008","journal-title":"Briefings Bioinform."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/bioinformatics\/16.1.16","article-title":"DNA binding sites: Representation and discovery","volume":"16","author":"Stormo","year":"2000","journal-title":"Bioinformatics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nbt1053","article-title":"Assessing computational tools for the discovery of transcription factor binding sites","volume":"23","author":"Tompa","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Steuernagel, L., Meckbach, C., Heinrich, F., Zeidler, S., Schmitt, A.O., and G\u00fcltas, M. (2019). Computational identification of tissue-specific transcription factor cooperation in ten cattle tissues. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0216475"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"D76","DOI":"10.1093\/nar\/gku887","article-title":"AnimalTFDB 2.0: A resource for expression, prediction and functional study of animal transcription factors","volume":"43","author":"Zhang","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/nar\/29.1.281","article-title":"Match-a tool for searching transcription factor binding sites in DNA sequences","volume":"29","author":"Wingender","year":"2001","journal-title":"Nucl. Acids Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gks1123","article-title":"TFClass: An expandable hierarchical classification of human transcription factors","volume":"41","author":"Wingender","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1534-5807(02)00190-9","article-title":"E2Fs regulate adipocyte differentiation","volume":"3","author":"Fajas","year":"2002","journal-title":"Dev. Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fendo.2017.00311","article-title":"E2F1, a novel regulator of metabolism","volume":"8","author":"Denechaud","year":"2017","journal-title":"Front. Endocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1080\/15548627.2015.1094597","article-title":"Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1","volume":"11","author":"Haim","year":"2015","journal-title":"Autophagy"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bozek, K., Rel\u00f3gio, A., Kielbasa, S.M., Heine, M., Dame, C., Kramer, A., and Herzel, H. (2009). Regulation of clock-controlled genes in mammals. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0004882"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biochi.2016.12.019","article-title":"The role and regulation of the peroxisome proliferator activated receptor alpha in human liver","volume":"136","author":"Kersten","year":"2017","journal-title":"Biochimie"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1038\/sj.onc.1206271","article-title":"THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies","volume":"22","author":"Roussigne","year":"2003","journal-title":"Oncogene"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10858-012-9699-1","article-title":"NMR studies of a new family of DNA binding proteins: The THAP proteins","volume":"56","author":"Gervais","year":"2013","journal-title":"J. Biomol. NMR"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e36330","DOI":"10.7554\/eLife.36330","article-title":"TFAP2 transcription factors are regulators of lipid droplet biogenesis","volume":"7","author":"Scott","year":"2018","journal-title":"Elife"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.yexcr.2015.10.028","article-title":"Lipid droplets in leukocytes: Organelles linked to inflammatory responses","volume":"340","author":"Melo","year":"2016","journal-title":"Exp. Cell Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bbadis.2013.05.007","article-title":"Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis","volume":"1842","author":"Konige","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1242\/dev.121.8.2513","article-title":"Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development","volume":"121","author":"Cross","year":"1995","journal-title":"Development"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1128\/MCB.15.7.3813","article-title":"Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system","volume":"15","author":"Hollenberg","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1006\/dbio.1995.1245","article-title":"Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development","volume":"170","author":"Cserjesi","year":"1995","journal-title":"Dev. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1126\/science.270.5244.1995","article-title":"A subclass of bHLH proteins required for cardiac morphogenesis","volume":"270","author":"Srivastava","year":"1995","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/dev.01562","article-title":"The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner","volume":"132","author":"McFadden","year":"2005","journal-title":"Development"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3389\/fgene.2018.00189","article-title":"Removing background co-occurrences of transcription factor binding sites greatly improves the prediction of specific transcription factor cooperations","volume":"9","author":"Meckbach","year":"2018","journal-title":"Front. Genet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fgene.2016.00033","article-title":"Computational detection of stage-specific transcription factor clusters during heart development","volume":"7","author":"Zeidler","year":"2016","journal-title":"Front. Genet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1093\/emboj\/16.22.6762","article-title":"The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior","volume":"16","author":"Conquet","year":"1997","journal-title":"EMBO J."