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The high diversity of viral envelope proteins permits viruses to escape host immunity. Therefore, the development of a universal vaccine and broadly neutralizing antibodies (bnAbs) is essential for controlling various mutant viruses. Here, we review some potentially valuable bnAbs for influenza; one is a novel passive immunotherapy using a variable domain of heavy chain-only antibody (VHH), and the other is polymeric immunoglobulin A (pIgA) induced by intranasal vaccination. Recently, it was reported that a tetravalent multidomain antibody (MDAb) was developed by genetic fusion of four VHHs, which are bnAbs against the influenza A or B viruses. The transfer of a gene encoding the MDAb\u2013Fc fusion protein provided cross-protection against both influenza A and B viruses in vivo. An intranasal universal influenza vaccine, which can induce neutralizing pIgAs in the upper respiratory tract, is currently undergoing clinical studies. A recent study has revealed that tetrameric IgAs formed in nasal mucosa are more broadly protective against influenza than the monomeric and dimeric forms. These broadly neutralizing antibodies have high potential to control the currently circulating influenza virus.<\/jats:p>","DOI":"10.3390\/vaccines8030424","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T03:36:38Z","timestamp":1596080198000},"page":"424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Broadly Neutralizing Antibodies for Influenza: Passive Immunotherapy and Intranasal Vaccination"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-914X","authenticated-orcid":false,"given":"Mrityunjoy","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Aichi Medical University, Aichi 480-1195, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-6490","authenticated-orcid":false,"given":"Tatsuya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Aichi Medical University, Aichi 480-1195, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, Tokyo University of Science, Tokyo 125-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-3172","authenticated-orcid":false,"given":"Sachiko","family":"Akashi-Takamura","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, Aichi Medical University, Aichi 480-1195, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0033354916681490","article-title":"Fifty Years of Global Immunization at CDC, 1966-2015","volume":"132","author":"Mast","year":"2017","journal-title":"Public Health Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1126\/science.aah5869","article-title":"Generation of influenza A viruses as live but replication-incompetent virus vaccines","volume":"354","author":"Si","year":"2016","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"20748","DOI":"10.1073\/pnas.1113801108","article-title":"Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses","volume":"108","author":"Sandbulte","year":"2011","journal-title":"Proc. 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