{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:14:14Z","timestamp":1787030054756,"version":"build-2736575974"},"reference-count":9,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"HAV Vaccines Ltd","award":["HAV001"],"award-info":[{"award-number":["HAV001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses.<\/jats:p>","DOI":"10.3390\/vaccines9030262","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T02:50:58Z","timestamp":1615863058000},"page":"262","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-0240","authenticated-orcid":false,"given":"Pedro M.","family":"Folegatti","sequence":"first","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6460-1372","authenticated-orcid":false,"given":"Amy","family":"Flaxman","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3088-310X","authenticated-orcid":false,"given":"Daniel","family":"Jenkin","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Makinson","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7891-6359","authenticated-orcid":false,"given":"Lucy","family":"Kingham-Page","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-0032","authenticated-orcid":false,"given":"Duncan","family":"Bellamy","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-7879","authenticated-orcid":false,"given":"Fernando","family":"Ramos Lopez","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6806-2609","authenticated-orcid":false,"given":"Jonathan","family":"Sheridan","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Poulton","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Aboagye","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Tran","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Mitton","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Roberts","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Lawrie","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0900-9629","authenticated-orcid":false,"given":"Adrian V. S.","family":"Hill","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-9836","authenticated-orcid":false,"given":"Katie J.","family":"Ewer","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-9750","authenticated-orcid":false,"given":"Sarah","family":"Gilbert","sequence":"additional","affiliation":[{"name":"The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fimmu.2015.00096","article-title":"Mycobacterium avium ss. paratuberculosis Zoonosis\u2014The Hundred Year War\u2014Beyond Crohn\u2019s Disease","volume":"6","author":"Sechi","year":"2015","journal-title":"Front. 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