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Olds, W. (2014). Sleep, Circadian Rhythms, and Metabolism: The Rhythm of Life, Apple Academic Press.","DOI":"10.1201\/b17253"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1172\/JCI46043","article-title":"Circadian rhythms, sleep, and metabolism","volume":"121","author":"Huang","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.febslet.2007.06.079","article-title":"Sleep and circadian rhythms: Key components in the regulation of energy metabolism","volume":"582","author":"Laposky","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1152\/physiol.00006.2004","article-title":"Why trypanosomes cause sleeping sickness","volume":"19","author":"Lundkvist","year":"2004","journal-title":"Physiology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.physiol.63.1.647","article-title":"Molecular analysis of mammalian circadian rhythms","volume":"63","author":"Reppert","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"832","DOI":"10.4161\/cc.8.6.7869","article-title":"Cell \u201ccircadian\u201d cycle: New role for mammalian core clock genes","volume":"8","author":"Borgs","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00441-002-0585-0","article-title":"Clock genes in mammalian peripheral tissues","volume":"309","author":"Balsalobre","year":"2002","journal-title":"Cell Tissue Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0092-8674(90)90421-A","article-title":"Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm","volume":"63","author":"Wuarin","year":"1990","journal-title":"Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1053\/j.gastro.2015.11.043","article-title":"Circadian clock control of liver metabolic functions","volume":"150","author":"Reinke","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cmet.2011.01.006","article-title":"Crosstalk between components of circadian and metabolic cycles in mammals","volume":"13","author":"Asher","year":"2011","journal-title":"Cell Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cmet.2009.11.002","article-title":"Circadian clock-coordinated 12 hr period rhythmic activation of the IRE1\u03b1 pathway controls lipid metabolism in mouse liver","volume":"11","author":"Cretenet","year":"2010","journal-title":"Cell Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"14681","DOI":"10.1016\/S0021-9258(17)36679-6","article-title":"Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression","volume":"269","author":"Lee","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_81","first-page":"4230","article-title":"Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters","volume":"12","author":"Zannini","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1242\/dev.110.2.643","article-title":"Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland","volume":"110","author":"Plachov","year":"1990","journal-title":"Development"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ng0598-83","article-title":"PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis","volume":"19","author":"Macchia","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/PAS.0b013e318216c112","article-title":"A comprehensive analysis of PAX8 expression in human epithelial tumors","volume":"35","author":"Laury","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1042\/cs0430071","article-title":"The 24-hour plasma thyrotrophin profile","volume":"43","author":"Patel","year":"1972","journal-title":"Clin. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0034-5288(18)31253-0","article-title":"Effect of African trypanosomiasis on plasma cortisol and thyroxine concentration in goats","volume":"47","author":"Mutayoba","year":"1989","journal-title":"Res. Vet. Sci."},{"key":"ref_87","unstructured":"Abebe, G. (1991). The Integrity of Hypothalamic-Pituitary-Adrenal Axis in Boran (Bos Indicus) Cattle Infected with Trypanosoma Congolense. [Ph.D. Thesis, Brunel University]."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1210\/en.2002-220741","article-title":"Thyroid hormone regulates hepatic triglyceride mobilization and apolipoprotein B messenger ribonucleic acid editing in a murine model of congenital hypothyroidism","volume":"144","author":"Mukhopadhyay","year":"2003","journal-title":"Endocrinology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/nyas.12374","article-title":"Thyroid hormone signaling in energy homeostasis and energy metabolism","volume":"1311","author":"McAninch","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0005-2760(76)90290-3","article-title":"Effects of the thyroid state on cholesterol metabolism in the rat","volume":"441","author":"Mathe","year":"1976","journal-title":"Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1073\/pnas.70.12.3839","article-title":"Stimulation of hepatic \u03b2-hydroxy-\u03b2-methylglutaryl coenzyme A reductase activity in hypophysectomized rats by L-triiodothyronine","volume":"70","author":"Ness","year":"1973","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/0006-291X(90)91568-D","article-title":"Effect of thyroid hormone on hepatic cholesterol 7\u03b1 hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein AI mRNA levels in hypophysectomized rats","volume":"172","author":"Ness","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbadis.2011.02.014","article-title":"PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation","volume":"1812","author":"Varga","year":"2011","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.1073\/pnas.0406882102","article-title":"The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity","volume":"102","author":"Clouaire","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0968-0004(02)00013-0","article-title":"The THAP domain: A novel protein motif with similarity to the DNA-binding domain of P element transposase","volume":"28","author":"Roussigne","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Zakirova, Z., Fanutza, T., Bonet, J., Readhead, B., Zhang, W., Yi, Z., Beauvais, G., Zwaka, T.P., Ozelius, L.J., and Blitzer, R.D. (2018). Mutations in THAP1\/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007169"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1177\/030098587801500504","article-title":"The pathogenesis of Trypanosoma congolense infection in calves. I. Clinical observations and gross pathological changes","volume":"15","author":"Valli","year":"1978","journal-title":"Vet. Pathol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"190036","DOI":"10.1098\/rsob.190036","article-title":"Tissue tropism in parasitic diseases","volume":"9","author":"Trindade","year":"2019","journal-title":"Open Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/sj.gene.6364345","article-title":"Gene expression profiling in a mouse model for African trypanosomiasis","volume":"7","author":"Kierstein","year":"2006","journal-title":"Genes Immun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3892\/or.2016.5240","article-title":"The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma","volume":"37","author":"Zhao","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Aftab, S., Semenec, L., Chu, J.S.C., and Chen, N. (2008). Identification and characterization of novel human tissue-specific RFX transcription factors. BMC Evol. Biol., 8.","DOI":"10.1186\/1471-2148-8-226"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1128\/MCB.20.10.3364-3376.2000","article-title":"A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y","volume":"20","author":"Villard","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/1074-7613(94)90003-5","article-title":"Thymic selection: Two pathways to life and two to death","volume":"1","author":"Janeway","year":"1994","journal-title":"Immunity"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1242\/dev.113.4.1093","article-title":"The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain","volume":"113","author":"Lazzaro","year":"1991","journal-title":"Development"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"8108","DOI":"10.1074\/jbc.270.14.8108","article-title":"Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells","volume":"270","author":"Ikeda","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1607-551X(09)70214-1","article-title":"Role of TTF-1, CK20, and CK7 immunohistochemistry for diagnosis of primary and secondary lung adenocarcinoma","volume":"22","author":"Su","year":"2006","journal-title":"Kaohsiung J. Med Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1159\/000450973","article-title":"TTF-1 expression in rectal adenocarcinoma: A case report and review of the literature","volume":"9","author":"Belalcazar","year":"2016","journal-title":"Case Rep. Oncol."},{"key":"ref_108","first-page":"6405125","article-title":"TTF1 Expression in Pulmonary Metastatic Rectal Adenocarcinoma","volume":"2018","author":"Aversa","year":"2018","journal-title":"Case Rep. Gastrointest. Med."},{"key":"ref_109","first-page":"4744","article-title":"Expression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasms","volume":"54","author":"Fabbro","year":"1994","journal-title":"Cancer Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0300-9084(99)80086-8","article-title":"Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis","volume":"81","author":"Ros","year":"1999","journal-title":"Biochimie"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1440-1827.2006.01959.x","article-title":"Immunohistochemical analysis of thyroid-specific transcription factors in thyroid tumors","volume":"56","author":"Zhang","year":"2006","journal-title":"Pathol. Int."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tem.2012.05.001","article-title":"PPARs at the crossroads of lipid signaling and inflammation","volume":"23","author":"Wahli","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nri912","article-title":"Emerging roles of PPARs in inflammation and immunity","volume":"2","author":"Daynes","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI14006","article-title":"CD36: A class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism","volume":"108","author":"Febbraio","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","article-title":"PPAR\u03b3 is required for the differentiation of adipose tissue in vivo and in vitro","volume":"4","author":"Rosen","year":"1999","journal-title":"Mol. Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"41245","DOI":"10.1074\/jbc.M103241200","article-title":"The mechanisms by which both heterozygous peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) deficiency and PPAR\u03b3 agonist improve insulin resistance","volume":"276","author":"Yamauchi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"16367","DOI":"10.1038\/s41598-017-16590-0","article-title":"Functional interplay between the transcription factors USF1 and PDX-1 and protein kinase CK2 in pancreatic \u03b2-cells","volume":"7","author":"Spohrer","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1073\/pnas.95.7.3758","article-title":"Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice","volume":"95","author":"Sirito","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1600-0749.2005.00262.x","article-title":"Upstream stimulating factors: Highly versatile stress-responsive transcription factors","volume":"18","author":"Corre","year":"2005","journal-title":"Pigment Cell Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cellsig.2018.09.013","article-title":"USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis","volume":"53","author":"Tan","year":"2019","journal-title":"Cell. Signal."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3389\/fonc.2014.00305","article-title":"Forkhead box transcription factors in cancer initiation, progression and chemotherapeutic drug response","volume":"4","author":"Lam","year":"2014","journal-title":"Front. Oncol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-018-0266-6","article-title":"Regulation of the master regulator FOXM1 in cancer","volume":"16","author":"Liao","year":"2018","journal-title":"Cell Commun. Signal."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.bbagrm.2014.09.016","article-title":"FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance","volume":"1839","author":"Zona","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)-Gene Regul. Mech."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcancer.2017.08.009","article-title":"FoxM1: Repurposing an oncogene as a biomarker","volume":"Volume 52","author":"Nandi","year":"2018","journal-title":"Seminars in Cancer Biology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/dev.02285","article-title":"Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis","volume":"133","author":"Han","year":"2006","journal-title":"Development"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1515\/cclm-2015-0766","article-title":"HAND1 loss-of-function mutation associated with familial dilated cardiomyopathy","volume":"54","author":"Zhou","year":"2016","journal-title":"Clin. Chem. Lab. Med. (CCLM)"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/01.moh.0000160737.52349.aa","article-title":"Hox regulation of normal and leukemic hematopoietic stem cells","volume":"12","author":"Abramovich","year":"2005","journal-title":"Curr. Opin. Hematol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0925-5710(98)00093-0","article-title":"Homeobox genes in normal hematopoiesis and leukemogenesis","volume":"68","author":"Chiba","year":"1998","journal-title":"Int. J. Hematol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/jcp.1115","article-title":"Homeobox genes in normal and malignant cells","volume":"188","author":"Cillo","year":"2001","journal-title":"J. Cell. Physiol."},{"key":"ref_130","first-page":"154","article-title":"The pathophysiology of HOX genes and their role in cancer","volume":"205","author":"Grier","year":"2005","journal-title":"J. Pathol. J. Pathol. Soc. G. B. Irel."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1101\/gad.303123.117","article-title":"Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock","volume":"31","author":"Deschamps","year":"2017","journal-title":"Genes Dev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1387\/ijdb.180206at","article-title":"HOX genes in normal, engineered and malignant hematopoiesis","volume":"62","author":"Collins","year":"2020","journal-title":"Int. J. Dev. Biol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Elias, M.H., Baba, A.A., Husin, A., Sulong, S., Hassan, R., Sim, G.A., Wahid, A., Fadilah, S., and Ankathil, R. (2013). HOXA4 gene promoter hypermethylation as an epigenetic mechanism mediating resistance to imatinib mesylate in chronic myeloid leukemia patients. BioMed Res. Int., 2013.","DOI":"10.1155\/2013\/129715"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.exphem.2008.10.015","article-title":"Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal","volume":"37","author":"Dickson","year":"2009","journal-title":"Exp. Hematol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/cmi.2011.20","article-title":"HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D\/DAP10 signaling pathway","volume":"8","author":"Wu","year":"2011","journal-title":"Cell. Mol. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nature08114","article-title":"The AP-1 transcription factor Batf controls T H 17 differentiation","volume":"460","author":"Schraml","year":"2009","journal-title":"Nature"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00018-008-8335-4","article-title":"The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease","volume":"66","author":"Kumar","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/75490","article-title":"Mice deficient in Six5 develop cataracts: Implications for myotonic dystrophy","volume":"25","author":"Klesert","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bbadis.2014.05.019","article-title":"Myotonic dystrophies: An update on clinical aspects, genetic, pathology, and molecular pathomechanisms","volume":"1852","author":"Meola","year":"2015","journal-title":"Biochim. Et Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.intimp.2018.12.057","article-title":"Knockdown of FOXM1 attenuates inflammatory response in human osteoarthritis chondrocytes","volume":"68","author":"Zeng","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3389\/fimmu.2018.01022","article-title":"Lipid droplet, a key player in host-parasite interactions","volume":"9","author":"Vallochi","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/ejh.12211","article-title":"Small MAF genes variants and chronic myeloid leukemia","volume":"92","year":"2014","journal-title":"Eur. J. Haematol."