{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:07:03Z","timestamp":1792058823484,"version":"4.4.0"},"reference-count":140,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of congenital diseases including microcephaly in newborn and Guillain-Barr\u00e9 syndrome (GBS) in adults. The unprecedented nature of the epidemic and serious diseases associated with the viral infections prompted the global research community to understand the immunopathogenic mechanisms of the virus and rapidly develop safe and efficacious vaccines. This has led to a number of ZIKV vaccine candidates that have shown significant promise in human clinical trials. These candidates include nucleic acid vaccines, inactivated vaccines, viral-vectored vaccines, and attenuated vaccines. Additionally, a number of vaccine candidates have been shown to protect animals in preclinical studies. However, as the epidemic has waned in the last three years, further development of the most promising vaccine candidates faces challenges in clinical efficacy trials, which is needed before a vaccine is brought to licensure. It is important that a coalition of government funding agencies and private sector companies is established to move forward with a safe and effective vaccine ready for deployment when the next ZIKV epidemic occurs.<\/jats:p>","DOI":"10.3390\/vaccines8020266","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T11:49:21Z","timestamp":1591012161000},"page":"266","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Current Status of Zika Virus Vaccines: Successes and Challenges"],"prefix":"10.3390","volume":"8","author":[{"given":"Aryamav","family":"Pattnaik","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA"},{"name":"Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash R.","family":"Sahoo","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA"},{"name":"Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-6787","authenticated-orcid":false,"given":"Asit K.","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA"},{"name":"Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika Virus (I). Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika Virus Outbreak on Yap Island, Federated States of Micronesia","volume":"360","author":"Duffy","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3201\/eid2006.140138","article-title":"Zika Virus, French Polynesia, South Pacific, 2013","volume":"20","author":"Roche","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"O595","DOI":"10.1111\/1469-0691.12707","article-title":"Rapid spread of emerging Zika virus in the Pacific area","volume":"20","author":"Musso","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/0074-02760150192","article-title":"First report of autochthonous transmission of Zika virus in Brazil","volume":"110","author":"Zanluca","year":"2015","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.cell.2018.02.027","article-title":"Genomic Insights into Zika Virus Emergence and Spread","volume":"172","author":"Grubaugh","year":"2018","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.antiviral.2016.03.010","article-title":"Zika virus: History, emergence, biology, and prospects for control","volume":"130","author":"Weaver","year":"2016","journal-title":"Antivir. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature22401","article-title":"Establishment and cryptic transmission of Zika virus in Brazil and the Americas","volume":"546","author":"Faria","year":"2017","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika Virus Associated with Microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika Virus Infection in Pregnant Women in Rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.15585\/mmwr.mm6509e2","article-title":"Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy\u2014Brazil, 2015","volume":"65","author":"Henriques","year":"2016","journal-title":"MMWR. Morb. Mortal. Wkly. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0140-6736(16)00320-2","article-title":"Zika virus and microcephaly: Why is this situation a PHEIC?","volume":"387","author":"Heymann","year":"2016","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1056\/NEJMoa1709481","article-title":"Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas","volume":"378","author":"Hoen","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1128\/CMR.00014-16","article-title":"Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes","volume":"29","author":"Panchaud","year":"2016","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrmicro.2016.125","article-title":"Zika virus\u2014Reigniting the TORCH","volume":"14","author":"Coyne","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"20751","DOI":"10.2807\/1560-7917.ES2014.19.13.20751","article-title":"Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014","volume":"19","author":"Besnard","year":"2014","journal-title":"Eurosurveillance"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13690-017-0233-5","article-title":"Zika virus disease, microcephaly and Guillain-Barr\u00e9 syndrome in Colombia: Epidemiological situation during 21 months of the Zika virus outbreak, 2015\u20132017","volume":"75","author":"Pastrana","year":"2017","journal-title":"Arch. Public Heal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bjid.2018.02.005","article-title":"Prevalence of Guillain-Barr\u00e9 syndrome among Zika virus infected cases: A systematic review and meta-analysis","volume":"22","author":"Barbi","year":"2018","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Styczynski, A.R., Malta, J.M.A.S., Krow-Lucal, E.R., Percio, J., N\u00f3brega, M.E., Vargas, A., Lanzieri, T.M., Leite, P.L., Staples, J.E., and Fischer, M.X. (2017). Increased rates of Guillain-Barr\u00e9 syndrome associated with Zika virus outbreak in the Salvador metropolitan area, Brazil. PLoS Neglected Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005869"},{"key":"ref_20","unstructured":"World Health Organisation (2020, April 20). Emergency Committee on Zika Virus and Observed Increase in Neurological Disorders and Neonatal Malformations. Available online: https:\/\/www.who.int\/news-room\/detail\/01-02-2016-who-statement-on-the-first-meeting-of-the-international-health-regulations-(2005)-(ihr-2005)-emergency-committee-on-zika-virus-and-observed-increase-in-neurological-disorders-and-neonatal-malformations."