{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:53:13Z","timestamp":1760233993736,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H04027"],"award-info":[{"award-number":["JP20H04027"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>The number of rubella cases has increased in Japan, especially among adults. Rubella infection in pregnant females can lead to congenital rubella syndrome (CRS). The Japanese government is promoting vaccination to prevent CRS. This study performs a cost-effectiveness analysis of the following four methods: (1) females who wished to become pregnant and partners, with an antibody-titer test; (2) females only, with an antibody-titer test; (3) females and males, without an antibody-titer test; (4) females only, without an antibody-titer test. A decision tree model with a hypothetical cohort of 500 males and 500 females was used for the analysis, and the parameters were obtained from previous studies. The number of avoidances of CRS was defined as the effect. Compared to the case where methods were not implemented, the number of CRS cases that can be prevented by implementing the methods was 0.0115589 by (1) and (3) and 0.0147891 by (2) and (4). The cost effectiveness of (1) to (4) was 287,413,677 JPY, 135,050,529 JPY, 388,524,974 JPY, and 197,744,219 JPY, respectively (1 JPY = 0.00963247 USD). Method (2) was the most cost-effective and did not change by sensitivity analysis. We conclude that the vaccination for females only with an antibody-titer test is recommended.<\/jats:p>","DOI":"10.3390\/vaccines9030233","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T23:04:39Z","timestamp":1615244679000},"page":"233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Model Comparisons of the Cost Effectiveness of Rubella Vaccination Method in Japanese Adults"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-2909","authenticated-orcid":false,"given":"Tomoya","family":"Itatani","sequence":"first","affiliation":[{"name":"Division of Nursing, Faculty of Health Science Institute of Medical, Pharmaceutical and Health Science Kanazawa University, Kanazawa 920-0942, Ishikawa Prefecture, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Horiike","sequence":"additional","affiliation":[{"name":"Susaki Regional Welfare and Health Center, Kochi 785-8585, Kochi Prefecture, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Nakai","sequence":"additional","affiliation":[{"name":"Nursing Department, Kanazawa Medical University, Uchinada 920-0265, Ishikawa Prefecture, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Kyoto Prefecture, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Honda","sequence":"additional","affiliation":[{"name":"Center for Twin Research, Osaka University Graduate School of Medicine, Suita 565-0871, Osaka Prefecture, Japan"},{"name":"Faculty of Nursing, Shiga University of Medical Science, Otsu 520-2192, Shiga Prefecture, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumie","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Nursing, Morinomiya University of Medical Sciences, Osaka 559-8611, Osaka Prefecture, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Konishi","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita 565-0871, Osaka Prefecture, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"ref_1","unstructured":"National Institute of Infectious Diseases (2020, December 29). 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