},{"key":"ref_143","first-page":"470","article-title":"Chronic myeloid leukaemia in central Africans","volume":"80","author":"Mukiihi","year":"2003","journal-title":"East Afr. Med. J."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.molimm.2019.07.029","article-title":"SKI and SMAD4 are essential for IL-21-induced Th17 differentiation","volume":"114","author":"Zhang","year":"2019","journal-title":"Mol. Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1136\/annrheumdis-2015-208953","article-title":"Inhibition of BATF\/JUN transcriptional activity protects against osteoarthritic cartilage destruction","volume":"76","author":"Rhee","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng1732","article-title":"Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes","volume":"38","author":"Grant","year":"2006","journal-title":"Nat. Genet."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"research0030-1","DOI":"10.1186\/gb-2002-3-6-research0030","article-title":"Phylogenetic analysis of the human basic helix-loop-helix proteins","volume":"3","author":"Ledent","year":"2002","journal-title":"Genome Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/humu.20935","article-title":"Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome","volume":"30","author":"Mathieu","year":"2009","journal-title":"Hum. Mutat."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Hrckulak, D., Janeckova, L., Lanikova, L., Kriz, V., Horazna, M., Babosova, O., Vojtechova, M., Galuskova, K., Sloncova, E., and Korinek, V. (2018). Wnt effector tcf4 is dispensable for wnt signaling in human cancer cells. Genes, 9.","DOI":"10.3390\/genes9090439"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Schoof, M., Hellwig, M., Harrison, L., Holdhof, D., Lauffer, M.C., Niesen, J., Virdi, S., Indenbirken, D., and Sch\u00fcller, U. (2020). The basic helix-loop-helix transcription factor TCF4 impacts brain architecture as well as neuronal morphology and differentiation. Eur. J. Neurosci.","DOI":"10.1111\/ejn.14674"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nri2358","article-title":"Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases","volume":"8","author":"Gilliet","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-immunol-031210-101345","article-title":"Plasmacytoid dendritic cells: Recent progress and open questions","volume":"29","author":"Reizis","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1084\/jem.20132522","article-title":"Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus","volume":"211","author":"Sisirak","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4110\/in.2016.16.1.61","article-title":"TCF4-targeting miR-124 is differentially expressed amongst dendritic cell subsets","volume":"16","author":"Han","year":"2016","journal-title":"Immune Netw."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"eaav5599","DOI":"10.1126\/scitranslmed.aav5599","article-title":"Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma","volume":"11","author":"Jain","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1399-0004.2010.01380.x","article-title":"Two percent of patients suspected of having Angelman syndrome have TCF4 mutations","volume":"78","author":"Takano","year":"2010","journal-title":"Clin. Genet."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"eaau4139","DOI":"10.1126\/sciadv.aau4139","article-title":"Deconvolution of Transcriptional Networks Identifies TCF4 as a Master Regulator in Schizophrenia","volume":"5","author":"Torshizi","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/s41380-019-0353-0","article-title":"Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities","volume":"24","author":"Li","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"eaat7615","DOI":"10.1126\/science.aat7615","article-title":"Integrative functional genomic analysis of human brain development and neuropsychiatric risks","volume":"362","author":"Li","year":"2018","journal-title":"Science"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1756-3305-1-3","article-title":"The history of African trypanosomiasis","volume":"1","author":"Steverding","year":"2008","journal-title":"Parasites Vectors"}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/8\/2\/246\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:31:44Z","timestamp":1760175104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/8\/2\/246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,23]]},"references-count":160,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["vaccines8020246"],"URL":"https:\/\/doi.org\/10.3390\/vaccines8020246","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,23]]}}}