{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:54:27Z","timestamp":1765486467390,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>The safe and secure containment of infectious poliovirus (PV) in facilities where live PV are handled is the condition to achieve and maintain poliomyelitis eradication. Despite precautions to minimize the risk of release of PV from such facilities to the environment, breaches of containment have already been documented. Here, we report the management of an incident that occurred on 30 November 2018 in a French vaccine manufacturing plant. Five adequately vaccinated operators were exposed to a Sabin poliovirus type 3 (PV3) spill. A microbiological risk assessment was conducted and the operators were monitored for PV shedding. On day 5 after exposure, Sabin PV3 was detected only in the stool sample of the most exposed worker. Shedding of Sabin PV3 (as detected by viral culture) was restricted to a very short period (less than 15 days). Monitoring of this incident was an opportunity to assess the relevance of our national response plan. We concluded that the measures undertaken and reported here were appropriate and proportional.<\/jats:p>","DOI":"10.3390\/vaccines8020331","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T06:11:02Z","timestamp":1592892662000},"page":"331","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk Assessment and Virological Monitoring Following an Accidental Exposure to Concentrated Sabin Poliovirus Type 3 in France, November 2018"],"prefix":"10.3390","volume":"8","author":[{"given":"Marion","family":"Jeanno\u00ebl","sequence":"first","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Ent\u00e9rovirus et Parechovirus, WHO National Poliovirus Laboratory, Institut des Agents Infectieux, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69317 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Antona","sequence":"additional","affiliation":[{"name":"Sant\u00e9 publique France, 94410 Saint Maurice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Public Health Emergency Operations Centre, Division of Surveillance and Health Security, General Directorate for Health, Ministry of Solidarity and Health, 75350 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8959-2123","authenticated-orcid":false,"given":"Bruno","family":"Lina","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Ent\u00e9rovirus et Parechovirus, WHO National Poliovirus Laboratory, Institut des Agents Infectieux, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69317 Lyon, France"},{"name":"Laboratoire Virpath, Centre International de Recherche en Infectiologie (CIRI), Universit\u00e9 de Lyon, Inserm U1111, CNRS UMR 5308, ENS de Lyon, UCBL, 69372 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Schuffenecker","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Ent\u00e9rovirus et Parechovirus, WHO National Poliovirus Laboratory, Institut des Agents Infectieux, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69317 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"ref_1","unstructured":"(2020, June 08). 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Available online: https:\/\/www.santepubliquefrance.fr\/determinants-de-sante\/vaccination\/donnees-de-couverture-vaccinale-diphterie-tetanos-poliomyelite-coqueluche-par-groupe-d-age."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/infdis\/jiq140","article-title":"Outbreak of Type 2 Vaccine-Derived Poliovirus in Nigeria: Emergence and Widespread Circulation in an Underimmunized Population","volume":"203","author":"Wassilak","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_14","unstructured":"World Health Organization (2019). Public Health Management of Facility Related Exposure to Live Polioviruses, World Health Organization."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/8\/2\/331\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:41:11Z","timestamp":1760175671000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/8\/2\/331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["vaccines8020331"],"URL":"https:\/\/doi.org\/10.3390\/vaccines8020331","relation":{},"ISSN":["2076-393X"],"issn-type":[{"type":"electronic","value":"2076-393X"}],"subject":[],"published":{"date-parts":[[2020,6,22]]}}}