{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:08:55Z","timestamp":1791234535866,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["N\u00b0 SYNERGIE RE00001902"],"award-info":[{"award-number":["N\u00b0 SYNERGIE RE00001902"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["N\u00b0 SYNERGIE RE00001902"],"award-info":[{"award-number":["N\u00b0 SYNERGIE RE00001902"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INSERM-TRANSFERT","award":["CoPoC N\u00b0 MAT-16225-A-02"],"award-info":[{"award-number":["CoPoC N\u00b0 MAT-16225-A-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>The neurological complications of infection by the mosquito-borne Zika virus (ZIKV) include Guillain\u2013Barr\u00e9 syndrome (GBS), an acute inflammatory demyelinating polyneuritis. GBS was first associated with recent ZIKV epidemics caused by the emergence of the ZIKV Asian lineage in South Pacific. Here, we hypothesize that ZIKV-associated GBS relates to a molecular mimicry between viral envelope E (E) protein and neural proteins involved in GBS. The analysis of the ZIKV epidemic strains showed that the glycan loop (GL) region of the E protein includes an IVNDT motif which is conserved in voltage-dependent L-type calcium channel subunit alpha-1C (Cav1.2) and Heat Shock 70 kDa protein 12A (HSP70 12A). Both VSCC-alpha 1C and HSP70 12A belong to protein families which have been associated with neurological autoimmune diseases in central nervous system. The purpose of our in silico analysis is to point out that IVNDT motif of ZIKV E-GL region should be taken in consideration for the development of safe and effective anti-Zika vaccines by precluding the possibility of adverse neurologic events including autoimmune diseases such as GBS through a potent mimicry with Heat Shock 70 kDa protein 12A (HSP70 12A).<\/jats:p>","DOI":"10.3390\/vaccines9030283","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T23:47:41Z","timestamp":1616370461000},"page":"283","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Zika E Glycan Loop Region and Guillain\u2013Barr\u00e9 Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9664-3486","authenticated-orcid":false,"given":"Gr\u00e9gorie","family":"Lebeau","sequence":"first","affiliation":[{"name":"Processus Infectieux en Milieu Insulaire et Tropical (PIMIT), Universit\u00e9 de La R\u00e9union 1, La R\u00e9union, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-7737","authenticated-orcid":false,"given":"Etienne","family":"Frumence","sequence":"additional","affiliation":[{"name":"Processus Infectieux en Milieu Insulaire et Tropical (PIMIT), Universit\u00e9 de La R\u00e9union 1, La R\u00e9union, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-345X","authenticated-orcid":false,"given":"Jonathan","family":"Turpin","sequence":"additional","affiliation":[{"name":"Processus Infectieux en Milieu Insulaire et Tropical (PIMIT), Universit\u00e9 de La R\u00e9union 1, La R\u00e9union, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floran","family":"Begue","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de La R\u00e9union, INSERM, UMR 1188 Diab\u00e8te ath\u00e9rothombose R\u00e9union Oc\u00e9an Indien (D\u00e9TROI), 97490 Saint-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-2018","authenticated-orcid":false,"given":"Jean-Jacques","family":"Hoarau","sequence":"additional","affiliation":[{"name":"Processus Infectieux en Milieu Insulaire et Tropical (PIMIT), Universit\u00e9 de La R\u00e9union 1, La R\u00e9union, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-4866","authenticated-orcid":false,"given":"Gilles","family":"Gadea","sequence":"additional","affiliation":[{"name":"Processus Infectieux en Milieu Insulaire et Tropical (PIMIT), Universit\u00e9 de La R\u00e9union 1, La R\u00e9union, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-1716","authenticated-orcid":false,"given":"Pascale","family":"Krejbich-Trotot","sequence":"additional","affiliation":[{"name":"Processus Infectieux en Milieu Insulaire et Tropical (PIMIT), Universit\u00e9 de La R\u00e9union 1, La R\u00e9union, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-4050","authenticated-orcid":false,"given":"Philippe","family":"Despr\u00e8s","sequence":"additional","affiliation":[{"name":"Processus Infectieux en Milieu Insulaire et Tropical (PIMIT), Universit\u00e9 de La R\u00e9union 1, La R\u00e9union, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-8635","authenticated-orcid":false,"given":"Wildriss","family":"Viranaicken","sequence":"additional","affiliation":[{"name":"Processus Infectieux en Milieu Insulaire et Tropical (PIMIT), Universit\u00e9 de La R\u00e9union 1, La R\u00e9union, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0188-4409(02)00378-8","article-title":"The Global Emergence\/Resurgence of Arboviral Diseases as Public Health Problems","volume":"33","author":"Gubler","year":"2002","journal-title":"Arch. 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