{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:58:12Z","timestamp":1793757492881,"version":"4.6.1"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Seronegative women are susceptible to primary rubella virus (RV) infection during pregnancy, which can cause fetal damage. Vaccination represents the main strategy in rubella prevention. The aim of this study was to analyze changes in the rubella seroprevalence and identify populations with a high susceptibility to RV. A cross-sectional study was performed on 6914 Caucasian fertile women who had Toxoplasma gondii, other viruses, Rubella, Cytomegalovirus, and the herpes simplex virus (TORCH) screening in two distinct periods\u20141452 at the Timi\u0219oara Municipal Hospital, Romania (Group 1: 2008\u20132010) and 5462 at the laboratory Bioclinica S.A., Timi\u0219oara, Romania (Group 2: 2015\u20132018). The RV seroprevalence decreased (Group 1 versus Group 2; 94.1% (92.7\u201395.2) versus 91.4% (90.6\u201392.1), OR = 0.76 (p = 0.0007)). According to the year of birth and eligibility to vaccination program, RV seroprevalence rates were 82.4% (76.8\u201386.8)\/1997\u20132004, 85.4% (80.5\u201389.3)\/1995\u20131996, 90.1% (89.0\u201391.1)\/&lt;1989, and 95.8% (94.7\u201396.6)\/1989\u20131994. No significant difference in the RV seropositivity according to the place of residence was found. The overall RV susceptibility increased from 2008\u20132010 to 2015\u20132018. The highest susceptibility was found in women born between 1997\u20132004 eligible for measles-mumps-rubella (MMR) vaccine through the family practice system and the lowest in women born between 1989\u20131994 eligible for monovalent rubella vaccine conducted in schools.<\/jats:p>","DOI":"10.3390\/vaccines9020104","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T09:25:22Z","timestamp":1611912322000},"page":"104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence of Rubella Antibodies among Fertile Women in the West of Romania, 18 Years after the Implementation of Immunization"],"prefix":"10.3390","volume":"9","author":[{"given":"Florin","family":"Gorun","sequence":"first","affiliation":[{"name":"Department of Obstetrics-Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square nr. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Malita","sequence":"additional","affiliation":[{"name":"Department of Radiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square nr. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Ciohat","sequence":"additional","affiliation":[{"name":"Laboratory of Antenatal Medicine, City Unversitary Emergency Hospital Timisoara, str. Odobescu, nr. 1-3, 300202 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1877-5547","authenticated-orcid":false,"given":"Tatjana","family":"Vilibic-Cavlek","sequence":"additional","affiliation":[{"name":"Department of Virology, Croatian Institute of Public Health, Rockefeller str. 12, 10000 Zagreb, Croatia"},{"name":"School of Medicine, University of Zagreb, Salata 3, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horea","family":"Feier","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square nr. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2518-522X","authenticated-orcid":false,"given":"Irena","family":"Tabain","sequence":"additional","affiliation":[{"name":"Department of Virology, Croatian Institute of Public Health, Rockefeller str. 12, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Craina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics-Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square nr. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian","family":"Cretu","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square nr. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Navolan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics-Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square nr. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/S0140-6736(14)60539-0","article-title":"Rubella","volume":"385","author":"Lambert","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/pd.4467","article-title":"Rubella and pregnancy: Diagnosis, management and outcomes","volume":"34","author":"Bouthry","year":"2014","journal-title":"Prenat. 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