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3201\/eid1705.101939","article-title":"Probable non-vector-borne transmission of Zika virus, Colorado, USA","volume":"17","author":"Foy","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/S0140-6736(16)30775-9","article-title":"Late sexual transmission of Zika virus related to persistence in the semen","volume":"387","author":"Turmel","year":"2016","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"940","DOI":"10.3201\/eid2205.160107","article-title":"Detection of Zika Virus in Semen","volume":"22","author":"Atkinson","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s13669-016-0171-1","article-title":"The Zika Virus and Pregnancy","volume":"5","author":"Fiorentino","year":"2016","journal-title":"Curr. Obstet. Gynecol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e1402143","DOI":"10.1080\/21688370.2017.1402143","article-title":"Maternal-fetal transmission of the zika virus: An intriguing interplay","volume":"6","author":"Zanluca","year":"2018","journal-title":"Tissue Barriers"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"k4431","DOI":"10.1136\/bmj.k4431","article-title":"Maternal-fetal transmission and adverse perinatal outcomes in pregnant women infected with Zika virus: Prospective cohort study in French Guiana","volume":"363","author":"Pomar","year":"2018","journal-title":"BMJ"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0140-6736(16)30428-7","article-title":"Zika virus: A new challenge for blood transfusion","volume":"387","author":"Musso","year":"2016","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Liu, R., Wang, X., Ma, Y., Wu, J., Mao, C., Yuan, L., and Lu, J. (2019). Prevalence of Zika virus in blood donations: A systematic review and meta-analysis. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-4226-6"},{"key":"ref_29","unstructured":"World Health Organsiation (2020, April 20). Zika Virus. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/zika-virus."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5858\/arpa.2016-0382-RA","article-title":"Zika Virus Infection in Pregnancy, Microcephaly, and Maternal and Fetal Health: What We Think, What We Know, and What We Think We Know","volume":"141","author":"Alvarado","year":"2017","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature20556","article-title":"Zika virus infection damages the testes in mice","volume":"540","author":"Govero","year":"2016","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.cell.2016.11.016","article-title":"Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice","volume":"167","author":"Ma","year":"2016","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Avelino-Silva, V.I., Alvarenga, C., Abreu, C., Tozetto-Mendoza, T.R., Canto, C.L.M.D., Manuli, E.R., Mendes-Correa, M.C., Sabino, E.C., Figueiredo, W.M., and Segurado, A.C. (2018). Potential effect of Zika virus infection on human male fertility?. Rev. Inst. Med. Trop. Sao Paulo, 60.","DOI":"10.1590\/s1678-9946201860064"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41426-018-0096-z","article-title":"ZIKA virus infection causes persistent chorioretinal lesions","volume":"7","author":"Manangeeswaran","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1016\/j.celrep.2016.08.079","article-title":"Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears","volume":"16","author":"Miner","year":"2016","journal-title":"Cell Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.celrep.2016.07.049","article-title":"Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype","volume":"16","author":"Dowd","year":"2016","journal-title":"Cell Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3201\/eid2205.160065","article-title":"Phylogeny of Zika Virus in Western Hemisphere, 2015","volume":"22","author":"Lanciotti","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.aaf5316","article-title":"The 3.8 A resolution cryo-EM structure of Zika virus","volume":"352","author":"Sirohi","year":"2016","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature17994","article-title":"Structure of the thermally stable Zika virus","volume":"533","author":"Kostyuchenko","year":"2016","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S935","DOI":"10.1093\/infdis\/jix515","article-title":"Zika Virus Structure, Maturation, and Receptors","volume":"216","author":"Sirohi","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_41","first-page":"81","article-title":"The Antigenic Structure of Zika Virus and Its Relation to Other Flaviviruses: Implications for Infection and Immunoprophylaxis","volume":"81","author":"Heinz","year":"2017","journal-title":"Microbiol. Mol. Boil. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika Virus Infection in Human Skin Cells","volume":"89","author":"Hamel","year":"2015","journal-title":"J. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embr.201642627","article-title":"Zika virus inhibits type-I interferon production and downstream signaling","volume":"17","author":"Kumar","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A Mouse Model of Zika Virus Pathogenesis","volume":"19","author":"LaZear","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Serman, T., and Gack, M.U. (2019). Evasion of Innate and Intrinsic Antiviral Pathways by the Zika Virus. Viruses, 11.","DOI":"10.3390\/v11100970"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Tripathi, S., Balasubramaniam, V., Brown, J.A., Mena, I., Grant, A., Bardina, S.V., Maringer, K., Schwarz, M.C., Maestre, A.M., and Sourisseau, M. (2017). A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006258"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature20564","article-title":"Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice","volume":"540","author":"Sapparapu","year":"2016","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaf8505","article-title":"Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection","volume":"353","author":"Stettler","year":"2016","journal-title":"Science"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"369ra179","DOI":"10.1126\/scitranslmed.aai8336","article-title":"Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus","volume":"8","author":"Wang","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"14722","DOI":"10.1038\/ncomms14722","article-title":"A human antibody against Zika virus crosslinks the E protein to prevent infection","volume":"8","author":"Hasan","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2017.09.002","article-title":"A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential","volume":"171","author":"Wang","year":"2017","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/ni.3849","article-title":"Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection","volume":"18","author":"Fernandez","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.chom.2016.04.013","article-title":"Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody","volume":"19","author":"Dai","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_54","first-page":"194","article-title":"Human T cell responses to Dengue and Zika virus infection compared to Dengue\/Zika coinfection","volume":"6","author":"Barbosa","year":"2017","journal-title":"Immunity, Inflamm. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e01469-17","DOI":"10.1128\/JVI.01469-17","article-title":"Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans","volume":"91","author":"Grifoni","year":"2017","journal-title":"J. Virol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1038\/ncomms12204","article-title":"A rhesus macaque model of Asian-lineage Zika virus infection","volume":"7","author":"Dudley","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1038\/nm.4206","article-title":"Zika viral dynamics and shedding in rhesus and cynomolgus macaques","volume":"22","author":"Osuna","year":"2016","journal-title":"Nat. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Pardy, R., Rajah, M.M., Condotta, S.A., Taylor, N.G., Sagan, S.M., and Richer, M.J. (2017). Analysis of the T Cell Response to Zika Virus and Identification of a Novel CD8+ T Cell Epitope in Immunocompetent Mice. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006184"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.chom.2016.12.010","article-title":"Mapping and Role of the CD8+ T Cell Response During Primary Zika Virus Infection in Mice","volume":"21","author":"Ngono","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Huang, H., Li, S., Zhang, Y., Han, X., Jia, B., Liu, H., Liu, D., Tan, S., Wang, Q., and Bi, Y. (2017). CD8+ T Cell Immune Response in Immunocompetent Mice during Zika Virus Infection. J. Virol., 91.","DOI":"10.1128\/JVI.00900-17"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1038\/s41467-018-05519-4","article-title":"Critical role of CD4+ T cells and IFN\u03b3 signaling in antibody-mediated resistance to Zika virus infection","volume":"9","author":"Lucas","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e00038-18","DOI":"10.1128\/JVI.00038-18","article-title":"Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice","volume":"92","author":"Scott","year":"2018","journal-title":"J. Virol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"eaax2388","DOI":"10.1126\/sciadv.aax2388","article-title":"NS1 DNA vaccination protects against Zika infection through T cell\u2013mediated immunity in immunocompetent mice","volume":"5","author":"Wijesundara","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.immuni.2017.02.005","article-title":"Prospects for a Zika Virus Vaccine","volume":"46","author":"Barouch","year":"2017","journal-title":"Immunity"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.chom.2018.05.021","article-title":"Zika Virus Vaccine: Progress and Challenges","volume":"24","author":"Shan","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-med-040717-051127","article-title":"Zika Virus Vaccine Development: Progress in the Face of New Challenges","volume":"70","author":"Diamond","year":"2019","journal-title":"Annu. Rev. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1016\/j.mayocp.2019.05.016","article-title":"Zika Vaccine Development: Current Status","volume":"94","author":"Poland","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"ref_68","unstructured":"Tebas, P., Roberts, C.C., Muthumani, K., Reuschel, E.L., Kudchodkar, S., Zaidi, F.I., White, S., Khan, A.S., Racine, T., and Choi, H. (2017). Safety and Immunogenicity of an Anti\u2013Zika Virus DNA Vaccine\u2014Preliminary Report. N. Engl. J. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.aai9137","article-title":"Rapid development of a DNA vaccine for Zika virus","volume":"354","author":"Dowd","year":"2016","journal-title":"Science"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.aah6157","article-title":"Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys","volume":"353","author":"Abbink","year":"2016","journal-title":"Science"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature21428","article-title":"Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination","volume":"543","author":"Pardi","year":"2017","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0140-6736(17)33106-9","article-title":"Preliminary aggregate safety and immunogenicity results from three trials of a purified inactivated Zika virus vaccine candidate: Phase 1, randomised, double-blind, placebo-controlled clinical trials","volume":"391","author":"Modjarrad","year":"2018","journal-title":"Lancet"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0140-6736(17)33105-7","article-title":"Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: Randomised, open-label, phase 1 clinical trials","volume":"391","author":"Gaudinski","year":"2018","journal-title":"Lancet"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/CVI.00131-10","article-title":"Correlates of Protection Induced by Vaccination","volume":"17","author":"Plotkin","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41467-019-09391-8","article-title":"Structure mapping of dengue and Zika viruses reveals functional long-range interactions","volume":"10","author":"Huber","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"13975","DOI":"10.1128\/JVI.78.24.13975-13986.2004","article-title":"Localization and Characterization of Flavivirus Envelope Glycoprotein Cross-Reactive Epitopes","volume":"78","author":"Crill","year":"2004","journal-title":"J. Virol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1128\/JVI.00080-06","article-title":"Cryptic Properties of a Cluster of Dominant Flavivirus Cross-Reactive Antigenic Sites","volume":"80","author":"Stiasny","year":"2006","journal-title":"J. Virol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chom.2010.08.007","article-title":"The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity","volume":"8","author":"Beltramello","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1126\/science.1185181","article-title":"Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans","volume":"328","author":"Dejnirattisai","year":"2010","journal-title":"Science"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ni.3058","article-title":"A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus","volume":"16","author":"Dejnirattisai","year":"2015","journal-title":"Nat. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0065-3527(03)60011-4","article-title":"Neutralization and antibody-dependent enhancement of dengue viruses","volume":"60","author":"Halstead","year":"2003","journal-title":"Adv. Virus Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1073\/pnas.1607931113","article-title":"Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus","volume":"113","author":"Priyamvada","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni.3515","article-title":"Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus","volume":"17","author":"Dejnirattisai","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_84","first-page":"781","article-title":"Dengue Virus-Specific Antibodies Enhance Brazilian Zika Virus Infection","volume":"215","author":"Castanha","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aal4365","article-title":"Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity","volume":"356","author":"Bardina","year":"2017","journal-title":"Science"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/infdis\/jiw377","article-title":"Zika-induced antibody response enhances dengue serotype 2 replication in vitro","volume":"214","author":"Kawiecki","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/cid\/cix558","article-title":"Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus-Infected Patients","volume":"65","author":"Terzian","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41591-019-0746-2","article-title":"Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor","volume":"26","author":"Dussupt","year":"2020","journal-title":"Nat. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature18938","article-title":"Structural basis of potent Zika\u2013dengue virus antibody cross-neutralization","volume":"536","author":"Spaeth","year":"2016","journal-title":"Nature"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"14769","DOI":"10.1038\/s41598-017-15039-8","article-title":"A Zika Vaccine Targeting NS1 Protein Protects Immunocompetent Adult Mice in a Lethal Challenge Model","volume":"7","author":"Brault","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1038\/s41467-018-07008-0","article-title":"Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model","volume":"9","author":"Bailey","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e02861-18","DOI":"10.1128\/mBio.02861-18","article-title":"Antibodies Elicited by an NS1-Based Vaccine Protect Mice against Zika Virus","volume":"10","author":"Bailey","year":"2019","journal-title":"mBio"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/viro.1993.1015","article-title":"The Fc Portion of Antibody to Yellow Fever Virus NS1 Is a Determinant of Protection against YF Encephalitis in Mice","volume":"192","author":"Schlesinger","year":"1993","journal-title":"Virology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1016\/S0264-410X(03)00310-4","article-title":"Evaluation of protective efficacy and immune mechanisms of using a non-structural protein NS1 in DNA vaccine against dengue 2 virus in mice","volume":"21","author":"Wu","year":"2003","journal-title":"Vaccine"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"9551","DOI":"10.1128\/JVI.00879-07","article-title":"Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells","volume":"81","author":"Chung","year":"2007","journal-title":"J. Virol."},{"key":"ref_96","unstructured":"World Health Organisation (2020, April 25). Zika Virus Vaccine Product Development. Available online: https:\/\/www.who.int\/immunization\/research\/development\/zika\/en\/."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e00009-17","DOI":"10.1128\/JVI.00009-17","article-title":"Animal Models of Zika Virus Infection, Pathogenesis, and Immunity","volume":"91","author":"Morrison","year":"2017","journal-title":"J. Virol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-065X.2010.00980.x","article-title":"DNA vaccines: An historical perspective and view to the future","volume":"239","author":"Liu","year":"2010","journal-title":"Immunol. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd.2017.243","article-title":"mRNA vaccines\u2014A new era in vaccinology","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"and Liu, M.A. (2019). A Comparison of Plasmid DNA and mRNA as Vaccine Technologies. Vaccines, 7.","DOI":"10.3390\/vaccines7020037"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nature18952","article-title":"Vaccine protection against Zika virus from Brazil","volume":"536","author":"LaRocca","year":"2016","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/infdis\/jiz338","article-title":"Protective Efficacy of Nucleic Acid Vaccines Against Transmission of Zika Virus During Pregnancy in Mice","volume":"220","author":"Jagger","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"16021","DOI":"10.1038\/npjvaccines.2016.21","article-title":"In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine","volume":"1","author":"Muthumani","year":"2016","journal-title":"npj Vaccines"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"15743","DOI":"10.1038\/ncomms15743","article-title":"DNA vaccination protects mice against Zika virus-induced damage to the testes","volume":"8","author":"Griffin","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.immuni.2005.06.008","article-title":"Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA","volume":"23","author":"Kariko","year":"2005","journal-title":"Immunity"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1038\/mt.2008.200","article-title":"Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability","volume":"16","author":"Kariko","year":"2008","journal-title":"Mol. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2015.08.051","article-title":"N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice","volume":"217","author":"Andries","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2017.03.016","article-title":"Modified mRNA Vaccines Protect against Zika Virus Infection","volume":"169","author":"Richner","year":"2017","journal-title":"Cell"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.06.040","article-title":"Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease","volume":"170","author":"Richner","year":"2017","journal-title":"Cell"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nm.4322","article-title":"A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models","volume":"23","author":"Shan","year":"2017","journal-title":"Nat. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41467-017-00737-8","article-title":"A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage","volume":"8","author":"Shan","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e01348-17","DOI":"10.1128\/JVI.01348-17","article-title":"Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated and Defective in Neuroinvasion","volume":"91","author":"Annamalai","year":"2017","journal-title":"J. Virol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Annamalai, A.S., Pattnaik, A., Sahoo, B.R., Guinn, Z.P., Bullard, B.L., Weaver, E.A., Steffen, D., Natarajan, S.K., Petro, T., and Pattnaik, A.K. (2019). An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse Model. Vaccines, 7.","DOI":"10.3390\/vaccines7030112"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e02134-16","DOI":"10.1128\/mBio.02134-16","article-title":"Understanding Zika Virus Stability and Developing a Chimeric Vaccine through Functional Analysis","volume":"8","author":"Xie","year":"2017","journal-title":"mBio"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41467-018-02975-w","article-title":"Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1128\/JVI.75.16.7290-7304.2001","article-title":"Construction, Safety, and Immunogenicity in Nonhuman Primates of a Chimeric Yellow Fever-Dengue Virus Tetravalent Vaccine","volume":"75","author":"Guirakhoo","year":"2001","journal-title":"J. Virol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1080\/21645515.2018.1445448","article-title":"Safety issues from a Phase 3 clinical trial of a live-attenuated chimeric yellow fever tetravalent dengue vaccine","volume":"14","author":"Halstead","year":"2018","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.4049\/jimmunol.1602180","article-title":"Cutting Edge: Innate Immune Augmenting Vesicular Stomatitis Virus Expressing Zika Virus Proteins Confers Protective Immunity","volume":"198","author":"Betancourt","year":"2017","journal-title":"J. Immunol."},{"key":"ref_119","first-page":"e01485-18","article-title":"A Measles Virus-Based Vaccine Candidate Mediates Protection against Zika Virus in an Allogeneic Mouse Pregnancy Model","volume":"93","author":"Bodmer","year":"2018","journal-title":"J. Virol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/s41467-018-03662-6","article-title":"A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses","volume":"9","author":"Prow","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"eaao4163","DOI":"10.1126\/scitranslmed.aao4163","article-title":"Durability and correlates of vaccine protection against Zika virus in rhesus monkeys","volume":"9","author":"Abbink","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/infdis\/jiy187","article-title":"Immunization With a Novel Human Type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models","volume":"218","author":"Guo","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e01722-17","DOI":"10.1128\/JVI.01722-17","article-title":"Recombinant Chimpanzee Adenovirus Vaccine AdC7-M\/E Protects against Zika Virus Infection and Testis Damage","volume":"92","author":"Xu","year":"2018","journal-title":"J. Virol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"18017","DOI":"10.1038\/s41598-018-35755-z","article-title":"Efficacy of a T Cell-Biased Adenovirus Vector as a Zika Virus Vaccine","volume":"8","author":"Bullard","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.celrep.2019.08.005","article-title":"A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy","volume":"28","author":"Hassan","year":"2019","journal-title":"Cell Rep."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Boigard, H., Alimova, A., Martin, G.R., Katz, A., Gottlieb, P., and Galarza, J.M. (2017). Zika virus-like particle (VLP) based vaccine. PLoS Neglected Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005608"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s12250-018-0030-5","article-title":"Zika Virus Baculovirus-Expressed Virus-Like Particles Induce Neutralizing Antibodies in Mice","volume":"33","author":"Dai","year":"2018","journal-title":"Virol. Sin."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ebiom.2017.12.010","article-title":"Passive Transfer of Immune Sera Induced by a Zika Virus-Like Particle Vaccine Protects AG129 Mice Against Lethal Zika Virus Challenge","volume":"27","author":"Espinosa","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1038\/s41598-020-61103-1","article-title":"Virus Like Particles (VLP) as multivalent vaccine candidate against Chikungunya, Japanese Encephalitis, Yellow Fever and Zika Virus","volume":"10","author":"Garg","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/s41590-019-0477-z","article-title":"A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection","volume":"20","author":"Dejnirattisai","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1038\/s41467-019-12677-6","article-title":"Oligomeric state of the ZIKV E protein defines protective immune responses","volume":"10","author":"Metz","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1016\/j.vaccine.2017.04.052","article-title":"Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus","volume":"35","author":"Yang","year":"2017","journal-title":"Vaccine"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e02187-18","DOI":"10.1128\/JVI.02187-18","article-title":"Rational Design of Zika Virus Subunit Vaccine with Enhanced Efficacy","volume":"93","author":"Tai","year":"2019","journal-title":"J. Virol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Cabral-Miranda, G., Lim, S.M., Mohsen, M.O., Pobelov, I.V., Roesti, E.S., Heath, M.D., Skinner, M.A., Kramer, M.F., Martina, B.E.E., and Bachmann, M.F. (2019). Zika Virus-Derived E-DIII Protein Displayed on Immunologically Optimized VLPs Induces Neutralizing Antibodies without Causing Enhancement of Dengue Virus Infection. Vaccines, 7.","DOI":"10.3390\/vaccines7030072"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13073-015-0245-0","article-title":"Immunoinformatics and epitope prediction in the age of genomic medicine","volume":"7","author":"Backert","year":"2015","journal-title":"Genome Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"37313","DOI":"10.1038\/srep37313","article-title":"Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins","volume":"6","author":"Mirza","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3389\/fimmu.2017.00640","article-title":"An Approach for a Synthetic CTL Vaccine Design against Zika Flavivirus Using Class I and Class II Epitopes Identified by Computer Modeling","volume":"8","author":"Rosa","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"100506","DOI":"10.1016\/j.nmni.2019.01.002","article-title":"Identification of relevant regions on structural and nonstructural proteins of Zika virus for vaccine and diagnostic test development: An in silico approach","volume":"29","author":"Salvador","year":"2019","journal-title":"New Microbes New Infect."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"104199","DOI":"10.1016\/j.meegid.2020.104199","article-title":"Immunoinformatics guided rational design of a next generation multi epitope based peptide (MEBP) vaccine by exploring Zika virus proteome","volume":"80","author":"Shahid","year":"2020","journal-title":"Infect. Genet. Evol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.vaccine.2018.12.040","article-title":"Demonstrating vaccine effectiveness during a waning epidemic: A WHO\/NIH meeting report on approaches to development and licensure of Zika vaccine candidates","volume":"37","author":"Vannice","year":"2019","journal-title":"Vaccine"}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/8\/2\/266\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:34:14Z","timestamp":1760175254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/8\/2\/266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,31]]},"references-count":140,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["vaccines8020266"],"URL":"https:\/\/doi.org\/10.3390\/vaccines8020266","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,31]]}}}